Clinical trials: Population Medicine
Anesthesia, Local, Anesthesia
Prediction Models for Cardiovascular and Neurocognitive Disease Risk in the General Population
More accurate and earlier identification of people at risk of cardiovascular disease (CVD) and neurodegenerative diseases (memory, cognition, dementia) through the appropriate use of biomarkers could lead to earlier initiation of…
- Trial name
- CME (NCT05951764)
- Testing
- Non-invasive measurement of arterial stiffness by Pulse Wave Velocity (PWV)
- Where
- France
- Volunteers
- 396 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type 2
Effects of Nateglinide on Postprandial Glucose Excursion by Restoring Early Phase Insulin Secretion
A 3-week, multi-center, open-label, randomized, active-control, parallel-group study to compare effects of Nateglinide and Acarbose on postprandial glucose fluctuation in Chinese drug-naive patients type 2 diabetes mellitus…
- Trial name
- NCT01030952
- Testing
- Nateglinide, Acarbose
- Where
- 3 sites in China
- Volunteers
- 103 people
- Sponsor
- Novartis Pharmaceuticals
Hepatitis C
Drug-Drug Interaction Study of VCH-222 and Telaprevir in Healthy Subjects
The purpose of this study is to investigate the pharmacokinetics, safety, and tolerability of the co-administration of VCH-222 and telaprevir in healthy subjects.
- Trial name
- NCT00958152
- Testing
- VCH-222, telaprevir
- Where
- New Zealand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Acute Coronary Syndrome, Lipid Disorder
Polypill in Acute Coronary Syndrome
Acute coronary syndromes (ACS) represent a major contributor to mortality, morbidity, and healthcare costs. Effective therapies are widely available; however, adherence is low.
- Conditions
- Acute Coronary Syndrome, Lipid Disorder, Coronary Artery Disease
- Trial name
- POLY-ACS (NCT05514938)
- Testing
- Polypill, Usual Care (individual medications prescribed by primary cardiologist)
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Texas Southwestern Medical Center
Generalized Anxiety Disorder
An Efficacy and Safety Study of Vortioxetine (Lu AA21004) in Treating Generalized Anxiety Disorder
The purpose of this study is to determine the safety and efficacy of vortioxetine, once daily (QD), in treating Generalized Anxiety Disorder.
- Trial name
- NCT00734071
- Testing
- Vortioxetine
- Where
- 33 sites in United States
- Volunteers
- 304 people
- Sponsor
- Takeda
Arthritis, Rheumatoid
A Study of CNTO 136 (Sirukumab), Administered Subcutaneously, in Patients With Active Rheumatoid Arthritis Despite Disease-Modifying Antirheumatic Drug (DMARD) Therapy (SIRROUND-D)
The purpose of this study is to assess the efficacy of sirukumab as measured by the reduction of the signs and symptoms of rheumatoid arthritis (RA) and inhibition of radiographic progression in patients with active RA who are…
- Trial name
- NCT01604343
- Testing
- Sirukumab
- Where
- 156 sites in United States, Bulgaria and 16 more
- Volunteers
- 1,670 people
- Sponsor
- Janssen Research & Development, LLC
Rheumatoid Arthritis
A Study of Liquid Certolizumab Pegol as Additional Medication to Methotrexate in the Treatment of Signs and Symptoms of Rheumatoid Arthritis and in Prevention of Joint Damage in Patients With Active Rheumatoid Arthritis
A 24 week study in which patients are given study medication and assessed for signs and symptoms of rheumatoid arthritis. X-rays are performed to assess the progress of joint damage during the study.
- Trial name
- NCT00160602
- Testing
- Certolizumab Pegol
- Where
- 70 sites in United States, Bulgaria and 13 more
- Volunteers
- 590 people
- Sponsor
- UCB Pharma
Down Syndrome
Caregiver-Involved Nutrition Education in Down Syndrome
This single-arm, quasi-experimental pre-post study evaluated an 8-week online nutrition education program for individuals with Down syndrome and their caregivers in Ataşehir, Istanbul, Türkiye.
- Trial name
- NCT07330128
- Testing
- Caregiver-Involved Nutrition Education
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Hülya YILMAZ ÖNAL
Healthy Volunteers
A Study to Investigate the Effect of the CYP3A Inducer Phenytoin and the CYP3A Inhibitor Itraconazole on the Pharmacokinetics of BGB-58067 in Healthy Participants
This study is being done to understand how the body processes the study drug (BGB-58067) when it is taken together with other medicines. BGB-58067 is mainly broken down in the body by a liver enzyme called CYP3A.
- Trial name
- NCT07590102
- Testing
- BGB-58067, Phenytoin, Itraconazole
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- BeOne Medicines
Pelvic Floor Muscle Weakness, Pelvic Pain
Movement-Based Pelvic Health Education for Women in Underserved Communities
It is essential to provide the community with evidenced-based care to optimize healthcare outcomes; more specifically, women in underserved communities undergoing health disparities in rehabilitation.
