Clinical trials: Pleural Infection
Therapy, Pleural Infections
Comparison of Early Pleural Irrigation Strategy With Saline to the Standard of Care for the Management of Complicated Pleural Infections.
Intrapleural enzyme therapy (IET) is regarded by recent guidelines as a "rescue" therapy for managing complicated pleural infections; however, it is associated with significant side effects, including pleural bleeding, pain, and…
- Trial name
- EPISSOC (NCT07666464)
- Testing
- intrapleural irrigation, Standard care
- Where
- France
- Volunteers
- 244 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Thoracic Diseases, Thoracic Neoplasms
Comparison Between McGrath and Macintosh Laryngoscopes for DLT Intubation in Thoracic Surgery Patients.
The goal of this RCT is to compare outcome with McGrath vs Macintosh laryngoscopes among patients undergoing thoracic surgery. The main questions it aims to answer are, 1. Rate of successful intubation at first attempt and 2.
- Conditions
- Thoracic Diseases, Thoracic Neoplasms, Thoracic Empyema
- Trial name
- NCT05988736
- Testing
- MaCintosh Laryngoscope (DL), McGrath Laryngoscope (VL)
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Aga Khan University
Complicated Pleural Effusion/ Empyema
Efficacy of Fibrinolytic Agents in Complicated Pleural Effusion
Intrapleural administration of fibrinolytic therapy, urokinase in parapneumonic effusion and empyema has been shown to decrease the need for surgical intervention and length of hospital stay.
- Trial name
- NCT03716375
- Testing
- Intrapleural Medications
- Volunteers
- 80 people
- Sponsor
- Beijing Children's Hospital
Complicated Parapneumonic Effusion, Empyema, Pleural
Flush, Lyse, Operate
The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space.
- Trial name
- FLO (NCT07592520)
- Testing
- Intrapleural Saline with possible escalation to intraplerual alteplase and dornase.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Respiratory Failure, Pneumothorax
Mechanical Ventilation During Cardiac Surgery
Background There is no unanimous opinion about a lung-protective strategy in cardiac surgery. Small randomized clinical and animals trials suggest that ventilation during cardio-pulmonary bypass (CPB) could be protective on the…
- Conditions
- Respiratory Failure, Pneumothorax, Atelectasis, Aspiration Pneumonia
- Trial name
- NCT02090205
- Testing
- Non-ventilation during CPB, Ventilation with CPAP, Ventilation with 5 act/minute
- Where
- 13 sites in Italy
- Volunteers
- 780 people
- Sponsor
- Ospedale San Raffaele
Pleural Diseases, Infection
Impact of Respiratory Physiotherapy in the Management of Infectious Pleural Effusion
Chest physiotherapy (CP) facilitates the absorption of fluid in the pleural cavity and reduces the formation of fibrous adhesions in patients with pleural infection, allowing a faster clinical, functional and radiological…
- Trial name
- FISIOPLEURA (NCT02359383)
- Testing
- Chest physiotherapy
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital de Granollers
Empyema, Pleural
Uniportal VATS Versus Chest Tube for Early Empyema
This randomized controlled study compared uniportal video-assisted thoracoscopic surgery (U-VATS) versus chest tube drainage for initial (first-line) treatment of stage I (exudative) and stage II (fibrinopurulent) empyema in…
- Trial name
- NCT06325904
- Testing
- Uniportal VATS, Tube thoracostomy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University
Aspergillosis, Immunosuppression
Evaluation of Performance of An Aspergillus PCR in Tissue and Pleural Effusion Samples of Immunocompromised Patients
Although being a frequent and lethal complication in patients (pts) with hematologic malignancies, diagnosing invasive aspergillosis (IA) still remains a difficult issue as culture-based methods show low sensitivity especially…
- Trial name
- NCT01902030
- Where
- 12 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Heidelberg University
Pleuritis
Predictive Factors and Outcome in Medical Thoracoscopy
Retrospective survey for factors predicting the outcome of medical thoracoscopy
- Trial name
- NCT02288065
- Testing
- sterile talc pleurodesis
- Where
- Belgium
- Volunteers
- 155 people
- Sponsor
- KU Leuven
Healthy
Central Venous Catheter Insertion Train the Trainer
The investigators previously successfully implemented a central venous catheter (CVC) simulation-based mastery learning (SBML) curriculum at Northwestern University.
- Trial name
- NCT02402257
- Testing
- CVC Train the Trainer
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Northwestern University
Pneumonia, Pleural Effusion
Procoagulant Activity in Patients With Community Acquired Pneumonia, Pleural Effusion and Empyema
Community acquired pneumonia (CAP) is still one of the most important causes of morbidity in adults. (1) In severe cases, parapneumonic effusions or empyema may develop.
- Conditions
- Pneumonia, Pleural Effusion, Empyema
- Trial name
- NCT01178580
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Meir Medical Center
Infectious Pleural Effusion
Efficacy of Non-instrumental Pleural Chest Physiotherapy
The main purpose of this study is to assess efficacy of non instrumental pleural chest physiotherapy on the recovery of respiratory function, at hospital discharge or 15 days after beginning the pleural chest physiotherapy…
- Trial name
- KINEPANCH (NCT03861897)
- Testing
- KRP-NI + KM, KM
- Where
- 11 sites in France
- Volunteers
- 82 people
- Sponsor
- Hôpital NOVO
Pulmonary Infection, Complication
the Effect of Chest Expansion Exercises on Pleural Effusion
the study attempted to assess and evaluate the efficacy of implementing chest expansion exercises on patients with pleural effusion and how this programme contribute to reduce pulmonary infection and complications.
- Trial name
- PE (NCT04553315)
- Testing
- chest expansion exercises
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sarah Asmaa
Tuberculosis, Pleural, Pleural Biopsy
Diagnostic Utility of Mycobacterium Tuberculosis Cell-free DNA in Hong Kong
Tuberculosis (TB) is an endemic infectious disease in Hong Kong and a global health threat. Tuberculous pleuritis (TBP) is the most common form of extrapulmonary tuberculosis in China.
- Trial name
- MYDNITE-3 (NCT06646237)
- Where
- Hong Kong
- Volunteers
- 350 people
- Sponsor
- Chinese University of Hong Kong
Other Acute Illnesses Presenting to the Hospital, Heart Failure
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
This VA QUERI Partnered Evaluation Initiative will evaluate the impact of an immersive Point-of-care Ultrasound (POCUS) Training Course on provider skill acquisition and retention; the frequency of POCUS use by trained providers…
- Conditions
- Other Acute Illnesses Presenting to the Hospital, Heart Failure, Pneumonia, Deep Venous Thrombosis
- Trial name
- NCT03296280
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pleural Diseases
Outcome of Patients Undiagnosed Under Medical Thoracoscopy
Medical thoracoscopy (MT) under local anaesthetic and mild sedation, an established method in the diagnosis of pleural diseases.
- Trial name
- NCT01356979
- Testing
- Medical thoracoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 355 people
- Sponsor
- Eskisehir Osmangazi University
Pleural Effusion, Tuberculosis, Pleural
TBP Survey Among Respiratory Physicians
Tuberculosis is a major infectious disease with a high mortality burden in the Asia-Pacific region and worldwide. Among various types of extrapulmonary tuberculosis, tuberculous pleuritis (TBP) is amongst the most common…
- Trial name
- NCT06390969
- Testing
- Survey
- Where
- Hong Kong
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Appendix Adenocarcinoma, Human Papillomavirus-Related Anal Squamous Cell Carcinoma
Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors
This phase II trial studies how well atezolizumab and bevacizumab work in treating patients with rare solid tumors. Immunotherapy with monoclonal antibodies, such as atezolizumab and bevacizumab, may help the body's immune system…
- Conditions
- Appendix Adenocarcinoma, Human Papillomavirus-Related Anal Squamous Cell Carcinoma, Human Papillomavirus-Related Cervical Squamous Cell Carcinoma, Human Papillomavirus-Related Squamous Cell Carcinoma of the Penis
- Trial name
- NCT03074513
- Testing
- Atezolizumab, Bevacizumab, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- M.D. Anderson Cancer Center
Pyothorax, Fungal Infection Lungs
Fungal Empyema Thoracis
Background: Fungal empyema thoracis is a rare but life-threatening pleural infection caused by fungal organisms such as Aspergillus and Candida species.
- Conditions
- Pyothorax, Fungal Infection Lungs, Pleural Empyema
- Trial name
- NCT07337993
- Testing
- pleural lavage followed by surgery, Decortication, Conservative Arm
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Health Sciences Lahore
Pleural Neoplasms, Aspiration, Respiratory
Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures
This study aims to evaluate the efficacy of single dose analgesia in combination with local anesthesia to control pain during Trans Ultrasound guided procedures.
- Conditions
- Pleural Neoplasms, Aspiration, Respiratory, Pleural Effusion, Lung Neoplasms
- Trial name
- NCT05121233
- Testing
- Diclofenac
- Volunteers
- 100 people
- Sponsor
- Assiut University