Clinical trials: Pollution Exposure
Coronary Disease
The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin
The purpose of this study is to identify the role of endothelin 1 (a natural vasoconstrictor) in the adverse vascular effects demonstrated after exposure to air pollution
- Trial name
- NCT00745693
- Testing
- Endothelin-1, BQ-123 and BQ-788
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Tobacco Smoke Pollution
Reduction of Environmental Tobacco Smoke (ETS) Exposure at Home: the BIBE Study
Main objective: to determine the effectiveness of a brief opportunist educational performance directed to the parents who smoke -- inside the context of programmed visits of paediatrics in primary care -- to reduce the exposure…
- Trial name
- BIBE (NCT00788996)
- Testing
- Brief intervention based in clinical practice guide
- Where
- Spain
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Exposure to Environmental Pollution
Impact of Exposure to Environmental Pollutants on Birth Outcomes in an Israeli Cohort
Objectives and hypothesis The scale and diversity of chemicals in worldwide use today is vast. Many of these chemicals are released into the environment where they are found in air, water, soil, house dust, and in the food…
- Trial name
- NCT03084445
- Where
- 3 sites in Israel
- Volunteers
- 2,394 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Exposure to Environmental Pollution, Non-occupational
Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers
The purpose of this protocol is to assess whether epigenetic factors in healthy individuals make a person more or less responsive to lung inflammation following ozone exposures.
- Trial name
- Geminoz (NCT02469428)
- Testing
- Clean air, Ozone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Pollution; Exposure, Health Behavior
Improving the Behavioural Impact of Air Quality Alerts
The evidence shows that adherence to air quality advice to adopt protective behaviours during pollution episodes is suboptimal, and that the traditional strategy of simply informing people about high pollution episodes is not…
- Trial name
- NCT03552198
- Testing
- Alternative health advice
- Where
- United Kingdom
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- King's College London
Cardiovascular Morbidity
Experimental Exposure to Air Pollutants and Sympathetic Nerve Activity in Human Subjects
The primary hypothesis of the study is that in healthy elderly subjects experimental exposure to air pollutants increases sympathetic nervous system activity compared with sham (clean air) exposure.
- Trial name
- Particles (NCT01914783)
- Testing
- ultrafine particles, ultrafine particles and ozone, clean air
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Healthy Adults
Statins Against Bushfire Smoke
The goal of this clinical trial is to test whether statins can protect the heart and brain from the biological stress and inflammatory responses caused by breathing bushfire smoke in healthy adult volunteers aged 18-64 years.
- Trial name
- SABS (NCT07462715)
- Testing
- Atorvastatin
- Where
- Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Menzies Institute for Medical Research
Blood Pressure, Cardiac Ischemia
The Use of L-arginine to Mitigate the Cardiovascular Effects of Exposure to Traffic-related Air Pollution
The present study is aimed to investigate whether oral L-arginine supplementation reduces the adverse cardiovascular effects of exposure to traffic-related air pollution among a group of non-smoking adults with elevated blood…
- Trial name
- NCT03433963
- Testing
- L-Arg supplement
- Where
- 3 sites in China
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Peking University
Air Pollution
Health Effects of Repeated Exposure to Low Levels of Concentrated Ambient Particles in Healthy Young Volunteers
Purpose: To determine whether 3-day consecutive exposures to levels of fine particulate matter (PM2.5) that are close to the current 24-hr national standard will cause changes in inflammatory and cardiopulmonary endpoints in…
- Trial name
- NCT05323240
- Testing
- PM exposure, Filtered air exposure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- U.S. EPA Human Studies Facility
Water-Related Diseases, Enteric Pathogens
Rural Appalachia Pilot Water Treatment Trial
Consumption of unsafe drinking water is associated with a substantial burden of disease globally. In the USA, the burden of disease associated with consumption of contaminated drinking water from non-regulated private wells and…
- Conditions
- Water-Related Diseases, Enteric Pathogens, Exposure to Chemical Pollution
- Trial name
- NCT06120985
- Testing
- Countertop pitcher water filter
- Where
- 2 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Air Pollution
Particulate Matter, Blood Pressure, and the Sympathetic Nervous System
Healthy volunteers will be exposed to ambient air near a roadway under the conditions of with and without a facemask and their responses will be evaluated.
