Clinical trials: Platelet Survival
Glioblastoma, Glioma
Development of Therapeutic Approaches Modulating Molecular Targets Implicated on Cancer Stem Cell-related Aggressiveness
Tumors of the central nervous system affect 21 people per 100,000 every year, a figure that refers to countries with advanced economies, with an increase in incidence over time.
- Conditions
- Glioblastoma, Glioma, Glioma Glioblastoma Multiforme
- Trial name
- NCT06348693
- Testing
- cell isolation from tumor biopsies and biomarker investigation
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Advanced Epithelial Ovarian Cancer
Comparison of Weekly Versus Every Three Weeks of Carboplatin Plus Paclitaxel in Patients With Advanced Epithelial Ovarian Cancer
The aim of the current study is to compare weekly versus three-week collective of carboplatin/paclitaxel in advanced epithelial ovarian cancer.
- Trial name
- NCT05963334
- Testing
- Carboplatin/paclitaxel
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Cairo University
Healthy
A Controlled, In Vivo, Pilot Study to Assess the Recovery and Survival of Radiolabeled Autologous INTERCEPT Treated 7-Day Stored Apheresis Platelet Components in 35% Plasma and 65% InterSol and 7-Day Stored Apheresis Platelet Components in 100% Plasma
The objective of this study is to test the hypothesis that INTERCEPT platelet components stored for 7 days retain sufficient viability for therapeutic efficacy.
- Trial name
- NCT02310412
- Testing
- INTERCEPT treated platelets
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cerus Corporation
Pancreatic Neoplasms, Pancreas Cancer
The Effect of Albumin Value, HALP Score, and LCR Value on Predicting Survival and Recurrence in Patients With Pancreatic Adenocarcinoma
The aim of this study is to investigate whether the albumin value and the ratios of biochemical markers; hemoglobin, albumin, lymphocyte and platelet (HALP score) and lymphocyte-C-reactive protein ratio (LCR) can predict the…
- Trial name
- NCT06553040
- Volunteers
- 87 people
- Sponsor
- Ege University
Healthy
In Vivo Study to Assess the Recovery and Survival of Radiolabeled Autologous INTERCEPT Apheresis Platelet Components Suspended in 100% Plasma Stored for up to 7 Days
The principle objective of this study is to evaluate the hypothesis that INTERCEPT Platelets in 100% plasma stored for 5 or more days (up to 7 days) after apheresis collection retain sufficient viability for therapeutic…
- Trial name
- NCT04022889
- Testing
- INTERCEPT Treated Platelets
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Cerus Corporation
Healthy Volunteers
In Vivo Recovery and Survival Study of Platelets Collected on Trima Accel System and Stored in InterSol Solution
The purpose of this study is to evaluate the quality of platelets collected on the Trima Accel system after storage for 5 days in a Platelet Additive Solution (PAS), called InterSol.
- Trial name
- NCT03097289
- Testing
- Trima Accel system
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Terumo BCT
Glioma, Blood Platelets
Platelets Activation in Brain Neoplasms
Platelets are primarily known for their central role in primary hemostasis. However, they are increasingly recognized for their participation in various non-hemostatic processes, such as cancer progression and clinical…
- Conditions
- Glioma, Blood Platelets, Inflammation, Brain Neoplasms
- Trial name
- Platon (NCT05049148)
- Testing
- Platelet count in excised tumors
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Platelet Cryopreservation, Platelet Survival
STUDY OF SURVIVAL AND FUNCTIONALITY IN CRYOPRESERVED PLATELETS
Platelets correspond to one of the most widely used blood components in transfusion medicine, given their importance in the prevention of bleeding disorders in patients with multifactorial thrombocytopenia and non-immunological…
- Trial name
- NCT04754841
- Testing
- platelet cryopreservation
- Where
- 2 sites in Argentina
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- HOSPITAL BRITANICO DE BUENOS AIRES
Healthy
Feasibility Study of Mirasol-Treated Whole Blood Red Cell Recovery and Survival
Feasibility trial to evaluate recovery and survival of red blood cells (RBCs) from Mirasol-treated whole blood
- Trial name
- IMPROVE (NCT00742001)
- Testing
- Mirasol System for Whole Blood.
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Terumo BCTbio
Hemodialysis Patient
High Neutrophil-to-Lymphocyte Ratio and Patients With Hemodialysis
To explore the role of neutrophil-to-lymphocyte ratio ( NLR ) and platelet-to-lymphocyte ratio ( PLR ) in predicting mortality in hemodialysis (HD) patients.
