Clinical trials: Pleural Effusions, open to volunteers
Empyema, Pleural, Pleural Infection
Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas
Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material.
- Trial name
- RELIEF (NCT06427538)
- Testing
- Saline Flush
- Where
- 5 sites in United States
- Volunteers
- 96 people
- Sponsor
- Vanderbilt University Medical Center
Peritoneal Dialysis, Peritoneal Dialysis (PD)
Iodine Starch Test Use in Pleuroperitoneal Leak
This is a study to see how a simple test can be used to check if fluid in the chest cavity contains starch. Some people with kidney failure have dialysis treatment by putting fluid in the tummy cavity, and sometimes the fluid can…
- Conditions
- Peritoneal Dialysis, Peritoneal Dialysis (PD), Pleural Cavity Effusion, Hydrothorax
- Trial name
- PIT-PLPD (NCT07857564)
- Testing
- Iodine tincture
- Volunteers
- 30 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Pleural Effusion
Effect of Bubble Positive Expiratory Pressure and Segmental Breathing Versus Incentive Spirometry in Pleural Effusion
Conducted as a randomized clinical trial, this study will include 40 pediatric participants aged 5-16, recruited from Gulab Devi Chest Hospital and Children's Hospital, Lahore.
- Trial name
- NCT07248774
- Testing
- Bubble PEP, Incentive Spirometery
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
NSCLC
Safety and Efficacy of NK510 to Treat NSCLC
This study assesses the safety and efficacy of NK510 combined with PD-(L)1 inhibitors for relapsed/refractory advanced NSCLC, with two administration routes: intravenous infusion and intrapleural perfusion for malignant pleural…
- Trial name
- NCT06097962
- Testing
- NK510, Tislelizumab，atezolizumab or sugemalimab, systemic therapy as selected by the investigator
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Base Therapeutics (Shanghai) Co., Ltd.
Advanced Solid Tumors, Malignant Pleural Effusions
WSK-IM02 in Advanced Solid Tumors With Malignant Effusions (Phase I)
This is a prospective, single-center, interventional, phase I, dose-escalation, single-arm study designed to evaluate the safety, tolerability, and preliminary efficacy of intrapleural/intraperitoneal infusion of WSK-IM02 in…
- Conditions
- Advanced Solid Tumors, Malignant Pleural Effusions, Malignant Ascites
- Trial name
- NCT07615894
- Testing
- WSK-IM02
- Where
- China
- Volunteers
- 9 people
- Sponsor
- WestVac Biopharma Co., Ltd.
Tuberculosis, Pleural
Diagnostic Utility of Mycobacterium Tuberculosis Cell-free DNA
Tuberculosis (TB) is one of the major global health threats and is the second leading infectious cause of death after COVID-19 in 2022.
- Trial name
- MYDNITE-2 (NCT06439810)
- Testing
- Mycobacterium tuberculosis (MTB) cell-free DNA (cfDNA)
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- Chinese University of Hong Kong
Complicated Pleural Effusion/ Empyema
Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion
The goal of this clinical trial is to evaluate the safety and efficacy of sodium bicarbonate pleural lavage in treating complex pleural effusion in adult.
- Trial name
- SAPLIC (NCT06734481)
- Testing
- Sodium bicarbonate pleural lavage, Saline pleural lavage
- Where
- China
- Volunteers
- 260 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Pleural Effusion Associated With Pulmonary Infection, Pleural Effusion Disorder
Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +]
The purpose of this protocol is to conduct a pilot prospective non-blind clinical trial to evaluate the efficacy and safety of a novel saline irrigation technique as an adjunct to standard interventions for treating retained…
- Conditions
- Pleural Effusion Associated With Pulmonary Infection, Pleural Effusion Disorder, Pleural Effusions
- Trial name
- [LYTICS+] (NCT06713382)
- Testing
- Pleural Saline Irrigation
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Beth Israel Deaconess Medical Center
Malignant Pleural Effusion
Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural Effusion
Pleural effusion is common in different diseases and especially malignant effusions can have fast onset symptoms such as chest pain, dyspnoea, and coughing.
- Trial name
- NCT06964321
- Testing
- intercostal tube drainage, big tail catheter drainage, ultrasound-guided aspiration
- Volunteers
- 66 people
- Sponsor
- Assiut University
Pleural Effusion Disorder
Ultrasounic Elastography-guided Pleural Biopsy Followed by As-needed Medical Thoracoscopic Pleural Biopsy Versus Immediate Medical Thoracoscopic Pleural Biopsy for the Diagnosis of Pleural Effusion
Brief Summary The goal of this clinical trial is to determine whether an initial diagnostic approach using ultrasound elastography-guided pleural biopsy (UEPB) is non-inferior to immediate medical thoracoscopic pleural biopsy in…
- Trial name
- NCT07419620
- Testing
- Ultrasoinc elastography-guided pleural biopsy followed by as-needed medical thoracoscopic pleural biopsy, Semi-rigid thoracoscopic pleural biopsy
- Where
- China
- Volunteers
- 420 people
- Sponsor
- China-Japan Friendship Hospital
Non-expandable Lung, Trapped Lung
ARMSTRONG - Air entRainMent vS sTandard tReatment in nOn-expandable luNG
This is a randomised controlled trial evaluating whether controlled air introduction into pleural space (air entrainment) during pleural effusion drainage reduces pain, improves patient satisfaction, and facilitates more…
- Conditions
- Non-expandable Lung, Trapped Lung, Pleural Effusion, Malignant Pleural Effusions (Mpe)
- Trial name
- ARMSTRONG (NCT06959719)
- Testing
- Air Entrainment - intentional introduction of the atmospheric air into the pleural space.
