Clinical trials: Polyp of Nasal Sinus
Nasal Polyps
A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
The aim of this study is to assess the efficacy and safety of GSK5784283 administered as add-on maintenance therapy to participants with CRSwNP.
- Trial name
- PERSISTCRSwNP1 (NCT07782970)
- Testing
- GSK5784283, Standard of Care
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 218 people
- Sponsor
- GlaxoSmithKline
Chronic Rhinosinusitis (Diagnosis)
Nasal Microbiota Transfer Therapy in Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
Chronic Rhinosinusitis (CRS) is a chronic inflammatory condition of the nasal passage and paranasal sinuses that places significant burden on affected patients and global healthcare systems.
- Trial name
- NCT05400616
- Testing
- Microbiome Transplant
- Where
- 3 sites in Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Nasal Polyposis, Sinusitis
The Effect of RF Turbinoplasty in Polypoid Change of Middle Turbinates
The aim of this study is to evaluate the effect of middle turbinate Radio Frequency (RF) turbinoplasty with middle turbinate resection and medialization
- Trial name
- NCT01906697
- Testing
- middle turbinate Radio Frequency (RF) turbinoplasty, middle turbinate resection, middle turbinate medialization
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Tehran University of Medical Sciences
Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS)
Study of Dupilumab 300 mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhinosinusitis (AFRS) on a Background Therapy With Intranasal Corticosteroid Spray
Background: Allergic fungal rhinosinusitis (AFRS) is a severe type of sinus infection. People with AFRS develop heavy mucus and growths called polyps that apply pressure to the sinuses and block their breathing.
- Conditions
- Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS), Asthma, Nasal Polyps
- Trial name
- NCT06461949
- Testing
- Dupilumab
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Comparison of Airway Management Techniques in Functional Endoscopic Sinus Surgery, Rhinosinusitis With Polyps
Comparison of Laryngeal Mask and Tracheal Intubation With and Without Topical Lidocaine Application
The study aims to identify the advantages and disadvantages of each of the three methods of airway management during FESS.
- Conditions
- Comparison of Airway Management Techniques in Functional Endoscopic Sinus Surgery, Rhinosinusitis With Polyps, Deviated Nasal Septum, Osteoma of the Paranasal Sinuses
- Trial name
- NCT07548866
- Testing
- anesthesia of the respiratory tract with lidocaine, tracheal intubation, laryngeal mask placement
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Chronic Sinusitis, Nasal Polyps
Biologics in Chronic Rhinosinusitis With Nasal Polyposis
The prevalence of Chronic Sinusitis with Nasal Polyps (CRSwNP) in the United States is estimated at roughly 4%, which equates to over 13 million Americans.
- Trial name
- CRSwNP (NCT06824649)
- Testing
- Biologic Agents
- Where
- 3 sites in United States
- Volunteers
- 504 people
- Sponsor
- Medical University of South Carolina
Chronic Sinusitis With Nasal Polyps and Eosinophilia
Study of Dexpramipexole Chronic Sinusitis With Nasal Polyps and Eosinophilia
Phase 2, open-label, multi-center study to evaluate the clinical effects of oral administration of dexpramipexole for 6 months in subjects with chronic sinusitis with nasal polyps and eosinophilia.
- Trial name
- CS201 (NCT02217332)
- Testing
- dexpramipexole
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Knopp Biosciences
Chronic Rhinosinusitis With Nasal Polyps
Dupilumab for Prevention of Recurrence of CRSwNP After ESS
The investigators believe that administering Dupilumab during the pre- and peri-operative period of surgery for chronic rhinosinusitis with nasal polyps (CRSwNP) will safely downregulate Type 2 inflammation of the healing sinus…
- Trial name
- NCT04596189
- Testing
- Dupilumab 300 MG in 2 ML Prefilled Syringe, Mometasone Furoate nasal spray
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Nasal Polyps, Chronic Sinusitis
Wound Healing After Endoscopic Sinus Surgery
This study aims to determine the effect of Thymoquinone (0.5%) and olive oil ointment on Wound healing after Endoscopic sinus surgery.
- Trial name
- NCT06070311
- Testing
- Thymoquinone (0.5%) and Olive oil ointment
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Sinus Infection
The Use of Prophylactic Antibiotics in Endoscopy Sinus Surgery for Chronic Rhinosinusitis With or Without Polyp
This is a randomized, double-blind clinical trial on the prophylactic use of antibiotics in postoperative endoscopic sinus vs placebo surgery.
- Trial name
- NCT03809312
- Testing
- Amoxicillin / Clavulanic acid 875mg / 125mg
- Where
- Canada
- Volunteers
- 134 people
- Sponsor
- CHU de Quebec-Universite Laval
Chronic Rhinosinusitis (Diagnosis), Surgery
A Study of Different Endoscopic Surgery Procedures in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
CRS remains a common challenging clinical entity due to variable phenotypes with different underlying mechanisms that lead to persistence or recurrence polyps.
- Trial name
- NCT03878355
- Testing
- radical endoscopic sinus surgery (RESS) plus Draf 3 surgery., radical endoscopic sinus surgery (RESS), functional endoscopic sinus surgery (FESS)
- Volunteers
- 27 people
- Sponsor
- Beijing Tongren Hospital
Rhinosinusitis Chronic, Sinus Cancer
TIVA vs TXA in Sinus Surgery to Evaluate Operative Blood Loss and Surgical Field Quality
The goal of this interventional study is to compare the efficacy (surgical field quality and intra-operative blood loss) or cost of TIVA alone to general inhalational anesthetics with intravenous TXA in patient participants who…
- Conditions
- Rhinosinusitis Chronic, Sinus Cancer, Sinus Polyp, Encephalocele
- Trial name
- NCT05639686
- Testing
- Tranexamic acid injection, Total Intravenous Anesthesia, Inhalational isoflurane
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Our Lady of the Lake Hospital
Chronic Rhinosinusitis, Endoscopic Sinus Surgery
Perioperative Oral Steroids for Chronic Rhinosinusitis Without Polyps (CRSsNP)
While oral steroids have been shown to be effective in the management of patients with chronic rhinosinusitis with polyps, its role in treating chronic rhinosinusitis without polyps (CRSsNP) is ambiguous.
- Conditions
- Chronic Rhinosinusitis, Endoscopic Sinus Surgery, Chronic Rhinosinusitis Without Polyps, Oral Steroids
- Trial name
- NCT02748070
- Testing
- Prednisone, Flonase
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Stanford University
Endoscopic Sinus Surgery, Nasal Polyps
Comparing Blood Loss and Visualization After the Preoperative Use of Topical 0.05% Oxymetazoline Versus 1:1000 Epinephrine Prior to Endoscopic Sinus Surgery
The purpose of this study is to compare the effects of Oxymetazoline and Epinephrine (which are 2 different nasal decongestants both of which are routinely used before sinus surgery) on blood loss and the surgeon's view of the…
- Trial name
- NCT03228914
- Testing
- Oxymetazoline, Epinephrine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Sinusitis
Safety and Performance of the Steroid-Releasing S8 Sinus Implant
The purpose of this study was to assess the safety and performance of the steroid-releasing S8 Sinus Implant when used in post-sinus surgery patients who presented with recurrent sinus obstruction.
- Trial name
- S8PK (NCT01894503)
- Testing
- S8 Sinus Implant (mometasone furoate, 1350 mcg)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Intersect ENT
Nasal Polyps, Anesthesia
Auriculotherapy for Intraoperative Blood Pressure Control
The endoscopic surgery of the paranasal sinuses (FESS) requires careful control of arterial pressure to prevent bleeding of the nasal mucosa that may lead to a reduction in the visual field.
- Conditions
- Nasal Polyps, Anesthesia, Sinusitis, ENT Surgical Result - Nose Nasal Congestion
- Trial name
- AuriFESS (NCT06182982)
- Testing
- auricolotherapy
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Chronic Sinus Disease, Nasal Polyps
Does The Combined Use Of Local And Intravenous Tranexamic Acid Offer Better Surgical Field Quality During Functional Endoscopic Sinus Surgery? A Placebo-Controlled Clinical Trial
Functional Endoscopic Sinus surgery (FESS) is a surgery done for chronic rhinosinusitis after failure of medical treatment. Intraoperative bleeding poses a challenge to both the surgeon and anaesthetist.
- Trial name
- NCT03965767
- Testing
- Tranexamic Acid
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Sinus Disease, EGPA - Eosinophilic Granulomatosis With Polyangiitis
Effectiveness on Sino-Nasal Symptoms Of Mepolizumab 300
OBJECTIVES The primary objective of this study is evaluating the reduction of dimension of nasal polyps measured with Nasal Polyp Endoscopic Score (NPS) The secondary objective is to evaluate the improvement in nasal symptoms and…
- Conditions
- Sinus Disease, EGPA - Eosinophilic Granulomatosis With Polyangiitis, Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
- Trial name
- MEPO300REAL (NCT07592104)
- Testing
- Mepolizumab 300 mg
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sinusitis, Nasal Polyps
A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps
This study will evaluate the effect and safety of 611 in patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).
- Conditions
- Sinusitis, Nasal Polyps, Polyps
- Trial name
- NCT05865496
- Testing
- 611
- Where
- 4 sites in China
- Volunteers
- 90 people
- Sponsor
- Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
Sinusitis, Nasal Polyps
Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery
1. objectives. To compare the efficacy and the safety of mometasone furoate nasal spray (MFNS; Nasonex 200μg, daily) alone versus a combination with montelukast (singulair 10mg, daily) in chronic rhinosinusitis (CRS) with asthma…
- Conditions
- Sinusitis, Nasal Polyps, Asthma
- Trial name
- NCT02110654
- Testing
- Montelukast, mometasone furoate nasal spray
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University