Clinical trials: Polymorphism-Genetic
Type 1 and 2 Diabetes
Genetic Polymorphisms, Steatosis and Diabetes
Our research hypothesis is to show that a certain number of genetic polymorphisms of the proteins involved in glucose, lipid and adipocyte metabolism are factors that favour the development of steatosis in patients with Type 2…
- Trial name
- NCT02045563
- Testing
- prise de sang, magnetic resonance imaging and magnetic resonance spectroscopy
- Where
- France
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Anovulation, Hyperandrogenism
Whole Genome Analysis for the Detection of Key Genes in the Polycystic Ovary Syndrome
Background: Infertility affects up to 15% of married couples. About half are attributable to female factors, among which anovulation is the leading cause.
- Conditions
- Anovulation, Hyperandrogenism, Polycystic Ovary Syndrome, Single Nucleotide Polymorphism
- Trial name
- NCT00665171
- Where
- Israel
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Maaynei Hayesha Medical Center
Genetics, Skin Aging
Relationship of Skin Related SNP to Topical Skin Care Product
Demonstrate the relationship between single nucleotide polymorphisms (SNP) and response to a topical skin care product.
- Trial name
- NCT03446079
- Testing
- Topical Anti Aging Cream
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- HelicalCodeMD
Adult Respiratory Distress Syndrome
ACE Gene Polymorphism and ARDS Outcome
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory failure with a high mortality rate. The mechanism of resolution of the late organizing phase remains uncertain.
- Trial name
- NCT00155779
- Where
- Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Huntington Disease
Study of Biomarkers That Predict the Evolution of Huntington's Disease
Huntington's disease (HD) is a rare, autosomal dominant, progressive neurodegenerative disorder typically becoming noticeable in middle age.
- Trial name
- BIOHD (NCT01412125)
- Testing
- Huntington patient evaluation, Healthy subject evaluation
- Where
- France
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontitis, Chronic Periodontitis (Disorder)
Cofilin-2 (rs80358250) and Lactoferrin (rs1126478) Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontitis Patients With and Without CHD
Periodontitis is a chronic multifactorial inflammatory disease associated with the accumulation of dental plaque and characterized by progressive destruction of the teeth-supporting apparatus, including the periodontal ligament…
- Conditions
- Periodontitis, Chronic Periodontitis (Disorder), Coronary Heart Disease
- Trial name
- NCT07353606
- Testing
- Scaling and root planing
- Where
- 2 sites in India
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Asthma
The Genetics of Severe Asthma in Children
Near fatal asthma exacerbations are one of the most common causes of critical illness in children, accounting for approximately ten thousand intensive care unit (ICU) admissions per year in the United States.
- Trial name
- NCT01238432
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Connecticut Children's Medical Center
Pharmacogenetics
Naproxen Pharmacogenetic Study (Project 1, Aim 2)
This is a mechanism-based study in healthy adults to determine the effect of the CYP2C9 M1L gene polymorphism on the functional activity of the encoded CYP2C9 enzyme towards the probe substrate naproxen.
- Trial name
- NCT04449471
- Testing
- Naproxen tablet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Washington
Patients With Postoperative Mechanical Ventilation After Liver Transplantation
Inflammatory Gene Polymorphism and Prolonged Mechanical Ventilation After Liver Transplantation
Mechanical ventilatory lung care is essential for postoperative care in liver transplantation recipients, for such patients are under massive fluid challenge and hemodynamic alterations perioperatively.
- Trial name
- NCT02402634
- Testing
- Mechanical ventilatory lung care
- Where
- South Korea
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Nutrition, Metabolic Syndrome
Impact of Genetic Polymorphisms And DASH Diet On Weight Loss Progression In Climacteric Women With Metabolic Syndrome
Metabolic syndrome is a multifactorial inflammatory condition that is very prevalent in overweight women with type 2 diabetes. However, there seems to be great benefit in changing lifestyle and dietary patterns in the treatment…
- Conditions
- Nutrition, Metabolic Syndrome, Obesity, Weight Loss
- Trial name
- NCT06978504
- Testing
- DASH diet
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nutrindo Ideais Research Center
Asthma
The Relationship Between Single Nucleotide Polymorphisms of Chitinase 3-like 1 Gene,YKL-40 Serum Levels and Adult Asthma
The objective of this study was to investigate the relationship between single nucleotide polymorphism of chitinase 3-like 1 and human asthma.
