Clinical trials: Platelets Dysfunction
Platelet Dysfunction, Hemodilution
Effect of Aspirin, Hemodilution and Desmopressin on Platelet Dysfunction
Study hypothesis: Desmopressin (DDAVP) can improve platelet function under influence of aspirin, hemodilution and mild hypothermia Mild hypothermia (34-35oC) is known to cause platelet dysfunction.
- Conditions
- Platelet Dysfunction, Hemodilution, Mild Hypothermia, NSAID
- Trial name
- NCT01382134
- Testing
- Aspirin, desmopressin
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Heart Diseases, Coronary Disease
CES1 Carriers in the PAPI Study
This study builds, in part, upon preliminary results generated as part of the Pharmacogenomics Anti-Platelet Intervention (PAPI) Study (NCT00799396).
- Conditions
- Heart Diseases, Coronary Disease, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- NCT03188705
- Testing
- Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Erectile Dysfunction, Erectile Dysfunction With Diabetes Mellitus
Serum YKL-40 Level and Platelets Indices Among Patients With Diabetic Erectile Dysfunction
The aim of this current study is to estimate serum level of YKL-40, serum total testosterone and platelets indices in diabetic patients with erectile dysfunction treated by daily tadalafil 5mg for 3 months.
- Trial name
- NCT05446493
- Testing
- Tadalafil 5mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aswan University
Erectile Dysfunction
Evaluating the Efficacy of Platelet-Rich-Plasma (PRP) for Erectile Dysfunction
There is great interest in restorative therapies (platelet-rich plasma (PRP) injections, shockwave therapy and stem cell therapy) for ED given their non-invasive nature.
- Trial name
- NCT06264635
- Testing
- Platelet-Rich-Plasma, Saline
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Perioperative Bleeding, Coagulopathy During Cardiac Surgery
Flow-Based Platelet Function Assessment Using Total Thrombus-Formation Analysis System (T-TAS) and Early Bleeding After Cardiac Surgery With Cardiopulmonary Bypass (CPB)
The goal of this observational study is to learn how flow-based platelet function measured with the Total Thrombus-formation Analysis System (T-TAS) relates to early postoperative bleeding in adults undergoing cardiac surgery…
- Conditions
- Perioperative Bleeding, Coagulopathy During Cardiac Surgery, Platelet Dysfunction, Cardiac Surgery
- Trial name
- TTAS-CPB (NCT07619261)
- Testing
- Total Thrombus-formation Analysis System (T-TAS)
- Volunteers
- 30 people
- Sponsor
- Hospital de la Santa creu i Sant Pau - Barcelona
Platelet Dysfunction Due to Drugs
The Effect of empagliFlozin on Platelet Function profilEs in diabetiC patienTs - The EFFECT Study.
The mechanistic effects of empagliflozin on platelet function profiles have not yet been ascertained.
- Trial name
- EFFECT (NCT04342819)
- Testing
- SGLT2 inhibitor
- Where
- Trinidad and Tobago
- Volunteers
- 25 people
- Sponsor
- The University of The West Indies
Erectile Dysfunction
The Role of Platelet Rich Plasma for Erectile Dysfunction
Purpose of Study: This randomized controlled trial investigates the role that platelet rich plasma injections into the penis may play to improve erectile function in men with erectile dysfunction.
- Trial name
- NCT04357353
- Testing
- Platelet rich plasma
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Platelet Dysfunction Due to Drugs, Bleeding
PLATelet Function Operating Room Monitoring
Prospective cohort study on adult cardiac surgery patients. Platelet function evaluated before and after cardiopulmonary bypass. Bleeding and transfusion recorded.
- Trial name
- PLATFORM (NCT03121898)
- Testing
- Platelet function test
- Where
- Italy
- Volunteers
- 490 people
- Sponsor
- IRCCS Policlinico S. Donato
Erectile Dysfunction
PRP for the Treatment of Erectile Dysfunction (ED)
Researchers are trying to determine the safety and efficacy of Platelet Rich Plasma (PRP) in the treatment of Erectile Dysfunction (ED).
- Trial name
- NCT04350125
- Testing
- Autologous Platelet Rich Plasma
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Erectile Dysfunction With Diabetes Mellitus
Combining Shockwave Therapy and Platelet Rich Plasma to Treat Erectile Dysfunction in Diabetic Men (COCKTAIL-DM)
The purpose of this research study is to evaluate whether the combination of Shockwave Therapy (SWT) with Platelet Rich Plasma (PRP) is synergistic and can reverse the pathology of microvascular Erectile Dysfunction (ED) and…
- Trial name
- COCKTAIL-DM (NCT05525572)
- Testing
- Shockwave Therapy (SWT), Autologous Platelet-Rich Plasma (PRP)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Miami
Platelet Dysfunction
Influence of Anesthesia Drugs on Impedance Aggregometry
Impedance aggregometry (IA) (Multiplate®)is a new whole blood platelet function test with potential use in anesthesia and intensive care. Most anesthetic drugs have been shown to have in vitro antiplatelet activity.
