Clinical trials: Platelets Dysfunction
Viral Pneumonia, Serotonin Syndrome
Cyproheptadine in Severe COVID-19 : A Unblinded Randomized Trial
This randomized controled open label clinical trial is to evaluate the effect of Cyproheptadine on the clinical course of patients presenting a severe SARS-COV 2 pneumonia.
- Conditions
- Viral Pneumonia, Serotonin Syndrome, Platelet Dysfunction
- Trial name
- NCT04820751
- Testing
- Cyproheptadine Hydrochloride 4 MG
- Volunteers
- 200 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Surgery, Platelet Dysfunction
Low-dose Acetylsalicylic Acid Before Non-cardiac Surgery
This study aims to assess independent factors associated with the clinical decision to discontinue ASA preoperatively in patients undergoing elective non-cardiac surgery.
- Trial name
- NCT03049566
- Testing
- preoperative questionnaires
- Where
- Germany
- Volunteers
- 805 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Psoriasis, Inflammation
Subclinical Impairment of Cardiovascular System in Patients With Psoriasis
A cross-sectional study will be conducted, which will include 80 young patients with psoriasis, aged 30-45 years, treated with five different types of antipsoriatic treatment, and 20 healthy patients.
- Conditions
- Psoriasis, Inflammation, Endothelial Dysfunction, Metabolic Disturbance
- Trial name
- PaS (NCT05957120)
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Erectile Dysfunction Due to Arterial Insufficiency
Platelet-rich Plasma (PRP) Injection for Treatment of Erectile Function
The primary objective of the present study is to investigate and compare the treatment efficacy of PRP injection vs placebo treatment in men with mild-moderate vasculogenic ED, as measured by IIEF.The secondary objective of the…
- Trial name
- NCT04050020
- Testing
- Platelet-Rich Plasma (PRP), Normal saline injection
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Institute for the Study of Urological Diseases, Greece
Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia
Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunction
Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Phase I trial to study the effectiveness of imatinib mesylate in treating patients who have advanced cancer and liver…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia, AIDS-related Peripheral/Systemic Lymphoma, AIDS-related Primary CNS Lymphoma
- Trial name
- NCT00025415
- Testing
- imatinib mesylate, pharmacological study
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Erectile Dysfunction
Efficacy of Intracavernous Platelet-rich Plasma Injection in the Treatment of Erectile Dysfunction
Investigation of the efficacy of autologous platelet-rich plasma administration on the potency of patients with vasculogenic and/or neurogenic erectile dysfunction
- Trial name
- NCT06942988
- Testing
- intracavernous platelet rich plasma therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Systemic Lupus Erythematosus, Systemic Scleroderma
Microparticles's Role in the Pathophysiology of Systemic Lupus Erythematosus and Systemic Sclerosis
Our study aims at defining the role of circulating microparticles in the physiopathology of two rare auto-immune diseases: systemic lupus erythematosus (SLE) and systemic scleroderma (SSc).
- Trial name
- MICROLUPS (NCT03575156)
- Testing
- blood sample, urine sample
- Where
- France
- Volunteers
- 208 people
- Sponsor
- University Hospital, Bordeaux
Viral Pneumonia, COVID-19 Pneumonia
Pilot Study for Cyproheptadine in Hospitalized Patient for COVID-19
This is a Pilot study for evaluating the feasibility, security and efficacy of the use of Cypropheptadine, an antihistaminic and antiserotonin drug, as an adjunct of the standardized treatment in a population of patient who are…
- Conditions
- Viral Pneumonia, COVID-19 Pneumonia, Serotonin Syndrome, Platelet Dysfunction
- Trial name
- NCT04876573
- Testing
- Cyproheptadine Hydrochloride 4 MG
- Volunteers
- 60 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Erectile Dysfunction Following Radiation Therapy, Phosphodiesterase Inhibitor Adverse Reaction
A Randomized Trial to Evaluate Efficacy and Safety of Intracavernosal Injection of Platelet-Rich Plasma Versus Phosphodiesterase Type-5 Inhibitors for Treatment of Erectile Dysfunction.
The aim of this study is to evaluate the efficacy and safety of intracavernosal injection of PRP in patients with moderate to severe ED.
- Conditions
- Erectile Dysfunction Following Radiation Therapy, Phosphodiesterase Inhibitor Adverse Reaction, Platelet- Rich Plasma (PRP)
- Trial name
- NCT05787769
- Testing
- P shot arm ( Autologous Platelet Rich Plasma), PDE5i arm
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Mansoura University
Platelet Dysfunction
Evaluation of a New Approach of the Diagnosis of Constitutional Functional Disorders of Platelets
The primary purpose of the study is to evaluate a standardized method of screening for platelet signalling defects in patients with constitutional disorders of platelet function of unknown origin.
- Trial name
- NCT01957345
- Testing
- Blood punction
- Where
- France
- Volunteers
- 322 people
- Sponsor
- University Hospital, Toulouse
Platelet Dysfunction Due to Aspirin Ingestion
AggreGuide 325 mg. Aspirin Study for Aspirin Induced Platelet Dysfunction
To test the AggreGuide A-100 AA Assay's effectiveness for detecting aspirin induced platelet dysfunction.
- Trial name
- NCT01915407
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Aggredyne, Inc.
Subarachnoid Hemorrhage, Platelet Dysfunction
Hemostasis Profile in Patients With Severe Subarachnoid Hemorrhage
Patients with severe subarachnoid hemorrhage (SAH) may present platelet and coagulation dysfunctions immediately after the stroke on admission at the hospital, and persisting up to 3-4 weeks after the onset.
- Conditions
- Subarachnoid Hemorrhage, Platelet Dysfunction, Coagulation Disorder
- Trial name
- NCT03745456
- Testing
- Blood samples for ROTEM and platelet function.
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Coronary Arterioscleroses, Platelet Dysfunction Due to Drugs
The IDEAL-PCI Extended Registry
The purpose of this study is to determine the efficacy and safety of a routine individualized antiplatelet therapy after coronary stent implantation by evaluating "on-treatment" platelet reactivity with Multiple Electrode…
- Trial name
- IDEAL-PCI ext (NCT02974777)
- Testing
- DAPT reduction, DAPT on-target, DAPT intensification
- Where
- Austria
- Sponsor
- Kaiser Franz Josef Hospital
Takotsubo Syndrome
Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome
The aim of this prospective single-center study is to evaluate endothelial function, arterial compliance, sympathetic nervous activity at rest and after mental and physical stress, carotid atherosclerosis, oxidative stress…
- Trial name
- NCT01249599
- Testing
- blood sample analysis
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- University of Zurich
Cardiopulmonary Bypass, Platelet Disorder
Preoperative Dual Antiplatelet Therapy: Platelet Function and Influence of Cardiopulmonary Bypass
Patients admitted for coronary artery bypass surgery taking antiplatelet medicine have an increased risk for bleeding. Present study aims to compare the platelet function in two patient groups using different types of heart-lung…
- Conditions
- Cardiopulmonary Bypass, Platelet Disorder, Bleeding Disorder, Platelet Dysfunction Due to Drugs
- Trial name
- NCT02979158
- Testing
- CPB Low Dose, CPB High Dose
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Umeå University
Traumatic Olfactory Nerve Injury With Anosmia (Diagnosis), Effect of Drug
The Effect of Platelet-rich Plasma Nasal Injection in the Treatment of Traumatic Olfactory Dysfunction
The purpose of this study is to explore the efficacy of injecting high-concentration platelet plasma combined with hyaluronic acid into the nasal olfactory mucosa in the treatment of traumatic anosmia.
- Trial name
- PRP (NCT06290219)
- Testing
- platelet-rich plasma combined with hyaluronic acid, Zinc Gluconate 10 MG Oral Tablet, 4 bottles of phenyl ethyl alcohol, lemon, eucalyptus, and clove oil
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
Platelet Dysfunction, Traumatic Brain Injury
Correcting Platelet Dysfunction After Traumatic Brain Injury
This study evaluates the impact of platelet transfusion on geriatric patients with platelet dysfunction from Traumatic Brain Injury.
- Trial name
- NCT03182946
- Testing
- Platelet mapping Thromboelastography
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypercholesterolemia, Endothelial Dysfunction
Effects of Nutraceutical Therapies on Endothelial Function, Platelet Aggregation, and Coronary Flow Reserve
Hypercholesterolemia is considered one of the most important cardiovascular risk factors. Cardiovascular prevention include a class I indication to statins in addition to non-pharmacologic intervention and prevention strategies…
- Trial name
- NUTRENDO (NCT02969070)
- Testing
- LopiGLIK™ therapy, Armolipid Plus® therapy
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federico II University
Platelet Dysfunction
Platelet Function After Cardiac Surgery.
Intraoperative cell salvage is commonly used in cardiac surgery to reduce the administration of allogeneic red blood cells and thus improve the outcome for the patient.
- Trial name
- PLFICS (NCT06405516)
- Testing
- Autologous blood cell salvage with in-house device, Autologous cell salvage with i-Sep SAME device
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Erectile Dysfunction
Safety and Efficacy of Autologous Platelet-Rich Plasma for Erectile Dysfunction.
The purpose of this study is to evaluate changes in vascular parameters and International Index of Erectile Function (IIEF) scores with the administration of Platelet Rich Plasma (PRP) to participants with Erectile Dysfunction…
- Trial name
- NCT04396795
- Testing
- Autologous Platelet Rich Plasma, Saline solution
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Miami