Clinical trials: Pollen Allergy
Seasonal Allergic Rhinitis
Effects of Orotic Acid Derivatives With or Without Glutathione on Allergic Rhinitis
The purpose of this study is to learn if two nutritional supplements, Orotic Acid and Glutathione will have any effect on the immune system response and if there will be any effect on the symptoms of seasonal allergies.
- Trial name
- NCT00227058
- Testing
- Orotic acid and Glutathione-(Nutritional Supplements)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Hypersensitivity
DBPC-Dose-finding-trial of Vitamin D3 for SCIT in Birch Pollen Allergic Patients.
Low Vitamin D3 (VD3) levels have been reported to be associated with the risk of allergic diseases like asthma. VD3 has been demonstrated in vitro, ex vivo and in animal models to program the immune system towards…
- Trial name
- BM4SIT (NCT02686827)
- Testing
- Paricalcitol
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Laurian Jongejan
Allergic Rhinitis
The Effects of OC000459 on Nasal Mediators
This is the first proof of concept study for OC000459 and is undertaken to assess the effects of the compound on the development of inflammatory cytokines in a model (nasal allergen challenge model) that is validated and…
- Trial name
- NCT00290381
- Testing
- Oxagen OC000459
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Trevor Hansel
Healthy, Allergic Rhinitis
Tolerability/Safety of Intranasal AZD8848 in Healthy Male Volunteers and Seasonal Allergic Rhinitis Male Patients Out of Season
Investigate safety/tolerability after a single dose intranasal administration of AZD8848 comparator placebo to healthy male volunteers and seasonal allergic rhinitis male patients out of season
- Trial name
- SAD (NCT00688779)
- Testing
- AZD8848
- Where
- Sweden
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Birch Pollen Allergy
Comparison of the Influence of Different Skin Conditions on the Allergic Skin Reactivity to Epicutanous Allergen Exposure
It is an open-label physiological investigation of the allergic skin reactivity to epicutaneous allergen exposition in 20 allergic patients in two different skin conditions.
- Trial name
- NCT02074930
- Testing
- Microporation by P.L.E.A.S.E. Professional / Prick needle
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Bronchial Hyperreactivity, Hypersensitivity
Influence of Nutrition on Nasal and Bronchial Affliction in Patients With Allergy on Grass-Pollen
The study is meant to observe the influence of nutrition on nasal and bronchial discomfort in patients with allergy on grass pollen after specific bronchial provocation.
- Conditions
- Bronchial Hyperreactivity, Hypersensitivity, Allergy, Bronchial Asthma
- Trial name
- NCT00519740
- Testing
- inhalative specific bronchial provocation with grass-pollen
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Allergic Rhinitis Due to Pollen
Nasal Allergen Challenge Test as a Method to Detect Clinical Reactivity Against Birch Pollen
Clinical efficacy and tolerability for allergen specific immunotherapy (AIT) with Itulazax (birch pollen extract tablet) is well established.
- Trial name
- NAC (NCT06085963)
- Testing
- ITULAZAX 12 SQ-Bet, Nacl
- Where
- Sweden
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Allergic Conjunctivitis
Alleviation of Cedar Pollen Induced Allergic Symptoms by Orally Taken Superfine Beta-1,3-Glucan
Intravenous- injection of beta-1,3-glucan in human is known to induce T helper type 1 response, while oral uptake did not. It was examined whether superfine dispersed beta-1,3-glucan (SDG) contrived to absorbed by intestinal…
- Trial name
- NCT00276445
- Testing
- beta-1,3-glucan
- Where
- Japan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meiji University of Oriental Medicine
Allergy to House Dust, Allergy Pollen
Validation and Reproducibility of S.P.A.T. With Allergens
To improve accuracy and take out human error opportunities, Hippo Dx developed S.P.A.T., an automated skin prick test. This study will provide a comparison between manual and automated skin prick test in allergic and non-allergic…
- Trial name
- NCT05824637
- Testing
- Skin Prick Automated Test, Skin Prick Manual Test
- Where
- Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hippocreates
Allergy Pollen, Healthy
Iron and Pollen Allergy in Women
Iron deficiency and anemia are clearly associated with the onset of allergy and allergic diseases, whereas an improved iron status seems to prevent the onset of allergy in humans. Iron-deficiency can be absolute or functional.
