Clinical trials: Polyphenol
Prevention of Hyperglycaemia
Effects of an Apple Extract on Glycaemia: The GLU-Pomme Study
Postprandial hyperglycaemia can lead to adverse modifications to functional proteins within the body and eventually lead to the development of type 2 diabetes.
- Trial name
- GLU-Pomme (NCT02940249)
- Testing
- Apple polyphenols
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- King's College London
Vitamin b12, Supplementation During Endurance Performance
Effects of Vitamin B12 and Natural Orange Extract, and Their Combination on Physical and Mental Performance
The aim of this study was to determine the effects of a new formulation of vitamin B12, natural orange extract, and their combination on physical and mental performance.
- Conditions
- Vitamin b12, Supplementation During Endurance Performance, Flavonoids, Mental Fatigue
- Trial name
- MECHEPS (NCT07341789)
- Testing
- Vitamin B 12, Natural orange extract, Vitamina B12 + natural orange extract
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Cardiovascular Diseases
Combined Bioactive Therapy Effects Over Cardiovascular Markers in Statin Treated Patients
Atherosclerosis, one major cause of morbidity and mortality worldwide, is a complex and multifactorial disease triggered especially due to high level of plasma lipids and that involves three mainly conditions: chronic…
- Trial name
- NCT02732223
- Testing
- Functional treatment, Control treatment
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Hypoxia, Altitude, Brain
The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at Stimulated Altitude.
Background: Vaso-active polyphenols have been proposed to enhance cognitive performance. Oral administration with the non-flavonoid polyphenol, resveratrol, has been found to modulate cerebral blood flow (CBF); yet, this has not…
- Trial name
- NCT03541993
- Testing
- Resveratrol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Body Weight
Effect of Polyphenol-rich Dark Chocolate on Body Weight in Overweight and Obese Adults
The aim of this study is to investigate if dark chocolate rich in polyphenols decreases body weight/ body fat in the overweight and obese adult population.
- Trial name
- NCT01749852
- Testing
- Polyphenol-rich Dark chocolate
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Healthy Ageing
Effect of Polyphenol-rich Cocoa Products on Cognitive Function
This project aims to investigate whether consumption of cocoa polyphenols has an impact on cognitive function in individuals aged 50 to 60 years of age and if such an improvement is a result of an improvement in risk factors…
- Trial name
- NCT02996578
- Testing
- polyphenol rich chocolate bar, polyphenol rich cocoa powder, low polyphenol content chocolate bar
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Cardiovascular Disease, Oxidative Stress
Study of Chokeberry to Reduce Cardiovascular Disease Risk in Former Smokers
The purpose of this project is to determine whether chokeberry polyphenols mitigate cardiovascular disease risk in former smokers.
- Trial name
- NCT01541826
- Testing
- Chokeberry Extract, Chokeberry extract capsule, acute
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Healthy
Interactions Between Fibre and Polyphenols on Colonic Phenolic Acid Production and Biomarkers of Health ( 6 Weeks)
The investigators have studied the acute interactions of polyphenols and NDC in a single meal in a human study containing tomatoes, lovage \& onions, with and without inulin.
- Trial name
- NCT03840746
- Testing
- Tomato, onion and lovage soup (TOL), TOL soup with inulin
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Pharmacokinetics of Flavonoids in Humans
An Acute Human Intervention With Flavonoid to Investigate Absorption, Metabolism and Excretion
The era of general dietary recommendations for the whole population may be coming to an end, as it is becoming apparent that we are all unique and do not respond in the same way to the same foods.
- Trial name
- COB (NCT01922869)
- Testing
- Flavonoids
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Overweight, Healthy
Maximizing the Anti-inflammatory Effects of Strawberry Bioavailability
Primary objective is to determine if the efficacy of strawberries delivering polyphenols to prevent metabolic inflammation will be influenced by timing of consumption relative to meal intake.
- Trial name
- NCT01856153
- Testing
- Before meal, With Meal, After meal
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Dyslipidemias, Hyperglycemia
Role of Ajwa Derived Polyphenols in Dyslipidaemias
World Health Organization report notifies of the escalating global burden of cardiovascular diseases (CVD), projecting that it will become the major worldwide cause of death and disability by 2020.
