Clinical trials: Pneumothorax, active
Pneumothorax Spontaneous Secondary
Stop Air Leak by Talc or Autologous Blood Patch Therapy
Background: A pilot study to assess the feasibility of a randomisation trial protocol comparing intrapleural talc pleurodesis versus autologous blood patch therapy (ABPT) in patients with secondary spontaneous pneumothorax (SSP)…
- Trial name
- STOP (NCT06883188)
- Testing
- talc powder, patient's own venous blood
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Non-steroidal Anti-inflammatory Drugs, Pleurodesis
Non-steroidal Anti-inflammatory Drugs in Pleurodesis
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use.
- Conditions
- Non-steroidal Anti-inflammatory Drugs, Pleurodesis, Pneumothorax, Pain Management
- Trial name
- KETOTHORAX (NCT06731647)
- Testing
- pleurodesis procedures, KETOPROFEN(RP19583)
- Where
- France
- Volunteers
- 358 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary
Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis
Pleural effusion is characterized by the accumulation of fluid in the pleural space, which typically contains about 10-20 mL of pleural fluid that is crucial for the movement of the lungs against the chest wall.
- Conditions
- Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary, Pleural Effusion, Malignant, Pleurodesis
- Trial name
- NCT07167992
- Testing
- Pleurodesis
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- University of Health Sciences Lahore
Pulmonary Edema, Pneumonia
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second.
- Conditions
- Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion
- Trial name
- NCT06538376
- Testing
- Portable Dynamic Digital Radiography (DDR)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Brigham and Women's Hospital
Pneumothorax Iatrogenic Postprocedural
Clinical Value of Routine Chest Radiography and Point-of-Care Lung Ultrasound Following Ambulatory Thoracic Sympathectomy
The goal of this observational study is to find out whether routine chest X-rays after surgery actually change patient care, and whether lung ultrasound could be a suitable alternative for detecting important postoperative…
- Trial name
- LUNG_US_SIMP (NCT07854340)
- Where
- Chile
- Volunteers
- 200 people
- Sponsor
- Clinica Alemana de Santiago
Consolidation, Lung Injury
Evaluation of the Efficacy of Diagnostic Support Algorithms in Chest X-rays- LuAna Trial
This study aims to evaluate whether the use of AI as a physician support tool is associated with an increase in the detection rate of chest radiographic findings in adults with respiratory complaints, compared to diagnosis…
- Conditions
- Consolidation, Lung Injury, Pleural Effusion, Pneumothorax
- Trial name
- NCT06686251
- Testing
- App LuAna
- Where
- Brazil
- Volunteers
- 2,400 people
- Sponsor
- Hospital Israelita Albert Einstein
Air Leak From Lung, Pneumothorax
Feasibility and Accuracy of a Novel Pleural Drain Gas Analyzer in Detecting Air Leaks
The goal of this study is to assess the clinical feasibility of a novel, reusable, low cost gas analyzer that detects breath in chest drains in order to diagnose and heal air leaks.
- Trial name
- NCT06548386
- Testing
- Pleural gas analysis
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Lung Healing Technologies Inc
Endotracheal Tube, Nasogastric Tube
AI-Assisted Chest X-Ray for Misplaced Endotracheal and Nasogastric Tubes and Pneumothorax in Emergency and Critical Care Settings
Background Advancements in artificial intelligence (AI) have driven significant breakthroughs in computer-aided detection (CAD) for chest X-ray imaging.
- Conditions
- Endotracheal Tube, Nasogastric Tube, Pneumothorax
- Trial name
- NCT06842043
- Testing
- AI-assisted model
- Where
- Taiwan
- Volunteers
- 10,900 people
- Sponsor
- National Taiwan University Hospital
Pneumothorax, Pleural Effusion
16F vs 24F Chest Drain After Minimally Invasive Lobectomy and/or Segmentectomy
The aim of the study is to evaluate postoperative pain in patients receiving a small-bore (16F) chest drain compared to those receiving the standard large-bore (24F) chest drain after minimally invasive pulmonary lobectomy and/or…
- Trial name
- ChestDrain (NCT06958848)
- Testing
- 16 F chest tube, 24 F chest tube, Early removal
- Where
- Switzerland
- Volunteers
- 124 people
- Sponsor
- University Hospital, Basel, Switzerland
Pneumothorax, Biopsy, Needle
CT-guided Lung Biopsy Risk Optimization Method
The purpose of this randomized controlled study is to evaluate the extent to which injection of a small amount of fluid in the pleural cavity at the biopsy site may reduce the risk of pneumothoraces, in addition to patient…
- Conditions
- Pneumothorax, Biopsy, Needle, Risk Factors, Radiology, Interventional
- Trial name
- BROM-I (NCT06340178)
- Testing
- Fluid application during ct-guided lung biopsy
- Where
- Switzerland
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pneumothorax, Primary Spontaneous, VATS
Optimal Postoperative Chest Tube and Pain Management in Patients Surgically Treated for Primary Spontaneous Pneumothorax (Pneumotrial)
Guidelines lack high quality evidence on optimal postoperative chest tube and pain management after surgery for primary spontaneous pneumothorax (PSP).
