Clinical trials: Pleural Effusion Associated With Pulmonary Infection
Empyema, Pleural Effusion
Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion
The purpose of this study is to assess the benefit to patients with empyema or complicated parapneumonic effusion (CPE) using a daily versus twice daily Alteplase regimen of two different dose strategies compared with saline…
- Trial name
- NCT00103766
- Testing
- Alteplase
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- O'Brien, Jeana D., MD, FACP, FCCP
Parapneumonic Effusion, Empyema, Pleural
Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication
This study aims to standardize the treatment of pleural space (parapneumonic) infections by comparing the difference in outcomes between 2 methods of treatment: early VATS (Video Assisted Thorascopic Surgery) decortication versus…
- Conditions
- Parapneumonic Effusion, Empyema, Pleural, Coagulopathy
- Trial name
- NCT03583931
- Testing
- VATS Decortication, Fibrinolytic Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Denver Health and Hospital Authority
Pleural Infection, Empyema
Fibrinolysis Compared to Thoracoscopy for Pleural Infection
The purpose of this prospective randomized clinical trial is to compare two currently accepted standard-of-care treatment strategies: Medical thoracoscopy as compared to instillation of intrapleural tissue Plasminogen Activator…
- Conditions
- Pleural Infection, Empyema, Pleural Diseases, Parapneumonic Effusion
- Trial name
- NCT03468933
- Testing
- tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase), Medical Thoracoscopy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Tulane University
Pleural Infection
Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE)
Objectives: A pilot study to assess the feasibility of a randomization trial protocol comparing low (2.5mg) and standard (10mg) doses of intrapleural tissue plasminogen activator (tPA) with deoxyribonucleases (DNase) in…
- Trial name
- NCT05766124
- Testing
- Tissue Plasminogen Activator
- Where
- 2 sites in Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Pleural Effusion Associated With Pulmonary Infection, Pleural Effusion Disorder
Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +]
The purpose of this protocol is to conduct a pilot prospective non-blind clinical trial to evaluate the efficacy and safety of a novel saline irrigation technique as an adjunct to standard interventions for treating retained…
- Conditions
- Pleural Effusion Associated With Pulmonary Infection, Pleural Effusion Disorder, Pleural Effusions
- Trial name
- [LYTICS+] (NCT06713382)
- Testing
- Pleural Saline Irrigation
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Beth Israel Deaconess Medical Center
Empyema, Pleural, Parapneumonic Effusion
Management of Pleural Space Infections
Currently, there is no high-quality evidence comparing the clinical outcomes and cost effectiveness of surgical drainage combined with antibiotics versus dual-agent intrapleural fibrinolytic therapy (IPFT) catheter drainage of…
- Trial name
- NCT03873766
- Testing
- Intrapleural Medications, Surgery, Pleural Sampling
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Swedish Medical Center
Complicated Parapneumonic Effusion, Pleural Empyema
Early Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural Empyema
Multicenter, randomized controlled study to compare early mini-invasive thoracoscopy to simple chest tube drainage in complicated parapneumonic effusions or pleural empyema. 100 patients will be recruited.
- Trial name
- NCT00234208
- Testing
- Medical thoracoscopy, Simple chest tube drainage
- Where
- 5 sites in Greece, Italy and 1 more
- Volunteers
- 2 people
- Sponsor
- University Hospital, Basel, Switzerland
Empyema, Pleural
Retrospective Review on Patients With Culture Negative Empyema
Empyema is associated with a wide range of complication and mortality. It is defined by either a positive pleural fluid culture or grossly pus appearance.
- Trial name
- NCT04477980
- Testing
- Disease outcome (mortality)
- Where
- Hong Kong
- Volunteers
- 153 people
- Sponsor
- Chinese University of Hong Kong
Parapneumonic Effusion
Metagenomic Study in Parapneumonic Effusion
Objective: To identify known and unknown bacterial pathogens in patients with pleural infections using a combination of conventional culture and next-generation sequencing approaches.
- Trial name
- NCT05394220
- Testing
- 16S rRNA gene amplicon sequencing
- Where
- Hong Kong
- Volunteers
- 115 people
- Sponsor
- Chinese University of Hong Kong
Parapneumonic Effussion
Video-assisted Thoracoscopic Surgery (VATS) Has Revolutionised Management of Complicated PPE, Our Study to Determine VATS Decortication Technique is Needed, Compared to VATS Debridement in PPE, Also RAPID Score and Pleural US Parameters Can Predict Which VATS Procedure is Needed.
Video-assisted thoracoscopic surgery (VATS) has revolutionised management of complicated parapneumonic effusion ( PPE). So our study is prospective cohort study will be conducted at Departments of Chest Diseases and…
- Trial name
- VATs-PPE (NCT07188714)
- Testing
- VATs decortication, VATs debridement
- Where
- Egypt
- Volunteers
- 95 people
- Sponsor
- Assiut University
Pleural Effusion Associated With Pulmonary Infection, Bacterial Pleural Effusion Other Than Tuberculosis
Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas
The purpose of this study is to document the efficacy and safety of intrapleural instillation of Activase vs Placebo in the management of complicated pleural effusions and empyemas
- Trial name
- CPE (NCT00468104)
- Testing
- Alteplase
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Midwest Pulmonary and Critical Care
Community Acquired Bacterial Pneumonia, Paraneumonic Effusion
Study of Fluid Collection of the Chest in Children With Pneumonia
The purpose of this study is to determine the best treatment for children with a fluid collection in the chest associated with an underlying pneumonia.
- Trial name
- NCT00202826
- Testing
- Video Assisted Thorascopic Surgery Thoracostomy Tube Placement & Drainage
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Corewell Health West
Complicated Parapneumonic Effusion, Empyema, Pleural
Flush, Lyse, Operate
The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space.
- Trial name
- FLO (NCT07592520)
- Testing
- Intrapleural Saline with possible escalation to intraplerual alteplase and dornase.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Empyema, Pleural, Pleural Effusion
Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema
1. Objectives: Main objective: To evaluate the efficacy and safety of intrapleural alteplase vs urokinase in patients with complex complicated parapneumonic pleural effusion and empyema.
- Conditions
- Empyema, Pleural, Pleural Effusion, Pleural Diseases
- Trial name
- NCT01246453
- Testing
- Intrapleurally Alteplase vs Intrapleurally Urokinase
- Where
- 2 sites in Spain
- Volunteers
- 204 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pleural Infection
Diagnostic Utility of Pleural Infection-specific Multiplex PCR Panel
Pleural effusion is a common cause of hospitalization. Pleural infection ranked third among the pleural effusions requiring hospitalization in the United States.
- Trial name
- PRISM (NCT07077096)
- Testing
- PRISM PCR panel, Conventional bacterial culture
- Where
- Hong Kong
- Volunteers
- 800 people
- Sponsor
- Chinese University of Hong Kong
Pleural Infection
Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion
The purpose of this study is to see if there is any benefit in adding saline irrigation through a chest tube to the standard course of treatment for people diagnosed or suspected of having a pleural space infection.
- Trial name
- NCT06434324
- Testing
- Saline Irrigation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pleural Infection Bacterial, Pleural Infections
Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema
The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections around the lungs (called pleural infections).
- Conditions
- Pleural Infection Bacterial, Pleural Infections, Pleural Infections and Inflammations, Empyema, Pleural
- Trial name
- ONLY ONCE (NCT07095361)
- Testing
- Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily
- Where
- 11 sites in United States
- Volunteers
- 270 people
- Sponsor
- University of North Carolina, Chapel Hill