Clinical trials: Polyunsaturated Fatty Acids
Coronary Artery Disease, Arrhythmia
Effect of Supplemental Intake of Omega-3 Polyunsaturated Fatty Acids on the Rate and Complexity of Spontaneously Occurring Ventricular and Supraventricular Arrhythmias in Patients With Implantable Cardioverter Defibrillator (ICD) - A Randomized Clinical Trial
We hypothesize that oral supplementation with omega-3 PUFA will decrease occurrence of arrhythmic events among post-MI, ICD recipients.
- Trial name
- NCT00290056
- Testing
- Eicosapentanoic acid (EPA) and Docosahexanoic acid (DHA).
- Where
- 2 sites in Israel
- Volunteers
- 105 people
- Sponsor
- Sheba Medical Center
Bipolar Disorder
The Effect of Omega-3 Polyunsaturated Fatty Acids in the Treatment and Prevention of Relapse of Bipolar Disorder
The whole study will be divided into two major parts: (A) A 12-week, double-blind, randomized controlled, parallel n-3 fatty acids adjunctive therapy study in 30 bipolar disorder patients with mild to moderate depression.
- Trial name
- NCT01371383
- Testing
- n-3 fatty acids
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- National Science and Technology Council, Taiwan
Polyunsaturated Fatty Acid (PUFA) Status
The Influence of Fish Consumption on Polyunsaturated Fatty Acid (PUFA) Status
Polyunsaturated fatty acids (PUFA) are important for health, for example for the immune system, heart health and the brain. PUFA are found in fish, nuts and oils; including these foods in the diet provides the body with PUFA.
- Trial name
- iFish (NCT03765580)
- Testing
- Fish, Control
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Acute Lymphoblastic Leukemia, Malnutrition
Effect of Enteral Docosahexaenoic Acid Administration in Children With Acute Lymphoblastic Leukemia
The purpose of this study is to evaluate if enteral docosahexaenoic acid (DHA) administration during the first three months of treatment reduces the deterioration of nutritional status, treatment toxicity and early mortality in…
- Trial name
- DHA-ALL (NCT01051154)
- Testing
- Docosahexaenoic acid (DHA)
- Where
- Mexico
- Volunteers
- 72 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Tobacco Dependence
Preventing Tobacco Relapse With Omega-3s Trial
Almost 12% of women report smoking during pregnancy. Smoking during pregnancy is associated with adverse fetal outcomes and up to 35-75% of women quit smoking during their pregnancy.
- Trial name
- PRO-3 (NCT03113370)
- Testing
- Fish Oil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Age-related Macular Degeneration, Cataract
Age-Related Eye Disease Study 2 (AREDS2)
Oral supplementation with the Age-Related Eye Disease Study (AREDS) formulation (antioxidant vitamins C and E, beta carotene, and zinc) has been shown to reduce the risk of progression to advanced age-related macular degeneration…
- Trial name
- AREDS2 (NCT00345176)
- Testing
- Lutein/zeaxanthin, DHA/EPA, Lutein/zeaxanthin and DHA/EPA
- Where
- 91 sites in United States
- Volunteers
- 4,203 people
- Sponsor
- National Eye Institute (NEI)
Sleep Deprivation
Study on the Mechanism of Central Obesity Induced by Sleep Restriction and the Therapeutic Effect of n-3 Polyunsaturated Fatty Acid: a Randomized, Double-blind, Placebo-controlled Trial (COSPA Study)
This randomized, double-blind, placebo-controlled trial aims to investigate whether n-3 polyunsaturated fatty acid (PUFA) supplementation attenuates abdominal visceral fat accumulation induced by experimental sleep restriction.
- Trial name
- NCT07897097
- Testing
- n-3 PUFA Supplementation, Experimental Sleep Restriction
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Premature, Extremely Low Birth Weight Infants, Polyunsaturated Fatty Acid Levels
PUFA Supplementation in Premature Infants
The purpose of this study is to determine if buccal administration of a concentrated formulation of long-chain polyunsaturated fatty acids (LCPUFA) can help to maintain docosahexaenoic acid (DHA) levels in extremely low birth…
- Trial name
- NCT01955044
- Testing
- LCPUFA supplement
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Lipid Depletion, Human Milk
Effect of Tube Feeding on LCPUFAs Delivery
Long-chain polyunsaturated fatty acids (LCPUFAs) docosahexaenoic (DHA) arachidonic acid (AA) are major building blocks for the lipid bilayer of neuronal and retinal membranes and play a crucial role in brain and visual…
- Conditions
- Lipid Depletion, Human Milk, Tube Feeding
- Trial name
- NCT03459209
- Testing
- tube feeding
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Lipid Metabolism Disorders
Stearidonic Acid and Lipid Metabolism
Evidence exists that EPA (eicosapentaenoic acid or C20:5n-3) supplementation can reduce the risk for coronary heart disease. EPA can be synthesized from α-linolenic acid (ALA or C18:3n-3), but conversion is low.
