Clinical trials: Polyuria
Nocturia Due to Nocturnal Polyuria
Specified Drug Use-results Survey (Long-term Use) on MINIRINMELT® OD Tablet (Nocturia)
To investigate the incidence and risk factors of desmopressin-induced hyponatremia during long-term treatment (1 year [52 weeks]) of MINIRINMELT orally disintegrating (OD) tablets 25μg/50μg (drug) for nocturia caused by nocturnal…
- Trial name
- NOC01 (NCT04329975)
- Testing
- Desmopressin
- Where
- Japan
- Volunteers
- 1,087 people
- Sponsor
- Ferring Pharmaceuticals
Nocturnal Polyuria
A Cross-Functional, Population-Representative, Web-Based, Epidemiologic Study to Estimate the Prevalence and Burden of Nocturia Due to Nocturnal Polyuria in the US
To estimate the prevalence of nocturia due to nocturnal polyuria (NP) in the US and describe the demographic and clinical characteristics as well as the burden of illness in participants with nocturia due to NP.
- Trial name
- NCT04125186
- Testing
- Baseline EpiNP survey, Bladder diary, Testing of EpiNP baseline survey, bladder diary and a qualitative interview
- Where
- United States
- Volunteers
- 10,190 people
- Sponsor
- Ferring Pharmaceuticals
Healthy, Polyuria-polydipsia Syndrome
Copeptin After Arginine Infusion in Polyuria-Polydipsia Syndrome
the purpose of the study is to investigate whether arginine infusion is a new tool to differentiate patients with diabetes insipidus, primary polydipsia and healthy subjects.
- Trial name
- NCT01879137
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Nocturia
Trial Investigating the Long Term Safety and Tolerability of Desmopressin Orally Disintegrating Tablets (ODT) for Nocturia Due to Nocturnal Polyuria in Japanese Subjects
Demonstrate the safety and tolerability of desmopressin ODT during long-term treatment of subjects with nocturia due to nocturnal polyuria, for up to 1 year
- Trial name
- NCT03051009
- Testing
- Desmopressin ODT 25 μg, Desmopressin ODT 50 μg
- Where
- Japan
- Volunteers
- 503 people
- Sponsor
- Ferring Pharmaceuticals
Nocturia
Trial of Desmopressin Orally Disintegrating Tablets (ODT) for Nocturia Due to Nocturnal Polyuria in Japanese Male Subjects
The purpose of this trial is to demonstrate efficacy of desmopressin ODT against placebo for the treatment of male subjects with nocturia due to nocturnal polyuria, during 12 weeks of treatment.
- Trial name
- NCT02904759
- Testing
- Desmopressin
- Where
- Japan
- Volunteers
- 342 people
- Sponsor
- Ferring Pharmaceuticals
Polyuria, Polydipsia
Copeptin in Differentiation of Polyuria and Polydipsia
The differential diagnosis of patients with polyuria/ polydipsia is often complex, but important for the therapeutic strategy. Challenging is in particular the clinical differentiation between patients with a partial Diabetes…
- Trial name
- NCT01056887
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Wuerzburg
Nocturnal Polyuria
Desmopressin Melt Therapy in Patients With Nocturnal Polyuria: a Pharmacokinetic/Dynamic Study
The objective of this study is to find out what the pharmacokinetic/dynamic (PK/PD) characteristics of desmopressin melt are in nocturia patients (compared to healthy volunteers and children).
- Trial name
- NCT01435083
- Testing
- Desmopressin
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Ghent
Lower Limb Lymphedema, Urogenital Cancer
Lymphoedema and Nocturia/ Nocturnal Polyuria After Pelvic Lymph Node Dissection for Urogenital Cancer
After the treatment of urogenital cancer, a person may develop lymphoedema of the leg(s) and/ or midline region. Lymphoedema is the result of a dysfunction in the lymphatic system and is characterized by excessive retention of…
- Trial name
- UroLymph (NCT05266157)
- Testing
- Manual lymph drainage, Usual care
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Oliguria, Polyuria
Evaluation of a Novel Electronic Urine Output Monitor (eUOM)
Urine output and urine drain line pressure were monitored while urine was drained into either: 1. Accuryn Urine Output Monitor (Potrero Medical) OR 2. Criticore Monitor (Bard Medical)
- Trial name
- NCT02195713
- Testing
- Accuryn
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Potrero Medical
Nocturnal Enuresis
Biomarkers in Urine for Children With Monosymptomatic Nocturnal Enuresis and Nocturnal Polyuria
The aim of the study is to identify protein markers in relation to the enuresis related nocturnal polyuria by using mass spectrometry on nocturnal urine samples.