- Trial name
- PHEd (NCT05569694)
- Testing
- Movement-based pelvic health education
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Arkansas Colleges of Health Education
Chronic Kidney Diseases
Kidney Coordinated Health Management Partnership
As part of a 42-month pragmatic, cluster randomized trial in 1,650 primary care patients with high-risk Chronic Kidney Disease (CKD), the investigators will test the effectiveness of a multifaceted Electronic Health Record…
- Trial name
- Kidney-CHAMP (NCT03832595)
- Testing
- EHR-based PHM, Usual Care
- Where
- United States
- Volunteers
- 1,596 people
- Sponsor
- University of Pittsburgh
Hypertension, Resistant Hypertension
A Phase II Study of VB19055 in Uncontrolled or Resistant Hypertension
A multicenter, randomized, double-blind, placebo-controlled, dose-ranging Phase II trial of VB19055 for 12 weeks in 240 adults with uncontrolled hypertension (including resistant hypertension).
- Conditions
- Hypertension, Resistant Hypertension, Uncontrolled Hypertension
- Trial name
- NCT07833098
- Testing
- VB19055 Dose A QD, VB19055 Dose B QD, VB19055 Dose C QD
- Where
- 24 sites in China
- Volunteers
- 240 people
- Sponsor
- Zhejiang Yangli Pharmaceutical Technology Co., Ltd.
Physical Activity, Diet Quality
Advancing Precision Medicine for Cardiovascular Disease and Diabetes in Asian Populations: Digital Intervention Cohort
The overarching aim is to improve cardiometabolic health and promote healthy ageing by supporting adults to adopt favourable lifestyle patterns identified through our observational research.
- Conditions
- Physical Activity, Diet Quality, Sleep, Cardiometabolic Health
- Trial name
- COBRA+ (NCT07728799)
- Testing
- Lifestyle intervention targeting physical activity, sleep, and diet
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Acne Vulgaris
Clinical Study Between Two Clindamycin 1%/Benzoyl Peroxide 5% Topical Gels
The purpose of this study is to compare the efficacy and safety profiles of Perrigo Israel Pharmaceuticals, Ltd. Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel and Benzaclin® Topical Gel (Clindamycin- Benzoyl Peroxide Gel).
- Trial name
- NCT01138514
- Testing
- Clindamycin 1% / Benzoyl Peroxide 5% (Perrigo), Clindamycin 1% / Benzoyl Peroxide 5% (Benzaclin)
- Volunteers
- 1,555 people
- Sponsor
- Padagis LLC
Atopic Dermatitis
The Role of Genetic Factors in the Development of Atopic Dermatitis in the Kazakh Population
This is a GWAS study that aims to identify possible candidate genes associate to atopic dermatitisby exploring single nucleotide polymorphism (SNP) in a group of atopic dermatitis, in the Kazakh population.
- Trial name
- NCT05090631
- Testing
- DNA analysis
- Where
- Kazakhstan
- Volunteers
- 600 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
Rheumatoid Arthritis
A Study to Evaluate the Pharmacokinetics of Abatacept Converted From Drug Substance by Two Different Processes
The main objective of this study is to compare the pharmacokinetics (PK) of the abatacept drug product converted from drug substance by a new drug substance process (Treatment A) relative to the current drug substance process…
- Trial name
- NCT03714022
- Testing
- Abatacept
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Acute Coronary Syndrome
Effect of Free Ticagrelor Fraction on Platelet Membrane Post MI
The purpose of this study is to assess: the population pharmacokinetics of unbound ticagrelor and its metabolite in acute coronary syndrome patients treated by ticagrelor ticagrelor and its metabolite levels by LC-MS/MS
- Trial name
- PLATIME (NCT03658005)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Senior High Cost Users (HCU)
Characterizing the Senior High Cost User (HCU) in Ontario
High cost users (HCUs) are a small group of patients who use a disproportionate amount of health care resources. This study is a retrospective population-based matched cohort analysis of newly incident senior High Cost Users…
- Trial name
- NCT02815930
- Testing
- HCU Status
- Volunteers
- 700,000 people
- Sponsor
- McMaster University
Pain, Acute Pain
Optimal Management of Pain in Hospitalized Patients - Opioid Tolerant Populations.
Pain is a symptom that drives hospital admissions, and pain management is required by most patients during their hospital stay. Further, the use of medications such as opioids can lead to upward-spiraling doses, especially among…
- Conditions
- Pain, Acute Pain, Postoperative Pain
- Trial name
- NCT02470728
- Testing
- New Clinical Pathway
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Heart Transplantation, Kidney Transplantation
A Study to Compare How the Body Absorbs and Processes Two Different Formulations of the Anti-rejection Medication Tacrolimus (Advagraf® or Prograf®) in Children Receiving an Organ Transplant, and How Safe and Effective They Are Over a Longer Period of Time
The purpose of this study is to compare how the body absorbs and processes two different formulations of the anti-rejection medication tacrolimus (Advagraf® or Prograf®) in children receiving an organ transplant, and how safe and…
- Conditions
- Heart Transplantation, Kidney Transplantation, Liver Transplantation
- Trial name
- NCT01614665
- Testing
- Tacrolimus, Tacrolimus prolonged release
- Where
- 10 sites in Czechia, France and 3 more
- Volunteers
- 44 people
- Sponsor
- Astellas Pharma Europe Ltd.
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