Clinical trials: Platelets Dysfunction
Sickle Cell Disease, Thalassemia
Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells
This is a clinical trial of bone marrow transplantation for patients with the diagnosis of a genetic disease of blood cells that do not have an HLA-matched sibling donor.
- Conditions
- Sickle Cell Disease, Thalassemia, Anemia, Granuloma
- Trial name
- NCT00730314
- Testing
- Hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Children's Hospital Los Angeles
Sleep Apnea, Cardiovascular Diseases
Platelet Activation and Circadian Rhythms of Clotting-Fibrinolysis Factors in Patients With Sleep Apnea Syndrome
The objective of the study is to define and compare clotting- fibrinolysis patterns, platelet function markers and endothelial dysfunction in patients with SAHS before and after treatment and normal controls age and weight…
- Trial name
- NCT00456287
- Testing
- CPAP (Continuous Positive Airway Pressure)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Oxidative Stress Induction, Endothelial Dysfunction
Role of Traditional Cigarettes, Electronic and IQOS Cigarettes on Oxidative Stress.
Electronic cigarettes (E-cigarettes) and new heat-not-burn tobacco products such as IQOS®, an electronic device that heats a cigarette-like stick without combustion, are a modern and technological surrogate of traditional tobacco…
- Conditions
- Oxidative Stress Induction, Endothelial Dysfunction, Platelet Activation
- Trial name
- NCT03301129
- Testing
- Smoke
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Low Back Pain
Comparison Between Platelet-rich Fibrin and Steroid for Intra-articular Injection for Sacroiliac Joint Dysfunction
Low back pain is one of the commonest complaints nowadays affecting nearly 20% of the population, Sacroiliac joint has been accused of being the primary cause of pain in about 10%: 27% of this population.
- Trial name
- NCT04757740
- Testing
- intra-articular Platelet rich fibrin and lidocaine, methylprednisolone acetate and lidocaine
- Where
- Egypt
- Volunteers
- 94 people
- Sponsor
- Fayoum University Hospital
Erectile Dysfunction
Erectile Dysfunction Treatment Using Stem Cells
A prospective clinical study to investigate the safety and efficacy of intracavernosal injections of umbilical cord stem cells (UCSCs) combined with platelet-rich plasma (PRP) for erectile dysfunction
- Trial name
- NCT06550752
- Testing
- UC-MSCs and PRP
- Where
- Lebanon
- Volunteers
- 30 people
- Sponsor
- COR clinic of Regenerative Medicine
Coronary Artery Disease in Transplanted Heart (Diagnosis), Platelet Dysfunction
Coronary Artery Disease After Heart Transplantation
This study evaluates coronary artery disease after heart transplantation and its relation to platelet function. Furthermore, we will evaluate extracorporeal photopheresis as treatment of coronary artery disease after heart…
- Trial name
- ECP (NCT03583229)
- Testing
- Aspirin 75mg, Extracorporeal photopheresis
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Aarhus University Hospital
Glioma, Coagulopathy
Hemostasis Alterations in Neurosurgical Patients
Prospective, observational study aimed to investigate the specific hemostatic alterations in patients undergoing glial tumor resection.
- Conditions
- Glioma, Coagulopathy, Acquired Platelet Function Disorder, Thromboelastometry
- Trial name
- ABCD (NCT02652897)
- Testing
- Exposure to glioma resection surgery, Exposure to colon resection surgery
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Santiago R. Leal-Noval
Platelet Dysfunction in Blood Donors
Platelet Dysfunction in Blood Donors
Platelets are circulating blood cells. They bind to each other and to the damaged vessel wall to prevent excessive bllod loss. Unlike quantitative platelet defects, there is no automated, simple test to diagnose qualitative…
- Trial name
- DysPlaq (NCT03599219)
- Testing
- sample
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Etablissement Français du Sang
Erectile Dysfunction, PRP
Platelet-rich Plasma(PRP) Injection in ED
RPR contains rich-in growth factors and has the properties of helping tissue regeneration and nerve repair. In theory, it is possibility of curing ED.
- Trial name
- NCT05241964
- Testing
- PRP
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Hurler Syndrome, Fanconi Anemia
Bone Marrow Transplant With Abatacept for Non-Malignant Diseases
This is a single arm, phase I study to assess the tolerability of abatacept when combined with cyclosporine and mycophenolate mofetil as graft versus host disease prophylaxis in children undergoing unrelated hematopoietic stem…
- Conditions
- Hurler Syndrome, Fanconi Anemia, Glanzmann Thrombasthenia, Wiskott-Aldrich Syndrome
- Trial name
- NCT01917708
- Testing
- Abatacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Depression
Platelet Function in Patients Treated With SSRI and Non-SSRI Antidepressants
This study will examine the effect of a class of antidepressant medications called selective serotonin reuptake inhibitors (SSRIs) on platelet function.
