Clinical trials: Polymers
Dentin Hypersensitivity, Non-carious Cervical Lesions, Gingival Recession Localized Moderate
Polymeric Nano Calcium Fluoride Varnish, Diode Laser, and Their Combination for Dentin Hypersensitivity
The aim of the study is to assess the effect of polymeric nano calcium fluoride Varnish (Oli-NANO seal), 976 nm diode laser solely and combination of both therapies in the treatment of dentin hypersensitivity
- Trial name
- NCT07418788
- Testing
- Olinano seal, Diode Laser, Olinano seal and Diode Laser
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Coronary Artery Disease
SWiss Evaluation of Bioabsorbable Polymer-coated Everolimus-eluting Coronary sTent
Bioresorbable polymer drug eluting stents (DES) are an indisputable improvement over first-generation DES with promising results on long-term adverse events. But the thicker polymer and/or strut may hinder its deliverability.
- Trial name
- NCT02150876
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University of Freiburg
Patient Population With Multivessel Disease
CRUZ Tunisia-Multivessel Registry
The primary objective of this registry is to evaluate the safety and clinical performance of the biodegradable polymer-coated Supraflex Cruz Sirolimus-eluting Stent (SES) in an unselected, all-comer patient population with…
- Trial name
- NCT06663696
- Testing
- Supraflex Cruz Sirolimus-eluting Coronary Stent System
- Where
- 2 sites in Tunisia
- Volunteers
- 1,000 people
- Sponsor
- Sahajanand Medical Technologies Limited
Chronic Pain
A Randomized, Controlled Study of Repeat Dose Sustained Release Lidocaine for Treatment of Chronic Scrotal Pain
This multi-center, phase 2, randomized, single-blind, three-arm, active-controlled study is comparing repeat doses, every 28 days, of standard of care (SOC) plus ST-01 against SOC plus 1% lidocaine HCL in men experiencing chronic…
- Trial name
- NCT05707208
- Testing
- ST-01, 1% Lidocaine HCL
- Where
- 8 sites in Canada
- Volunteers
- 63 people
- Sponsor
- Sustained Therapeutics Inc.
Osteoarthritis (OA) of the Knee
Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty
Participants are being invited to take part in a research study about pain control after total knee replacement surgery (also called total knee arthroplasty or TKA).
- Trial name
- NCT07775248
- Testing
- Periarticular Injection, Adductor Canal Block, Bupivacaine-Meloxicam
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Henry Ford Health System
Coronary Artery Disease
Non-inferiority Trial to Assess the Safety and Performance of the Evolution Coronary Stent
The purpose of the EVOLVE Trial is to assess the safety and performance of the everolimus-eluting Evolution stent for the treatment of a de novo atherosclerotic lesion of up to 28 mm in length in a native coronary artery 2.25 mm…
- Trial name
- Evolve (NCT01135225)
- Testing
- PROMUS(TM) Element (TM) Stent System, Evolution Stent System
- Where
- 29 sites in Australia, Belgium and 7 more
- Volunteers
- 291 people
- Sponsor
- Boston Scientific Corporation
STEMI - ST Elevation Myocardial Infarction
Laser Atherectomy for ST Elevation Myocardial Infarction
The objectives of this study are to observe and examine prospectively whether excimer laser coronary angioplasty (ELCA) and percutaneous coronary intervention with biodegradable-polymer platinum chromium everolimus-eluting stent…
- Trial name
- NCT03950310
- Testing
- Excimer laser catheter
- Where
- Japan
- Volunteers
- 142 people
- Sponsor
- Tokai University
Head and Neck Cancer
A Single Arm, Prospective, Open Label, Multi Center, Phase Ib Study to Evaluate the Safety, Tolerability and Initial Efficacy of a Single Intra-tumoral Injection of IntraGel's Polymer-based Cisplatin-loaded Gel (TumoCure) in Subjects With Progressive or Radio-resistant Primary Head and Neck Tumor
IntraGel's polymer-based Cisplatin loaded Gel (TumoCure) is a single injectable compound, aimed at localized chemotherapy treatment.
- Trial name
- NCT05200650
- Testing
- TumoCure
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- IntraGel Therapeutics
Squamous Cell Lung Cancer
Phase II Study of Platinum (Cisplatin/Carboplatin)and Polymeric Micelles Paclitaxel(Pm-Pac) With Ivonescimab in First Line Metastatic Squamous NSCLC.
This is a prospective, single-arm, multi-center, phase Ⅱ trial to evaluate the efficacy and safety of Polymeric Micelles paclitaxel(pm-Pac), platinum (cisplatin/carboplatin) in combination with Ivonescimab as first-line treatment…
- Trial name
- NCT07009925
- Testing
- Ivonescimab 20mg/kg intravenous every 3 weeks
- Volunteers
- 38 people
- Sponsor
- Jiangsu Cancer Institute & Hospital
Metastatic Breast Cancer, Stage IV Breast Cancer
BP-C1 Monotherapy in Patients With Metastatic Breast Cancer Cancer: Estimation of Optimal Duration of Treatment
The purpose of this study is to establish an optimal treatment duration and tolerable cumulative dose for BP-C1 in the treatment of metastatic breast cancer patients who had previously undergone at least three lines of…
- Trial name
- NCT03789019
- Testing
- BP-C1
- Where
- 7 sites in Russia, Thailand
- Volunteers
- 29 people
- Sponsor
- Meabco A/S
Subtalar Arthrorisis, Flat Feet
Arthrorisis of the Subtalar Joint With a Polymeric Endorthesis for Flexible Flatfoot Treatment During the Growth Age Prospective Evaluation
Arthrorisis of the subastragalus joint represents one of the surgical treatments for addressing flexible flatfoot, a condition caused by joint deformity.