- Trial name
- NCT01454427
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Diabetic Wounds, Platelet Rich Plasma
Allogeneic vs Autologous PRP for Diabetic Wounds in Renal Dysfunction: a Randomized Controlled Trial
Diabetic wounds are difficult to heal. Autologous platelets in diabetic patients with renal insufficiency have poor function. Allogeneic platelet plasma has a promising application prospect.
- Conditions
- Diabetic Wounds, Platelet Rich Plasma, Allogeneic Blood Transfusions, Renal Dysfunction
- Trial name
- NCT07020559
- Testing
- allogeneic platelet plasma, autologous platelet plasma
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Peking University Third Hospital
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Leukemia in Remission
Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer
This phase II trial studies how well fludarabine phosphate, cyclophosphamide, total body irradiation, and donor stem cell transplant work in treating patients with blood cancer.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Leukemia in Remission, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- NCT03333486
- Testing
- Cyclophosphamide, Fludarabine Phosphate, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Roswell Park Cancer Institute
Thrombotic Microangiopathies, Atypical Hemolytic Uremic Syndrome
Eculizumab to Treat Thrombotic Microangiopathy/Atypical Hemolytic Uremic Syndrome -Associated Multiple Organ Dysfunction Syndrome in Hematopoietic Stem Cell Transplant Recipients
Hematopoietic stem cell transplantation (HCT)-associated thrombotic microangiopathy (TMA) is an understudied complication of HCT that significantly affects transplant related morbidity and mortality.
- Conditions
- Thrombotic Microangiopathies, Atypical Hemolytic Uremic Syndrome, Multiple Organ Dysfunction Syndrome
- Trial name
- NCT03518203
- Testing
- Eculizumab
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Systemic Lupus Erythematosus, Systemic Scleroderma Meeting
ROLE of PLATELETS in the PATHOPHYSIOLOGY of SYSTEMIC LUPUS
Blood platelets, well known for their role in hemostasis, are abnormally activated in patients suffering from systemic lupus erythematosus (SLE), but also from other immunomediated diseases (scleroderma, vasculitis, myositis…
- Conditions
- Systemic Lupus Erythematosus, Systemic Scleroderma Meeting, ANCA Vasculitis, Inflammatory Myositis
- Trial name
- PLAQUETTOLUP (NCT06593041)
- Where
- France
- Volunteers
- 450 people
- Sponsor
- University Hospital, Strasbourg, France
Platelet Dysfunction
Documentation of the Efficacy of Desmopressin Within the Context of Surgical Procedures
In this non-interventional multicentre, prospective, observational cohort study, the efficacy of desmopressin is evaluated in patients with platelet dysfunction due to acetylsalicylic acid or cox-1-inhibitors within the context…
- Trial name
- RAPID (NCT02368730)
- Testing
- desmopressin
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Ferring Pharmaceuticals
Platelet Dysfunction Due to Drugs
Trimetazidine as an Adjunct to Enhance Clopidogrel Response.
Hypothesis: Trimetazidine improves Clopidogrel response in patients. The investigators postulate that the inhibition of platelet aggregation in response to Clopidogrel may be accentuated by Trimetazidine, i.e.
- Trial name
- TRACER (NCT03603249)
- Testing
- Trimetazidine
- Where
- Trinidad and Tobago
- Volunteers
- 24 people
- Sponsor
- The University of The West Indies
Platelet Dysfunction Due to Drugs
The Effects of loW Dose tIcagrelor on Platelet Function Testing in Patients With Stable Coronary arTery Disease
This study aims to assess the effects of low dose ticagrelor on platelet function testing in patients with stable coronary artery disease.
- Trial name
- TWIST (NCT04206176)
- Testing
- Ticagrelor
- Where
- Trinidad and Tobago
- Volunteers
- 25 people
- Sponsor
- The University of The West Indies
Platelets Dysfunction, Hematological Diseases
Daily Ginger Drinking and Platelet Function
This study aims to examine the effect of ginger beverage consumption on platelets activity in apparently healthy Saudi adult volunteers.
- Trial name
- NCT02882776
- Testing
- Ginger drink
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Abdullah International Medical Research Center
Bleeding, Platelet Dysfunction
Platelet Glycoproteins in Inherited Thrombocytopathy: Association With Aggregation Studies and Bleeding Severity
Disorders of platelet function are characterized by variable mucocutaneous bleeding manifestations and excessive hemorrhage following surgical procedures or trauma.
- Trial name
- NCT03648190
- Testing
- Flowcytometry analysis of platelets surface receptors
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University