- Trial name
- CHI3L1 (NCT01348932)
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Quality of Life
Effects of Genetic Variation on the Efficacy of Aerobic Exercise
This study investigates whether, after six weeks of exercise, a genetic variant (Val66Met) in the gene that makes a molecule (BDNF) important for brain health and function, influences the beneficial effects of a further session…
- Trial name
- NCT03670186
- Testing
- High-Intensity Interval Training (HIIT)
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McMaster University
Neonatal Respiratory Distress Syndrome
Association of SCNN1A Single Nucleotide Polymorphisms With Neonatal Respiratory Distress Syndrome
Lung fluid absorption disorders are largely mediated by transepithelial Na+ reabsorption through alpha epithelial sodium channels (α-ENaCs) in alveolar epithelial cells.
- Trial name
- NCT02333669
- Testing
- no intervention
- Where
- China
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Genotype Guided(HNF4a), Healthy Subjects
STUDY The Effect of HNF-4A G60D Variant on the In VIVO CYP2D6 Activity By Tolterodine Pharmacokinetic Study
This study was to investigate the pharmacokinetics of tolterodine, substrate of CYP2D6 in healthy subject in relation to the presence of HNF-4A G60D variant.
- Trial name
- HNF4a (NCT01181505)
- Testing
- Tolterodine
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Inje University
Renal Transplantation
Identification of Patients With High Probability of Poorly Responding to Therapy With Mycophenolic Acid Prodrugs
This study is designed to define groups of patients (among patients with a heart or kidney graft or a glomerular disease and nephrotic range proteinuria) who would either not profit from a therapy with mycophenolate-mofetil (MMF)…
- Trial name
- NCT00978965
- Testing
- MPA SNP
- Where
- Austria
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy
Apomorphine Effects on Experimental Pain
The aims of this study were to assess the effects of the dopamine agonist apomorphine on experimental pain models in healthy subjects and to explore the possible association between these effects and a common polymorphism within…
- Trial name
- NCT01744964
- Testing
- Apomorphine
- Where
- Israel
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Blood Pressure
Blood Pressure Lowering Effect of B-vitamins in Adults With a Genetic Pre-disposition to Elevated Blood Pressure.
Approximately 12% of the world's population have a have a common C677T polymorphism in the gene encoding the folate metabolising enzyme, methylenetetrahydrofolate reductase (MTHFR).
- Trial name
- RAFA (NCT04278378)
- Testing
- Riboflavin, Folic acid
- Where
- United Kingdom
- Volunteers
- 2,564 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Osteoporosis
The Genetic and Life Style Determinants of Bone Mass of Young Greek Males
The genetic bases of peak bone mass in males, as determinants of an individual's risk of developing osteoporotic fractures in old age and their interaction with dietary and lifestyle factors are still poorly understood.
- Trial name
- NCT00449215
- Where
- Greece
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- University of Athens
Energy Metabolism
Erythrocyte Transport of Lactate During Exercise (TELE Project)
The goals of this clinical trial are: 1. to study lactate kinetic between plasma and erythrocytes during an intervallic exercise and its subsequent recovery, considering the blood pH, the genotype for the T1470A polymorphism of…
- Trial name
- TELE (NCT06104150)
- Testing
- Intervallic submaximal exercise test
- Where
- 2 sites in Spain
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Technical University of Madrid
Healthy
Investigation of Drug-drug Interaction Between Clopidogrel and Fluoxetine
Clopidogrel is a platelet aggregation inhibitor witch prevents thrombotic events in patients with atherosclerotic vascular disease. To date, 4 to 30 % of patients are considered as poor, low or non-responder to this therapeutic.
- Trial name
- PLATINE (NCT00732290)
- Testing
- Clopidogrel then fluoxetine+clopidogrel, Fluoxetine+clopidogrel then clopidogrel
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne