Clinical trials: Polyps, open to volunteers
Colon Polyp
PULSed Field ablAtion of coloRectal Polyps
The goal of this observational study is to learn about the role of electroporation (the use of small electric pulses applied to tissue) in the treatment (ablation) of colorectal polyps.
- Trial name
- PULSAR (NCT06317727)
- Testing
- Irreversible Electroporation using EndoVE(Endoscopic Vacuum Electrode) and electrical pulses generated using ePORE(electroporation device)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
Endometrial Polyp
The Effect of Levonorgestrel Intrauterine System in Preventing Endometrial Polyps Recurrence
The goal of this clinical trial is to determine whether the LNG-IUS is more effective to that of expectant in preventing endometrial polyp recurrence after hysteroscopic polypectomy.
- Trial name
- NCT06620939
- Testing
- Levonorgestrel Intrauterine System (LNG-IUS)
- Volunteers
- 558 people
- Sponsor
- Zhang Jian
Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
A Study of CM512 in Patients With Chronic Rhinosinusitis With Nasal Polyposis (NEZHA-3)
This is a multi-center, randomized, double blind, placebo-controlled Phase III study to evaluate the efficacy and safety of CM512, and to observe the life quality of subjects, the Pharmacokinetics, Pharmacodynamics and…
- Trial name
- NCT07807826
- Testing
- CM512
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Keymed Biosciences Co., Ltd.
Colorectal Polyps
Metatranscriptomic Markers of Colonic Neoplasia
This study is a collaboration between Viome Life Sciences and Scripps Research Institute to develop and validate a noninvasive molecular diagnostic test for the detection of colorectal polyps.
- Trial name
- NCT07786818
- Testing
- This is an observational study that has no interventions
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Viome
Polyp of Colon, Endoscopic Mucosal Resection
Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.
The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps.
- Trial name
- NCT06937671
- Testing
- Cold EMR, Hybrid EMR
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- The Cleveland Clinic
Chronic Rhinosinusitis With Nasal Polyps, Allergic Rhinitis
Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps
During this project, the investigators want to explore in vitro changes in basal cells and the crosstalk with residing immune cells as potential pathogenic mechanisms in CRSwNP vs healthy controls by using surgically resected…
- Trial name
- NCT06129552
- Testing
- Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Colorectal Polyps, Colorectal Adenoma
AI-Assisted Optical Diagnosis (CADx) for Diminutive Colorectal Polyps
This study evaluates whether an artificial intelligence system (GI Genius, Medtronic), already approved by Health Canada, can help doctors accurately identify, in real time during colonoscopy, which small colorectal polyps (5 mm…
- Conditions
- Colorectal Polyps, Colorectal Adenoma, Diminutive Colorectal Polyp
- Trial name
- CADxGIG (NCT07738484)
- Testing
- GI Genius CADx module (Medtronic)
- Volunteers
- 840 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Polyp of Colon, Artificial Intelligence (AI)
Video/Image Library of Endoscopy Procedures for the Development of AI-empowered Endoscopy Quality Reporting and Educational Modules
The goal of this observational study is to establish a video/image library dataset of complete endoscopy or partial colonoscopy procedures for patients with rectal cancer or inflammatory bowel disease (IBD).
- Trial name
- Videotheque (NCT06822816)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Sinusitis, Nasal Polyps
In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps
Chronic rhinosinusitis, also called chronic sinusitis, is a very common life-long disease affecting over 5% of the Canadian population.
- Trial name
- NCT02975310
- Testing
- Endoscopic polypectomy in clinic (EPIC), Endoscopic Sinus Surgery (ESS), General Anesthesia
- Where
- 4 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Ottawa Hospital Research Institute
Colorectal Polyp, Colorectal Adenoma
Social Software-Based Intelligent Management System for Bowel Preparation
Colorectal cancer (CRC) is one of the most common malignancies worldwide, and colonoscopy is an important method for CRC screening and early detection.
- Conditions
- Colorectal Polyp, Colorectal Adenoma, Bowel Preparation, Artificial Intelligence
- Trial name
- NCT07901257
- Testing
- AI-assisted Bowel Preparation Management, Conventional Bowel Preparation Management
- Where
- China
- Volunteers
- 740 people, healthy volunteers welcome
- Sponsor
- Shandong University
Colorectal Polyp
Effects of UNICLA-A2 Dairy Products on Patients at High-risk of Colorectal Cancer Development
Dietary intervention with UNICLA-A2 milk products containing beta casein A2 protein, and higher levels of omega-3 fatty acids and selenium may contribute to maintain the intestinal integrity, reduce inflammatory processes…
- Trial name
- NCT04824053
- Testing
- Milk from genetically selected homozygous- β-casein-A2 cows fed with forages and a concentrate enriched on linseed and selenized yeast as sources of PUFAs and selenium, Conventional milk, Yogurt made from milk of genetically selected homozygous- β-casein-A2 cows fed with forages and a concentrate enriched on linseed and selenized yeast as sources of PUFAs and selenium
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Olfactory Dysfunction, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Neural Dissimilarity in Patients With Chronic Rhinosinusitis With Nasal Polyps Treated With Biologics
This project will focus on rehabilitation of olfactory dysfunction in patients with chronic rhinosinusitis with polyps given biological treatment based on functional magnetic resonance imaging.
- Conditions
- Olfactory Dysfunction, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Functional Magnetic Resonance Imaging (fMRI)
- Trial name
- NCT07819162
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pedunculated Colorectal Polyp
UEMR Versus HSP in the Treatment of Pedunculated Colorectal Polyps Less Than 10mm in Size
A prospective, single-center, open-label, randomized controlled study to compare the effectiveness and safety of underwater endoscopic mucosal resection (UEMR) and hot snare polypectomy (HSP) in treating Pedunculated colorectal…
- Trial name
- NCT06996522
- Testing
- underwater endoscopic mucosal resection, Hot snare polypectomy
- Where
- China
- Volunteers
- 338 people
- Sponsor
- Fudan University
Intestinal Metaplasia, Chronic Gastritis
UC Davis Cohort of Pre-Malignant and Malignant Gastro-Intestinal DisEases Study
The UC Davis Cohort of Pre-Malignant and Malignant GastroIntestinal DisEases (TUMMIE) Study is a prospective longitudinal cohort study designed to improve understanding of the natural history, risk factors, and biological…
- Conditions
- Intestinal Metaplasia, Chronic Gastritis, Atrophic Gastritis, Autoimmune Gastritis
- Trial name
- TUMMIE (NCT05021029)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of California, Davis
Nasal Polyps
A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
The aim of this study is to assess the efficacy and safety of GSK5784283 administered as add-on maintenance therapy to participants with CRSwNP.
- Trial name
- PERSISTCRSwNP2 (NCT07782957)
- Testing
- GSK5784283, Standard of Care
- Where
- 4 sites in United States, Australia
- Volunteers
- 218 people
- Sponsor
- GlaxoSmithKline
Colorectal Carcinoma
Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps
This clinical trial tests a multilevel intervention at the clinic, provider and patient levels, to improve colonoscopy surveillance in patients with high risk colon polyps.
- Trial name
- NCT06376565
- Testing
- Best Practice, Communication Intervention, Interview
- Where
- United States
- Volunteers
- 1,680 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Chronic Rhinosinusitis With Nasal Polyps
Mepolizumab and in Office-office Nasal Polypectomy in Patients With Chronic Rhinosinusitis (CRS).
This randomized, controlled multicenter trial will recruit patients aged 18 to 70 years with recurrent nasal polyposis requiring surgery and indication for biologic treatment according to EPOS 2020 guideline.
- Trial name
- MELYSA (NCT07814924)
- Testing
- surgical arm, Mepolizumab 100 MG, combined arm
- Where
- 7 sites in Spain
- Volunteers
- 75 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Colorectal Polyps
COLO-PREDICT: Digital Training and Optical Diagnosis of Colorectal Polyps
Colorectal cancer prevention relies on high-quality colonoscopy and accurate optical characterization of colorectal polyps. Optical diagnosis may allow optimization of management strategies such as resect-and-discard for…
- Trial name
- COLO-PREDICT (NCT07424391)
- Testing
- Digital Training Program (Colo-ID)
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Clinique Paris-Bercy
Colonoscopy, Adenoma Detection Rate
Comparison of Adenoma Detection Rate in 3D vs. 2D Surveillance Colonoscopy
There is substantial evidence confirming that identifying and removing colorectal adenomas during colonoscopy helps prevent the development of colorectal cancer.
- Conditions
- Colonoscopy, Adenoma Detection Rate, Three Dimensional, Colon Polyps and Adenomas
- Trial name
- NCT07076966
- Testing
- 3D device
- Where
- 3 sites in Taiwan
- Volunteers
- 660 people
- Sponsor
- National Taiwan University Hospital
FAP, Familial Adenomatous Polyposis
Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis
The aim of this study is to evaluate the potential of BHB supplementation as a novel strategy to impede the development and progression of intestinal adenomas in individuals with FAP, thus potentially reducing the need for…
- Trial name
- BHB-FAP (NCT06578637)
- Testing
- R-1,3-Butanediol (10G-A), R-1,3-Butanediol (20G-A), R-1,3-Butanediol (30G-A)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Abramson Cancer Center at Penn Medicine