Clinical trials: Polyphenols
Overweight, Obese
Characterization of Wild Blueberry Polyphenols Bioavailability and Kinetic Profile Over 24-hour Period
Primary objective is to characterize the relative bioavailability and kinetic profile of wild blueberry polyphenols over 24-hours period.
- Conditions
- Overweight, Obese, Healthy
- Trial name
- WBB (NCT02167555)
- Testing
- Active Comparator
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Hypertrophy
Supplemental Protein And Resistance Training Adaptations
Chronic resistance training has been shown to increase muscle cross-sectional area, volume and strength. Individuals participating in a resistance training program may wish to consume protein supplements to aid recovery and…
- Trial name
- SPARTA (NCT03918395)
- Testing
- Protein-polyphenol beverage
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Healthy Aging, Healthy
Investigating the Effects of Daily Consumption of Blueberry (Poly)Phenols on Vascular Function and Cognitive Performance
Foods rich in certain (poly)phenols, particularly flavonoids, such as berries and cocoa, have been shown to improve measures of vascular function as well as cognitive performance in human intervention studies.
- Trial name
- BluFlow (NCT04084457)
- Testing
- Wild Blueberry powder
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- King's College London
Overweight
Bioavailability, Pharmacokinetic and Mechanistic Study of Sinetrol® Xpur, a Polyphenol-rich Ingredient
The purpose of the study is to investigate the metabolization and the bioavailability of bioactive compounds from Sinetrol® Xpur, a polyphenol-rich ingredient, during a 16-week long chronical supplementation.
- Trial name
- NCT03823196
- Testing
- Verum900, Verum1800
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fytexia
Mechanisms, Defense
The Effect of Concord Grape Polyphenol-soy Protein Isolate Complex (GP-SPI) on Gut Microbiota
The overall purpose of this study is to evaluate the effect of nutritional supplementation with a well-characterized preparation of Concord grape polyphenol-soy protein isolate (GP-SPI) on the composition of the gut microbiota.
- Trial name
- NCT04018066
- Testing
- GP-SPI
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Healthy
Effect of Blueberries on Vascular Function in Healthy Men
Scientific question to be addressed: To determine the effects of acute blueberry ingestion on vascular function and blood pressure in humans Hypothesis: Acute consumption of blueberry induces an improvement in blood pressure and…
- Trial name
- NCT01292954
- Testing
- Blueberries
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Reading
Iron Metabolism Disorders, Iron Overload
Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement
Polyphenolic compounds are very strong Inhibitors of non-heme iron absorption, as they form insoluble complexes with ferrous iron.
- Conditions
- Iron Metabolism Disorders, Iron Overload, Polyphenols
- Trial name
- NCT03990181
- Testing
- meal matrix & NPPS, meal matrix & CS, no-matrix & NPPS
- Where
- 2 sites in Portugal, Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Healthy Men and Women
The Effects of a Polyphenol-enriched Fruit Drink on Metabolic Health(2)
The purpose of this study is to determine whether consumption of the active product affects postprandial changes in metabolic indices, in comparison to the control product.
- Trial name
- NCT01836887
- Testing
- Very low polyphenol fruit based drink (control), Polyphenol-enriched fruit-based drink - low, Polyphenol-enriched fruit-based drink - high
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- King's College London
Healthy
The Absorption and Metabolism of Seaweed Polyphenols in Humans
Brown seaweeds are a rich source of phlorotannins, a characteristic class of polyphenols which are unique to seaweeds of this type and can comprise 5 to 15 % of the dried weight.
- Trial name
- SWAFAX (NCT02496806)
- Testing
- Seaweed extract
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Reading
Skin Ageing
Effect of Pomanox® on Skin Ageing (POMASKIN)
The state of skin health impacts not only on the general health of individuals, but also on mental health. Ultraviolet radiation (UV) is one of the main external factors that causes skin ageing, producing photo-aging…
- Trial name
- POMASKIN (NCT05842447)
- Testing
- 367 mg Pomanox group, 700 mg Pomanox group, Control group
- Where
- 2 sites in Spain
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Healthy Non-smoker
Matrix on Fruit Constituent Bioavailability
Primary objective is to evaluate the influence of matrix on the bioavailability of key phytochemical constituents in fruits and their subsequent effect on chronic disease risk factors.
- Trial name
- FRT (NCT01908634)
- Testing
- Milk-based Strawberry Beverage without meal, Water-Based Strawberry Beverage without meal, Milk-based strawberry Beverage with meal
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Obesity
Effects of Flavanol-rich Dark Chocolate Consumption on Metabolic Profiles Among Obese Adults Using Metabolomics Approach
Obesity has become a global issue due to its alarming high and increasing prevalence worldwide and the roles it plays in occurrence of many chronic diseases.
- Trial name
- NCT04347304
- Testing
- Dark chocolate (20 grams) per day providing 508 mg of polyphenols, white chocolate (20 grams) with no polyphenols
- Where
- Malaysia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Hypercholesterolemia, Healthy
Effects of Dietary Antioxidants to Prevent Cardiovascular Disease
Background \& Aims: The role of red wine in cardiovascular risk prevention has been documented by several epidemiological studies in patients and normocholesterolemic healthy individuals.
- Trial name
- RWTAC (NCT02409537)
- Testing
- red wine, resveratrol
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Aeromedical Center, Thessaloniki
Microbiota, Cognitive Function
Effect of Tomato Paste Consumption on the Microbiota-gut-brain Axis in Healthy Adults
Tomatoes and tomato-based products could play an important role in modulating microbiota-gut-brain axis (MGBA) interactions due to their high content of fiber and phytochemicals.
- Conditions
- Microbiota, Cognitive Function, Healthy Lifestyle
- Trial name
- MITOS (NCT05891977)
- Testing
- Intervention A - Tomato paste, Intervention B - Control
- Where
- Spain
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Healthy
Effects of Polyphenols Supplementation on Cycling Endurance
Endurance performance during high intensive exercises is mainly determined by the capacity of the aerobic metabolism. It generally induces muscle fatigue defined as the reversible decline in skeletal muscle contractile…
- Trial name
- NCT03214276
- Testing
- Vinitrox polyphenols
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Burgundy
Healthy
CABALA Diet & Health Study
During digestion of fatty foods, the liver produces a substance called bile which helps with the absorption of fat in the gut (small intestine).
- Trial name
- CABALA (NCT03369548)
- Testing
- Apple, Oats, Lactobacillus reuteri NCIMB 30242
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Reading
Stress Response, Mental Stress
Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults
This randomized, double-blind, placebo-controlled clinical trial evaluates whether 70 days of daily cranberry juice consumption improves cognitive performance and motor accuracy and reduces psychological and physiological stress…
- Conditions
- Stress Response, Mental Stress, Multitasking Behavior and Multitasking Ability, Physiological Stress
- Trial name
- CRAN-MULTI (NCT07453537)
- Testing
- Cranberry juice
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Florida
GI Health, Microbial Composition
Polyphenol/Prebiotic Blend Effects on GI Health and Microbial Composition
The gastrointestinal (GI) ecosystem is a complex network of bacterial cells, host cells and tissues that change with age. Fewer numbers and less diversity of beneficial bacteria and greater number and diversity of non-beneficial…
- Trial name
- NCT02743195
- Testing
- Polyphenol/prebiotic blend
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Cognitive Dysfunction
Effect of Raisins on Cognitive Function in Healthy Older Adults
Objective:To assess the effect of an intervention based on including 50 g of raisins (sultanas) daily in the diet for 3 months on improving cognitive performance, cardiovascular risk factors and inflammatory markers in a…
- Trial name
- NCT04966455
- Testing
- Raisins
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Healthy
Bioavailability of the Polyphenols Contained in a Red Grape Extract-based Drink and Their Metabolic Effects
Randomized placebo-controlled crossover study during which participants undergo two different experimental days. The participants consume a red grape based- drink (polyphenols: 300 mg/100 ml and sugar: 9.8g/100 ml) or a placebo…
- Trial name
- BIOP (NCT02865278)
- Testing
- Standard meal
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federico II University