- Trial name
- PM-SNS (NCT03079843)
- Testing
- exposure to particulate matter with N 95 facemask, exposure to particulate matter with no face mask
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Respiratory Tract Infections, Pneumonia
Randomised Exposure Study of Pollution Indoors and Respiratory Effects
The purpose of this study was to determine whether reduced exposure to indoor air pollution would reduce ALRI incidence in children <18 months of age.
- Trial name
- RESPIRE (NCT01047696)
- Testing
- Plancha
- Where
- Guatemala
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Sleep Apnea, Allergic Rhinitis
Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study
It has been demonstrated that allergic rhinitis (AR) reduces sleep quality by some components such as nasal obstruction. Pollution and allergen exposure worsening AR, sleep quality is deteriorated.
- Conditions
- Sleep Apnea, Allergic Rhinitis, Allergic Asthma, Pollution Exposure
- Trial name
- POLLAR (NCT03776773)
- Testing
- Pollution exposure
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Inflammation
Effects of Dietary Supplements on Response to Air Pollution
This study will determine if a comprehensive antioxidant/anti-inflammatory dietary supplement pack can offer protection against a decline in lung function and increase in inflammation and oxidative stress following acute exposure…
- Trial name
- NCT01488656
- Testing
- Antioxidant, anti-inflammatory dietary supplement
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Utah State University
Tobacco Use, Pollution; Exposure
FRESHAIR4Life: Building the Case for Action
The goal of this observational study is to understand the burden and determinants of tobacco use and air pollution (AP) exposure among mid- to late adolescents in Greece, the Kyrgyz Republic, Pakistan, Romania, and Uganda.
- Conditions
- Tobacco Use, Pollution; Exposure, Non-communicable Disease
- Trial name
- NCT06074939
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Biomarkers of Air Pollution Exposure
Biomarkers of Exposure to Air Pollutants (AEROTOX-2)
Nowadays, an increase of inflammatory chronic diseases and/or tumors incidence has been reported in part due to the rising in life expectancy.
- Trial name
- AEROTOX-2 (NCT02765529)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Air Pollution
The Effect of Juice Types on the Responses to Air Pollution
The study hypothesis is that drinking different juices will affect the body's responses to air pollution. Subjects will be exposed to air pollution during a 2-hour car ride on the NJ (New Jersey) Turnpike.
- Trial name
- NCT02027415
- Testing
- Beet juice, Orange juice
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cardiovascular Effects
Diesel Exhaust and Vascular Function
Double-blind, sham- and placebo-controlled randomized study of effects of freshly-generated diluted diesel exhaust inhalation on vascular function.
- Trial name
- CVDTRAP4 (NCT01508637)
- Testing
- Diesel Exhaust, Filtered Air, Terazosin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Washington
Sister-chromatic-exchange(SCE), Micronuclei(MN)
A Research on the Hospital Pollution Control and Hygine Intervention of Chemotherapy Drugs Exposure
Several epidemiological studies found that exposure to antineoplastic agents were associated with some reproductive, carcinogenic effects, higher rates of advance micronuclei (MN), sister-chromatic-exchange (SCE) and spontaneous…
- Trial name
- NCT01253057
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Innate Inflammatory Response, Vaccination
PFAS Exposure and Immune Response to Vaccination in Adults
This clinical trial aims to investigate how exposure to Perfluorononanoic acid (PFNA), a type of per- and polyfluoroalkyl substance (PFAS), affects the immune response to the standard tetanus and diphtheria (Td) vaccine.
- Conditions
- Innate Inflammatory Response, Vaccination, Diphtheria, Tetanus
- Trial name
- NCT06588530
- Testing
- TENIVAC
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey