Clinical trials: Pneumonitis
Sjogren's Syndrome, Interstitial Lung Disease
Sjogren's Lung Study
Lung involvement in Sjögren's syndrome is common and causes reduced quality of life and increased mortality. Sjögren's syndrome-related lung diseases (SS-RLD) are classified and treated as the primary lung diseases they resemble.
- Conditions
- Sjogren's Syndrome, Interstitial Lung Disease, Primary Pulmonary Lymphoma (Disorder), Chronic Bronchiolitis
- Trial name
- NCT04843345
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Stanford University
Asthma, Distal Lung Inflammation
Mentored Patient-Oriented Research Career Development Award
Asthmatics have inflammation in the large airways (tubes through which air travels in and out of the lungs). The large airways are located in the central lung.
- Trial name
- NCT00203684
- Testing
- Flunisolide-HFA, Flunisolide-CFC
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Avian Hypersensitivity Pneumonitis
Research for Specific Proteins of Interest for the Serological Diagnosis of Bird Fancier's Lung
This study aims at identifying bird proteins useful for diagnostic tests to determine the cause of Bird Fancier's Lung (BFL).
- Trial name
- HYPERSENS (NCT03056404)
- Testing
- additional blood sample, respiratory functional exploration
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Lung Diseases, Pulmonary Disease
A Study of the Safety and Tolerability of Inhaled SNSP113 in Healthy Subjects and Subjects With Stable Cystic Fibrosis
Although Cystic Fibrosis is a complex genetic disease affecting many organs, lung disease is the primary cause of mortality. The objective of this study is to determine the safety and tolerability of SNSP113 in healthy subjects…
- Conditions
- Lung Diseases, Pulmonary Disease, Cystic Fibrosis, Cystic Fibrosis Lung
- Trial name
- NCT03309358
- Testing
- Inhaled SNSP113
- Where
- 2 sites in United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Synspira, Inc.
Viral Pneumonia, Bacterial Pneumonia
Use of TREM-1 Protein to Differentiate Viral and Bacterial Pneumonias in Intubated Children
The purpose of this study is to determine whether a protein called TREM-1 can be used to differentiate viral and bacterial pneumonias in children who are on ventilator support.
- Trial name
- NCT00645619
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Asthma
Asthma and Osteopathic Manipulative Technique
Asthma is a common respiratory condition that can be difficult to control despite the use of medications such as inhalers, oral steroids or even injectable medications.
- Trial name
- NCT07071194
- Testing
- OMT, Light touch
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
Non-Small Cell Lung Cancer
Study of Non-Small Cell Lung Cancer Patients in the US Receiving Standard-of-Care and Initiating an Approved Therapy With Risk of Pneumonitis/ILD
This is an observational, prospective, multicenter study conducted in the US to gather evidence in the context of lung cancer to complement the development of a digital solution.
- Trial name
- LOOP (NCT06192004)
- Testing
- None (Observational Study)
- Where
- 23 sites in United States
- Volunteers
- 83 people
- Sponsor
- AstraZeneca
Lung Diseases, Lung Inflammation
Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery
The purpose of this study is to analyze the impact of the intravenous (IV) or paravertebral (PV) lidocaine administration during the intraoperative period of lung resection surgery on the appearance of postoperative…
- Conditions
- Lung Diseases, Lung Inflammation, Lung Injury, Acute, Postoperative Complications
- Trial name
- NCT03905837
- Testing
- Lidocaine, Remifentanil
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Francisco Andres de la Gala
Cystic Fibrosis
Pro-resolving Effect of MAG-DHA in Cystic Fibrosis (PREMDIC)
Monoglyceride of DHA (DHA-MAG) is a lipid compound for which intestinal absorption would increase the ratio DHA / arachidonic acid (AA) and promote the synthesis of specific metabolites involved in the resolution of inflammation.
- Trial name
- PREMDIC (NCT02518672)
- Testing
- MAG-DHA
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- SCF Pharma
IPF, Fibrotic Lung Disease
Prognostic Score Comparison in IPF and HP
The goal of this retrospective observational study is to evaluate and compare the prognostic value of GAP, ILD-GAP, and CPI scoring systems in patients diagnosed with interstitial lung diseases (ILDs), specifically Idiopathic…
- Conditions
- IPF, Fibrotic Lung Disease, Hypersensitivity Pneumonitis, Interstitial Lung Disease (ILD)
- Trial name
- NCT07169253
- Testing
- GAP Index, ILD-GAP Index, Composite Physiologic Index (CPI)
- Where
- Turkey (Türkiye)
- Volunteers
- 143 people
- Sponsor
- Saglik Bilimleri Universitesi
Lung Diseases, Lung Cancer
Cough Capture as a Portal Into the Lung
The lung is a privileged organ; blood does not reflect most lung processes well, if at all. Therefore, for population scale diagnostics, the investigator team is developing non-invasive portals to the lung, for eventual early…
- Conditions
- Lung Diseases, Lung Cancer, Lung Diseases, Obstructive, Lung Diseases, Interstitial
- Trial name
- CC1 (NCT05854563)
- Testing
- Observational only, all subjects; measure DNA mutation and proteomic survey.
