Clinical trials: Polyethylene Glycols
Constipation
Maintenance Treatment for Children With Constipation
Constipation is a common problem among children. The majority of children suffering from constipation have no underlying disease.
- Trial name
- NCT01566409
- Testing
- Polyethylene glycol 3350
- Where
- Denmark
- Volunteers
- 115 people
- Sponsor
- Line Modin
Colon Polyp, Colon Adenoma
Study Comparing the Bowel Cleansing Efficacy of PLENVU® Versus SELG-ESSE® Using a 2-Day Split Dosing Regimen.
This study is a multicentre randomized parallel group phase IV study comparing the bowel cleansing efficacy, safety and tolerability of PLENVU® (a 1 litre PEG Bowel Cleansing Solution) versus SELG-ESSE® (a 4 litre PEG Bowel…
- Conditions
- Colon Polyp, Colon Adenoma, Colon Lesion
- Trial name
- NCT03742232
- Testing
- PEG3350, Macrogol 4000
- Where
- 5 sites in Italy
- Volunteers
- 399 people
- Sponsor
- Istituto Clinico Humanitas
Constipation
Polyethylene Glycol for Childhood Constipation
Background: Aim: Clinical evaluation of the effectiveness of two different polyethylene glycol doses for the maintenance treatment of functional constipation in children. Study design: Randomized, open-label trial.
- Trial name
- NCT01875744
- Testing
- Polyethylene glycol 4000
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Medical University of Warsaw
Constipation
Efficacy and Safety of Polyethylene Glycol 3350 (PEG 3350) for Relief of Constipation (MK-8114-005)
The purpose of this study is to evaluate the complete resolution of constipation in participants taking PEG 3350 compared to those taking PEG 4000, based on analysis of the number of bowel movements from self-reported bowel…
- Trial name
- NCT02292459
- Testing
- Polyethylene Glycol 3350 Powder for Solution (PEG 3350), Polyethylene Glycol 4000 Powder for Solution (PEG 4000)
- Sponsor
- Bayer
Kidney Transplantation, Anemia
Correcting Anemia and Native Vitamin D Supplementation in Kidney Transplant Recipients
The purpose of this study is to evaluate the effect of anemia correction and vitamin D supplementation in kidney transplant recipients.
- Conditions
- Kidney Transplantation, Anemia, Vitamin D Deficiency, Renal Insufficiency, Chronic
- Trial name
- CANDLE-KIT (NCT01817699)
- Testing
- High Hb target, cholecalciferol
- Where
- Japan
- Volunteers
- 161 people
- Sponsor
- CANDLE-KIT Trial Study Group
Healthy
Safety, Tolerance, and Pharmacokinetics of BILN 2061 ZW in Healthy Male Subjects, Combined With Preliminary Evaluation of Food Effect
To assess the safety, tolerance and pharmacokinetics of 5 mg to 2400 mg BILN 2061 ZW 1. In rising single doses 2. With and without a 64 g fat breakfast at one selected dose
- Trial name
- NCT02268760
- Testing
- BILN 2061 ZW single rising doses, BILN 2061 ZW fixed dose, Standardized breakfast
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Type 2 Diabetes
A Phase I Study of Polyethylene Glycol Loxenatide in Patients With Type 2 Diabetes
Polyethylene Glycol Loxenatide (PEX168) is a new human glucagon-like peptide 1 (GLP-1) analogue that created on the basis of the Exenatide and modified by polyethylene glycol (PEG).
- Trial name
- NCT01965496
- Testing
- PEX168
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Polyps, Colon Preparation
Comparison Between Asymmetric And Standard Split-Dose Regimen For Bowel Preparation
We aimed to compare the efficacy for bowel cleansing of a split-dose regimen with a low morning dose of PEG solution (Asymmetric; 25% of the dose is given on the day of the procedure and 75% of the dose is given on the day…
- Trial name
- NCT03146052
- Testing
- PEG-4000 added with citrates and simethicone (PEG-CS) plus Bisacodyl
- Where
- Italy
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- ASST Rhodense
Colonic Neoplasms
Comparison of Oral Lactulose Versus Polyethylene Glycol for Bowel Preparation in Low-risk Patients
Adequate quality of bowel preparation(BP) is essential for colonoscopy. In recently, Kang suggested that for low-risk patients, single dose of 2L PEG is an effective regimen for bowel preparation.However, due to the poor…
- Trial name
- NCT05648318
- Testing
- Lactulose oral solution, PEG
- Where
- China
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Zhang Xiaofeng,MD
Hepatitis C
Efficacy of Polyethylene Glycol-Interferon Alfa-2B (PEG-Intron, SCH 54031) Compared to Interferon Alfa-2B in Participants With Chronic Hepatitis C (MK-4031-016)
This study will determine the efficacy of PEG-Intron (SCH 54031) in participants with chronic Hepatitis C virus (HCV) infection who have not been previously treated with interferon.
