Clinical trials: Pneumonia; Pulmonary Infection
COVID-19 Pneumonia
The Role of High Dose Co-trimoxazole in Severe Covid-19 Patients
Coronavirus Disease 19 (COVID-19) is a worldwide pandemic and a major global health concern which is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
- Trial name
- NCT04884490
- Testing
- Co-trimoxazole
- Where
- Bangladesh
- Volunteers
- 94 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Osteoarthritis, Knee, Osteochondral Defect
The Impact of Covid-19 on Patients Waiting for Knee Surgery
The Covid-19 pandemic has led to the postponement and cancellation of elective orthopaedic surgeries worldwide. These delays to elective procedures combined with ongoing demand have led to increasingly longer waiting list times.
- Conditions
- Osteoarthritis, Knee, Osteochondral Defect, Cartilage Injury, Cartilage Damage
- Trial name
- NCT05124613
- Testing
- Survey
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Manchester
COVID-19
A 2nd Generation E1/E2B/E3-Deleted Adenoviral COVID-19 Vaccine: The TCELL VACCINE TRIAL
This is a phase 2/3, multicenter, randomized, placebo-controlled, observer-blind study assessing the safety, tolerability, immunogenicity, and efficacy of prophylactic hAd5-S-Fusion+N-ETSD against COVID-19.
- Trial name
- NCT06022224
- Testing
- hAd5-S-Fusion+N-ETSD
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- ImmunityBio, Inc.
Coronavirus Infection, Pneumonia, Viral
Hydroxychloroquine Plus Azithromycin Versus Hydroxychloroquine for COVID-19 Pneumonia (COVIDOC Trial)
Double blinded randomized clinical trial designed to evaluate the efficacy and safety of hydroxychloroquine combined with azithromycin compared to hydroxychloroquine monotherapy in patients hospitalized with confirmed COVID-19…
- Trial name
- COVIDOC (NCT04345861)
- Testing
- hydroxychloroquine + azithromycin
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Montpellier
Ventilator Associated Pneumonia
Ceragenin Coated Endotracheal Tubes for the Prevention of Ventilator Associated Pneumonia
Critically ill patients are at high risk of acquiring pneumonia during the time that they are mechanically ventilated. This is known as ventilator-associated pneumonia (VAP).
- Trial name
- CEASEVAP (NCT05761613)
- Testing
- CeraShield Endotracheal Tube, Endotracheal tube with subglottic secretion drainage
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Dr. John Muscedere
Pneumonia, Bacterial
Urease Breath Test for Rapid Characterization of Pneumonia
This is a Phase 1, open label, evaluation of a 13C-urea breath test for the detection of urease-producing bacteria in patient with pneumonia in the emergency department.
- Trial name
- NCT03100760
- Testing
- 13C-urea breath test
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of New Mexico
Burnout, Psychological, Anxiety
The Effect of Demographic, Mental, and Physical Activity Profiles Towards Burnout in Frontline Healthcare Workers Facing COVID-19 Pandemics in Dr. Soetomo General Hospital Surabaya
This was a randomized controlled trial study to measure the effect of intervention of Zumba dance towards psychological and biological markers in hospital residents managing COVID-19 patients
- Trial name
- NCT05246124
- Testing
- Zumba dance exercise
- Where
- Indonesia
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Dr. Soetomo General Hospital
Covid19
Reliability and Validity of the Turkish Version of SMİLE-C
How the life style changed multidimensionally with home isolation in the period of COVID-19 is a new research question. Physical and social isolation, home isolation, and quarantine policies applied during epidemic periods such…
- Trial name
- SMİLE-C (NCT04894279)
- Where
- Turkey (Türkiye)
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Marmara University
Covid19, ARDS
A Prospective Clinical Study to Explore Response to Prone Positioning in ARDS Patients
The proposed study will be conducted to investigate the mechanism of patients' responses to prone positioning with coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) and non-COVID-19 ARDS utilizing…
- Trial name
- NCT04692779
- Testing
- Lung Ultrasound (LUS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rush University Medical Center
COVID-19
Clinical Evaluation for Batch Consistency of Ad5-nCoV in Chinese Healthy Adults
This is a randomized, double-blind, parallel-controlled, equivalence trial, for evaluation of safety and immunogenicity, and batch-to-batch consistency of a recombinant adenovirus type-5-vectored Covid-19 vaccine Convidecia in…
- Trial name
- NCT05313646
- Testing
- batch 1 of Ad5-nCoV, batch 2 of Ad5-nCoV, batch 3 of Ad5-nCoV
- Where
- China
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
COVID-19
JINZHEN for Treatment of Mild to Moderate COVID-19
JINZHEN is a botanical drug that contains eight chemical constituents extracted from plant, mineral and animal origin raw materials.
