Clinical trials: Polyp of Large Intestine, active
Rectal Polyp, Rectal Polyps
Rectal Tumor Resection Using the UNI-VEC Multichannel Transanal Access Device
The aim of the clinical trial is to investigate whether the use of a new multichannel endoscopic transanal access device (named UNI-VEC) is safe and effective in the resection of a rectal polyp or tumor that sits in the distal…
- Conditions
- Rectal Polyp, Rectal Polyps, Rectal Lesion, Sessile Colonic Polyp
- Trial name
- UNI-VEC (NCT06286956)
- Testing
- Treatment of rectal lesions with UNI-VEC
- Where
- 11 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Vecmedical Spain, S.L.
Colorectal Cancer Prevention
The Beans to Enrich the Gut Microbiome vs. Obesity's Negative Effects (BE GONE) Trial
You are being asked to take part in this study because either you are a survivor who has a previous history of colorectal cancer or an MD Anderson patient who had a precancerous colorectal polyp or you have a previous history of…
- Trial name
- NCT02843425
- Testing
- Regular Diet, Navy Beans (Canned)
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- M.D. Anderson Cancer Center
KLF4 Methylation, Epigenetic
KLF4 Epigenetic Modulation
The study investigates the epigenetic regulation of KLF4 during the progression from colorectal polyps to adenomas and carcinomas.
- Trial name
- POLYEP (NCT07901335)
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Colorectal Neoplasms, Colorectal Neoplasms Malignant
Robotic Right Hemicolectomy Versus Laparoscopic Right Hemicolectomy
Robotic right hemicolectomy with intra-corporeal anastomosis may have better short-term recovery outcomes and decreased incidence of incisional hernia when compared to the laparoscopic actual standard of care, for similar safety…
- Conditions
- Colorectal Neoplasms, Colorectal Neoplasms Malignant, Colorectal Neoplasms, Benign, Colorectal Cancer
- Trial name
- PRORHEM (NCT06067620)
- Testing
- Robotic right hemicolectomy, Laparoscopic right hemicolectomy
- Volunteers
- 70 people
- Sponsor
- Jeremy Meyer
Colorectal Polyp, Inflammation
Impact of Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy
This study aims to investigate the impact of various healthy diets, specifically a modified plant-based Mediterranean diet, on the gut microbiome and overall well-being post-colonoscopy.
- Conditions
- Colorectal Polyp, Inflammation, Dietary Intervention, Microbiota
- Trial name
- NCT06603519
- Testing
- Modified Plant-Based Mediterranean Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Colorectal Adenoma, Colorectal Polyps
Advanced Adenoma Detection With 3D Imaging Device During Colonoscopy
The goal of this clinical trial is to learn if 3-dimensional (3D) imaging device works to identify patients with high risk adenomas during colonoscopy to guide proper follow-up strategy.
- Trial name
- NCT06924489
- Testing
- Colonoscopy after bowel cleansing with 2D imaging device, Colonoscopy after bowel cleansing with 3D imaging device
- Where
- China
- Volunteers
- 1,566 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Artificial Intelligence
Using AI-assisted Optical Polyp Diagnosis for Diminutive Colorectal Polyps
This is a prospective study that is the first to implement resect and discard and diagnose and leave strategies in real-time practice using stringent documentation and adjudication by 2 expert endoscopists as the gold standard.
- Trial name
- AI-OD (NCT06059378)
- Testing
- Artificial intelligence-assisted classification (CADx)
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Polyp, Colorectal Adenoma
Evaluation of a CAM System for Colorectal Polyp Size Measurement
Accurate polyp size measurements are essential for risk stratification, selection of polypectomy techniques, and surveillance interval assignments.
- Trial name
- CAM (NCT06715384)
- Testing
- Polyp size measurement using autonomous AI measurement or AI-assisted human measurement with the CAM system
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Changhai Hospital
Familial Adenomatous Polyposis (FAP)
A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP).
This is a Phase 1b, open- label, dose-optimization study evaluating ST316 in adult participants with familial adenomatous polyposis (FAP) who have undergone colectomy and have recurrent polyps.
- Trial name
- FAP (NCT07729371)
- Testing
- ST316 IV
- Volunteers
- 40 people
- Sponsor
- Sapience Therapeutics
Colonic Lesions
Prospective Image Collection of Colorectal Polyps.