- Trial name
- NCT03537274
- Testing
- PEG-Intron, Interferon Alfa-2B
- Volunteers
- 1,224 people
- Sponsor
- Merck Sharp & Dohme LLC
Hepatic Encephalopathy, HE
Hepatic Encephalopathy: Lactulose or Polyethylene Glycol (H.E.L.P.)
The purpose of this study is to evaluate whether the use of polyethylene glycol is superior and more safe in treating hepatic encephalopathy compared to lactulose and also to determine if treatment with polyethylene glycol will…
- Conditions
- Hepatic Encephalopathy, HE, Cirrhosis, Altered Mental Status
- Trial name
- HELP (NCT01923376)
- Testing
- Lactulose, Polyethylene Glycol 3350
- Where
- United States
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Healthy
A Study of 99mTc-3PRGD2 Injection in Healthy Volunteers
The study drug 99mTc-3PRGD2 of this study is a new radioactive diagnostic preparation for clinical use as a nuclear medicine molecular probe for tumor SPECT/CT imaging.
- Trial name
- NCT03974685
- Testing
- 99mTc niacinamide polyethylene glycol bicyclic RGD peptide (99mTc-3PRGD2)
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- RDO Pharm.
Appendicitis, Appendicitis Acute
Clinical Study of PEG Bowel Preparation in Appendectomy Patients
Colonoscopy is a necessary item of physical examination for colorectal cancer. For high-risk groups, annual physical examination is the most effective way of early prevention; At present, a large amount of polyethylene glycol…
- Trial name
- NCT07478029
- Testing
- Bowel Preparation with Polyethylene Glycol (PEG) Laxatives
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Huaping Xie
Anemia
A Non-Interventional Study of Mircera (Methoxy Polyethylene Glycol-Epoetin Beta) in Patients With Chronic Kidney Disease Not on Dialysis
This multicenter observational study will evaluate the efficacy and safety of Mircera (methoxy polyethylene glycol-epoetin beta) in patients with chronic kidney disease not on dialysis in routine clinical practice.
- Trial name
- NCT01892202
- Testing
- Cohort
- Sponsor
- Hoffmann-La Roche
Bowel Preparation Before Colonoscopy
A Trial to Evaluate the Efficacy and Safety of PMF104 Compared to a Conventional PEG-electrolyte Solution in Children
A randomised, single-blind, active controlled, multi-centre trial to evaluate the efficacy, safety, tolerability, acceptability and palatability of PMF104 compared to a conventional PEG-electrolyte solution in paediatric subjects…
- Trial name
- NCT03106922
- Testing
- PMF104, Klean-prep
- Where
- 9 sites in Belgium, France and 1 more
- Volunteers
- 430 people
- Sponsor
- Alfasigma S.p.A.
Colonoscopy
Polyethylene Glycol Versus Low Volume Solutions Prior to Colonoscopy
Study evaluates the efficacy and tolerability of low volume preparations compared with conventional 4L polyethylene glycol prior to colonoscopy
- Trial name
- NCT02956057
- Testing
- Polyethylene Glycols, Natrium picosulfate / Magnesium citrate, Polyethylene glycol / Ascorbic acid
- Where
- Czechia
- Volunteers
- 1,044 people
- Sponsor
- Tomas Bata Hospital, Czech Republic
Anemia
An Observational Study of Hemoglobin Stability in Chronic Kidney Disease Patients on Dialysis Treated With Mircera (Methoxy Polyethylene Glycol-epoetin Beta)
This prospective, multicenter, observational study will evaluate the impact of comorbidities on hemoglobin stability in chronic kidney disease patients on dialysis treated with Mircera (methoxy polyethylene glycol-epoetin beta).
- Trial name
- NCT01974271
- Where
- 76 sites in France
- Volunteers
- 661 people
- Sponsor
- Hoffmann-La Roche
Constipation
Itopride as an Adjuvant for Bowel Preparation in Patients With Chronic Constipation is Effective
Bowel preparation is a major determinant of colonoscopy and colorectal surgery. Polyethylene glycol electrolyte solutions (PEG-E) are the most commonly used laxatives in China.
- Trial name
- NCT01513811
- Testing
- Polyethylene glycol electrolyte solutions, Itopride and Polyethylene glycol electrolyte solutions
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Quality of Small Bowel Preparation
The Effect of Transcutaneous Electrical Acustimulation on Small Bowel Preparation for Capsule Endoscopy
Transcutaneous elctroacupuncture(TEA) at ST36 can improve gastrointestinal motility. Therefore,the investigators hypothesized that if TEA is applied to the preparation of small bowel capsule endoscopy, the small bowel peristalsis…
- Trial name
- NCT06099392
- Testing
- digital stimulators (SNM-FDC01, Ningbo MaidaMedical Device, Inc, Ningbo, China)
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Healthy
Single Rising Dose Study of BI 201335 ZW in Healthy Male Subjects
The objective of the current study is to investigate safety, tolerability, and pharmacokinetics of BI 201335 ZW following administration of single rising doses from 5 mg to 1500 mg.
- Trial name
- NCT02182271
- Testing
- BI 201335 ZW - single rising dose
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim