Clinical trials: Polyphenol
Nutrition, Absorption
Bioavailability From Chickpea Meals in Ileostomists?
The matrix of a food can significantly affect how well humans can absorb and use nutrients. Plants like fruits, vegetables, nuts, grains, and legumes have cell walls that form a network around their cells.
- Conditions
- Nutrition, Absorption, Polyphenolic Compounds and Metabolism, Polyphenols Absorption Profile
- Trial name
- NCT06921811
- Testing
- Intact chickpeas, Broken chickpeas
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Postprandial Period
Acute Effects of Blackcurrant and Citrus Polyphenol Extracts on Postprandial Glycaemia
Large postprandial glucose responses are associated with increased risk of chronic diseases, including diabetes and cardiovascular disease.
- Trial name
- Glu-FX (NCT03184064)
- Testing
- Blackcurrant extract (low dose), Citrus extract (low dose), Blackcurrant extract (high dose)
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Lucozade Ribena Suntory
Overweight
Whole Grain Polyphenol Bioavailability and Effects on Health
Whole grains (WG) contain numerous physiologically bioactive compounds, a key group being polyphenolic compounds such as ferulic acid (FA).
- Trial name
- NCT01293175
- Testing
- Whole grains
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federico II University
Healthy
The Effect of Meat and Food Drived Polyphenols on Oxidize LDL Level
The postprandial increase in MDA level following meat meal could cause modification to LDL particles in healthy volunteers. Co-consumption of food drived polyphenols with the meat will result in a significant decrease in LDL…
- Trial name
- NCT01389492
- Testing
- frozen meat cutlets meal, meat meals
- Where
- Israel
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Diabetes, Insulin Resistance
Glycemic Index and Polyphenol Bioavailability of Potatoes
The purpose of this study is to determine the glycemic index of four varieties of potatoes and to determine the bioavailability of polyphenols contained in these potatoes.
- Trial name
- GI (NCT01053793)
- Testing
- Glycemic response to different varieties of potatoes
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Guelph Food Research Centre
Healthy
Acute Effect of a Standardized Botanical Blend Rich in Polyphenols on Cognitive Functions in Healthy Students
Available literature suggests that flavanols-rich foods, and more especially monomeric flavanols-rich foods such as grape, can have an acute effect on cognitive functions via different mechanisms such as cerebral blood flow…
- Trial name
- NCT03508206
- Testing
- SBRP
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Activ'inside
Overweight
Bioavailability, Pharmacokinetic and Mechanistic Study of Sinetrol® Xpur, a Polyphenol-rich Ingredient
The purpose of the study is to investigate the metabolization and the bioavailability of bioactive compounds from Sinetrol® Xpur, a polyphenol-rich ingredient, during a 16-week long chronical supplementation.
- Trial name
- NCT03823196
- Testing
- Verum900, Verum1800
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fytexia
Obesity & Overweight, Healthy Adult
Vitis Intervention Trial in Substrate Metabolism
Obesity is associated with reduced metabolic flexibility (MetFlex), the capacity to shift between carbohydrate and lipid oxidation in response to nutrient availability.
- Trial name
- VITIS (NCT07800988)
- Testing
- Freeze-Dried Whole Grape Powder
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy, Normal Weight
Olive Oil Polyphenols and Cardiovascular Health Biomarkers
The purpose of this research is to investigate whether consuming two different kinds of olive oil will change risk factors related to cardiovascular disease, including levels of good and bad cholesterol, levels of inflammation…
- Conditions
- Healthy, Normal Weight, Overweight, Obese
- Trial name
- NCT04149288
- Testing
- High-polyphenol olive oil, Low-polyphenol olive oil
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cardiovascular Diseases
Combined Bioactive Therapy Effects Over Cardiovascular Markers in Statin Treated Patients
Atherosclerosis, one major cause of morbidity and mortality worldwide, is a complex and multifactorial disease triggered especially due to high level of plasma lipids and that involves three mainly conditions: chronic…
- Trial name
- NCT02732223
- Testing
- Functional treatment, Control treatment
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Healthy Men
Effects of Cranberry Consumption in Vascular Function in Healthy Individuals
Accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content.
- Trial name
- Cranberry (NCT02517775)
- Testing
- Cranberry 320, Cranberry 640, Cranberry 960
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Glucose Intolerance, Glucose Metabolism Disorders
Acute Study of Anthocyanin-rich Bilberry and Polyphenol-rich Apple Extracts on Postprandial Glycaemic Response
Strategies to control chronic postprandial hyperglycaemia by optimizing the functionality of foods would strengthen efforts to reduce the risk of developing T2D in the general population.
- Trial name
- NCT04004182
- Testing
- Fruit bar with addition of polyphenols
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Healthy Young
Cranberry (Poly)Phenol Consumption on Vascular Function
Epidemiological studies suggest that the consumption of (poly)phenols rich foods such as cocoa, tea, fruits and vegetables is associated with lower blood pressure, reduced cholesterol and decreased cardiovascular risk.
- Trial name
- NCT02764749
- Testing
- cranberry (poly)phenol containing supplement
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Obesity
Grape Polyphenols and Second-meal Effect
The aim of this is study is to evaluate the effects of a single intake of grapes (a polyphenol-rich food) in postprandial metabolism in subjects with obesity, including a first intake (high-fat breakfast) after overnight fasting…
- Trial name
- GRAPESECOND (NCT03741218)
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Hypertension
Effect of Polyphenols Combined to L-citrulline on Ambulatory Blood Pressure
The general objective of this project is to investigate the chronic effect of consuming supplements combining polyphenols from cranberry and grape seed extracts and L-citrulline (Nitric Oxide Ultra capsules, Pure Encapsulations…
- Trial name
- NCT03679195
- Testing
- NO Ultra
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Laval University
Healthy
Intake-dependent Effect of Cocoa Flavanol Absorption, Metabolism and Excretion in Humans
A randomized, double-masked and cross-over dietary intervention study in healthy young adult males to evaluate the concentration of F-derived metabolites in plasma and urine after single acute intakes of F-containing drinks on…
- Trial name
- NCT03201822
- Testing
- 100 mg of Cocoa Flavanols/70 kg BW, 200 mg of Cocoa Flavanols/70 kg BW, 400 mg of Cocoa Flavanols/70 kg BW
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Dental Caries
Delivery of Polyphenols in Gum as an Anti-Caries Agent
The short-term effects of chewing gum containing xylitol and/or blackberry extract on oral microbiota was studied. Fifty healthy adults participated in a randomized, placebo-controlled, cross-over design study.
- Trial name
- BBE (NCT05133557)
- Testing
- Chewing gum containing xylitol and blackberry extract (BBE)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Craig Miller
Inflammation, Heart Failure
Beer, Marathon, Genetics, Inflammation and the Cardiovascular System: Be-MaGIC-Trial
The purpose of the study is to determine the myocardial function and vascular adaptation after strenuous exercise in association with consumption of polyphenols.
- Conditions
- Inflammation, Heart Failure, Sudden Cardiac Death
- Trial name
- Be-MaGIC (NCT00933218)
- Testing
- polyphenols (non-alcoholic beer), beverage without polyphenols
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Microbial Colonization, Metabolic Disease
Pilot Haskap Metabolite Timing Project
Diet is a key factor in managing health and individuals at risk of developing metabolic syndrome or other chronic diseases have the opportunity to use diet as a tool to improve their health.
- Conditions
- Microbial Colonization, Metabolic Disease, Digestion
- Trial name
- PHMTiming (NCT06938386)
- Testing
- Haskap
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Montana State University
Endothelial Dysfunction, Aging
Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults
Aging is the primary risk factor for cardiovascular disease (CVD) largely due to vascular endothelial dysfunction, a major initial step in the development of atherosclerosis.
- Trial name
- NCT03824041
- Testing
- Aronia full spectrum - half dose, Aronia full spectrum - full dose
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Colorado State University