Clinical trials: Population Study
Cholecystitis
Establishing Visualization Grading Scale on LESS Cholecystectomy
Essential to laparoscopic operations is adequate visualization. Unfortunately there is no grading system to assess the degree or quality of visualization.
- Trial name
- NCT02264444
- Testing
- Cholecystectomy visualization
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida Hospital Tampa Bay Division
Lateral Canthal Lines
Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
The purpose of this study is to determine the safety and efficacy of 2 sequential doses of RT001 compared to vehicle control following applications at Baseline (Day 0) and Week 2.
- Trial name
- NCT00884234
- Testing
- Vehicle Control, RT001 (Botulinum Toxin Type A Topical Gel)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Healthy, Cannabis
A Study Investigating the Bioavailability of CBD and THC in an Emulsion Product in a Healthy Population
The objective of this study is to investigate the bioavailability of Cannabidiol (CBD) and Tetrahydrocannabinol (THC) in an emulsion product against a comparator product.
- Trial name
- NCT04601207
- Testing
- Cannabis Preparation
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- New Age Ventures LLC
Smoking
Reduced Exposure Study in Smokers Using THS 2.2 With 5 Days in a Confinement Setting.
The overall goal of the study is to evaluate if the ad libitum use of the Tobacco Heating System 2.2 (THS 2.2) for 5 days by adult healthy smokers results in a reduction in the levels of biomarkers of exposure (BoExp) for…
- Trial name
- NCT01959932
- Testing
- Tobacco Heating System (THS 2.2), Smoking abstinence (SA), Conventional cigarette (CC)
- Where
- Poland
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Healthy Volunteers
A Study to Demonstrate the Bioequivalence of Lecanemab Supplied in Vials and a Single-Use Auto-Injector (AI) in Healthy Participants
The primary purpose of this study is to demonstrate the bioequivalence (BE) of a single subcutaneous (SC) dose of lecanemab via vial and AI in healthy participants.
- Trial name
- NCT05533801
- Testing
- Lecanemab
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Metastatic Breast Cancer
Clinical Trial of Comparative Study of GB221 Pharmacokinetics
The primary objective is to assess the safety of a single dose of GB221 compared to Herceptin® when administered as a single IV injection at a dose of 8 mg/kg.
- Trial name
- NCT04175171
- Testing
- Coprelotamab Injection, Trastuzumab Injection
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Genor Biopharma Co., Ltd.
Chronic Kidney Disease
Renal Impairment Study for Oral EC5026
The goal of this Phase 1 clinical trial is to assess single dose pharmacokinetics of oral EC5026 in a population with chronic kidney disease. The main questions it aims to answer are: 1.
- Trial name
- NCT07694544
- Testing
- EC5026 oral tablet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- EicOsis Human Health Inc.
Lung Carcinoma
Evaluating the Impact of a Virtually Supervised Exercise Intervention and Group Counseling on Inflammation and the Microbiome of Smokers at High Risk for Lung Cancer, BE FIT Trial
This phase II trial evaluates how a virtually supervised exercise intervention in combination with group counseling affects inflammation and the bacterial composition (microbiome) of the gut in smokers who are at high risk for…
- Trial name
- NCT06445192
- Testing
- Best Practice, Biospecimen Collection, Exercise Counseling
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Healthy
A Phase 1 Study to Investigate the Effects of Talampanel on the Heart Rhythm
The purpose of this study is to assess whether multiple doses of Talampanel increase the QT interval when compared to placebo
- Trial name
- NCT00964730
- Testing
- Talampanel, Moxifloxacin
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Nicotine Dependence, Other Tobacco Product, Tobacco Use
Identify Biomarkers of Tobacco Exposure and Nicotine Uptake From JUUL 5% in Adult Smokers
The JUUL 5% Electronic Nicotine Delivery System (ENDS) is being studied as an alternative to combustible cigarette use. This study aims to find out how much nicotine is in the blood and urine of healthy adult subjects after using…
- Conditions
- Nicotine Dependence, Other Tobacco Product, Tobacco Use, Smoking, Tobacco
- Trial name
- Diamond (NCT03463837)
- Testing
- Treatment with JUUL 5%, Virginia Tobacco, Treatment with JUUL 5%, Cool Mint, ENDS, Treatment with JUUL 5%, Mango, ENDS
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Contraception
To Compare SH T00658ID Over Ortho Tri-Cyclen Lo (US/Canada)
The objective of the study is to compare the oral contraceptive (OC) SH T00658ID over Ortho Tri-Cyclen Lo administered for 13 cycles to healthy female volunteers between 18 and 50 years of age who request oral contraceptive…
- Trial name
- NCT00754065
- Testing
- Estradiol valerate, Dienogest (Natazia, Qlaira, BAY86-5027), Ortho Tri Cyclen Lo
- Where
- 59 sites in United States, Canada
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Bayer
COVID-19 Vaccine
ARVAC-A New Recombinant Coronavirus Disease 2019 (COVID-19) Vaccine
The goals of this clinical trial are: 1. Phase 2: to test a gamma adapted recombinant vaccine against SARS-CoV-2 in healthy adult volunteers, previously vaccinated against the SARS-CoV-2 virus. 2.
- Trial name
- ARVAC-F2/3 (NCT05752201)
- Testing
- Gamma Variant RBD-based ARVAC-CG vaccine, Omicron Variant RBD-based ARVAC-CG vaccine, Bivalent RBD-based ARVAC-CG vaccine
- Where
- 11 sites in Argentina
- Volunteers
- 2,014 people, healthy volunteers welcome
- Sponsor
- Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
Meningitis
A Phase 3 Study to Assess the Immune Response And Safety Of Rmenb+Omv Nz In Primed Healthy Participants (10 To 20 Years Old)
The main purpose of this study is to evaluate the immune response and safety of a booster dose of the meningococcal group B vaccine, rMenB+OMV NZ (also known as Bexsero), in adolescents and young adults aged 10 to 20 years.
- Trial name
- NCT06995430
- Testing
- rMenB+OMV NZ vaccine
- Where
- 17 sites in Finland, Italy and 2 more
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth Loss
Prevalence of Constructed Space Maintainers in a Group of Egyptian Children
The purpose of the study is To determine the Prevalence of constructed space maintainers at Pediatric Dentistry and Dental Public Health Department, Faculty of Oral and Dental Medicine, Cairo University.
- Trial name
- NCT03027765
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Cairo University
Psoriasis
BAY1003803 Single and Multiple Dose Escalation, Safety, Tolerability and Pharmacokinetics Study
Systemic safety following single and multiple dermal administration of BAY1003803
- Trial name
- NCT02936492
- Testing
- BAY1003803 0.01% lipophilic cream, BAY1003803 0.1% lipophilic cream, BAY1003803 0.01% ointment
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Number of Root Canals and it's Configurations in Lower Anteriors
The Prevalence of Extra Root Canals and the Root Canal Configuration in Mandibular Anterior Teeth in a Sample of Egyptian Population Using Cone Beam Computed Tomography
The considerable incidence of extra root canals of anterior mandibular teeth that is usually missed due to lack of knowledge and scarce studies leading to improper endodontic treatment, Therefore, endodontists are in need of…
- Trial name
- NCT03935711
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Cairo University
Primary Dysmenorrhea
Effect on Primary Dysmenorrhea
To investigate the potential benefits of a new oral contraceptive (SH T00658ID) on alleviating complaints of dysmenorrhea associated with oral contraceptive use.
- Trial name
- NCT00909857
- Testing
- Estradiol valerate, Dienogest (Natazia, Qlaira, BAY86-5027), Ethinyl estradiol, Levonorgestrel (Miranova)
- Where
- 41 sites in United States, Canada and 4 more
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- Bayer
Chronic Obstructive Pulmonary Disease
Pharmacokinetics and Safety Study of PT010 and PT003 in Healthy Chinese Adult Subjects
A study to assess the pharmacokinetics and safety of two doses of PT010 and a single dose of PT003 in healthy Chinese adult subjects
- Trial name
- NCT03075267
- Testing
- PT010 (BGF MDI) 320/14.4/9.6 µg, PT010 (BGF MDI) 160/14.4/9.6 µg, PT003 (GFF MDI) 14.4/9.6 µg
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Pearl Therapeutics, Inc.
Lyme Borreliosis
Phase 2 Study Of VLA15, A Vaccine Candidate Against Lyme Borreliosis, In A Healthy Pediatric And Adult Study Population
VLA15-221 is a Phase 2 study, which will be conducted in two parts: Main Study Phase (Part A) and Booster Phase (Part B). The study will compare the safety and immunogenicity of two different primary immunization schedules…
- Trial name
- NCT04801420
- Testing
- VLA15
- Where
- 19 sites in United States
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- Pfizer
Drug Interaction
A Drug-Drug Interaction Study Between AZD1981 and Pravastatin to Study the Effect of AZD1981 on the Kinetics of Pravastatin
The primary purpose of this study is to determine whether the treatment with AZD1981 will affect the pharmacokinetics of pravastatin.
- Trial name
- NCT01254461
- Testing
- AZD1981, pravastatin
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
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