Clinical trials: Poor Ovarian Response
Infertility
Poor Ovarian Stimulation Response in In Vitro Fertilization (IVF) Program
The aim of this study is to assess the role of AMH in prediction of poor ovarian response as well as the relation between ESR2 (+1730G>A) (rs4986938), FSHR p.Thr307Ala (c.919A>G, rs6165) and FSHR p.Asn680Ser (c.2039A>G, rs6166)…
- Trial name
- NCT02640976
- Testing
- Human menopausal gonadotrophin (HMG), GnRH antagonist Cetrorelix, Human chorionic gonadotrophin (hCG)
- Volunteers
- 216 people
- Sponsor
- Cairo University
Poor Ovarian Reserve, Infertility (IVF Patients)
Drospirenone-Primed Ovarian Stimulation Versus GnRH Antagonist Protocol in Poor Ovarian Responders Undergoing Freeze-All IVF/ICSI
Participants will: Take either drospirenone (a daily pill) or the standard daily injection during their ovarian stimulation cycle, alongside their regular fertility hormone injections Undergo egg retrieval, with all resulting…
- Trial name
- PPOS (NCT07736261)
- Testing
- Drospirenone drug, Cetrorelix 0.25 mg
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ahmed Saad
Infertility
Efficacy and Safety of Shen Que (RN8) Moxibustion in Unexpected POR
Moxibustion of Shen Que (RN8) can increase the number of embryos available for transfer, thus improving pregnancy outcomes in women of advanced reproductive age who experience unexpected poor ovarian response.
- Trial name
- NCT05653557
- Testing
- Shen Que Moxibustion
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Subfertility
Does Dehydro Epiandrosterone (DHEA) Improve Pregnancy Rate in Women Undergoing IVF/ICSI With Expected Poor Ovarian Response?
140 women with expected poor ovarian response undergoing IVF/ICSI will be randomly divided into 2 groups using computer generated random numbers .
- Trial name
- NCT02151006
- Testing
- DHEA
- Where
- 2 sites in Egypt
- Volunteers
- 140 people
- Sponsor
- Cairo University
Poor Ovarian Response, Female Infertility of Other Origin
Exosome-Enriched Culture Media to Enhance In Vitro Maturation and Embryo Development in Poor Ovarian Responders Undergoing IVF
Evaluating the Efficacy of Exosome-Enriched Culture Media to Enhance In Vitro Maturation and Embryo Development in Poor Ovarian Responders Undergoing IVF Summary: This is a prospective, randomized controlled trial designed to…
- Conditions
- Poor Ovarian Response, Female Infertility of Other Origin, Oocyte Immaturity
- Trial name
- EXOMAT (NCT07085312)
- Testing
- Exosome-Enriched IVF Culture
- Where
- Venezuela
- Volunteers
- 10 people
- Sponsor
- Fertiaguerrevere
Infertility
Dual Ovarian Stimulation in the Same IVF/ICSI Cycles for Treatment of Poor Ovarian Responders
This study is a prospective before \& after clinical trial to investigate the efficacy of double stimulations during both the follicular and luteal phases in patients with poor ovarian response undergoing IVF and intracytoplasmic…
- Trial name
- NCT02732808
- Testing
- Ovulation stimulation
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Royan Institute
Female Infertility, Ovarian Insufficiency
Efficacy Study Comparing the Effect of Clomiphencitrate to an Antagonist Protocol
The aim of this study is to assess the oocyte yield of infertile women with suspected or known poor ovarian reserve (POR) undergoing a GnRH antagonist protocol for IVF with Merional® starting either with a low (150 IU) or a high…
- Trial name
- CANTAPOR (NCT01577472)
- Testing
- High Dose Clomiphencitrat, Low Dose Clomiphencitrat
- Where
- Switzerland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Infertility
Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders
This is a prospective, randomized clinical trial to compare the efficiency and safety of mild stimulation and controlled ovarian stimulation protocol on the treatment of POR.
- Trial name
- POR (NCT01926210)
- Testing
- mild stimulation protocol, controlled ovarian stimulation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Huang Rui
Androgen Receptor Gene Overexpression, Normal Responders
Androgen Receptor mRNA Expression is Positively Associated With Live Birth in Women Undergoing IVF Independently of the Type of Ovarian Response
AR is a steroid hormone receptor that regulates various genes' expression and affects cellular proliferation and differentiation.