- Conditions
- Dyslipidemias, Hyperglycemia, Liver Dysfunction, Oxidative Stress
- Trial name
- NCT03805139
- Testing
- Ajwa Date (phoenix dactylifera)
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Prediabetic State, Dysglycemia
Mode of Action (MoA) Study of TOTUM-63 in Individuals at Increased Cardio-metabolic Risk
This clinical study aims to investigate the effects of TOTUM-63, a mix of 5 plant extracts, consumed at the daily regimen of three times per day, on cardiometabolic health and gut microbiota profile in overweight-obese…
- Conditions
- Prediabetic State, Dysglycemia, Overweight and Obesity
- Trial name
- NCT05369585
- Testing
- TOTUM-63
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Overweight, Obesity
Effects of Red Beetroot Juice on High-Fat Meal-Induced Endothelial Dysfunction and Cardiometabolic Disturbances
Aside from aging, numerous factors increase the risk for developing cardiovascular disease (CVD) including diet and nutrition. High-fat meal consumption induces postprandial vascular endothelial dysfunction and other…
- Conditions
- Overweight, Obesity, Aging, Menopause
- Trial name
- NCT02949115
- Testing
- 70 mL red beetroot juice, 70 mL red beetroot juice without nitrate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Bioavailability
Bioavailability of Ration Items Containing Tart Cherry Extract
To determine how consuming food items containing shelf-stored tart cherry impacts your body's ability to absorb and use the compounds within tart cherry.
- Trial name
- Tart Cherry (NCT07063173)
- Testing
- Fruit Bar, Powdered Drink, Commercially available 100% tart cherry juice
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Healthy
Effect of Blueberries on Vascular Function in Healthy Men
Scientific question to be addressed: To determine the effects of acute blueberry ingestion on vascular function and blood pressure in humans Hypothesis: Acute consumption of blueberry induces an improvement in blood pressure and…
- Trial name
- NCT01292954
- Testing
- Blueberries
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Reading
Metabolic Dysfunction-Associated Steatotic Liver Disease, Overweight
Study of Grape Consumption in Adaptation to Seasonal Photoperiod
The goal of this randomized clinical trial is to learn whether consuming grapes during their natural season can help the body adapt to the shorter daylight hours of winter.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Overweight, Obesity & Overweight
- Trial name
- PhotoGrape (NCT07886788)
- Testing
- Freeze-Dried Grape Powder, Plain Low-Fat Yogurt, Mediterranean-Style Dietary Guidance
- Where
- Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Healthy
Acute Effect of a Standardized Botanical Blend Rich in Polyphenols on Cognitive Functions in Healthy Students
Available literature suggests that flavanols-rich foods, and more especially monomeric flavanols-rich foods such as grape, can have an acute effect on cognitive functions via different mechanisms such as cerebral blood flow…
- Trial name
- NCT03508206
- Testing
- SBRP
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Activ'inside
Inflammation
Banana Cultivars and Exercise Performance and Recovery
In a previous study at the Appalachian State University (ASU) Human Performance Laboratory at the North Carolina Research Campus (NCRC), investigators showed that cyclists ingesting about one-half of a banana with water every 15…
- Trial name
- NCT02994628
- Testing
- Water, Mini banana, Cavendish banana
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Polyphenols, Obesity
Effect of a Low-calorie Diet With a Prebiotic Supplement on Health of Overweight-obese Subjects.
The main objective of this project is to evaluate the effect of prebiotic supplementation on weight loss and other physiological and metabolic parameters related to excess weight in overweight/obese adult men and women, as well…
- Conditions
- Polyphenols, Obesity, Weight Loss
- Trial name
- POSTBIOTICS (NCT06710106)
- Testing
- Prebiotic + hypocaloric diet
- Where
- Spain
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Low Education, Cognition
MINDSpeed Food and Brain Training RCT
The purpose of this study is to learn how foods high in polyphenols and brain training exercises affect older adults' cognitive performance
- Conditions
- Low Education, Cognition, Cognitive Training, Polyphenols
- Trial name
- MINDSpeed (NCT03419052)
- Testing
- Speed of processing training, MIND foods, Cognitive training control
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Indiana University