- Trial name
- NCT04049019
- Testing
- Urine collection through a collecting device (Uridome®) for maximum 1 week, Urine collection
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Nocturia
Bioavailability of [14C]-SK-1404 ADME & IV Microtracer Study
The primary objectives of the study are: To determine the absolute bioavailability of SK-1404 To assess the mass balance recovery after a single oral (PO) dose of carbon-14 (14C)-SK-1404 To provide plasma, urine and faecal…
- Trial name
- NCT02878096
- Testing
- [14C]-SK-1404
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sanwa Kagaku Kenkyusho Co., Ltd.
Nocturia Associated With Nocturnal Polyuria
Efficacy and Safety of Desmopressin (Nocturin®) 0.1 mg Tablets in Treatment of Nocturia in Participants With Benign Prostate Syndrome (BPS)
Documentation of the efficacy and safety of desmopressin (Nocturin®) 0.1 mg tablet. Observation of patients with benign prostate syndrome, in whom nocturia associated with nocturnal polyuria is treated with desmopressin…
- Trial name
- NCT00902265
- Testing
- desmopressin
- Where
- 140 sites in Germany
- Volunteers
- 138 people
- Sponsor
- Ferring Pharmaceuticals
Nocturia
Desmopressin in the Treatment of Mixed Nocturia With Nocturnal Polyuria and Low Nocturnal Bladder Capacity
Nocturia is defined as waking one or more times to void during the period between going to bed with the intention of sleeping and waking with the intention of arising.The pathophysiology of nocturia is multifactorial and can be…
- Trial name
- NCT00902655
- Testing
- Desmopressin
- Where
- 6 sites in South Korea
- Volunteers
- 103 people
- Sponsor
- Samsung Medical Center
Total Body Water, Nocturnal Polyuria
Watershift - Pilot Study
The aim of this pilot was to study how body water behaves between the different internal water pools of the human body, what the role and influence of the interstitium is and what the effect is of body position on the…
- Trial name
- WATERSHIFT (NCT04520477)
- Testing
- Bio Impedance assesement (BIA), Blood and salava sample, Ingestion of deuterated water
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Nocturia, Pelvic Organ Prolapse
Severe Pelvic Organ Prolapse and Post-Obstructive Diuresis (SOPPO) Pilot Study
In our experience, women with severe pelvic organ prolapse (POP) frequently have bothersome nocturia. The International Continence Society (ICS) defines nocturia as "having to wake at night one or more times to void." Though some…
- Trial name
- SOPPO (NCT02060331)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loyola University
Arginine Vasopressin Deficiency, Primary Polydipsia
Plasma Copeptin in Response to Oral Urea in Healthy Adults and Patients With Polyuria-polydipsia Syndrome
The aim of this study is to investigate whether oral urea stimulates copeptin release and, if so, whether it may provide a novel diagnostic test in the differentiation between AVP-D (Arginine vasopressin deficiency) and PP…
- Trial name
- URANOS (NCT05890690)
- Testing
- Urea
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Polyuria-polydipsia Syndrome
Copeptin After an Oral Stimulation With Macimorelin in Healthy Volunteers
This study investigates stimulation of the posterior pituitary gland by oral Macimorelin (a ghrelin receptor Agonist) to be a novel diagnostic test in the polyuria-polydipsia syndrome.
- Trial name
- Macicop (NCT03844217)
- Testing
- Macimorelin 0.5mg/kg body weight, Macimorelin 0.75mg/kg body weight
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Enuresis, Polyuria
Influence of Food-intake on Desmopressin Oral Tablets and MELT-formulation
Alarm-treatment as well as Desmopressin, a synthetic analogue of human vasopressin, are considered the only evidence-based medicine (EBM) IA treatments in monosymptomatic nocturnal enuresis (MNE).
- Trial name
- TM (NCT01036841)
- Testing
- desmopressin tablet, desmopressin MELT formulation
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- University Hospital, Ghent
Primary Polydipsia, Central Diabetes Insipidus
Arginin-stimulated Copeptin in Polyuria-polydipsia Syndrome in Children
The exploration of polyuro-polydipsia syndrome (PPS) with hypotonic polyuria should distinguished, primary polydipsia (PP) due to excessive water intake, central diabetes insipidus (CDI) related to insufficient secretion of…
- Conditions
- Primary Polydipsia, Central Diabetes Insipidus, Nephrogenic Diabetes Insipidus
- Trial name
- COPEPCHILD (NCT06604975)
- Testing
- Measure of Basal Copeptin level, Measure of arginine-stimulated copeptin, IRM
- Where
- 14 sites in France
- Volunteers
- 155 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Nephrogenic Diabetes Insipidus
Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus
The purpose of this research study is to determine if two investigational medications will be more effective in decreasing urine output than the currently available and routinely used medications in patients with congenital…
- Trial name
- NCT00478335
- Testing
- sildenafil, calcitonin, hydrochlorothiazide/amiloride
- Where
- 2 sites in United States, Denmark
- Volunteers
- 4 people
- Sponsor
- University of Colorado, Denver