Clinical trials: Pneumonia; Pulmonary Infection
COVID, Sars-CoV2
Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease
The purpose of this study is to assess the efficacy of N-acetylcysteine (NAC) in preventing those with mild or moderate COVID-19 from progressing to severe disease
- Conditions
- COVID, Sars-CoV2, SARS-Associated Coronavirus as Cause of Disease Classified Elsewhere, Oxidative Stress
- Trial name
- NCT04419025
- Testing
- N-acetylcysteine
- Where
- 4 sites in United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Nosocomial Pneumonia
High-dose Inhaled NO Therapy for the Prevention of Nosocomial Pneumonia After Cardiac Surgery With CPB
The primary aim of this single-center, prospective, randomized, controlled, pilot study is to test the hypothesis that inhalation of NO 200 ppm prevents the development of nosocomial pneumonia in patients at risk after cardiac…
- Trial name
- NCT06162455
- Testing
- 200- ppm NO
- Where
- Russia
- Volunteers
- 74 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
COVID-19
Study of COVID-19 Prognostic Factors in Hospitalized Patients
Severe COVID-19 prognostic factors have been studied worldwide throughout the pandemic, but there is considerable variability. Therefore, the investigators will summarize the identified prognostic factors in the international…
- Trial name
- NCT05102708
- Testing
- Prognostic factors of severe COVID-19
- Where
- Spain
- Volunteers
- 3,725 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Covid19, TSH
Physiopathology and Sequelae of COVID-19 Infection
The data obtained from Covid-19 infections seem to suggest that the immunogenesis of Covid-19 could in some cases be the result of immune dysregulation.
- Conditions
- Covid19, TSH, Cortisol
- Trial name
- SEQ-COV-PHYSIO (NCT04563676)
- Testing
- blood test
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
COVID 19
An Online Survey to Understand Feelings Related to COVID-19 Among ILBS Patients With Liver Disease
The current outbreak of COVID-19 pandemic has been marked by severe psychological problems. People around the world experienced a similarly frightening public health emergency, on a global scale, with the spread of this corona…
- Trial name
- NCT04352491
- Testing
- No intervention
- Where
- India
- Volunteers
- 347 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
ARDS: Acute Respiratory Distress Syndrome, Covid19
Single-cell Landscape of BALF in Patients With Severe ARDS and CARDS
The goal of this observational study is to learn about the effect of steroid therapy in patients with COVID-19 ARDS. The main questions it aims to answer are: Differences between patients with COVID-19 ARDS before and after…
- Trial name
- NCT05933291
- Testing
- steroid
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking Union Medical College Hospital
Type2 Diabetes, Covid19
Advancing DSME/S and COVID-19 Prevention and Protection Through "emPOWERed to Change" Program
African Americans (AA)/People of Color (POC) are disproportionately impacted by COVID-19 to an extent not observed in other racial/ethnic subgroups.
- Trial name
- NCT04993326
- Testing
- emPOWERed To Change Program
- Sponsor
- Charles Drew University of Medicine and Science
COVID
Long-term Impact of Infection With Novel Coronavirus (COVID-19)
LIINC is a study of volunteers who were previously infected with SARS-CoV-2 (also known as novel coronavirus or COVID-19) who have recovered from acute infection.
- Trial name
- LIINC (NCT04362150)
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of California, San Francisco
Pneumonia, Ventilator Associated Pneumonia
Safety and Pharmacokinetics of KBPA-101 in Hospital Acquired Pneumonia Caused by O11 Pseudomonas Aeruginosa
The objectives of this open study are to assess the safety, tolerability, pharmacokinetics and clinical outcome of patients who have HAP caused by Pseudomonas aeruginosa serotype O11 after three separate administrations of…
- Trial name
- NCT00851435
- Testing
- KBPA-101
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Kenta Biotech Ltd
Long COVID, Heart Rate Variability (HRV)
Effects os Physiotherapeutic Rehabilitation on Function Autonomic and Inflammatory in Patients With Long Covid
Introduction: Long COVID is characterized by persistent symptoms that persist for weeks or months after the acute phase of infection, with a significant impact on the cardiovascular and autonomic systems.