- Trial name
- NCT05092503
- Testing
- JINZHEN Granules for Oral Solution
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Lianyungang Kanion Group, Ltd.
Sars-CoV2, Critical Illness
COVID-19 and ICU-acquired MDR Bacteria
This multicenter before-after study aimed to determine the impact of infection related to SARS-CoV-2 on the incidence of ICU-acquired multidrug resistant (MDR) bacteria.
- Trial name
- COVID-BMR (NCT04378842)
- Where
- 7 sites in France
- Volunteers
- 368 people
- Sponsor
- University Hospital, Lille
Obesity, Telemedicine
Feasibility of a Telematics Pre-operative Assessment in a Bariatric Surgery During Covid-19
Coronavirus (COVID-19) is a respiratory disease caused by a newly discovered coronavirus, SARS-CoV-2. Several recent papers on the pandemic recognized obesity as a risk factor for the COVID-19 infection.
- Conditions
- Obesity, Telemedicine, Bariatric Surgery
- Trial name
- NCT04486417
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
HIV, Pneumonia
A Study To Learn About The Effects Of Pneumococcal Vaccine In People With HIV
The purpose of this study is to learn about how well a vaccine (Prevnar 13, PCV13) works in preventing disease in adults with HIV. The diseases studied are pneumonia. Mostly the ones caused by the bacteria - pneumococcus.
- Conditions
- HIV, Pneumonia, Infections, Pneumococcal
- Trial name
- NCT05794191
- Testing
- Vaccine Administration
- Where
- United States
- Volunteers
- 350,399 people
- Sponsor
- Pfizer
Pneumonia
Telithromycin, Treating Adult Outpatients With Mild to Moderate Community-acquired Pneumonia (CAP) in High Bacterial Resistance Areas
Demonstrate efficacy of telithromycin over single-agent oral antibiotics usually prescribed by local guidelines ("usual care") for treating adult outpatients with mild to moderate community-acquired pneumonia (CAP) in high…
- Trial name
- NCT00538018
- Testing
- Telithromycin
- Volunteers
- 978 people
- Sponsor
- Sanofi
Sars-CoV-2 Infection, Long Covid19
Long Term Outcomes in COVID-19 Patients Recruited in the CORIST Project
Months after seemingly recovering from COVID-19, many patients continue to suffer from major long-term effects. Interestingly, the existence of direct link between the severity of the disease in its acute phase and the severity…
- Trial name
- CORIST-2 (NCT04907890)
- Where
- Italy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Pneumonia, Respiratory Tract Diseases
Phase Ⅰa Clinical Trial of a Pneumococcal Vaccine
Infections with Streptococcus pneumoniae often cause serious health problems, especially for infants and the elderly.Failure to cover all polysaccharide types is an even greater problem with adults than with children.
- Conditions
- Pneumonia, Respiratory Tract Diseases, Respiratory Tract Infections
- Trial name
- PⅠCTPV (NCT04087460)
- Testing
- Protein based pneumococcal vaccine(Low dose), Protein based pneumococcal vaccine(Middle dose), Protein based pneumococcal vaccine(High dose)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
COVID-19
Telerehabilitation in People With Long COVID
The aim of our study is to investigate the effectiveness of telerehabilitation in Post-COVID patients.
- Trial name
- NCT05205460
- Testing
- Home-based telerehabilitation, Education and self-exercise
- Where
- Taiwan
- Volunteers
- 182 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Perinatal Anxiety, Covid19
Augmented CBGT for Perinatal Anxiety During a Global Pandemic (COVID-19)
This study will evaluate the effectiveness of an augmented version of our current evidence-based Cognitive Behavioural Group Therapy (CBGT) for perinatal anxiety protocol with cognitive and behavioural strategies composed of…
- Trial name
- NCT04495803
- Testing
- Cognitive Behavioural Group Therapy for Perinatal Anxiety
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- St. Joseph's Healthcare Hamilton
SARS Pneumonia
Respiratory Mechanics and Gas Exchange in Patients With COVID-19 and Hypoxemic Acute Respiratory Failure
Data on respiratory mechanics and gas exchange in acute respiratory failure in COVID-19 patients is limited. Knowledge of respiratory mechanics and gas exchange in COVID-19 can lead to different selection of mechanical…
- Trial name
- COVID-VENT (NCT04445961)
- Testing
- Respiratory mechanics measurement, Gas exchange measurement
- Where
- 3 sites in Russia
- Volunteers
- 117 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
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