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Malignant Pleural Effusions (Mpe), Medical Thoracoscopy
Safety and Feasibility of Medical Thoracoscopy Using Single-use Flexible Bronchoscope Versus SemiRigid Pleuroscope in Pleural Effusion
Pleural effusion is a common problem in hospital patients. It may arise from a wide range of diseases. There is a multitude of recognised causes of pleural effusion, and in addition, other pleural conditions such as pleural…
- Conditions
- Malignant Pleural Effusions (Mpe), Medical Thoracoscopy, Pleural Effusion
- Trial name
- FLEXPLEUR2 (NCT07726784)
- Testing
- Single-Use Flexible Bronchoscope, Semi-Rigid Pleuroscope
- Where
- 2 sites in Malaysia
- Volunteers
- 36 people
- Sponsor
- National University of Malaysia
Pleural Effusion, Chronic Kidney Disease
Pleural Effusion Types in Chronic Kidney Disease
The purpose of this observational study is to understand the causes of pleural effusion (a buildup of fluid around the lungs) in patients with advanced Chronic Kidney Disease (CKD Stages 3 to 5).
- Trial name
- NCT07547852
- Volunteers
- 100 people
- Sponsor
- Assiut University
Malignant Pleural Effusion, Non-small Cell Lung Cancer
Oncodrivers in Malignant Pleural Effusions Associated With Non-small Cell Lung Cancer: A Prospective Study.
Oncological treatment of patients with disseminated non-small cell lung cancer (NSCLC) is depending on the status of programmed death-ligand 1 (PD-L1), anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR)…
- Trial name
- NCT04806412
- Testing
- meassurement of PD-L1, ALK, EGFR
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Naestved Hospital
Pleural Effusion, Frist Time Indication to Perform a Thoracentesis
Improvement to Perform Thoracocentesis After a Specific Training in Medical Students With the Supervised Use of an Augmented Reality Simulator
Monocentric study, aiming to assess the improvement of medical students to perform a first-time thoracentesis after training using a specific training using an augmented virtual reality simulator, versus standard training.
- Conditions
- Pleural Effusion, Frist Time Indication to Perform a Thoracentesis, Medical Student Training
- Trial name
- ARPEGES (NCT05960747)
- Testing
- Simulation group
- Where
- 2 sites in France
- Volunteers
- 340 people
- Sponsor
- University Hospital, Strasbourg, France
Pneumothorax, Pleural Effusion
16F vs 24F Chest Drain After Minimally Invasive Lobectomy and/or Segmentectomy
The aim of the study is to evaluate postoperative pain in patients receiving a small-bore (16F) chest drain compared to those receiving the standard large-bore (24F) chest drain after minimally invasive pulmonary lobectomy and/or…
- Trial name
- ChestDrain (NCT06958848)
- Testing
- 16 F chest tube, 24 F chest tube, Early removal
- Where
- Switzerland
- Volunteers
- 124 people
- Sponsor
- University Hospital, Basel, Switzerland
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion
This study investigates whether alteplase can help to improve pleural fluid drainage and dyspnea (breathlessness) in patients with non-draining malignant pleural effusion.
- Trial name
- NCT06184321
- Testing
- Alteplase
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary
Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis
Pleural effusion is characterized by the accumulation of fluid in the pleural space, which typically contains about 10-20 mL of pleural fluid that is crucial for the movement of the lungs against the chest wall.
- Conditions
- Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary, Pleural Effusion, Malignant, Pleurodesis
- Trial name
- NCT07167992
- Testing
- Pleurodesis
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- University of Health Sciences Lahore
Malignant Pleural Effusions
Biomarker Levels During Indwelling Pleural cAtheter Sample Testing
Some patients that have a tunneled pleural catheter will not have the pleural fluid (water around the lung) return after some time (pleurodesis).
- Trial name
- BLAST (NCT02092155)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Johns Hopkins University
Pleural Effusion, Pleural Diseases
Strategy for Prompt and Effective Thoracentesis in the Emergency Department
The SPEEDTAP-trial is a prospective, randomised, investigator-initiated, multicenter, clinical superior trial investigating two thoracentesis methods in four emergency departments (ED) in Central Denmark Region.
- Conditions
- Pleural Effusion, Pleural Diseases, Heart Failure
- Trial name
- SPEEDTAP (NCT06180603)
- Testing
- Gravity fluid drainage in the radiology department, Manual drainage in the emergency department
- Where
- 6 sites in Denmark
- Volunteers
- 188 people
- Sponsor
- University of Aarhus