Clinical trials: Polymers
Asherman Syndrome, Intrauterine Adhesion
PREvention of Intrauterine Adhesion After Adhesiolysis With Novel Tri-block deGradable Polymer Film.
PREG2 is a randomized controlled trial that aims to evaluate efficacy in preventing intrauterine adhesion recurrence after hysteroscopic adhesiolysis of a novel intrauterine barrier film named Womed Leaf
- Trial name
- PREG2 (NCT04963179)
- Testing
- Womed Leaf
- Where
- 15 sites in Belgium, China and 5 more
- Volunteers
- 160 people
- Sponsor
- Womed
Percutaneous Coronary Intervention, Diabetes Mellitus
Comparison of Biodegradable Polymer vs Durable-polymer in Diabetic Patients
Both biodegradable polymer-based biolimus-eluting stents (BP-BES) and durable polymer-based everolimus-eluting stents (DP-EES) have been shown to improve long-term clinical outcomes as compared with early generation DES.
- Trial name
- RUDI 2D (NCT02854423)
- Testing
- percutaneous coronary interventions
- Volunteers
- 1,347 people
- Sponsor
- University of Roma La Sapienza
Coronary Heart Disease, Stable Angina Pectoris
Heterogeneity of Neointimal Healing Following Biodegradable-polymer Drug-Eluting Coronary Stent Implantation
The objective of this study is a comparative evaluation of Orsiro stent and of Resolute Integrity stent in terms of the extent of neointima formation at 4 months after implantation using optical coherence tomography (OCT).
- Conditions
- Coronary Heart Disease, Stable Angina Pectoris, Silent Myocardial Ischemia
- Trial name
- Healing (NCT04465669)
- Testing
- Orsiro stents, Resolute Integrity® stents
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Pulmonary Emphysema, Chronic Obstructive Pulmonary Disease(COPD)
A Continuation Study of the AeriSeal® System Administered at 3 to 4 Sites During a Single Treatment Session for Lung Volume Reduction in Patients With Advanced Emphysema
The purpose of this study is to assess the long term safety and efficacy of AeriSeal System treatment administered at up to 4 subsegments during a single treatment session for lung volume reduction in patients with advanced…
- Conditions
- Pulmonary Emphysema, Chronic Obstructive Pulmonary Disease(COPD), Lung Diseases
- Trial name
- NCT01320566
- Testing
- AeriSeal System
- Where
- 2 sites in Israel
- Volunteers
- 18 people
- Sponsor
- Aeris Therapeutics
Coronary Artery Disease, Atherosclerosis, Coronary
Safety and Effectiveness of the Orsiro Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions
The objective of this study is to assess the safety and efficacy of the Orsiro Sirolimus Eluting Coronary Stent System in the treatment of subjects with up to three native de novo or restenotic (standard PTCA only) coronary…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Coronary, Myocardial Ischemia, Ischemic Heart Disease
- Trial name
- BIOFLOW-V (NCT02389946)
- Testing
- Orsiro DES, Xience DES
- Where
- 92 sites in United States, Australia and 11 more
- Volunteers
- 1,334 people
- Sponsor
- Biotronik, Inc.
Dentin Sensitivity
Exploratory Clinical Study to Investigate the Ability of an Experimental Combination Dentifrice to Protect Sensitive Teeth
This proof of principle (PoP) study will evaluate the ability of an experimental combination toothpaste formulation to protect sensitive teeth from dentine hypersensitivity.
- Trial name
- NCT05243745
- Testing
- 3% PVM/MA + 5% KNO3 Combination, 3% PVM/MA only, 5% KNO3 Only
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- HALEON
Dental Restoration Failure
Clinical Performance of Two Different Resin-Matrix Ceramic Restorations
This study was designed to evaluate and compare the 2-year clinical performance of two different resin-matrix ceramic inlays
- Trial name
- NCT07265609
- Testing
- inlays
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Coronary Artery Disease, Percutaneous Coronary Intervention
Effectiveness and Safety of Abluminal Biodegradable Polymer Sirolimus-eluting Stent (GENOSS® DES)
In this study, the investigators evaluated the effectiveness and safety of using the GENOSS® DES, which has a biodegradable polymer only on the inner wall of the blood vessel, for patients(all-comers) with coronary artery disease…
- Trial name
- GENCOMX (NCT06086496)
- Testing
- GENOSS® DES Sirolimus Eluting Coronary Stent System
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Genoss Co., Ltd.
Acute Coronary Syndrome, Angina Pectoris
Comparison of BIOdegradable Polymer and DuRablE Polymer Drug-eluting Stents in an All COmeRs PopulaTion (BIO-RESORT)
The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity.
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- BIO-RESORT (NCT01674803)
- Testing
- Orsiro, Synergy, Resolute Integrity
- Where
- Netherlands
- Volunteers
- 3,514 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
Aortic Aneurysm, Abdominal
Expanding Patient Applicability With Polymer Sealing Ovation Alto Stent Graft Investigational Device Exemption (IDE) Study
A prospective clinical evaluation of the effectiveness of the Ovation Alto Abdominal Stent Graft System when used in the treatment of subjects with abdominal aortic aneurysm (AAA).
- Trial name
- ELEVATE (NCT02949297)
- Testing
- Ovation Alto Abdominal Stent Graft System
- Where
- 13 sites in United States
- Volunteers
- 75 people
- Sponsor
- Endologix
Ovarian Cancer
Paclitaxel-Loaded Polymeric Micelle and Carboplatin as First-Line Therapy in Treating Patients With Advanced Ovarian Cancer
RATIONALE: Drugs used in chemotherapy, such as paclitaxel-loaded polymeric micelle and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00886717
- Testing
- carboplatin, paclitaxel-loaded polymeric micelle
- Where
- 4 sites in South Korea
- Volunteers
- 74 people
- Sponsor
- Asan Medical Center
Coronary Artery Disease
Biomime Stent in All-comers PCI Patients Registry
Biomime stent is a novel sirolimus-eluting stent (SES) (Meril Life Sciences Pvt. Ltd., Gujarat, India) with an ultra-thin stent platform (65 μm) and a biodegradable polymer licensed for the treatment of de novo coronary lesions.
- Trial name
- BELLINI (NCT02398955)
- Testing
- percutaneous coronary intervention
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Coronary Heart Disease
Test Safety of Biodegradable and Permanent Limus-Eluting Stents Assessed by Optical Coherence Tomography
The objective of the study is to assess the superiority of the biodegradable polymer based limus-eluting stent (Nobori®) compared with the permanent polymer based everolimus-eluting stent (XIENCE V®) regarding absolute percentage…
- Trial name
- TEST-6-OCT (NCT01097434)
- Testing
- Biodegradable polymer limus-eluting stents, Permanent polymer limus-eluting stent
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Deutsches Herzzentrum Muenchen
With Left Main Coronary Artery Lesions
Angiolite Registry Study
Left main coronary artery (LMCA) is a major branch of coronary artery and supplies a large bulk of myocardium. Percutaneous coronary intervention (PCI) using contemporary drug eluting stent (DES) is one of the treatment options…
- Trial name
- NCT07004569
- Testing
- Percutaneous coronary intervention (PCI)
- Where
- Hong Kong
- Volunteers
- 55 people
- Sponsor
- Chinese University of Hong Kong
Coronary Artery Disease
Sort Out XI - Combo Stent Versus BioMatrix Alpha Stent
SORT OUT XI Comparison of Combo™ stent and BioMatrix Alpha™ stent in the treatment of unselected patients with ischemic heart disease.
- Trial name
- SORTOUTXI (NCT03952273)
- Testing
- PCI with BioMatrix Alpha™ stent, PCI with Combo™ stent
- Where
- 2 sites in Denmark
- Volunteers
- 3,141 people
- Sponsor
- Phillip Freeman
Acute Coronary Syndrome, Angina Pectoris
DUrable Polymer-based STent CHallenge of Promus Element Versus ReSolute Integrity in an All Comers Population
The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity but there are further demands on DES performance.
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- DUTCH PEERS (NCT01331707)
- Testing
- Resolute Integrity (Zotarolimus-eluting stent), Promus Element (Everolimus-eluting stent)
- Where
- 4 sites in Netherlands
- Volunteers
- 1,811 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
Rhinosinusitis Chronic
Effectiveness of Endonasal Polymeric Implant for Chronic Rhinosinusitis
Objective: The objective of this study is to evaluate a steroid-embedded Terpolymers polymer implant of L-lactide and trimethynele carbonate (TCM) at the level of disease control in patients with eosinophilic and central…
- Trial name
- NCT05450471
- Testing
- Corticosteroid Topical
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Sao Paulo
Stable Angina, Unstable Angina, Silent Coronary Ischemia, Coronary Artery Disease
ISAR-DAPT (A Comparative Evaluation of Efficacy and Safety in the 3-Months DAPT Group vs. the 6-Months DAPT Group of Patients Treated With the Coroflex ISAR Stent; A Prospective, Multicenter, Randomized, Open-Label Clinical Trial)
This clinical trial studies patients treated with the Coroflex ISAR Stent for coronary artery disease in order for the objective of verifying the non-inferiority of results that among patients who were administered DAPT for 3…
- Trial name
- NCT02609698
- Testing
- Coroflex ISAR, 3 months DAPT, 6 months DAPT
- Where
- South Korea
- Volunteers
- 906 people
- Sponsor
- Ajou University School of Medicine
Coronary Artery Disease
Observational Registry Study: FIREHAWK DES for Treating Coronary Artery Disease (CAD)
The study aims to further assess the safety, efficacy and the performance of its delivery system of FIREHAWK rapamycin-eluting stent up to five years.
- Trial name
- NCT01412164
- Testing
- FIREHAWK biodegradable polymer rapamycin-eluting stent
- Where
- China
- Volunteers
- 730 people
- Sponsor
- Shanghai MicroPort Medical (Group) Co., Ltd.
Acute Coronary Syndrome, Diabetes Mellitus, Type 2
The Effect of DPP4 Inhibitor on Vasclular Healing
This study evaluate the effect of dipeptidyl-peptidase 4 inhibitor on vascular healing after biodegradable polymer based sirolimus eluting stent implantation in diabetic pateints.
- Trial name
- NCT02802644
- Testing
- Sitagliptin, Non DPP-4 Inhibitor
- Where
- 6 sites in South Korea
- Volunteers
- 66 people
- Sponsor
- Chung-Ang University