Clinical trials: Pneumococcal Carriage
Pneumonia, Pneumonia - Bacterial
Urine Pneumococcal Antigen Project
Background: Pneumonia caused by the bacteria Streptococcus pneumoniae is a leading cause of death among children under five years of age, especially in sub-Saharan Africa.
- Trial name
- UPAP (NCT07181200)
- Where
- Malawi
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Streptococcus Pneumoniae Nasopharyngeal Carriage
Longitudinal Pattern of Streptococcus Pneumoniae Nasopharyngeal Carriage and Antimicrobial Susceptibility in Healthy Children Aged Less Then 5 Years, in the Area of Milan and Surroundings, Lombardy, Italy.
The objective of this active surveillance study is to make available crucial data about epidemiology, serotype distribution, and longitudinal pattern of antibiotic susceptibility of nasopharyngeal strains of Streptococcus…
- Trial name
- NCT01443793
- Where
- Italy
- Volunteers
- 1,300 people
- Sponsor
- University of Milan
Infections, Streptococcal
Prophylactic Antipyretic Treatment in Children Receiving Booster Dose of Pneumococcal Conjugate Vaccine GSK1024850A
The purpose of this trial is to assess if the rate of febrile reactions following the co-administration of a booster dose of pneumococcal conjugate vaccines with standard infant vaccines is lowered when paracetamol is given…
- Trial name
- NCT00496015
- Testing
- Pneumococcal conjugate vaccine GSK1024850A., Infanrix hexa., Meningococcal vaccine GSK134612.
- Where
- 10 sites in Czechia
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Streptococcus Pneumoniae Infection, Streptococcus Pneumoniae, Invasive Disease
Understanding Pneumococcal Carriage and Disease 2017-2020
Streptococcus pneumoniae is a type of bacteria that is carried (lives) in the nose of most individuals and can sometimes go on to cause severe infections such as meningitis and pneumonia.
- Conditions
- Streptococcus Pneumoniae Infection, Streptococcus Pneumoniae, Invasive Disease, Streptococcal Pneumonia
- Trial name
- NCT03102840
- Testing
- Nasopharyngeal swab, blood sampling
- Where
- United Kingdom
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pneumococcal Infection, Streptococcus Pneumoniae Infection
The Effect of Fractional Doses of Pneumococcal Conjugate Vaccines on Immunogenicity and Carriage in Kenyan Infants
Before the introduction of pneumonia vaccines in 2000, between 700,000 - 1 million children died each year as a result of infection with the bacteria Streptococcus pneumoniae and the resulting diseases, namely, meningitis, sepsis…
- Conditions
- Pneumococcal Infection, Streptococcus Pneumoniae Infection, Invasive Pneumococcal Disease, Protection Against
- Trial name
- FPCV (NCT03489018)
- Testing
- PCV10, PCV13
- Where
- Kenya
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Streptococcus Pneumoniae
PICR-b Nasopharyngeal S. Pneumoniae and Nasal S. Aureus Carriage Study
Objective: PCV effects on S. pneumoniae and S. aureus carriage in a population based study. The major specific aims: 1. To compare different PCV vaccination policies, by cross-sectional repeated surveillance of closely related…
- Trial name
- PICRcarriage (NCT03064620)
- Testing
- PCV
- Where
- Israel
- Volunteers
- 12,800 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
S. Pneumoniae, Pneumococcal Conjugate Vaccine
Paediatric Post Pneumococcal Conjugate Vaccine Nasopharyngeal Carriage Study
The investigators intend to investigate the carriage of pneumococci and other respiratory microbes since the introduction of pneumococcal conjugate vaccines (Prevenar 7 and Prevenar 13).
- Trial name
- NCT04401488
- Testing
- Prevenar 7 and Prevenar 13
- Where
- United Kingdom
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Streptococcus Pneumoniae Infection
Effect of Two Versus Three Pneumococcal Conjugate Vaccinations
Two( 2) or three (3) instead of four vaccinations before the age of 6 months with pneumococcal conjugate vaccine are presumed to protect children against invasive pneumococcal disease like meningitis, at least on the short term…
- Trial name
- MNOES (NCT00189020)
- Testing
- PCV7
- Volunteers
- 1,005 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Pneumococcus; Pneumonia, Hiv
Experimental Pneumococcal Carriage in People Living With HIV
The goal of this experimental pneumococcal carriage study is to to characterise rates and determinants of experimental pneumococcal carriage in PLHIV.
- Trial name
- NCT05698225
- Testing
- Streptococcus pneumoniae serotype 6B
- Where
- Malawi
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Pneumonia
Protecting From Pneumococcus in Early Life (The PROPEL Trial)
Streptococcus pneumoniae is responsible for over 10 percent of death in children under five and many of these deaths occur in early infancy before the current pneumococcal schedule is effective and nearly half occur in sub…
- Trial name
- PROPEL (NCT02628886)
- Testing
- 13-valent pneumococcal conjugate vaccine [Prevenar13®] plus tetanus toxoid, tetanus toxoid
- Where
- The Gambia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Bronchiolitis
Study of Pneumococcal Carriage in RSV Bronchiolitis in Infants Aged 6 to 18 Months
The relationship between RSV (human respiratory syncytial virus) infections and invasive infections or pneumonia caused by Streptococcus pneumoniae has been observed epidemiologically for several years.
- Trial name
- Synergy (NCT06722716)
- Testing
- Swab collection
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Otitis Media
Pneumococcal Vaccines Early and in Combination
The purpose of this study is to determine whether an early schedule of a combination of three doses of PHiD-CV and one dose of PCV13, is superior to three doses of either PCV13 or PHiD-CV.
- Trial name
- PREVIX_COMBO (NCT01174849)
- Testing
- Synflorix, Prevenar13, COMBO
- Where
- Australia
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
Streptococcus Pneumonia, Otitis Media
Pneumococcal Carriage and Serotype Distribution in Children With Otitis Media in Malaysia.
The purpose of this research is to conduct a multi-center prospective surveillance study focusing upon pneumococcal carriage and serotype epidemiology in patients with otitis media (OM).The data generated will be crucial…
- Trial name
- OM (NCT05429541)
- Where
- 2 sites in Malaysia
- Volunteers
- 360 people
- Sponsor
- IMU University, Malaysia
Preference, Patient
Pneumococcal Nasopharyngeal and Oropharyngeal Carriage in Adults
This is the first baseline pilot-study that will evaluate the NP and OP colonization with the underline of pneumococcal serotype distribution among adults older than 50 years of age in Serbia and Southeastern Europe.
- Trial name
- NCT04831788
- Where
- Serbia
- Volunteers
- 521 people, healthy volunteers welcome
- Sponsor
- University of Novi Sad
Infections, Streptococcal
COMPAS (Clinical Otitis Media & Pneumonia Study): Pneumonia & Acute Otitis Media (AOM ) Efficacy Study of the Pneumococcal Conjugate Vaccine
This is a study in a large number of healthy children less than 3 years old to measure the efficacy of GlaxoSmithKline (GSK) Biologicals' 10-valent pneumococcal conjugate candidate vaccine (Synflorix vaccine, or GSK1024850A) to…
- Trial name
- NCT00466947
- Testing
- Pneumococcal conjugate vaccine GSK1024850A, Havrix, Engerix-B
- Where
- 22 sites in Argentina, Colombia and 1 more
- Volunteers
- 23,802 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Vaccines, Pneumococcal, Vaccines, Pneumococcal Conjugate Vaccine
Study Comparing Prevenar® to Pneumo 23 in Reducing Carriage in Children
To compare the ability of Prevnar® to Pneumo® 23 in reducing and preventing nasopharyngeal carriage of vaccine-type pneumococci one year after respective immunization.
- Trial name
- NCT00580684
- Testing
- pneumococcus conjugate vaccine 7 valent to reduce carriage
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
13-valent Pneumococcal Vaccine, Streptococcus Pneumoniae
An Evaluation of PCV13 Vaccine Schedules, Comparing Impact of 2+1 vs 3+0 on Pneumococcal Carriage in Blantyre, Malawi
Pneumococcal conjugate vaccines (PCV) have been shown to be effective against invasive pneumococcal disease (IPD; including pneumococcal meningitis and sepsis) and all-cause mortality among young children when introduced into…
- Trial name
- PAVE (NCT04078997)
- Testing
- nasopharyngeal swab
- Where
- Malawi
- Volunteers
- 3,507 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Pneumococcal Infections
Study Evaluating Streptococcus Pneumoniae Nasopharyngeal Carriage Rate in Children Receiving Prevnar®
Primary Objective: To evaluate the impact of PCV7 vaccination on NP carriage rate of vaccine serotypes and serotype distribution Secondary Objective: To evaluate the impact of PCV7 vaccination on NP carriage of antibiotic…
- Trial name
- NCT00488371
- Testing
- Pneumococcal Conjugated Vaccine (Prevnar®)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Streptococcus Pneumoniae Infections
Nasopharyngeal Streptococcus Pneumoniae Carriage
Primary Objective: Evaluation of the Carriage rate of Streptococcus pneumoniae in the nasopharynx of children Secondary Objective: Carriage rate and distribution of Streptococcus pneumoniae serotypes Estimation of prevalence rate…
- Trial name
- NCT00471822
- Where
- Taiwan
- Volunteers
- 9,707 people, healthy volunteers welcome
- Sponsor
- Pfizer