- Conditions
- Subtalar Arthrorisis, Flat Feet, Growth Age
- Trial name
- NCT06091371
- Where
- Italy
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Locally Resectable Pediatrics Tumors
CEB-01 in Pediatrics With Locally Resectable Abdominal Tumors
The CEB-01 implant is a membrane containing SN-38, the active metabolite of irinotecan, an already authorized chemotherapeutic agent.
- Trial name
- NCT06986811
- Testing
- Standard surgery, CEB-01
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- CEBIOTEX
Acute Coronary Syndrome
Harmonizing Optimal Strategy for Treatment of Coronary Artery Diseases Trial - Comparison of REDUCTION of PrasugrEl Dose & POLYmer TECHnology in ACS Patients (HOST REDUCE POLYTECH RCT Trial)
Study objectives 1. To compare the safety and long-term efficacy of coronary stenting with biostable polymer drug-eluting stent (Promus PremierTM, Xience Alpine®, Resolute Onyx®) with biodegradable polymer drug-eluting stent…
- Trial name
- NCT02193971
- Testing
- BS-DES (Biostable polymer drug-eluting stent), BD-DES (Biodegradable polymer drug-eluting stent), Prasugrel 5mg
- Where
- South Korea
- Volunteers
- 3,429 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
A Trial Comparing a Paclitaxel Eluting Stent With Biodegradable Polymer Versus a Bare Metal Stent
The success of stent implantation has led to the increasingly widespread use of them in the treatment of coronary artery disease (Sigwart, Serruys, Fischman)and although stent restenosis is still a limit for this therapeutic mode…
- Trial name
- EUCATAX (NCT00825279)
- Testing
- Bare Metal Stent, Drug Eluting Stent
- Where
- 2 sites in Argentina
- Volunteers
- 300 people
- Sponsor
- Centro de estudios en Cardiologia Intervencionista
Coronary Stenosis
Study Comparing the MiStent SES Versus the XIENCE EES Stent
The primary objective of this study is to compare the performance of MISTENT to that of XIENCE in an all-comers patient population with symptomatic ischemic heart disease.
- Trial name
- DESSOLVE III (NCT02385279)
- Testing
- MiStent, XIENCE EES
- Where
- 20 sites in France, Germany and 2 more
- Volunteers
- 1,398 people
- Sponsor
- ECRI bv
Coronary Disease, Drug Eluting Stent
Outcome of CHAllenging lesioNs and Patients Treated With Polymer Free Drug-CoatEd Stent
Length of DAT (Dual Antiplatelet therapy) represents one of the most challenging choices for interventional cardiologist. Prolonged DAT reduces risk of subsequent MI (Myocardial Infarction) with an increase in major bleedings…
- Conditions
- Coronary Disease, Drug Eluting Stent, STEMI
- Trial name
- CHANCE (NCT03622203)
- Testing
- Biofreedom
- Volunteers
- 1,000 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Gender Dysphoria
Polyethylene-glycol Assisted Nerve Repair in Phalloplasty
Phalloplasty, a genitourinary surgery for transmasculine patients, reconstructs a neophallus using tissue transferred from other parts of the body to the groin.
- Trial name
- NCT05897086
- Testing
- Polyethylene Glycol 3350
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Pain During Caries Excavation
Comparison of Intraoperative Pain Perception During Caries Excavation Using Smart Burs and Carisolv to Conventional Diamond Burs
The goal of this randomized controlled trial is to compare the amount of pain experienced during removal of dental caries using Smart burs, Carisolv, and conventional diamond burs in adults aged 18-45 years with active caries in…
- Trial name
- NCT07869407
- Testing
- polymer burs, Carisolv, Conventional Diamond Burs
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Rehman Medical Institute - RMI
Postoperative Pain, Postsurgical Pain
Sustained Release Lidocaine for the Treatment of Postoperative Pain
In this study, the investigators are testing a new formulation of lidocaine for its suitability in managing postoperative pain after pelvic (circumcision, inguinal, scrotal), perineal (hemorrhoidectomy) or perianal (fistulotomy)…
- Trial name
- NCT05193227
- Testing
- ST-01, Control (Lidocaine Hydrochloride Injection USP Xylocaine® or Bupivacaine Hydrochloride Injection USP Marcaine®)
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia
Coronary Artery Disease, Acute Coronary Syndrome
A Comparison of an Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Stent With a Durable Polymer Everolimus-Eluting Stent for Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
PCI is considered as the reperfusion strategy of choice for patients with acute STEMI. Data from RCTs and meta-analyses demonstrate a consistent and strong signal towards a significant reduction in MACE among patients with STEMI…
- Trial name
- BIOSTEMI (NCT02579031)
- Testing
- Orsiro, Xience
- Where
- 10 sites in Switzerland
- Volunteers
- 1,300 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern