Clinical trials: Polyp, Colonic
Polyps of Colon
Prospective Study of a New Endolumenal Device Used During Endoscopic Polypectomy in the Colon
This prospective observational study will evaluate the performance of the DiLumen C2 Endolumenal Interventional Platform and its instruments. Up to 100 subjects will be enrolled at up to 5 clinical sites.
- Trial name
- DiLumenC2 (NCT04657601)
- Testing
- DiLumen C2 Endolumenal Interventional Platform
- Volunteers
- 100 people
- Sponsor
- Lumendi, LLC
Polyp of Colon
The Non-Optical Resect and Discard Study (NORD)
Eliminating the need for conventional histopathological assessment of diminutive colon polyps - The Non-Optical Resect and Discard (NORD) study
- Trial name
- NORD (NCT04032912)
- Testing
- iScan
- Where
- Canada
- Volunteers
- 1,200 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Adenomatous Polyposis Coli
Influence of Sulindac and Probiotics on the Development of Pouch Adenomas in Patients With Familial Adenomatous Polyposis
The purpose of this study is to determine whether sulindac and VSL#3 - inulin, either combined or alone, are effective in treating or preventing adenoma development in the ileal anal pouch in patients with familial adenomatous…
- Trial name
- NCT00319007
- Testing
- Sulindac (drug), VSL#3 (probiotic), Inulin (probiotic)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Precancerous Condition
S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000
RATIONALE: Studying tissue samples in the laboratory from participants receiving treatment on the Selenium and Vitamin E Cancer Prevention Trial (SELECT) SWOG-S0000 may help doctors predict a participant's response to treatment…
- Trial name
- ACP (NCT00706121)
- Testing
- Vitamin E, Selenium
- Where
- United States
- Volunteers
- 8,094 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Colonoscopy, Colon Polyp
The Effect of 1L Polyethylene Glycol Plus Ascorbic Acid With Prepackaged Low-Residue Diet for Bowel Preparation
Background 2L polyethylene glycol plus ascorbic acid (PEGA) is known to be as effective as standard 4L polyethylene glycol for bowel preparation. However, the volume of this regimen is still large.
- Conditions
- Colonoscopy, Colon Polyp, Bowel Preparation Solutions
- Trial name
- NCT03329339
- Testing
- 1 L PEG with ascorbic acid with prepackaged, low residue diet
- Volunteers
- 200 people
- Sponsor
- Seoul National University Bundang Hospital
Colonic Polyp
Computer Aided Diagnosis (CADx) for Colorectal Polyps Resect-and-Discard Strategy
Colonoscopic removal of adenomatous polyps reduce both the incidence and mortality of colorectal cancer (CRC). The common clinical management of colorectal polyp detected during colonoscopy is to remove them and send for…
- Trial name
- CADx (NCT06062095)
- Testing
- AI-powered computer-aided diagnosis (CADx)
- Where
- Hong Kong
- Volunteers
- 1,764 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer, Colorectal Neoplasms
Investigating the Use of Fluorescent Lectins to Identify Dysplasia and Cancer During Endoscopy and Surgery
This is a feasibility study investigating the use of a fluorescently conjugated lectin to identify colorectal dysplasia and cancer during colonoscopy and surgery.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp
- Trial name
- NCT03070613
- Testing
- Fluorescent Lectin Application
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Oxford
Colon Polyp
Comparison of Polyp Detection and False Alarm Rates in Water Exchange and Air Insufflation Colonoscopy
Water exchange (WE) improves adenoma detection rate (ADR) but missed polyps occur due to human limitations. Computer-aided detection (CADe) improves polyp detection and can overcome human omissions, but a limiting factor is feces…
- Trial name
- NCT04727814
- Testing
- Computer-aided detection system overlaid colonoscopy videos analysis
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- Dalin Tzu Chi General Hospital
Adenoma, Colon Polyps
Cap Assisted Colonoscopy for the Detection of Colon Polyps
This simple technique of attaching a transparent cap to the tip of the colonoscope has been evaluated in Japan for improving the detection of polyps and cecal intubation but has not been formally evaluated in the US and other…
- Conditions
- Adenoma, Colon Polyps, Colon Cancer
- Trial name
- NCT01211132
- Testing
- Cap - Transparent retractable extension device., Standard
- Where
- United States
- Volunteers
- 462 people
- Sponsor
- American Society for Gastrointestinal Endoscopy
Artificial Intelligence (AI), Colonoscopy Education
Artificial Intelligence-assisted Colonoscopy, Tandem Study
The goal of this clinical trial is to evaluate effect of artifial intelligent (AI) system, Endoscopy as AI-powered Device (ENAD) on adenoma miss rate from colonoscopy underwent by trainee endoscopist.
- Conditions
- Artificial Intelligence (AI), Colonoscopy Education, Adenoma Colon Polyp
- Trial name
- NCT07023471
- Testing
- Group A (Trainee --> expert), Group B (Trainee +AI --> expert), Group C (Trainee --> expert + AI)
- Where
- Thailand
- Volunteers
- 364 people
- Sponsor
- Mahidol University
Colonic Polyp, Colonic Sessile Serrated Lesion
The CARMA Technique Study
Colonoscopic removal of polyps is an important and well-established tool in the prevention of colorectal cancers. However, high polyp recurrence rates after endoscopic resection, with resultant development of interval cancers…
- Trial name
- NCT05099432
- Testing
- CARMA technique
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Princess Alexandra Hospital, Brisbane, Australia
Adenoma, Colonoscopy
Effect of Two Colonoscopy AI Systems for Colon Polyp Detection
Computer-aided detection (CADe) systems have been actively researched for polyp detection in colonoscopy. The investigators aim to identify the effect of two CADe systems according to the system performance on false positive rate
- Conditions
- Adenoma, Colonoscopy, Sessile Serrated Adenoma
- Trial name
- NCT05089071
- Testing
- Assist by artificial intelligence system for colon polyp detection
- Where
- South Korea
- Volunteers
- 3,046 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colonic Polyp
Implementation of Optical Diagnosis of Diminutive Colorectal Polyps: DISCARD3 Study (Incorporating AI-DETECT)
This is a prospective feasibility study. The aim of this work is to assess the acceptability and feasibility of optical diagnosis-led care in bowel cancer screening patients undergoing colonoscopy.
- Trial name
- NCT04710693
- Testing
- CAD polyp-detection system
- Where
- United Kingdom
- Volunteers
- 614 people, healthy volunteers welcome
- Sponsor
- London North West Healthcare NHS Trust
Colorectal Cancer, Hereditary Non-polyposis Colon Cancer
Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer
RATIONALE: Gathering medical and family history information from patients and family members may help doctors better understand hereditary colorectal cancer and hereditary polyposis syndrome and identify patients at high risk of…
- Conditions
- Colorectal Cancer, Hereditary Non-polyposis Colon Cancer, Precancerous Condition
- Trial name
- NCT00675636
- Testing
- study of socioeconomic and demographic variables, evaluation of cancer risk factors, study of high risk factors
- Where
- 3 sites in United States
- Volunteers
- 730 people
- Sponsor
- Vanderbilt University Medical Center
Colorectal Cancer
Is Barium Enema an Adequate Diagnostic Test for Patients With Positive FOBT?
The research protocol aim is to compare diagnostic tools for the proper evaluation of patient with fecal occult blood test positive (FOBT +), a routine screening test for colorecatl carcinoma.
- Trial name
- DCBE (NCT00619814)
- Testing
- Double-contrast Barium enema, colonoscopy
- Volunteers
- 50 people
- Sponsor
- VA Caribbean Healthcare System
Colorectal Cancer, Colon Polyp
Efficacy of Free Versus Low Residue Diet as Preparation for Screening Colonoscopy
One tricky aspect of the recommendations for colonoscopy prep is diet. This has a significant impact on the experience of the patient or participant in the screening program and, on the other hand, low adherence has been found in…
- Conditions
- Colorectal Cancer, Colon Polyp, Colon Adenoma
- Trial name
- CriLi (NCT04664543)
- Testing
- Free diet, Three days low residue diet
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Parc Taulí Hospital Universitari
Colon Polyps
Safety of Endoscopic Resection of Large Colorectal Polyps: A Randomized Trial.
The effectiveness of colonoscopy in reducing colorectal cancer mortality relies on the detection and removal of neoplastic polyps.
- Trial name
- NCT01936948
- Testing
- Clip closure
- Where
- United States
- Volunteers
- 928 people
- Sponsor
- White River Junction Veterans Affairs Medical Center
Familial Adenomatous Polyposis
Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients
The purpose of this study is to assess if curcumin, a commonly used food spice, can regress colorectal adenomatous polyps in patients with familial adenomatous polyposis, an inherited form of colorectal cancer.
- Trial name
- NCT00248053
- Testing
- curcumin
- Sponsor
- Johns Hopkins University
Endoscopic Hemostasis, Colonic Polyps
EndoClot for Hemostasis and Preventing Post-procedure Bleeding After Endoscopic Mucosal Resection
Endoscopic mucosal resection (EMR) has been widely used as a diagnostic and treatment techniques of gastrointestinal small lesions. Para-procedure bleeding is one of the common complication following EMR.
- Trial name
- EMR (NCT01496781)
- Testing
- Hemoclip, EndoClot
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Colorectal Cancer, Colorectal Adenoma
The Implementation of Genetic Risk for Colorectal Cancer Screening
The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp
- Trial name
- PRO-GENE-COLON (NCT07621757)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Endeavor Health