- Conditions
- Long COVID, Heart Rate Variability (HRV), Cardiac Biomarkers, Inflammatory Biomarkers
- Trial name
- LongCovidRehab (NCT07046208)
- Testing
- physiothreapy protocol
- Volunteers
- 58 people
- Sponsor
- Universidade do Estado do Pará
Mantle Cell Lymphoma, COVID-19
A Study in Healthy Subjects to Assess Bioavailability (Proportion of a Drug Which Enters the Circulation to Have an Active Effect) of Acalabrutinib Tablet and Protonpump Inhibitor Effect (Members of a Class of Medications That Inhibits in Gastric Acid Production) for Rabeprazole
This Phase 1 study is being conducted to support the clinical development of acalabrutinib in hospitalized patients who are unable to swallow acalabrutinib tablet or capsule due to respiratory failure, eg, they may require…
- Trial name
- NCT04564040
- Testing
- Acalabrutinib Treatment A, Acalabrutinib Treatment B, Acalabrutinib Treatment C
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pulmonary, Pneumonia
Hyperpolarized 129-Xenon Imaging in Adult Hematopoietic Cell Transplant Recipients With Pulmonary Impairment
This study is designed to measure the correlation of hyperpolarized 129-Xe magnetic resonance imaging (129-XeMRI) in allogeneic hematopoietic cell transplant (allo-HCT) recipients at MD Anderson Cancer Center (MDACC) who develop…
- Conditions
- Pulmonary, Pneumonia, Hematopoietic System--Cancer
- Trial name
- NCT05041140
- Testing
- 29-XeMRI imaging
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Pneumonia
Monitoring of Lung Sounds of Patients With Pneumonia
The aim of this study is to investigate if any correlation between lung sounds of pneumonia patients and the clinical development or therapy of the pneumonia exists.
- Trial name
- NCT01818089
- Testing
- Lung sound analyzer
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- RWTH Aachen University
COVID-19
DAS181 for STOP COVID-19
It is a multicenter, randomized, placebo-controlled, double-blind study. The study population is defined as subjects diagnosed with lower respiratory tract COVID-19 who require supplemental oxygen ≥2 LPM at the time of…
- Trial name
- NCT04354389
- Testing
- DAS181
- Where
- 2 sites in Italy
- Sponsor
- Ansun Biopharma, Inc.
Community Acquired Pneumonia (CAP), Pneumococcal Pneumonia
Pneumococcal Community-Acquired Pneumonia Requiring Hospitalization Among Colombian Adults
Pneumococcal Community-Acquired Pneumonia Requiring Hospitalization Among Adults in Colombia (Pneumo-CAP Colombia) This study aims to learn more about pneumococcal community-acquired pneumonia (CAP) caused by Streptococcus…
- Trial name
- PneumoCAP (NCT07354425)
- Where
- 11 sites in Colombia
- Volunteers
- 688 people
- Sponsor
- Universidad de la Sabana
Cytokine Release Syndrome in COVID-19-induced Pneumonia
Canakinumab MAP in COVID-19 Pneumonia With CRS
This is a global Managed Access Program (MAP) to provide access to canakinumab to patients with cytokine release syndrome resulting from COVID-19 pneumonia
- Trial name
- NCT04476706
- Testing
- canakinumab
- Sponsor
- Novartis Pharmaceuticals
COVID-19, Post COVID-19 Condition
Safety and Efficacy of Hyperbaric Oxygen Therapy for Long COVID Syndrome
Long COVID Syndrome (Long COVID), Post Acute COVID-19 Syndrome (PACS) or Post COVID-19 Syndrome (PCS) is defined as 'signs and symptoms that develop during or following an infection consistent with COVID-19, continue for more…
- Conditions
- COVID-19, Post COVID-19 Condition, Post COVID-19 Condition, Unspecified, Post COVID Condition
- Trial name
- HOT-LoCO (NCT04842448)
- Testing
- Hyperbaric oxygen
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska University Hospital
COVID-19
Randomized Controlled Clinical Trial to Evaluate The Efficacy and Safety of Healthtone as Prophylaxis for COVID-19
Background : Coronavirus disease known as COVID-19 is caused by the SARS-CoV-2. Transmission of SARS CoV-2 is spreading from human to human through direct or indirect droplets, this disease then spreads very quickly to various…
- Trial name
- NCT05308615
- Testing
- Rhea® Health Tone
- Where
- Indonesia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
COVID-19, SARS-CoV-2
COVID-19: A Pilot Study of Adaptive Immunity and Anti-PD1
This is an open-label, controlled, single-centre pilot study of nivolumab in adult patients with COVID-19. This clinical study aims to evaluate efficacy of anti-PD1 antibody in relation to viral clearance and its safety.
- Conditions
- COVID-19, SARS-CoV-2, 2019-nCoV, Pneumonia, Viral
- Trial name
- NCT04356508
- Testing
- Nivolumab
- Volunteers
- 15 people
- Sponsor
- Dr Gerry Gin Wai Kwok
Severe Pneumonia
Lung Response to a Higher PEEP During Severe Pneumonia: a CT Study
At their institution, the investigators routinely assess the individual response of mechanically ventilated patients with acute respiratory failure to higher positive end-expiratory pressure (PEEP) by examining changes in lung…
- Trial name
- NCT07112976
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Istituto Clinico Humanitas
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