- Trial name
- NCT00009568
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Platelet Aggregation Defects
Study to Assess Platelet Dysfunction With Verify Now Assay
The purpose of this study is to conduct a Verify now assay to detect platelet aggregation defects in patients with Myelodysplastic syndrome(MDS), immune thrombocytopenia purpura (ITP) and myeloproliferative disorders (MPD).
- Trial name
- NCT01167218
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Platelet Dysfunction Due to Drugs
Platelet Function With Various Storage Techniques
Platelet function will be tested in individuals on antiplatelet medications to determine the optimal storage methodology.
- Trial name
- NCT03338660
- Testing
- Infusion of Platelets
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
COPD, Emphysema
Anti-Platelets in Chronic Obstructive Pulmonary Disease
This is a 6 week crossover study in current and former smokers with and without COPD to evaluate whether 2 weeks of dual antiplatelet therapy (aspirin 81mg and clopidogrel 75mg) improves pulmonary perfusion (i.e.
- Conditions
- COPD, Emphysema, Emphysema or COPD
- Trial name
- NCT05567562
- Testing
- dual anti-platelet therapy
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Temporomandibular Joint Disorders, Temporomandibular Joint Internal Derangement
Intra-Articular PRP Versus Dexamethasone for TMJ Internal Derangement
This study looked at whether an injection into the jaw joint (temporomandibular joint, or TMJ) can help people who have pain, clicking, and difficulty opening their mouth due to a slipped joint disc.
- Conditions
- Temporomandibular Joint Disorders, Temporomandibular Joint Internal Derangement, Temporomandibular Joint Dysfunction Syndrome
- Trial name
- NCT07691684
- Testing
- Platelet-Rich Plasma (PRP), Dexamethasone with Local Anaesthetic
- Where
- Iraq
- Volunteers
- 30 people
- Sponsor
- University Of Anbar
Blood Platelet Disorders, Cardiac Surgery
Observational Study of Platelet Dysfunction Assessed by Thromboelastography in Cardiovascular Surgery (DISPLATEG)
Perioperative bleeding requiring blood transfusion is common during cardiovascular surgery, especially in procedures requiring cardiopulmonary bypass. Adenosine diphosphate (ADP) plays a fundamental role in platelet function.
- Conditions
- Blood Platelet Disorders, Cardiac Surgery, Postoperative Bleeding
- Trial name
- DISPLATEG (NCT06961175)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Diabetes Mellitus, Adult-Onset, Platelet Dysfunction
Oleocanthal Rich Olive Oil Acute Effects on Hyperglycemia and Platelet Activation in T2DM
This is a pilot acute dietary intervention study with a randomized cross-over design aiming to investigate whether acute supplementation of extra virgin olive oil (EVOO) rich in oleocanthal could attenuate postprandial…
- Conditions
- Diabetes Mellitus, Adult-Onset, Platelet Dysfunction, Postprandial Hyperglycemia, Lipidemia
- Trial name
- NCT04419948
- Testing
- White bread, Butter, Refined olive oil
- Where
- Greece
- Volunteers
- 15 people
- Sponsor
- Harokopio University
Erectile Dysfunction
Shockwave Therapy and Platelet Rich Plasma for the Treatment of Erectile Dysfunction
The purpose of this research study is to evaluate whether the combination of Shock Wave Therapy (SWT) with Platelet Rich Plasma (PRP) is synergistic and can reverse the pathology of microvascular Erectile Dysfunction (ED) and…
- Trial name
- COCKTAIL (NCT05048667)
- Testing
- Shock Wave therapy (SWT), Platelet Rich Plasma (PRP)
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Miami
Drug Toxicity, Platelet Dysfunction
The Influence of Tramadol on Platelet Function
The aim of this ex-vivo study is to quantify the effect of tramadol on platelet aggregation.
- Conditions
- Drug Toxicity, Platelet Dysfunction, Clotting Disorder
- Trial name
- NCT05237492
- Testing
- Tramadol
- Where
- Austria
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Immune Thrombocytopenia, Thrombotic Thrombocytopenic Purpura
Longitudinal Cohort of Thrombosis and Hemostasis Diseases
This is a multicenter, prospective, longitudinal, observational cohort study to investigate thrombosis and hemostasis diseases in Chinese patients.
- Conditions
- Immune Thrombocytopenia, Thrombotic Thrombocytopenic Purpura, Hemophilia A, Acquired, Disseminated Intravascular Coagulation
- Trial name
- NCT06727669
- Where
- 5 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital