Clinical trials: Pneumoconiosis
Occupational Diseases, Occupational Lung Disease
Multifaceted Intervention for Protection Against Cotton Dust Exposure Among Textile Workers
Textile workers are exposed to various harmful substances during work, including cotton dust, which is the dust present in air during the handling or processing of cotton.
- Trial name
- MultiTex-RCT (NCT03738202)
- Testing
- Multifaceted intervention package
- Where
- Pakistan
- Volunteers
- 2,031 people
- Sponsor
- Aga Khan University
Interstitial Lung Disease, Idiopathic Interstitial Pneumonias
FAPI PET for Lung Fibrosis
This is a prospective exploratory biodistribution study in patients with interstitial lung disease (ILD). The purpose of this research study is to determine where and to which degree the FAPI tracer (68Ga-FAPI-46) accumulates in…
- Conditions
- Interstitial Lung Disease, Idiopathic Interstitial Pneumonias, Drug-Induced Pneumonitis, Hypersensitivity Pneumonitis
- Trial name
- FAPI ILD (NCT05365802)
- Testing
- 68Ga-FAPi-46, Computed Tomography, Positron Emission Tomography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Asbestos Exposure
Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed Population
This is a single-arm phase II trial to assess the biological activity (in a sub-cohort using a Simon two-stage Phase II design) and toxicity of Artichoke Whole Phytocomplex Concentrate (WPC).
- Trial name
- ABOCA1 (NCT02076672)
- Testing
- Artichoke WPC
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Pneumoconiosis
Evaluation of Pneumoconiosis High Risk Early Warning Models
Precaution of pneumoconiosis is more important than treatment. However, the current process can't early warn the high-risk dust exposed workers until they are diagnosed with pneumoconiosis.
- Trial name
- NCT04952675
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Siderosis
A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product
This protocol intends to detail investigations necessary to evaluate the ocular safety of subjects enrolled in study A4321001 and who have received formulated Drug Product (Lot 8716-098).
- Trial name
- NCT00471224
- Testing
- Observational Trial
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Pfizer
Pneumoconiosis
Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis
The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for Pneumoconiosis.
- Trial name
- NCT02790762
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Chronic and Accelerated Silicosis
Safety of Stem Cells Intrabronchial Instillation for Silicosis
The aim of this study was to analyze the safety, pulmonary function, and quality of life data of patients with silicosis treated with intrabronchial instillation of bone marrow derived mononuclear cells (BMDMC, 2x107) through…
- Trial name
- SilicStemCell (NCT01239862)
- Testing
- Autologous cell transplantation
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Universidade Federal do Rio de Janeiro
History of Exposure to Silica or Asbestosis, Positive Testing for ANA as a Marker of Systemic Autoimmune Diseases
Effects of Silica and Asbestos Fibres on the Efferocytosis Capacities of Macrophages
Evaluation of the efferocytosis capacities of blood Monocyte Derived Macrophages (MDM) from patients with a history of asbestosis or silica exposure and comparison of these capacities with those of MDM from healthy donors.
- Trial name
- MacFibOsis (NCT04473742)
- Testing
- Blood collection, Blood sample
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Rennes University Hospital
Cerebral Amyloid Angiopathy, Siderosis
Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy
Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging…
- Trial name
- CSS (NCT05394636)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 111 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Silicosis
Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis
Silicosis is a chronic and incurable occupational disease that can progress independent of the end of exposure. Recent works suggest that the Forced Oscillation Technique (FOT) may help to improve our understanding of the changes…
- Trial name
- NCT01725971
- Where
- Brazil
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Pneumoconiosis Coal, Asbestosis
The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial
Prospective clinical pilot study for subjects diagnosed with Occupational Progressive Pneumoconiosis. Subjects will be treated with Nintedanib 150mg twice daily for 3 years.
- Conditions
- Pneumoconiosis Coal, Asbestosis, Silicosis
- Trial name
- NiPPs (NCT04161014)
- Testing
- Nintedanib 150 MG [Ofev]
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Holdsworth House Medical Practice
Coal Workers' Pneumoconiosis (Complicated)
Examination of Pirfenidone (Esbriet®) Therapy in Coal Workers' Pneumoconiosis With Pulmonary Fibrosis
Examination of pirfenidone (Esbriet®) therapy in coal workers' pneumoconiosis (black lung) with pulmonary fibrosis (scarring of the lung).
- Trial name
- NCT04461587
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Pulmonary Research of Abingdon, LLC
Silicosis, Pneumoconiosis; Silica
Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma
Silicosis, a preventable yet irreversible occupational lung disease, has an insidious onset with a latency period for diagnosis extending beyond 10 years from the initial exposure.
- Trial name
- NCT04205708
- Testing
- Tuberculosis test, Chest X-ray, Pulmonary Function Test
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- University of Oklahoma
Pneumoconiosis, Healthy Lifestyle
Acceptance-based Healthy Lifestyles Program for Patients With Pneumoconiosis
Symptoms, such as cough and shortness of breath, are common among patients with pneumoconiosis. Depression and anxiety can be elicited by the symptoms, while avoidance of daily activities is believed to reduce trigger of…
- Trial name
- NCT06563674
- Testing
- Acceptance-based healthy lifestyles program (intervention group), Acceptance-based healthy lifestyles program (control group)
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Silicosis
The SHIELD Whole Lung Lavage Study
An observational cohort study that will assess the efficacy of Whole Lung Lavage in workers with silicosis or silica-induced bronchitis.
- Trial name
- SHIELD (NCT05402176)
- Testing
- Whole Lung Lavage
- Where
- 4 sites in Australia
- Volunteers
- 30 people
- Sponsor
- The University of Queensland
Tobacco Use Cessation, Tobacco Use Disorder
Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid
Coal miners in Central Appalachia have among the highest rates of tobacco and nicotine product (TNP) use of any occupational group and face elevated rates of lung cancer and coal workers' pneumoconiosis ("black lung").
- Conditions
- Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
- Trial name
- NCT07694492
- Testing
- QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Pneumoconiosis
The Experience of Patients and Family Caregivers in Managing Pneumoconiosis in the Family Context
This is an exploratory qualitative study to understand the needs of patients with pneumoconiosis, and the care-giving experience of their family caregivers.
- Trial name
- NCT04022902
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 83 people
- Sponsor
- Chinese University of Hong Kong
Berylliosis, Beryllium Disease
Beryllium Infliximab Study: Clinical Interventional Trial
The goal of this research study is to test the clinical effectiveness of a drug called infliximab (Remicade) in chronic beryllium disease (CBD).
- Trial name
- BISCIT (NCT00111917)
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Maier, Lisa, M.D.
Silicosis, Tuberculosis
Silicosis and Silicotuberculosis Among Small Scale Gemstone Miners in Northern Tanzania
Artisanal, small-scale mining (ASM) is a large and essential component of the world's economy. Despite attendant risks, there is little research into risks to the health of artisanal miners.
- Conditions
- Silicosis, Tuberculosis, Silicosis; With Tuberculosis
- Trial name
- SilicoTB (NCT06403800)
- Testing
- No intervention
- Where
- Tanzania
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- National Heart and Lung Institute
COPD, Interstitial Pneumonia
Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results.
- Conditions
- COPD, Interstitial Pneumonia, Bronchiectasis, Respiratory Failure
- Trial name
- NCT06922916
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Zhejiang University