It concerns a study in which we wish to collect images and corresponding histological information (microscopic characteristics) in a prospective manner in various European and non-European centers (multicentric).
- Trial name
- NCT07401264
- Where
- Belgium
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Colorectal Polyp, Colorectal Neoplasms
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of…
- Conditions
- Colorectal Polyp, Colorectal Neoplasms, Colorectal Adenoma, Colorectal Cancer
- Trial name
- COOP (NCT05612347)
- Testing
- FIT, Colonoscopy
- Where
- 24 sites in United States, Canada
- Volunteers
- 6,434 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Colorectal Polyps
White Light, TXI, NBI and Computer-Aided Detection for Recurrence at Post-EMR Scars (PRINCESS)
Large colorectal polyps removed piece by piece (piecemeal endoscopic mucosal resection) can recur at the resection scar. Detecting this residual or recurrent tissue at surveillance colonoscopy is essential, because it can then be…
- Trial name
- PRINCESS (NCT07874152)
- Testing
- High-definition white light endoscopy (WLE), Texture and color enhancement imaging (TXI), Narrow-band imaging (NBI)
- Where
- 2 sites in Spain
- Volunteers
- 206 people
- Sponsor
- University Hospital Virgen de las Nieves
Colorectal Polyps
Efficacy and Safety of Cold Versus Hot Snare Polypectomy for Removal of 4-10 mm Pedunculated Colorectal Polyps
This was a non-inferiority randomized controlled trial designed to compare the efficacy and safety of cold versus hot snare polypectomy for the removal of 4-10 mm pedunculated colorectal polyps.
- Trial name
- NCT06937047
- Testing
- cold snare polypectomy, hot snare polypectomy
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Shandong University
Colorectal Cancer, Colorectal Polyp
IMPROVE-pT1: Accurate Allocation of Completion Resection in Early Colorectal Cancer
After introducing a nationwide screening program for colorectal cancer (CRC) in Denmark, more cases of early-stage CRC are being detected.
- Conditions
- Colorectal Cancer, Colorectal Polyp, Colorectal Cancer Stage I
- Trial name
- NCT06040632
- Where
- 9 sites in Denmark
- Volunteers
- 67 people
- Sponsor
- University of Aarhus
Colonic Polyp, Artificial Intelligence
Autonomous Artificial Intelligence Versus AI Assisted Human Optical Diagnosis
Computer-aided image-enhanced endoscopy can predict the nature of colorectal polyps with over 90% accuracy. This technology uses artificial intelligence (AI) to analyze video recordings of polyps, learning to make diagnoses in…
- Trial name
- CADx-Prosp (NCT06543862)
- Testing
- CADx (AI) system
- Where
- Canada
- Volunteers
- 540 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Polyp, Obesity
Feasibility and Colorectal Benefits of Pulses Supplementation
Beans are a forgotten staple food that shows promise in improving health. The goal of this study is to look at how bean supplementation affects metabolic and bowel health.
- Trial name
- NCT06032104
- Testing
- Dry beans, Usual diet
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Colonic Polyp
Computer Aided Diagnosis (CADx) for Colorectal Polyps Resect-and-Discard Strategy
Colonoscopic removal of adenomatous polyps reduce both the incidence and mortality of colorectal cancer (CRC). The common clinical management of colorectal polyp detected during colonoscopy is to remove them and send for…
- Trial name
- CADx (NCT06062095)
- Testing
- AI-powered computer-aided diagnosis (CADx)
- Where
- Hong Kong
- Volunteers
- 1,764 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Polyp, Colon Adenoma
Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC)
Randomised controlled trial comparing cold snare endoscopic mucosal resection (EMR) with cold snare EMR and adjuvant margin STSC in the complete resection of 15-40mm lateral-spreading adenomas
- Conditions
- Colorectal Polyp, Colon Adenoma, Colon Cancer
- Trial name
- NCT05041478
- Testing
- Cold Snare Endoscopic mucosal resection with adjuvant snare tip soft coagulation, Cold Snare Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Western Sydney Local Health District
Colorectal Adenoma, Colorectal Polyp
Validation of the Global Polypectomy Assessment Tool (GPAT)
Colorectal polypectomy is offten incompletely performed with high variability between endoscopists, resulting in interval cancer or repeated procedures.
- Conditions
- Colorectal Adenoma, Colorectal Polyp, Colo-rectal Cancer
- Trial name
- GPAT (NCT05877456)
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center