Clinical trials: Pleural Cavity Effusion
Malignant Pleural Effusion
Rocket® Pleural Catheters: QOL, Feasibility and Satisfaction in Recurrent MPE Patients
This study will take place in Ottawa, Ontario, and will include 100 patients who are receiving tunnelled pleural catheters to treat their symptoms of MPE.
- Trial name
- NCT03403855
- Testing
- Rocket® IPC- Long External Length, Rocket® IPC- Short External Length
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Pleural Effusion, Drainage
Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by EIT
Evacuation of pleural effusion (PE) represents a disputable therapy in mechanically ventilated patients. Patients on mechanical ventilation indicated by the physician to pleural fluid evacuation will be monitored throughout the…
- Conditions
- Pleural Effusion, Drainage, Electric Impedance Tomography
- Trial name
- NCT03231072
- Testing
- Electrical Impedance Tomography record
- Where
- Czechia
- Volunteers
- 19 people
- Sponsor
- Czech Technical University in Prague
Community Acquired Pneumonia
Pleural Fluid and Serum Procalcitonin in Patients With Parapneumonic Pleural Effusion
Key words : serum, pleural effusion, procalcitonin, pneumonia Pneumonia is the common cause of pleural effusion (ranged 2nd) and bacterial infection is the main etiology of pneumonia.
- Trial name
- NCT00646490
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Pleural Infection Bacterial, Pleural Infections
Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema
The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections around the lungs (called pleural infections).
- Conditions
- Pleural Infection Bacterial, Pleural Infections, Pleural Infections and Inflammations, Empyema, Pleural
- Trial name
- ONLY ONCE (NCT07095361)
- Testing
- Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily
- Where
- 11 sites in United States
- Volunteers
- 270 people
- Sponsor
- University of North Carolina, Chapel Hill
Pleural Effusion, Pleural Diseases
Pleural Cryobiopsies During Semirigid Thoracoscopy: A New Technique
The purpose of this study is to determine feasibility of pleural biopsies with the cryoprobe during semirigid thoracoscopy. The secondary aim is to evaluate safety with focus on bleeding intensity.
- Trial name
- NCT01472172
- Testing
- Cryobiopsy (Autoclavable cryoprobe 20416-032)
- Where
- Slovenia
- Volunteers
- 15 people
- Sponsor
- The University Clinic of Pulmonary and Allergic Diseases Golnik
Lung Cancer
Single Agent Alimta in Poor Performance Status in Non-small Cell Lung Cancer
The goal of this clinical research study is to learn how effective the drug pemetrexed (ALIMTA®) is in treating advanced NSCLC in patients with poor performance status (PS) (inability to perform every day activities without…
- Trial name
- NCT00508144
- Testing
- Alimta
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Pleural Effusions (Mpe), Non Small Cell Lung Cancer
First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion
This study aims to evaluate the safety of intrapleural injection of TolueneSulfonamide in patients with malignant pleural effusion and to explore its potential effectiveness.
- Trial name
- NCT07332858
- Testing
- Intrapleural administration of TolueneSulfonamide, Intrapleural administration of normal saline injection
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Gang Hou
Malignant Pleural Effusion
Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion
The purpose of this study is to compare the experiences of subjects who drain malignant (cancerous) pleural effusions (fluid) from around their lung(s) in a more frequent manner using a talc instilled via tunneled pleural…
- Trial name
- NCT04792970
- Testing
- Talc
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Duke University
Pleural Effusion, Pleural Effusion Malignant
The Effect of Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection
Following a lung resection procedure, patients have their pleural space drained of fluid that accumulates due to the severing of proximal vessels like lymph nodes.
- Trial name
- NCT01612975
- Testing
- Naproxen
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- McMaster University
Pleural Effusion, Pleural Effusion, Malignant
Medical Thoracoscopy for Diagnosing Unexplained Pleural Effusion: a National Multicenter Retrospective Study
This study is a national multicenter retrospective study. Patients with unexplained pleural effusion who underwent thoracoscopic or video-assisted thoracoscopic biopsy for patients in recent 10 years were retrospectively…
- Conditions
- Pleural Effusion, Pleural Effusion, Malignant, Fibrinous Pleuritis
- Trial name
- NCT06275178
- Testing
- Medical thoracoscopy
- Volunteers
- 5,000 people
- Sponsor
- China-Japan Friendship Hospital
Lung Cancer, Malignancy
Immune- and Microenvironment- Proteogenomics Profiling for Classifying Lung Cancer Patients
The excessive accumulation of fluid between the membranes surrounding the lung, a clinical condition commonly referred to as "pleural effusion", is caused by one of three factors: increased production of pleural fluid, decreased…
- Trial name
- NCT04887545
- Testing
- Proteomics analysis of pleural effusion
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Universidade Nova de Lisboa
Heart Surgery
Active Clearance Technology (ACT) II German Multicenter Trial
Postoperative bleeding is a common consequence after heart surgery which can significantly impact outcomes and costs [Wynne R, Christensen MC, Dixon B].
- Trial name
- NCT02479737
- Testing
- Blood drainage post cardiac surgery using PleuraFlow System
- Where
- 2 sites in Germany
- Volunteers
- 1,113 people
- Sponsor
- Prof. Dr. Theodor Fischlein
Metastatic Cancer
Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions
RATIONALE: Some drugs such as bleomycin or doxycycline, or other compounds like talc, may help to control fluid in the chest caused by cancer.
- Trial name
- NCT00002872
- Testing
- bleomycin sulfate, doxycycline, talc
- Volunteers
- 480 people
- Sponsor
- Eastern Cooperative Oncology Group
Advanced Cancers, Malignant Pleural Effusions
Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis
The goal of this clinical research study is to compare indwelling pleural catheters (IPC) in combination with saline (the current standard of care) versus IPC in combination with doxycycline as treatment for pleural effusions.
- Trial name
- NCT02623959
- Testing
- Questionnaires, Fentanyl Patch, Fentanyl (IV)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Pleural Effusions (Mpe)
A Phase II Study to Evaluate JMKX000197 Injection Versus Cisplatin in the Treatment of Malignant Pleural Effusion
This study aims to evaluate the efficacy and safety of intrapleural JMKX000197 compared with intrapleural cisplatin in patients with malignant pleural effusion.
- Trial name
- NCT07649369
- Testing
- JMKX000197, Cisplatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Jeyou Pharmaceutical Co., Ltd.
Deep Vein Thrombosis, Abdominal Aortic Aneurism
Point-of-care Ultrasound in Finland
This study has two aims. 1. Deep venous thrombosis (DVT) is a common suspected medical condition. If it cannot be excluded clinically and using D-dimer, ultrasound examination is required.
- Conditions
- Deep Vein Thrombosis, Abdominal Aortic Aneurism, Pneumothorax, Gallbladder Diseases
- Trial name
- NCT03327688
- Testing
- Point-of-care ultrasound
- Where
- 4 sites in Finland
- Volunteers
- 220 people
- Sponsor
- Ossi Hannula
NSCLC
Detection of EGFR Mutation in Malignant Pleural Effusion of Lung Cancer Patients and Cancer Cell Lines Establishment
1. Detection EGFR mutation of cancer cells from malignant pleural effusion. 2. Established the cancer cell lines with without EGFR mutation from malignant pleural effusion.
- Trial name
- EGFR (NCT00752076)
- Testing
- cancer cell lines establishment
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Stage IIIB or IV Non-Small Cell Lung Cancer
A Clinical Trial of Vorinostat (MK0683, SAHA) in Combination With FDA Approved Cancer Drugs in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)(0683-056)
This Phase III clinical trial which incorporates an initial Phase II component will determine the survival of advanced Non-small cell lung cancer patients when treated with MK0683 and paclitaxel plus carboplatin
- Trial name
- NCT00473889
- Testing
- vorinostat, Comparator: paclitaxel, Comparator: carboplatin
- Volunteers
- 253 people
- Sponsor
- Merck Sharp & Dohme LLC