Clinical trials: Polycystic Kidney Disease
Polycystic Ovary Syndrome, Urine Albumin \(UAlb\)
Urine Albumin/Creatinine Ratio and Renal Function Differences in Phenotypes of Polycystic Ovary Syndrome.
Since there are different metabolic effects in different phenotypes of polycystic ovary syndrome (PCOS); in this study; the investigators aimed to investigate whether there is a difference between glomerular filtration rate…
- Conditions
- Polycystic Ovary Syndrome, Urine Albumin \(UAlb\), Urine Creatinine \(UCr\), Glomerular Filtration Rate
- Trial name
- NCT07441811
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Uşak University
Autosomal Dominant Polycystic Kidney, Hypertension
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may…
- Conditions
- Autosomal Dominant Polycystic Kidney, Hypertension, Endothelial Dysfunction
- Trial name
- BEET-PKD (NCT05401409)
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
Autosomal Recessive Polycystic Kidney Disease
Imaging Assessments of ARPKD Kidney Disease Progression
Autosomal Recessive Polycystic Kidney Disease (ARPKD) is a potentially lethal genetic disorder for which there are currently no disease specific treatments.
- Trial name
- IMAGE-ARPKD (NCT07201025)
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Chronic Kidney Disease, Nephrolithiasis
Kidney Sodium Functional Imaging
The corticomedullary gradient is largely responsible for developing the gradients that are needed to concentrate urine (more solutes and less water).
- Conditions
- Chronic Kidney Disease, Nephrolithiasis, ADPKD
- Trial name
- NCT05014178
- Testing
- Sodium-23 MRI
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Polycystic Kidney Diseases
Sirolimus for Massive Polycystic Liver
The purpose of this study is to evaluate the effectiveness and safety of Sirolimus in reducing liver volume in autosomal dominant polycystic kidney disease.
- Trial name
- SILVER (NCT01680250)
- Testing
- Sirolimus
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Polycystic Liver Disease
Polycystic Liver Disease in Kidney Transplant
The purpose of this study is to see if one kind of immunosuppressive drug has better effects for the patient's polycystic liver disease than another type.
- Trial name
- NCT00934791
- Testing
- Tacrolimus, Sirolimus, Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Polycystic Kidney, Autosomal Dominant
Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults With Autosomal Dominant Polycystic Kidney Disease
The proposed research will determine the feasibility of delivering two behavioral weight loss interventions for 1 year in adults with autosomal dominant polycystic kidney disease (ADPKD) who are overweight or obese.
- Trial name
- NCT03342742
- Testing
- Weight Loss
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Colorado, Denver
ADPKD (Autosomal Dominant Polycystic Kidney Disease)
A Phase 1 Study of Single and Multiple Ascending Doses of GV-100
This is a first-in-human, multi-part clinical study designed to evaluate the safety, tolerability, pharmacokinetics (PK), food effect, and drug-drug interaction (DDI) potential of GV-100 following oral administration in healthy…
- Trial name
- NCT07788014
- Testing
- GV-100
- Where
- Australia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gilva Therapeutics Inc.
Polycystic Kidney, Autosomal Dominant
The Relation Between Uric Acid Level and Endothelial Dysfunction in Patients With Polycystic Kidney Disease
There are substantial data demonstrating increased endothelial dysfunction, inflammation and oxidative stress in patients with Autosomal dominant polycystic kidney disease (ADPKD), the association between serum uric acid level…
- Trial name
- NCT01589705
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- TC Erciyes University
Polycystic Liver Disease
Somatostatin Analogues as a Volume Reducing Treatment of Polycystic Livers (RESOLVE)
The aim of this study is to determine the effect of Lanreotide on polycystic liver and kidneys in patients with autosomal dominant polycystic kidney disease.
- Trial name
- RESOLVE (NCT01354405)
- Testing
- Lanreotide
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Radboud University Medical Center
Healthy Volunteers, Polycystic Kidney, Autosomal Dominant
Effect of Venglustat in Patients With Renal Impairment
Primary Objective: To study the effect of mild, moderate and severe renal impairment on the pharmacokinetics (PK) of Venglustat following a single dose.