- Trial name
- NCT01365078
- Testing
- Echium oil (SDA-rich oil), high-oleic acid sunflower oil (HOSO) (low in SDA)
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Polycystic Ovary Syndrome
n-3 Polyunsaturated Fatty Acids (PUFA) Supplementation in Young Women With Polycystic Ovary Syndrome (PCOS)
This is a dietary intervention study designed to assess the impact of long chain (LC) n-3 polyunsaturated fatty acids (PUFA) in young women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT01189669
- Testing
- LC n-3 PUFA (fish oil) Supplement
- Where
- 2 sites in Ireland
- Volunteers
- 25 people
- Sponsor
- The Adelaide and Meath Hospital
Obesity, Insulin Resistance
Intervention Study With Omega-3 Fatty Acids for Weight Loss and Insulin Resistance in Adolescents
The purpose of this study is to evaluate if a supplement containing omega-3 long chain polyunsaturated fatty acids for three months reduce obesity and insulin resistance to obese adolescents if administered together with a…
- Trial name
- O3WLIRADOL (NCT01456221)
- Testing
- Omega3 and an hypocaloric diet., Sunflower oil with an hypocaloric diet.
- Where
- Mexico
- Volunteers
- 366 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Migraine, Omega-3 Polyunsaturated Fatty Acids
Omega-3 Fatty Acid in the Prevention of Migraine
To understand the clinical efficacy for omega-3 PUFAs migraine prevention.To uncover the underlying biochemical or neurophysiological mechanisms by which omega-3 PUFAs for migraine prevention.
- Trial name
- NCT04572789
- Testing
- Omega-3 polyunsaturated fatty acids, omega-6 PUFAs
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kuang Tien General Hospital
ADHD
Efficacy Study of Polyunsaturated Fatty Acids in Children and Adolescents With Attention Deficit/ Hyperactivity Disorder
This study will determine the nutritional efficacy of Polyunsaturated Fatty Acids (PUFAs) in combination with zinc and magnesium, in children and adolescents diagnosed with Attention Deficit/ Hyperactivity Disorder (ADHD).
- Trial name
- PAD (NCT01340690)
- Testing
- ω-3 fatty acids suspension
- Where
- 5 sites in Germany
- Volunteers
- 284 people
- Sponsor
- Johannes Gutenberg University Mainz
Cystic Fibrosis
Omega 3 Supplementation in Cystic Fibrosis Patients
Essential fatty acids (EFA) deficiency has been often reported in patients with cystic fibrosis (CF), particularly in those homozygous for the DF508 mutation.
- Trial name
- NCT00959010
- Testing
- omega-3 triglycerides
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Queen Fabiola Children's University Hospital
Morbid Obesity
Intake of Omega 3 in Morbidly Obese Patients
Ingestion of capsules of omega 3 EPA and DHA, with 1.8 g of EPA and 1.2 g DHA for morbidly obese patients, will improve the inflammatory status? C-reactive protein? Weight?
- Trial name
- NCT02113696
- Testing
- Omega 3 intake, morbid obesity
- Volunteers
- 46 people
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Dyslipidemias, Fatty Acid; Metabolic Disorder
Short-term Cocoa Supplementation and Elite Soccer Players
The goal of this interventional study was to investigate the impact of daily ingestion of 30g of dark chocolate on omega-3 fatty acid status and gut microbial community in professional soccer players.
- Trial name
- COCOA (NCT06073327)
- Testing
- dark chocolate, White chocolate
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Padova
Lifestyle
Omega-3 Bioavailability From Vegetable-omega-3 Enriched Products
CSIRO's Food Program has developed a novel vegetable-based Omega-3 long-chain polyunsaturated fatty acid (Omega 3)encapsulant to be used as ingredient in various food products, however, it is unknown whether the vegetable-based…
- Trial name
- NCT04610983
- Testing
- Experimental: Control, Experimental: Treatment 1 - Semi-Solid food matrix, Treatment 2 - Solid food matrix
- Where
- 2 sites in Australia, Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Commonwealth Scientific and Industrial Research Organisation, Australia
Overweight, Obese
Impact of n-3 Polyunsaturated Fatty Acids in a Protein-enriched Diet With Low GI in Type 2 Diabetes Patients
Type 2 diabetes is tightly associated with overweight and obesity. Inflammatory processes are crucial triggers for insulin resistance that paves the way to type 2 diabetes.
- Conditions
- Overweight, Obese, Insulin Resistance, Diabetes
- Trial name
- IMPEDE-DM2 (NCT01474603)
- Testing
- n-3 PUFA in protein-enriched low-GI diet
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Preterm Birth, Child Development
Omega Tots: A Randomized, Controlled Trial of Long-chain Polyunsaturated Fatty Acid Supplementation of Toddler Diets and Developmental Outcomes
The purpose of this study is to examine whether supplementation with certain polyunsaturated fatty acids can help the cognitive development of children born preterm.
- Trial name
- NCT01576783
- Testing
- Docosahexaenoic Acid + Arachidonic Acid (DHA+AA)
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- Sarah Keim