- Conditions
- Pneumothorax, Primary Spontaneous, VATS, Pain, Postoperative, Locoregional Anaesthesia
- Trial name
- NCT06053476
- Testing
- Thoracic epidural analgesia, Single-shot paravertebral block, Late chest tube removal
- Where
- Netherlands
- Volunteers
- 366 people
- Sponsor
- Maxima Medical Center
Lung Disease, Pneumothorax
Study of the Disease Process of Lymphangioleiomyomatosis
Pulmonary lymphangioleiomyomatosis (LAM) is a destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor.
- Conditions
- Lung Disease, Pneumothorax, Tuberous Sclerosis, Lymphangioleiomyomatosis
- Trial name
- NCT00001465
- Testing
- Toshibia Aquilion One CT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
COPD, ILD
Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases
This upcoming case-control study aims to confirm the Lung Sliding Index (LSI), a new ultrasound score that measures how well the pleura moves, in various lung diseases.
- Conditions
- COPD, ILD, Bronchiectasis, Pneumothorax
- Trial name
- NCT06983366
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Respiratory Distress Syndrome, Barotrauma
Laboratory Biomarkers and Pulmonary Interstitial Emphysema in ARDS (PIE-ARDS)
Barotrauma (pneumothorax, pneumomediastinum) is a well-described complication of Acute Respiratory Distress Syndrome (ARDS), especially in patients with coronavirus disease 2019 (COVID-19) (16.1% in COVID-19, and about 6% in…
- Trial name
- PIE-ARDS (NCT06001645)
- Testing
- Blood and bronchoalveolar fluid collection and analysis, Chest CT scan
- Where
- 4 sites in Italy
- Volunteers
- 110 people
- Sponsor
- Università Vita-Salute San Raffaele
Lung Biopsy
Detection and Prediction of Clinically Significant Pneumothorax After Image-guided Transthoracic Lung Biopsy
Objective: The goal of this study is to evaluate the sensitivity and specificity of the presence of pneumothorax on a 4-hour CXR after image-guided transthoracic lung biopsy (TTLB) for diagnosing subsequent clinically significant…
- Trial name
- NCT06563167
- Testing
- CXR
- Where
- Hong Kong
- Volunteers
- 330 people
- Sponsor
- Chinese University of Hong Kong
Pneumothorax, Intestinal Obstruction
The Impact of Artificial Intelligence-Assisted X-ray Interpretation on Radiologists' Diagnostic Performance
This study tests whether an artificial intelligence (AI) tool helps radiologists read X-rays more accurately. Radiologists read X-rays to find diseases such as pneumonia, bone fractures, and abdominal problems.
- Conditions
- Pneumothorax, Intestinal Obstruction, Spondylolysis, Renal Calculus
- Trial name
- NCT07870928
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated Hospital of Southern Medical University
Pleural Diseases, Pneumothorax Spontaneous Primary
Evaluating the Use of an App in Pleural Disease: Algorithm-supported Clinical Decision Making Versus Usual Care
Pleural disease is a group of conditions that affect the membrane around the lungs. These conditions-fluid around the lungs, infections, cancer, and collapsed lung-are common and can cause serious illness.
- Conditions
- Pleural Diseases, Pneumothorax Spontaneous Primary, Pneumothorax Spontaneous Secondary, Pleural Effusion
- Trial name
- APPLAUS (NCT07625176)
- Testing
- Clinical decision-making support tool, Usual care
- Where
- 10 sites in Denmark
- Volunteers
- 828 people
- Sponsor
- Zealand University Hospital
Primary Spontaneous Pneumothorax
Early Chest Tube Removal After Surgery for Primary Spontaneous Pneumothorax: A Randomized Controlled Trial
Video-assisted thoracoscopic surgery (VATS) with blebectomy/wedge resection plus pleurodesis is the standard of care for recurrent primary spontaneous pneumothorax (PSP) or, in certain instances, after the first episode.
- Trial name
- NCT06411431
- Testing
- Early Chest Tube Removal, Standard Chest Tube Removal, Apical Chest Tube
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Swedish Medical Center
Pneumothorax Spontaneous Primary
Outpatient Management of Primary Spontaneous Pneumothorax: Pigtail Catheter With Unidirectional Valve vs. Exsufflation, Randomized Prospective Study
The management of large spontaneous pneumothorax is not consensual. Current practice involves placement of a Fuhrman catheter connected to a one-way valve, with outpatient monitoring in pneumology consultation.
- Trial name
- PNEUM-AMBU (NCT03691480)
- Testing
- Fuhrman catheter insertion, Three-way stopcock open, Manual aspiration
- Where
- 5 sites in France
- Volunteers
- 148 people
- Sponsor
- Rennes University Hospital
Pulmonary Nodule, Pneumothorax
Safety And Recovery Of Tubeless Strategy In Uniportal VATS Wedge Resection
Brief Summary The goal of this clinical trial is to evaluate the safety and recovery outcomes of different tubeless strategies in adult patients undergoing uniportal video-assisted thoracoscopic (VATS) wedge resection who are…
- Conditions
- Pulmonary Nodule, Pneumothorax, Postoperative Complications
- Trial name
- NCT07395349
- Testing
- Conventional Chest Tube Drainage, Single Intraoperative Aspiration Tubeless, Double Intraoperative Aspiration Tubeless
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University