- Trial name
- NCT07070557
- Testing
- neutrophil lymphocyte ratio and platelet lymphocyte ratio
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Thrombotic Thrombocytopenic Purpura (TTP), Immune Thrombotic Thrombocytopenic Purpura
Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA Center
Immune thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening disorder characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic organ damage due to microvascular thrombosis.
- Conditions
- Thrombotic Thrombocytopenic Purpura (TTP), Immune Thrombotic Thrombocytopenic Purpura, Thrombotic Microangiopathies, Microangiopathy, Thromboic
- Trial name
- TWILIGHT (NCT07205861)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Complication, Death
The Perioperative Value of Platelet Counts in Predicting Outcome After Liver Transplantation
Recent experimental and clinical studies have shown that platelets play a critical role in liver ischemia and regeneration. Thrombocytopenia, a frequent and potentially serious condition in liver transplantation (LT) recipients…
- Trial name
- NCT01711957
- Testing
- Liver transplantation
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University of Zurich
Infection by SARS-COV-2
RDW, Platelet Kinetics and Survival Outcome in Covid-19 Hospitalized Patients.
This is a retrospective, non-interventional nor experimental study conducted at the General Hospital of Athens "Sismanoglio - A. Fleming / A.
- Trial name
- HEMLABFORCOV19 (NCT06755658)
- Where
- Greece
- Volunteers
- 500 people
- Sponsor
- Sismanoglio General Hospital
Antiphospholipid Syndrome
Thrombocytopenia Trajectories in Antiphospholipid Syndrome: A Multicenter Cohort Study
Thrombocytopenia is common in antiphospholipid syndrome (APS) and is now included in the 2023 ACR/EULAR APS criteria as an important non criteria/hematologic feature.
- Trial name
- NCT07757789
- Testing
- Platelet count
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- New Valley University
Lipofilling, Human Autologous Fat Transfer
The Use of Activated Platelet Rich Plasma (PRP) in Human Autologous Fat Transfer
In this prospective, randomized clinical trial, lipofilling of the midface with Platelet Rich Plasma (PRP) is compared with lipofilling of the midface without PRP.
- Trial name
- NCT01461785
- Testing
- Addition of PRP ( platelet rich plasma) to the lipograft, Lipofilling of the midface
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bergman Clinics
Healthy Volunteers
The Primary Purpose of This Study is to Determine if Biotin, Vitamin B7 is an Effective Way to Label Platelets in Survival and Recovery Studies.
This is a platelet transfusion study. The primary purpose of this study is to determine if Biotin, vitamin B7 is an effective way to label platelets in survival and recovery studies.
- Trial name
- NCT07513532
- Testing
- Biotin labeled platelets
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Bloodworks
Blood Safety
Survival and Recovery of Radio-labeled Platelets Derived From Mirasol-treated Whole Blood
A total of twelve healthy volunteers will donate one unit of fresh whole blood. This unit will be treated with the Mirasol Pathogen Reduction Technology for Whole blood and then stored for 24h.
- Trial name
- Medic (NCT02330081)
- Testing
- Mirasol treatment of whole blood
- Where
- Norway
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Terumo BCTbio
Immune Thrombocytopenia
Eltrombopag and the Bcl-extra-large (xL) Pathway in Idiopathic Thrombocytopenic Purpura (ITP)
The purpose of this study is to further evaluate the effects that eltrombopag (and romiplostim) have on platelets in subjects with chronic ITP.
- Trial name
- NCT00902018
- Testing
- Eltrombopag, Romiplostim, healthy controls
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Myelodysplastic Syndrome
Platelet Response During the Second Cycle of Decitabine Can Predict Response and Survival for Myelodysplastic Syndrome
To assess the efficacy of decitabine and identify predictors for response to decitabine therapy.
- Trial name
- NCT02045654
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Samsung Medical Center
Healthy Subjects
A Study to Assess Recovery and Survival of Radiolabeled Apheresis Platelet Components Treated With the INTERCEPT Blood System for Platelets With LED Illuminator.
The objective of this study is to assess the post-infusion recovery and survival of platelets in 100% Plasma treated with INTERCEPT Blood System for Platelets with LED Illuminator and stored for 5 days after apheresis collection.
- Trial name
- NCT06697223
- Testing
- INTERCEPT Blood System for Platelets with LED Illuminator
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cerus Corporation