- Conditions
- Androgen Receptor Gene Overexpression, Normal Responders, Poor Ovarian Response, Bologna Criteria
- Trial name
- NCT03433768
- Testing
- Real time PCR
- Volunteers
- 67 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility
Effectiveness of Estradiol Valerate Pretreatment in Antagonist Protocol for Poor Ovarian Response Patient
The purpose of study is to assess the efficacy of add-on estrogen pretreatment in GnRH antagonist protocol on oocyte retrieval as compared with GnRH antagonist protocol for patients with poor ovarian response Add-on estrogen…
- Trial name
- NCT03300518
- Testing
- Follitropin Beta;MSD, Ganirelix, hCG
- Where
- China
- Volunteers
- 552 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV
Follicular Flushing Using Double Lumen Needle Versus Direct Aspiration in Low Prognosis Patients According to the POSEIDON Criteria
This is a prospective, randomized, controlled clinical trial designed to evaluate whether follicular flushing increases the number of cumulus-oocyte complexes (COCs) retrieved compared to single aspiration in patients with poor…
- Conditions
- Low Ovarian Reserve, Poor Response to Ovulation Induction Poseidon Type IV, Poor Response to Ovulation Induction
- Trial name
- FLUSHING (NCT07270081)
- Testing
- follicular flushing, follicular aspiration
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Bernabeu
Poor Ovarian Response, PRP Injection
A RCT Study on Autologous PRP Injection in Patients With POR
Poor ovarian response (POR) is a pathological condition where the ovaries do not respond well to the stimulation of gonadotropins.
- Trial name
- NCT07282314
- Testing
- PRP injection
- Volunteers
- 142 people
- Sponsor
- Peking University Third Hospital
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Female Infertility Due to Diminished Ovarian Reserve
Use of Dehydroepiandrosterone (DHEA) in Women With Normal and Poor Ovarian Reserve Undergoing IVF
The aim of the study is to evaluate the effect of DHEA supplement on ovarian reserve markers, ovarian response to gonadotrophins and cycle outcomes in patients with normal and poor ovarian reserve. Study Hypotheses: 1.
- Trial name
- NCT01915186
- Testing
- Dihydroepiandrosterone (DHEA)
- Where
- Hong Kong
- Volunteers
- 104 people
- Sponsor
- The University of Hong Kong
Infertility, Female
Growth Hormone Co-treatment Within a GnRH Antagonist Protocol in Patients With Poor Ovarian Response
In this study, the investigators will assess the efficacy of growth hormone co-stimulation to GnRH antagonist regimen in poor responders to COH for IVF.
- Trial name
- NCT03373149
- Testing
- Growth hormone/HPuFSH/GnRH antagonist, HPuFSH/GnRH antagonist
- Where
- Egypt
- Volunteers
- 228 people
- Sponsor
- Riyadh Fertility and Reproductive Health center
Infertility
Synchronization of Follicle Wave Emergence and Ovarian Stimulation
The objective of the study is to elucidate the effect of synchronizing initiation of ovarian stimulation treatment with follicular wave emergence in poor responder patients undergoing IVF/ICSI and ET.
- Trial name
- NCT00439829
- Testing
- Gonal F, Luveris, Cetrotide
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- University of Saskatchewan
Infertility
Effect of Treatment With Corifollitropin Alpha in Vitro Fertilization in Patients With Poor Ovarian Response.
Patients who have had or are expected to have a poor ovarian response (POR), because they meet any of the criteria of Bologna, can benefit from ovarian stimulation with 150 mg of alpha Corifollitropin (CFA) (Elonva ®) as single…
- Trial name
- NCT02118051
- Testing
- Ganirelix 0.25 mg., Recombinant choriogonadotropin alfa, Micronized natural progesterone.
- Where
- Spain
- Volunteers
- 234 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Poor Responders in IVF
Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients
Poor ovarian response population of ART are considered the biggest challenge for providers. Hitherto, no one protocol has been proven to be effect in this subgroup of IVF patients.
- Trial name
- NCT03560583
- Testing
- Metoclopramide
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
Ovarian Cancer
Safety and Efficacy of Ubamatamab With First-line Chemotherapy in Ovarian Cancer
The purpose of this clinical trial is to assess the safety and efficacy of ubamatamab in combination with first-line chemotherapy in patients with ovarian cancer.
- Trial name
- RegeNovar (NCT07637851)
- Testing
- Ubamatamab, Chemotherapy, Bevacizumab
- Where
- 11 sites in France
- Volunteers
- 43 people
- Sponsor
- ARCAGY/ GINECO GROUP
Premature Ovarian Insufficiency, Intrauterine Adhesion
Application of Platelet-rich Plasma (PRP) in Reproductive Medicine
Female fertility is affected by many factors, such as ovarian function, fallopian tube patency, uterine environment, and mental state, among which the ovaries and endometrium are more important.
- Conditions
- Premature Ovarian Insufficiency, Intrauterine Adhesion, Poor Ovarian Response, Repeated Implantation Failure
- Trial name
- NCT06645379
- Testing
- Platelet-Rich Plasma (PRP) Injections
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine