Clinical trials: Polyphenols
Hyperglycemia, Postprandial
Effect of Baobab Fruit on Postprandial Glycaemia in Healthy Adults
Baobab fruits have been traditionally used in Africa due to its therapeutic proprieties attributed to it high polyphenol content.
- Trial name
- NCT05140629
- Testing
- Baobab fruit aqueous extract
- Where
- Portugal
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Overweight, Obesity
Efficacy of a Tea Catechin Sports Drink for Enhancing Exercise-Induced Fat Loss
The primary objective of this trial is to evaluate the influence of consuming a tea catechin containing sports beverage on body fat mass during exercise-induced weight loss among overweight and obese men and women.
- Trial name
- NCT00692731
- Testing
- 500 mL/day of a beverage providing approximately 625 mg catechins, Control beverage matched for energy and caffeine content
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Provident Clinical Research
Inflammation, Atherosclerosis
Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL
Polyphenol supplements, including curcumin and resveratrol, are known to decrease inflammation, but previous polyphenol supplements were poorly absorbed and thus their effects were reduced.
- Conditions
- Inflammation, Atherosclerosis, Cardiovascular Disease
- Trial name
- PSI (NCT02998918)
- Testing
- PolyResveratrol Supplementation, Curcumin Supplementation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Human Health, Reactive Carbonyl Species
Scavenging of Reactive Carbonyl Species by Blueberries in Humans
This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of blueberry polyphenols in humans after a single dose of dietary flavonoids.
- Conditions
- Human Health, Reactive Carbonyl Species, Polyphenols
- Trial name
- NCT07873723
- Testing
- Blueberries, control group
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- North Carolina Agriculture & Technical State University
Power, Metabolic Disturbance
Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists
This clinical study evaluates the effect of 500 mg of 2S-hesperidin for 8 weeks on performance (power generated in different metabolic zones), body composition (fat and muscle mass) and biochemical (antioxidant, inflammatory…
- Conditions
- Power, Metabolic Disturbance, Change, Body Weight, Changes Fatty
- Trial name
- HESPERFORMAN (NCT04597983)
- Testing
- 2S-hesperidin
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Healthy
Bioavailability and Vascular Effects of Apple Polyphenols
The main purpose of this study is to determine the oral bioavailability of flavanols (polyphenolic compounds) from apple granules and an apple extract delivered in a water based beverage at two different doses.
- Trial name
- POLYMALUS (NCT01097226)
- Testing
- Apple extract delivering 70 mg epicatechin, Apple extract delivering 140 mg epicatechin, Apple granules delivering 70 mg epicatechin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Polyphenol Absorption in Healthy People
Bioactivity of Olive Oils Enriched With Their Own Phenolic Compounds (VOHF1)
Hypothesis: A functional olive oil tailored to provide the best relationship between phenolic compounds (amount and type) phenolic bioavailability and bioactivity (antioxidant and anti-endothelial dysfunction) will be a useful…
- Trial name
- VOHF1 (NCT01347515)
- Testing
- olive oil
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Hyperglycemia, Postprandial, Healthy
Effects of Enriched Fruit Juice on Blood Glucose Levels After a Meal in Healthy Subjects
Results from a large number of studies in humans have shown that diets rich in foods that give lower glucose response bring lower risk of type 2 diabetes.
- Trial name
- PolyGlucHeal (NCT03255876)
- Testing
- Enriched pomegranate juice
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Low Education, Cognition
MINDSpeed Food and Brain Training RCT
The purpose of this study is to learn how foods high in polyphenols and brain training exercises affect older adults' cognitive performance
- Conditions
- Low Education, Cognition, Cognitive Training, Polyphenols
- Trial name
- MINDSpeed (NCT03419052)
- Testing
- Speed of processing training, MIND foods, Cognitive training control
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Indiana University
Sarcopenia, Aging
Effects of Polyphenol Supplementation and Exercise on Physical Performance in Older Adults
After approximately age 40 years, individuals experience a natural loss of muscle mass, strength, and physical function that is linked to higher risks of falls, disability, loss of independence, and mortality.
- Conditions
- Sarcopenia, Aging, Frailty
- Trial name
- NCT07441343
- Testing
- Polyphenol Rich-Extract, Resistance Band-Based & Aerobic Stationary Cycling Exercise
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. Chris McGlory, PhD
Diet, Polyphenols, Flavonoids, Stilbenes, Aged, Dementia, Alzheimer's Disease, Epidemiology
Polyphenols and Risk of Dementia
This project aims to leverage existing data from a large observational prospective study on dementia, the Three-City study, to investigate the relationship between intakes of polyphenols and the risk to develop dementia in the 12…
- Trial name
- NCT03286608
- Testing
- observational study (no intervention)
- Volunteers
- 1,329 people, healthy volunteers welcome
- Sponsor
- Jean-François Dartigues
Overweight, Obese
Characterization of Wild Blueberry Polyphenols Bioavailability and Kinetic Profile Over 24-hour Period
Primary objective is to characterize the relative bioavailability and kinetic profile of wild blueberry polyphenols over 24-hours period.
- Conditions
- Overweight, Obese, Healthy
- Trial name
- WBB (NCT02167555)
- Testing
- Active Comparator
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Obesity Adult Onset, Diabetes Mellitus Type 2
Effect of Citrus Flavonoids on Obesity.
The aim of this study is to evaluate whether the intake of a functional juice enriched in citrus polymethoxylated flavonoids is able to improve the glycaemic profile and insulin resistance of obese patients by reversing the…
- Trial name
- NCT06680635
- Testing
- Flavonoid-enriched juice and a low-calorie diet
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Celia Bañuls
Oxidative Stress
Effect of Red Raspberry Consumption on Fasting Oxidative Stress Biomarkers
The purpose of this study is determine whether daily consumption of frozen red raspberries can improve the antioxidant capacity of the blood and reduce the effects of oxidative stress, dose-dependently, in a healthy adult…
- Trial name
- NCT00876811
- Testing
- individually quick frozen red raspberries
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy
The Absorption and Metabolism of Seaweed Polyphenols in Humans
Brown seaweeds are a rich source of phlorotannins, a characteristic class of polyphenols which are unique to seaweeds of this type and can comprise 5 to 15 % of the dried weight.
- Trial name
- SWAFAX (NCT02496806)
- Testing
- Seaweed extract
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Reading
Healthy
Absorption, Metabolism and Excretion of Dietary Polyphenolic Bioactives in Humans
The objectives of this study are to i) describe the absorption, distribution, metabolism and excretion (ADME) and pharmacokinetic parameters of selected dietary (poly)phenols in humans; and ii) to compare the ADME and…
- Trial name
- NCT03194620
- Testing
- Thearubigins, Theaflavins, Procyanidin Dimer B2 (DB2)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Mental Energy, Physical Performance
Dose Effect of a Plant Extract on Fatigue
Test the short-term effects of the acute consumption of two separate beverages containing different concentrations of polyphenols, a beverage containing 75 mg of caffeine and a flavored placebo beverage on mental energy and…
- Trial name
- NCT03870126
- Testing
- Flavored beverage
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Gut Health
Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms
The purpose of this study is the assess the effectiveness and safety of a Butyrate formulation and a Butyrate + Polyphenol formulation on gut health, permeability and associated symptoms
- Trial name
- NCT06419231
- Testing
- Butyrate Formulation, Butyrate + Polyphenol Formulation
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Overweight or Obesity, Healthy
Berries, Inflammation, and Gut Microbiome
The primary objectives are to characterize changes in indices of systemic and gut inflammation, assess host- and microbial-derived metabolite pools, and describe and link functional metagenomics and metatranscriptomic alterations…
- Trial name
- NCT04100200
- Testing
- Mixed berries, FOS, Control
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
GI Health, Microbial Composition
Polyphenol/Prebiotic Blend Effects on GI Health and Microbial Composition
The gastrointestinal (GI) ecosystem is a complex network of bacterial cells, host cells and tissues that change with age. Fewer numbers and less diversity of beneficial bacteria and greater number and diversity of non-beneficial…
- Trial name
- NCT02743195
- Testing
- Polyphenol/prebiotic blend
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Pharmanex