- Trial name
- NCT03687554
- Testing
- Venglustat GZ/SAR402671
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Genzyme, a Sanofi Company
Autosomal Dominant Polycystic Kidney
Treatment of Vascular Stiffness in ADPKD
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease characterized by cystic kidneys and caused by mutations in the polycystic kidney disease and other rare genes.
- Trial name
- TRAMPOLINE (NCT05228574)
- Testing
- Sodium chloride (NaCl), Amiloride Hcl 5mg Tab
- Where
- Netherlands
- Volunteers
- 46 people
- Sponsor
- Erasmus Medical Center
Uncontrolled Hypertension, Autosomal Dominant Polycystic Kidney Disease
Renal Denervation in ADPKD- RDN-ADPKD Study
RDN-ADPKD is a prospective, randomized (1:1, central randomization), single-center, hypothesis-generating, feasibility study. The purpose of the RDN-ADPKD study is to demonstrate efficacy and document safety of renal denervation…
- Conditions
- Uncontrolled Hypertension, Autosomal Dominant Polycystic Kidney Disease, Renal Denervation
- Trial name
- RDN-ADPKD (NCT05460169)
- Testing
- Renal denervation
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Autosomal Dominant Polycystic Kidney Disease
Somatostatin In Patients With Autosomal Dominant Polycystic Kidney Disease And Moderate To Severe Renal Insufficiency
The general aim of the trial is to assess the efficacy of one year treatment with long-acting somatostatin analogue (Octreotide LAR) compared with placebo in slowing kidney and liver growth rate in patients with ADPKD and…
- Trial name
- ALADIN2 (NCT01377246)
- Testing
- Octreotide-LAR, Saline solution.
- Where
- 6 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Healthy Volunteers
A Study of RGLS8429 in Healthy Volunteers
Primary Objective To assess the safety and tolerability of single ascending doses of RGLS8429 Secondary Objectives To identify dose-limiting toxicity (DLT) and to determine the maximum tolerated dose (MTD) of a single SC dose of…
- Trial name
- NCT05429073
- Testing
- RGLS8429
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Regulus Therapeutics Inc.
Autosomal Dominant Polycystic Kidney Disease
Efficacy of Tolvaptan on ADPKD Patients
Investigation of the therapeutic effects of tolvaptan in patients with autosomal dominant polycystic kidney disease This is a prospective 5-year study to compare the change in total kidney volume (TKV) before and after tolvaptan…
- Trial name
- NCT02729662
- Testing
- Tolvaptan
- Where
- Japan
- Volunteers
- 118 people
- Sponsor
- Kyorin University
Polycystic Kidney Disease
Evaluation of Gut Bacteria in Patients With Polycystic Kidney Disease
Gut microbes can influence numerous aspects of human biology. Alterations in the function and composition of gut microbial flora (gut microbiota ) have been linked to inflammatory bowel disease, chronic inflammation…
- Trial name
- NCT02142101
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Simulated and Synthetic Health Data: Improving Clinical Research on Rare Diseases. A Real-World Data Simulation of Autosomal Dominant Polycystic Kidney Disease (ADPKD) Trials. A Retrospective, Observational Study
This is a no-profit, retrospective observational study involving real-world data (RWD), retrieved from ADPKD-related electronic health records stored at Mario Negri Institute IRCCS.
- Trial name
- SAILING-ADPKD (NCT07016282)
- Where
- 2 sites in Italy, Sweden
- Volunteers
- 100 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
ADPKD, Autosomal Dominant Polycystic Kidney
Statin Therapy in Patients With Early Stage ADPKD
This study plans to learn if pravastatin is helpful in slowing down the progression of kidney disease in adults with autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT03273413
- Testing
- Pravastatin
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
PCOS, Infertility, Female
Effect of Acupuncture Plus Governor Vessel Moxibustion Combined With Letrozole on Live Birth in Anovulatory Infertile Women With Spleen-kidney Yang Deficiency PCOS
Investigators expected to verify this hypothesis through this study:acupuncture and moxibustion combined with LE induced ovulation in Chinese anovulatory PCOS women has a higher rate of live birth than LE induced ovulation alone.
- Trial name
- PCOS (NCT04987632)
- Testing
- Letrozole, acupuncture, Governor vessel moxibustion
- Volunteers
- 90 people
- Sponsor
- Qiu-ping Lin