Clinical trials: Pleural Empyema
Empyema Thoracis in Children
Early Results of Empyema Thoracis Treatment in Children by Video-assisted Thoracoscopic Surgery
The aim of study is to assess early results of Empyema Thoracis treatment in Children by Video-assisted Thoracoscopic Surgery
- Trial name
- NCT04177550
- Where
- Vietnam
- Volunteers
- 44 people
- Sponsor
- Nhan Pham Nguyen Hien
Pleural Empyema, Tuberculosis (TB)
The Role of Decortication in Complex Empyema Cases: Multidrug Resistance and Tuberculosis at the Forefront
Empyema is a problem that thoracic surgeons deal in everyday practice. The main goal of treatment is evacuating the pus and fibrin deposits in the thoracic cavity for complete lung expansion.
- Conditions
- Pleural Empyema, Tuberculosis (TB), Bacterial Sepsis
- Trial name
- NCT07167823
- Testing
- Decortication
- Where
- Pakistan
- Volunteers
- 350 people
- Sponsor
- University of Health Sciences Lahore
Pleural Infection, Pleural Adhesions
Chemical vs Mechanical Pleural Adhesiolysis for Liberation of Captive Pleura in Stacked Effusion
The purpose of this study is to compare the clinical and radiological efficacy of chemical pleural adhesiolysis (using either intrapleural 3% hydrogen peroxide or intrapleural corticosteroids) versus mechanical pleural…
- Conditions
- Pleural Infection, Pleural Adhesions, Pleural Effusion, Pleural Empyema
- Trial name
- NCT07713329
- Testing
- Intrapleural Hydrogen Peroxide (H_2O_2), Intrapleural Corticosteroids, Thoracoscopic Mechanical Pleurolysis
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Pleural Empyema
Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial)
Bacterial pneumonia can be complicated by the development of excess fluid and pus (pleural empyema) around the lungs in children. The incidence of pleural empyema in children has increased significantly in the last 10 years.
- Trial name
- NCT01717742
- Testing
- TPA (Tissue Plasminogen Activator), DNase
- Where
- 6 sites in Canada
- Volunteers
- 97 people
- Sponsor
- The Hospital for Sick Children
Empyema, Pleural Effusion
Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion
The purpose of this study is to assess the benefit to patients with empyema or complicated parapneumonic effusion (CPE) using a daily versus twice daily Alteplase regimen of two different dose strategies compared with saline…
- Trial name
- NCT00103766
- Testing
- Alteplase
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- O'Brien, Jeana D., MD, FACP, FCCP
Empyema, Pneumonia
Urokinase Versus Video-assisted Thoracoscopic to Treat Complicated Parapneumonic Empyema in Childhood
A great controversy exists about which is the best method to perform the evacuation of the collection. The purpose of this study is to evaluate which is the best initial treatment to drain complicated parapneumonic empyema…
- Trial name
- NCT00798278
- Testing
- Urokinase, Video-Assisted Thoracoscopic
- Where
- 6 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Spanish Society of Pediatric Surgery
Thoracic Diseases, Thoracic Neoplasms
Comparison Between McGrath and Macintosh Laryngoscopes for DLT Intubation in Thoracic Surgery Patients.
The goal of this RCT is to compare outcome with McGrath vs Macintosh laryngoscopes among patients undergoing thoracic surgery. The main questions it aims to answer are, 1. Rate of successful intubation at first attempt and 2.
- Conditions
- Thoracic Diseases, Thoracic Neoplasms, Thoracic Empyema
- Trial name
- NCT05988736
- Testing
- MaCintosh Laryngoscope (DL), McGrath Laryngoscope (VL)
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Aga Khan University
Pleural Effusion Associated With Pulmonary Infection, Bacterial Pleural Effusion Other Than Tuberculosis
Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas
The purpose of this study is to document the efficacy and safety of intrapleural instillation of Activase vs Placebo in the management of complicated pleural effusions and empyemas
- Trial name
- CPE (NCT00468104)
- Testing
- Alteplase
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Midwest Pulmonary and Critical Care
Infection, Cancer
Comparing Xperguide vs. Conventional Methods During Percutaneous Image Guided Procedures
Background: Procedures that use medical tools in or near a possible abnormality in the body often use computed tomography (CT) scans to locate the abnormality and guide the path that a needle will take to collect a sample of…
- Conditions
- Infection, Cancer, Neoplasm, Empyema
- Trial name
- NCT01287013
- Testing
- Cone-beam computed tomography (CT), Conventional Computed Tomography (CT)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Second Stage Empyema
Comparative Study Between Outcome of ICT Drainage and VATS in Management of Second Stage Empyema
The goal of this clinical trial is to compare between outcome of inter-costal tube drainage and video assisted thoracoscopic surgery in management of patients with second stage empyema.