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Albert Einstein College of Medicine
Hypersensitivity Pneumonitis, Exogenous Allergic Alveolitis
Stop Exogenous Allergic Alveolitis (EAA) in Childhood
Stop exogenous allergic alveolitis (EAA) or hypersensitivity pneumonitis in childhood: healthy into adulthood - a randomized, double-blind, placebo-controlled, parallel-group study to evaluate prednisolone treatment and course of…
- Trial name
- chILD-EU_EAA (NCT02631603)
- Testing
- Prednisolone
- Where
- 7 sites in Germany
- Volunteers
- 4 people
- Sponsor
- Matthias Griese
Pneumonitis, Interstitial, Immunotherapy
A Single-cell Approach to Identify Biomarkers of Pulmonary Toxicity for Immune Checkpoint Blockade
The main goal of this prospective non-interventional exploratory monocentric study is to characterize the immune cell composition of bronchoalveolar lavage (BAL) fluid from cancer patients experiencing cancer therapy-induced…
- Conditions
- Pneumonitis, Interstitial, Immunotherapy, Immune-related Adverse Events
- Trial name
- NCT04807127
- Testing
- Immune checkpoint blockade, Targeted therapy, Radiotherapy
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lung Cancer, Lung Diseases
Clinical Application Study of PET/CT for Differential Diagnosis of Non-small Cell Lung Cancer
This study aims to explore the efficacy of Trop2, EpCAM-specific PET/CT imaging for noninvasive visualization of Trop2 or EpCAM expression levels in non-small cell lung cancer; and to explore the differences between novel…
- Conditions
- Lung Cancer, Lung Diseases, Lung Neoplasms, Lung Cancer Metastatic
- Trial name
- NCT07026110
- Testing
- [68Ga]Ga-NOTA-T4, [68Ga]Ga-NOTA-RT4, [18F]F-RESCA-T4
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Metastatic Breast Cancer
Toxicity Markers to Trastuzumab-Deruxtecan (T-DXd) In Patients With Advanced Breast Cancer
the anti-Human Epidermal Growth Factor Receptor 2 (HER2) Trastuzumab-Deruxtecan (T-DXd) has shown impressive clinical activity in pretreated patients with metastatic breast cancer (MBC) but is also associated with a…
- Trial name
- Tox-DXd (NCT07049133)
- Testing
- T-DXd toxicity marker identification
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- European Institute of Oncology
Lung Inflammation, Sarcoidosis
Validation of the Analysis Methodology Behind the Use of Quantitative 18F-FDG PET/CT to Assess Lung Inflammation
The purpose of this study is to validate the method of analysing Positron Emission Tomography (PET) images to assess lung inflammation.
- Trial name
- VERIFY (NCT03312712)
- Testing
- PET/CT scan, LPS Challenge, Saline Challenge
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Lung Injury, Lung Inflammation
The Effects of Different Ventilation Modes on Patients With Pulmonary Lobe Resection
The objective of this study was to discuss the effects of different ventilation modes on patients with plasma inflammatory factor and respiratory function in patients with pulmonary removal.
- Trial name
- NCT06514729
- Testing
- Adopting different ventilation modes during the operation
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Mao Enting
Staphylococcus Aureus Pneumonias
Panton Valentine Leucocidin
Staphylococcus aureus expresses a variety of virulence factors, including Panton Valentine leukocidin (PVL), a cytotoxin. PVL is specifically associated with primary skin and soft-tissue infections and severe necrotizing…
- Trial name
- PVL (NCT02798497)
- Testing
- Serum and Blood samples
- Where
- France
- Volunteers
- 234 people
- Sponsor
- Hospices Civils de Lyon
COVID-19 Pneumonia, Viral Pneumonia
Mesenchymal Stromal Cells for COVID-19 and Viral Pneumonias
This is an open-label phase 1 clinical trial of allogeneic umbilical cord derived mesenchymal stromal cells (MSCs) for hospitalized individuals with COVID-19 or other viral pneumonias.
- Trial name
- SAMPSON-1 (NCT05286255)
- Testing
- Allogeneic Mesenchymal Stromal Cells
- Where
- United States
- Sponsor
- Medical University of South Carolina
Checkpoint Inhibitor-related Pneumonitis
Diagnostic Biomarkers for Checkpoint Inhibitor-related Pneumonitis
Checkpoint inhibitor-related pneumonitis (CIP) is a common fatal immune-related adverse events of PD-1/PD-L1 inhibitors. Early diagnosis of CIP is crucial for timely intervention and improved prognosis; however, the absence of…
- Trial name
- NCT07340892
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhou Chengzhi