Clinical trials: Platelet Rich Fibrin
Non-surgical Periodontal Therapy
PRF + Minocycline vs Arestin in Non-surgical Perio Therapy
Periodontitis is a chronic, biofilm-modulated inflammatory disease characterized by microbial dysbiosis and a dysregulated host immune response, eventually resulting in the gradual breakdown of the periodontal attachment…
- Trial name
- NCT07437209
- Testing
- Arestin, PRF + M
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Center for Advanced Rejuvenation and Esthetics
Platelet-Rich Fibrin
Effects of i-PRF on Non-surgical Periodontal Treatment
Injectable platelet-rich fibrin, a platelet concentrate in a liquid formulation, has been developed to provide clinicians with ease of use alone or in combination with various biomaterials.
- Trial name
- NCT05753631
- Testing
- non surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Pamukkale University
Osteoradionecrosis of the Jaw
Platelet-Rich Fibrin for Preventing Osteoradionecrosis After Dental Extractions
The goal of this clinical trial is to learn whether platelet-rich fibrin (PRF) can help prevent osteoradionecrosis (ORN) after dental extractions in adults who previously received radiation therapy to the head and neck.
- Trial name
- NCT07856875
- Testing
- Platelet-rich fibrin (PRF), Standard Dental Extraction Care
- Where
- 2 sites in Canada
- Volunteers
- 112 people
- Sponsor
- University of Manitoba
Platelet-Rich Fibrin
Titanium-prepared Platelet-rich Fibrin in Periodontal Regeneration
In this study, the possible effect of blood group distribution on the content of blood biomaterial was investigated. 64 volunteers were included in the study. Various parameters were evaluated.
- Trial name
- NCT05409495
- Testing
- periodontal surgical procedure (open flap debridement), periodontal surgical procedure (OFD +autogenous Titanium-prepared platelet-rich fibrin (OFD+ T-PRF))
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Tooth Extraction
Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation
This study evaluated the effectiveness of socket grafting material, combination of plate-rich fibrin and calcium sulfate. 5 subjects were grafted with this material, 5 subjects were grafted with combination of plate-rich fibrin…
- Trial name
- NCT03851289
- Testing
- platelet-rich fibrin and calcium sulfate, platelet-rich fibrin and xenograft
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Maxillary Sinus
Comparison Between PEEK With Platelet-rich Fibrin and PEEK Alone in Maxillary Sinus Augmentation
comparison between the resulted bone during maxillary sinus elevation by PEEK with and without platelet rich fibrin
- Trial name
- NCT06376708
- Testing
- platelet rich fibrin, Polyether ether ketone
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Alveolar Cleft
Xenografts With Platelet-rich Fibrin Versus Autogenous Bone in Alveolar Cleft Grafting
this work aims to evaluate xenografts mixed with PRF versus autogenous bone graft in alveolar cleft grafting.
- Trial name
- NCT04693741
- Testing
- secondary alveolar bone graft, Harvesting of the autogenous bone graft, Preparation of PRP
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetic Foot Ulcer (DFU), Ulcer
Evaluating Autologous Platelet-Rich Fibrin Plasma for Chronic Diabetic Foot Ulcers
To prospectively evaluate the safety and efficacy of an Autologous Platelet-Rich Fibrin Plasma system when applied in conjunction with Standard of Care for management of chronic Diabetic Foot Ulcers.
- Conditions
- Diabetic Foot Ulcer (DFU), Ulcer, Wound Closure, Wound Management
- Trial name
- NCT07840378
- Testing
- PRFM, Standard of Care (SoC)
- Volunteers
- 55 people
- Sponsor
- Tiger Biosciences, LLC.
Thin Peri-implant Mucosal Phenotype
Peri-implant Soft Tissue Augmentation Using Microneedling With i-PRF vs. Connective Tissue Graft
This randomized controlled clinical trial aims to evaluate a minimally invasive technique for peri-implant soft tissue augmentation using microneedling combined with injectable platelet-rich fibrin (i-PRF) compared with the…
- Trial name
- NCT07667855
- Testing
- Connective Tissue Graft (CTG), Microneedling with Injectable Platelet-Rich Fibrin (MN+i-PRF)
- Where
- Lebanon
- Volunteers
- 24 people
- Sponsor
- Beirut Arab University
Periodontal Pockets
Evaluation of Adjunctive Injectable PRF Therapy Used in Conjunction With Scaling and Root Planning
Clinical evaluation of local administration of injectable PRF (injectable platelet-rich fibrin) in periodontal pockets as adjunctive therapy to scaling and root planing.
- Trial name
- NCT03839849
- Testing
- : i-PRF, saline
- Where
- Syria
- Volunteers
- 15 people
- Sponsor
- Syrian Private University
Anal Fistula, Minimal Invasive Surgery
Treatment of Anal Fistulas With Obsidian RFT®
The study conducted a retrospective analysis from January 2018 to December 2022 on patients who received anal fistula closure with Obsidian RTF® at the Department of General Surgery, Medical University of Vienna.
- Conditions
- Anal Fistula, Minimal Invasive Surgery, Platelet-rich Fibrin Foam
- Trial name
- NCT06136325
- Testing
- Obsidian RFP anal fistula surgery
- Where
- Austria
- Volunteers
- 18 people
- Sponsor
- Medical University of Vienna
Facial Nerve Injuries, Facial Trauma
Neurorrhaphy Only vs Neurorrhaphy Plus PRF vs Neurorrhaphy Plus Nano-fat in Management of Traumatic Facial Nerve Injury
The current clinical trial aims to identify the most significant intervention that improves the outcome of post-traumatic facial nerve injury by comparing the following different modalities: neurorrhaphy alone, neurorrhaphy with…
- Trial name
- facialinjury (NCT06977607)
- Testing
- Platelets Rich Fibrin, Nano-fat stem cells (NFSCs), Repair only
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Assiut University
Periodontal Diseases, Periodontal Attachment Loss
Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects
The aim of the present study is to clinically and radiographically compare the efficacy of recombinant human platelet-derived growth factor (rhPDGF), Leukocyte-Platelet Rich Fibrin (L-PRF) and Enamel Matrix Derivatives (EMD) in…
- Conditions
- Periodontal Diseases, Periodontal Attachment Loss, Pocket, Periodontal, Intrabony Periodontal Defect
- Trial name
- NCT05858411
- Testing
- SRP+rhPDGF, SRP+L-PRF, MINST alone
- Where
- Albania
- Volunteers
- 88 people
- Sponsor
- G. d'Annunzio University
Immediate Implant With Bone Graft
Immediate Implant in Posterior Mandible Region
This study aims to evaluate implant stability and Width bone after placement of immediate implant and Xenograft mixed with Hyaluronic acid or with Platelet-Rich Fibrin (PRF) at posterior mandible region
- Trial name
- NCT07027904
- Testing
- Implant
- Volunteers
- 24 people
- Sponsor
- WASIM MHD JEHAD HALABI
Insufficient Keratinized Gingiva
Evaluation of the Effectiveness of Different Procedures on Palatinal Wound Healing After Free Gingival Graft Surgery.
This study aimed to help determine the appropriate method to accelerate wound healing at the free gingival graft donor site and to minimize the patient's postoperative complaints.
- Trial name
- NCT06867055
- Testing
- Injectable platelet-rich fibrin (I-PRF), 0.8% hyaluronic acide (HA), control group
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- SEVAL CEYLAN ŞEN
Odontogenic Cyst, Jaw Cysts
Bone Regeneration Using PRF After Cyst Enucleation
This randomized controlled clinical trial aims to evaluate the clinical efficacy of autologous platelet-rich fibrin (PRF) in promoting osseous regeneration following cystic enucleation in the jaws.
- Conditions
- Odontogenic Cyst, Jaw Cysts, Osseous Defect After Cyst Enucleation
- Trial name
- PRF-Bone (NCT07424716)
- Testing
- Autologous Platelet-Rich Fibrin (PRF), Conventional Surgical Management
- Where
- Yemen
- Volunteers
- 20 people
- Sponsor
- Sana'a University
Periodontitis, Smokers
This a Clinical Trial to Evaluate the Efficacy of I-PRF, Povidone-Iodine and Laser as Adjuncts to Non-surgical Periodontal Treatment in Smokers and Non-Smokers Periodontitis Patients
This study is a randomized, controlled, split-mouth clinical trial designed to evaluate and compare the effectiveness of four different subgingival adjuncts used along side standard Scaling and Root Planning (SRP).
- Conditions
- Periodontitis, Smokers, Non Smokers, Periodontal Disease
- Trial name
- NCT07707063
- Testing
- Injectable Platelet-Rich Fibrin (I-PRF), Diode Laser Activation, Povidone-Iodine Irrigation (1%)
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- Military Hospital of Tunis
Chronic Periodontitis, Bone Loss
Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).
The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis…
- Conditions
- Chronic Periodontitis, Bone Loss, Intrabony Periodontal Defect
- Trial name
- NCT04767243
- Testing
- open flap debridement and filled with A-PRF ( Advanced platelet rich fibrin), open flap debridement and filled with Bioactive glass (Perioglas®), open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Impacted Mandibular Third Molar Extraction
Effect of Titanium-Prepared Platelet-Rich Fibrin and Low-Level Laser Therapy on Postoperative Morbidity After Mandibular Third Molar Surgery
This randomized double-blind clinical trial aims to evaluate the effects of titanium-prepared platelet-rich fibrin (T-PRF), low-level laser therapy (LLLT), and their combination on postoperative outcomes following surgical…
- Trial name
- NCT07748585
- Testing
- Titanium-Prepared Platelet-Rich Fibrin (T-PRF), Low-Level Laser Therapy (LLLT)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cyprus Health and Social Sciences University
Dental Implants, Tooth Extraction
Bovine-derived Xenograft With or Without L-PRF for Alveolar Ridge Preservation After Tooth Extraction: a Randomized Controlled Trial
The study is prospective randomized clinical trial that aims to evaluate the adjunctive use of L-PRF in promoting the desired vascularization and bone fill in small and large defects following tooth extraction and report on the…
- Conditions
- Dental Implants, Tooth Extraction, Bone Regeneration
- Trial name
- NCT06172114
- Testing
- Alveolar ridge preservation using sticky bone
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mohammed Bin Rashid University of Medicine and Health Sciences