- Trial name
- NCT03816800
- Testing
- ImmunoBon
- Where
- Austria
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Allergic Rhinitis, Healthy Volunteer
DSP-3025 Study of Healthy Male Volunteers and Seasonal Allergic Rhinitis Male Patients Out of Season
Investigate safety/tolerability after a single dose intranasal administration of DSP-3025 comparator placebo to healthy male volunteers and seasonal allergic rhinitis male patients out of season.
- Trial name
- NCT00925678
- Testing
- DSP-3025
- Where
- Japan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sumitomo Pharma Co., Ltd.
Food Allergy
The Diagnosis of Oral Allergy Syndrome Through the Use of a Structured Questionnaire
Oral allergy syndrome is a type of food allergy which mainly affects people with springtime hay fever. It is caused by a cross-reaction, between antibodies to pollens, usually birch tree pollen, and allergens in many different…
- Trial name
- NCT00854958
- Where
- United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Pollen Allergy, Venom Allergy
Identification of B Regulatory Cells by Flow Cytometry
The goal of this laboratory and observational study is to develop a test to quantify B-regulatory cells in blood. This will be used to detect changes in B-regulatory cell populations in pollen and insect venom allergic patients…
- Trial name
- NCT06876506
- Testing
- Venepuncture, Allergen Specific Immunotherapy
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Asthma With Allergic Rhinitis
Tezepelumab in Allergic Rhinitis and Asthma Study (TEZARS)
The goal of this clinical trial is to learn about how well tezepelumab (pronounced TEZ e PEL ue mab), a Health Canada-approved drug for severe asthma, works in participants with coexisting allergic asthma and allergic rhinitis…
- Trial name
- TEZARS (NCT06189742)
- Testing
- Tezepelumab
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Dr. Anne Ellis
Pollen; Allergy, Asthma
Does Medicinal Mushroom Agaricus Blazei Protect Against Allergy and Asthma?
Asthma and allergy is increasing in Norway and Western countries. Treatment is still mostly symptomatic. Extracts of the immunomodulatory and edible mushroom Agaricus blazei, such as Andosan™, have been shown to protect against…
- Trial name
- NCT03198455
- Testing
- Agaricus blazei Murill-based mushroom extract, Andosan™
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Seasonal Allergic Rhinitis (SAR)
A Study to Determine the Optimal Dose and Frequency of ALDP001 Nasal Spray in Adults With Seasonal Allergic Rhinitis Under Allergen Exposure
This study aims to evaluate the effectiveness and safety of ALDP001 Nasal Spray in treating seasonal allergic rhinitis, and to identify the optimal dosage and administration frequency for this formulation.
- Trial name
- ALDP001 (NCT07219849)
- Testing
- ALDP001 Nasal Spray
- Where
- Canada
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Alixer Nexgen Therapeutics Limited
COVID-19, Coronavirus Infections
Audio Data Collection for Identification and Classification of Coughing
An open access study that will define and collect digital measures of coughing in multiple populations and public spaces using various means of audio data collection.
- Conditions
- COVID-19, Coronavirus Infections, Hay Fever, Asthma
- Trial name
- NCT04326309
- Where
- United States
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- HealthMode Inc.
Seasonal Allergic Rhinitis
A Single and Multiple Dose Study to Explore the Safety of JNJ-38224342 in Healthy Patients and Patients With Seasonal Allergies
A single and multiple dose study to assess the safety of JNJ 38224342 compared to placebo in healthy volunteers and in volunteers with seasonal allergies.
- Trial name
- NCT01054352
- Testing
- JNJ38224342
- Where
- Canada
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Allergic Conjunctivitis
Efficacy Investigation Study of Olopatadine Hydrochloride Ophthalmic Solution Using OHIO Chamber in Patients With Seasonal Allergic Rhinitis (SAR)
To evaluate the efficacy of olopatadine 0.1% using the OHIO Chamber in patients with seasonal allergic conjunctivitis.
- Trial name
- NCT00818805
- Testing
- Olopatadine 0.1%, Tranilast 0.5%
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Hayfever
Repeat Nasal Allergen Challenge
This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response to inhaled allergen, which will more…
- Trial name
- NCT00290368
- Testing
- Skin Prick Test, Nasal allergen challenge, Nasal filter paper placement
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Imperial College London