- Trial name
- ICT and VATS (NCT06680024)
- Testing
- Intercostal tube, Video assisted thoracoscope
- Volunteers
- 40 people
- Sponsor
- Sohag University
Pleural Infection, Pleural Diseases
The Oxford Pleural Infection Endotyping Study
Pleural infection is a severe disease with increasing incidence worldwide. The subphenotypes of pleural infection remain unknown.We designed a study to endotype the disease and assess the association between patient phenotype…
- Conditions
- Pleural Infection, Pleural Diseases, Pleural Effusion, Pleural Empyema
- Trial name
- TORPIDS-2 (NCT06513689)
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Loculated Empyema
Short Duration High Intensity Intrapleural Alteplase With Pulmozyme in Pleural Infection Management
The aim of this study was to assess the efficacy of the modified regimen short duration intrapleural 16mg alteplase (Actilyse, Boehringer Ingelheim) with 5mg DNase (Pulmozyme Hoffmann-La Roche Ltd) in patients with pleural…
- Trial name
- NCT04915586
- Testing
- Intra-pleural Alteplase 16mg with Pulmozyme (DNase) 5mg
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- National University of Malaysia
Pleural Infection
Diagnostic Utility of Pleural Infection-specific Multiplex PCR Panel
Pleural effusion is a common cause of hospitalization. Pleural infection ranked third among the pleural effusions requiring hospitalization in the United States.
- Trial name
- PRISM (NCT07077096)
- Testing
- PRISM PCR panel, Conventional bacterial culture
- Where
- Hong Kong
- Volunteers
- 800 people
- Sponsor
- Chinese University of Hong Kong
Empyema, Pleural, Pleural Effusion
Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema
1. Objectives: Main objective: To evaluate the efficacy and safety of intrapleural alteplase vs urokinase in patients with complex complicated parapneumonic pleural effusion and empyema.
- Conditions
- Empyema, Pleural, Pleural Effusion, Pleural Diseases
- Trial name
- NCT01246453
- Testing
- Intrapleurally Alteplase vs Intrapleurally Urokinase
- Where
- 2 sites in Spain
- Volunteers
- 204 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Tuberculosis, Tuberculous Pleurisy
Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion
Connective tissue growth factor (CTGF) is known to be a fibrogenic cytokine, it could be expressed in various fibrosis diseases. But, recent research showed that CTGF also be considered to be a tumor suppressive gene.
- Conditions
- Tuberculosis, Tuberculous Pleurisy, Malignant Pleural Effusion, Empyema
- Trial name
- NCT00313066
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
Empyema, Pleural
Trial of Antiseptic Irrigation for Pleural Infection
Pleural antiseptic irrigation (PAI) is used in conjunction with open drainage for treating adults with chronic post-thoracotomy empyema.
- Trial name
- RINSE (NCT05546762)
- Testing
- Povidone-iodine solution, Normal saline
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Alexandria University
Empyema, Pleural, Pleural Infections
VATS or Intrapleural Enzymatic Therapy for Patients With Empyema.
A parapneumonic pleural infection is a frequently encountered and serious medical emergency with high morbidity and mortality in specific patient groups (especially in the elderly and immunocompromised).
- Trial name
- VIETS (NCT07886541)
- Testing
- VATS group, IET
- Where
- Netherlands
- Volunteers
- 164 people
- Sponsor
- Amsterdam UMC
Empyema, Pleural, Parapneumonic Effusion
Management of Pleural Space Infections
Currently, there is no high-quality evidence comparing the clinical outcomes and cost effectiveness of surgical drainage combined with antibiotics versus dual-agent intrapleural fibrinolytic therapy (IPFT) catheter drainage of…
- Trial name
- NCT03873766
- Testing
- Intrapleural Medications, Surgery, Pleural Sampling
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Swedish Medical Center
Acute Cholecystitis, Empyema of Gallbladder
Effects of Drainage in Laparoscopic Cholecystectomy
During laparoscopic surgery for an acutely inflamed gallbladder, most surgeons routinely insert a drain. However, no consensus has been reached regarding the need for drainage in these cases, and the use of a drain remains…
- Conditions
- Acute Cholecystitis, Empyema of Gallbladder, Abscess of Gallbladder
- Trial name
- NCT02027402
- Testing
- Laparoscopic cholecystectomy with drain insertion
- Where
- South Korea
- Volunteers
- 198 people
- Sponsor
- Seoul St. Mary's Hospital
Pneumonia, Pleural Effusion
Procoagulant Activity in Patients With Community Acquired Pneumonia, Pleural Effusion and Empyema
Community acquired pneumonia (CAP) is still one of the most important causes of morbidity in adults. (1) In severe cases, parapneumonic effusions or empyema may develop.
- Conditions
- Pneumonia, Pleural Effusion, Empyema
- Trial name
- NCT01178580
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Meir Medical Center