Clinical trials: Pleurodesis
Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary
Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis
Pleural effusion is characterized by the accumulation of fluid in the pleural space, which typically contains about 10-20 mL of pleural fluid that is crucial for the movement of the lungs against the chest wall.
- Conditions
- Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary, Pleural Effusion, Malignant, Pleurodesis
- Trial name
- NCT07167992
- Testing
- Pleurodesis
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- University of Health Sciences Lahore
Pleural Effusion, Malignant, Non-small Cell Carcinoma
Intrapleural Docetaxel Administration Using Medical Pleuroscopy in Malignant Effusion With Lung Cancer
In this trial, the effect of intrapleural docetaxel administration using medical pleuroscopywill be evaluated in Lung Cancer patient with malignant effusion.
- Trial name
- NCT03394105
- Testing
- intrapleural docetaxel administration
- Where
- South Korea
- Volunteers
- 4 people
- Sponsor
- Asan Medical Center
Pleural Effusion, Malignant
EDIT Management Feasibility Trial
Malignant Pleural Effusion (MPE) is a collection of fluid inside the chest caused by cancer. It is a common medical problem and often causes severe breathlessness.
- Trial name
- Pre-EDIT (NCT03319186)
- Testing
- EDIT Management, Chest drain and talc pleurodesis
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Greater Glasgow and Clyde
Malignant Pleural Effusion, Respiratory Disease
AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion
The purpose of this study is to determine if an indwelling catheter is more effective than surgical pleurodosis in treating malignant pleural effusion.
- Conditions
- Malignant Pleural Effusion, Respiratory Disease, Cancer
- Trial name
- AMPLE-3 (NCT04322136)
- Testing
- Pleurodesis via Video-assisted thoracoscopic surgery, Indwelling pleural catheter (with talc pleurodesis if suitable)
- Where
- Australia
- Volunteers
- 158 people
- Sponsor
- The University of Western Australia
Malignant Pleural Effusion, Pleural Effusion
The First Therapeutic Intervention in Malignant Pleural Effusion Trial
Fluid caused by cancer cells may accumulate in the lining of the lung. Draining the fluid with a chest tube may relieve pain and shortness of breath.
- Trial name
- TIME-1 (NCT00896285)
- Testing
- Large bore chest drain + NSAID based analgesic regimen, Small bore chest drain + NSAID based analgesic regimen, Large bore chest drain + opiate based analgesic regimen
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, Davis
Primary Spontaneous Pneumothorax
Autologous Blood Patch for Primary Spontaneous Pneumothorax
The purpose of this study is to show that treatment with prophylactic autologous blood patch (ABP) after management of primary spontaneous pneumothorax (PSP) is feasible, reduces the incidence of prolonged air leaks, and reduces…
- Trial name
- NCT06088901
- Testing
- Autologous Blood Patch
- Where
- United States
- Sponsor
- Rush University Medical Center
Pleural Neoplasm
Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions
This study is designed to obtain preliminary data comparing indwelling pleural catheters (IPCs) versus IPCs plus doxycycline for pleurodesis as treatments for malignant pleural effusion (MPE).
- Trial name
- NCT03465774
- Testing
- Doxycycline, Indwelling Catheter, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Pleural Effusion
A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion
Malignant pleural effusion (MPE) arises in advanced-stages of malignancies and frequently heralds a poor prognosis.If the underlying malignancy is chemo sensitive (e.g., small-cell carcinoma of lung \& lymphoma), systemic…
- Trial name
- NCT02583282
- Testing
- Doxycycline, Iodopovidine
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Malignant Pleural Effusion
Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion
This is prospective randomized control trial study. The aim of this study is to evaluate the efficacy of Iodopovidone solution for pleurodesis in palliative malignant pleural effusion (MPE) patients comparing to Talc.
- Trial name
- NCT02674243
- Testing
- Iodopovidone solution, Talc
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Chiang Mai University
Pneumothorax
Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax
The estimated recurrence rate of primary spontaneous pneumothorax is 23-50% after the first episode, and the optimal treatment remains unknown.
- Trial name
- NCT00418392
- Testing
- Simple aspiration with minocycline pleurodesis, simple aspiration
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Malignant Pleural Effusion, Malignancy
Feasibility of Ambulatory Talc. Pleurodesis
Patients with malignant pleural disease often experience a significant symptom burden and a short life expectancy. The cornerstone of their treatment is relieving breathlessness by draining fluid from around the lungs and…
- Conditions
- Malignant Pleural Effusion, Malignancy, Palliative Care
- Trial name
- NCT06682936
- Testing
- ambulatory chest drain and talc pleurodesis
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- David Rollins
Metastatic Cancer
Ibuprofen or Morphine in Treating Pain in Patients Undergoing Pleurodesis for Malignant Pleural Effusion
RATIONALE: Morphine and ibuprofen help lessen pain caused by pleurodesis. It is not yet known whether one drug is more effective than the other in lessening pleurodesis-related pain or whether the size of the chest drain tube…
- Trial name
- NCT00644319
- Testing
- ibuprofen, morphine sulfate, management of therapy complications
- Where
- United Kingdom
- Volunteers
- 320 people
- Sponsor
- Oxford University Hospitals NHS Trust
Post Operative Pulmonary Air Leak
Effectiveness of Dextrose Pleurodesis for the Management of Post-Operative Air Leak
A common complication following lung resection surgery is the presence of a post-operative air leak. This occurs when the resected lung tissue does not seal adequately, resulting in continued leakage of air from the lung.
- Trial name
- NCT07548047
- Testing
- 50% Dextrose Pleurodesis, Standard of Care Chest Drainage
- Volunteers
- 80 people
- Sponsor
- Thomas Jefferson University
Primary Spontaneous Pneumothorax
Which is Better Between Single Chest Tube and Multiple Tubes Drainage in Primary Spontaneous Pneumothorax
There was no evidence that the number of chest tube do effect to the recurrence of pneumothorax, which placed after thoracoscopic wedge resection together with mechanical pleurodesis.This study evaluates the efficacy of single…
- Trial name
- NCT04831554
- Testing
- single chest tube drainage
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Lung Cancer
Cervical Video Assisted Thoracoscopic Surgery (C-VATS)
Although thoracic NOTES may not be ready for human trials, a new minimally invasive technique to access the pleural cavity and perform pleural, pulmonary and mediastinal procedures would be possible.
- Trial name
- CT0030 (NCT01440244)
- Testing
- Cervical mediastinoscopy
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Spontaneous Pneumothorax, Surgery
Absorbable Mesh Pleurodesis in Thoracoscopic Treatment of Spontaneous Pneumothorax
Primary spontaneous pneumothorax usually occurs in young, lean male without underlying lung disease. In most cases, the cause of pneumothorax is rupture of blebs at the apex of the lung.
- Trial name
- NCT01848860
- Testing
- Thoracoscopic bullectomy and pleural abrasion, Mesh coverage of the staple line
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- National Taiwan University Hospital
Primary and Secondary Spontaneous Pneumothorax
Does Non-Steroidal Anti-inflammatory Drugs Decrease the Quality of Pleurodesis After Mechanical Pleural Abrasion/Pleurectomy for Treatment of Pneumothorax?
Investigators aim to assess if NSAIDs affect the quality of pleurodesis resulting from mechanical pleurodesis (open surgery or VATS) regarding : Primary outcome: Recurrence of pneumothorax in 6 monthes.
- Trial name
- NCT06467318
- Testing
- Paracetamol, NSAID, Paracetamol
- Where
- Egypt
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Advanced Cancers, Malignant Pleural Effusions
Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis
The goal of this clinical research study is to compare indwelling pleural catheters (IPC) in combination with saline (the current standard of care) versus IPC in combination with doxycycline as treatment for pleural effusions.
- Trial name
- NCT02623959
- Testing
- Questionnaires, Fentanyl Patch, Fentanyl (IV)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer (NSCLC), Malignant Pleural Effusions (Mpe)- Pleurodesis
Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion
This study is designed as a prospective, multi-center investigation to explore the efficacy and safety of furmonertinib combined with upfront thoracic radiotherapy with or without metastatic lesion radiotherapy in subjects with…
- Trial name
- NCT07482605
- Testing
- Furmonertinib, Thoracic Radiotherapy (TRT)
- Volunteers
- 63 people
- Sponsor
- Jiangmen Central Hospital
Malignant Pleural Effusion
Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination
Title of study: Comparison of the Effectiveness of Povidone-Iodine alone to Povidone-Iodine--Tetracycline Combination for Chemical Pleurodesis in Malignant Pleural Effusion.
- Trial name
- NCT04039126
- Testing
- CHEMICAL PLEURODESIS WITH POVIDONE-IODINE-TETRACYCLINE COMBINATION, CHEMICAL PLEURODESIS WITH POVIDONE-IODINE ALONE
- Where
- Nigeria
- Volunteers
- 62 people
- Sponsor
- University College Hospital, Ibadan