Clinical trials: Population Study
Healthy Volunteers
A Pilot Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Needle Safety Device (PFS+NSD) in Healthy Participants
The purpose of this study is to compare the PK of single dose of vedolizumab SC 108 milligram (mg) administered as PFS vs investigational device.
- Trial name
- NCT03948581
- Testing
- Vedolizumab SC
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Takeda
Healthy Adult
Investigatory Study of Metformin's Pharmacokinetics, Pharmacodynamics and Drug Drug Interactions Classifying the Group by MATE1 Genotype in Healthy Volunteers
This is the investigatory study to find out metformin's pharmacokinetics, pharmacodynamics and drug-drug interactions classifying the group by MATE1 genotype in healthy volunteers.
- Trial name
- NCT01274130
- Testing
- Metformin
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Atherosclerosis
Phase I Study of SB-480848(Darapladib) -Repeat Dose Study in Healthy Japanese Male Subjects-
This study is being conducted to provide safety, tolerability, PK and PD data in repeat dosing that will allow further studies with darapladib in Japanese patients
- Trial name
- NCT00622830
- Testing
- SB-480848 (Darapladib)
- Where
- Japan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Injury in the Home
Cincinnati Home Injury Prevention Study
One aim of this study is to test the efficacy of the installation of multiple, passive measures to reduce exposure to injury hazards in the homes of young children of first-time mothers and reduce childhood injury.
- Trial name
- CHIP (NCT01327092)
- Testing
- Injury Intervention Group
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Immune Health
Impact of Lactoferrin, a Dietary Supplement, vs. Placebo on Respiratory Tract Infections
This is a randomized, double-blind, placebo-controlled study to evaluate the impact of bovine Lactoferrin (bLf) on respiratory tract infections (RTIs) in an elderly population in the United States.
- Trial name
- NCT04713735
- Testing
- bovine lactoferrin supplement
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Healthy
Study to Assess the Safety, Tolerability and Pharmacokinetics After Multiple Doses of AZD2066 in Japanese Subjects
The purpose of this study is to investigate the safety, tolerability and pharmacokinetics of AZD2066 when given as multiple doses to Japanese healthy male subjects. Four (4) consecutive multiple-ascending panels are planned.
- Trial name
- NCT00766012
- Testing
- AZD2066
- Where
- Japan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypertension
A Comprehensive Optical Blood Pressure Assessment Tool to Identify Cases of Unscreened Hypertension Across an Active Population in the U.S.
To screen for and identify subjects with potential undiagnosed hypertension using an optical blood pressure monitoring device across an active workforce population in the US (Nucor employees).
- Trial name
- CATCH-US (NCT06721611)
- Testing
- Optical Blood Pressure Monitoring Device (Aktiia G1)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nucor
Gynecologic Nursing, Training Group, Sensitivity
Improving Gynecological Examination Skills with the Use of a Model
Vaginal, abdominal, and breast examinations are among the essential gynecological examination skills for midwifery students and are crucial steps that need to be learned.
- Conditions
- Gynecologic Nursing, Training Group, Sensitivity, Gynecologic Disease
- Trial name
- NCT06536192
- Testing
- Model group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Karabuk University
SARS-CoV-2, COVID-19
Informing the Population of Their Level of Protection Against COVID-19 in Monaco: a Prospective Study (MonaVacc)
Vaccines against the coronavirus type 2 causing severe acute respiratory syndrome Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been created in a short period of time due to the rapid spread of the virus.
- Conditions
- SARS-CoV-2, COVID-19, Vaccines, Antibody
- Trial name
- MonaVacc (NCT05084950)
- Where
- Monaco
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Centre Scientifique de Monaco
Diabetes Mellitus, Type 2
Multiprofessional Approach in Diabetes Mellitus
OBJECTIVE: to verify the effectiveness of adopting the practice of educational groups in primary care and the multiprofessional role in the control of diabetes mellitus in adults.
- Trial name
- NCT04958980
- Testing
- Specific and educational guidelines on care for pathology (diabetes mellitus) according to each profession involved in the research
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Leonardo Paroche de Matos
Microcephaly
Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM)
Screening for microcephaly is important at birth and during early childhood. The Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM) aims to establish a multicentric surveillance system for microcephaly in newborns…
- Trial name
- NCT03651687
- Where
- China
- Volunteers
- 47,369 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Child Development
LIFE Child (LIFE Leipzig Research Centre for Civilization Diseases)
The Leipzig Research Centre for Civilization Diseases (LIFE) Child Study is a prospective longitudinal population-based study with a life course approach to health and disease.
- Trial name
- NCT02550236
- Where
- Germany
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Elderly Subjects 65 Years and Older, Healthy or With a Stable Disease and Treatment.
A Study to Assess Safety and Tolerability as Well as Absorption and Excretion of TC-5214 in Medically Stable Elderly Subjects
The purpose of the study is to assess safety, tolerability and pharmacokinetics of TC-5214 in medically stable elderly subjects following multiple oral doses.
- Trial name
- NCT01239771
- Testing
- TC-5214
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Non Toxic Multinodular Goiter, High Intensity Focused Ultrasound
HIFU Ablation vs Fixed-dose RAI-131 Therapy in Moderate-sized Non-toxic MNG
After obtaining informed consent, eligible subjects will be assigned randomly into either High intensity focused ultrasound group (HIFU) or Radioactive iodine (131I) therapy group (RAIT).
- Conditions
- Non Toxic Multinodular Goiter, High Intensity Focused Ultrasound, RAI
- Trial name
- NCT04009863
- Testing
- Echopulse, Radioactive iodine (Radioidine i131)
- Where
- Hong Kong
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Healthy
To Compare the Gastroprotective Effects and Pharmacokinetic Profile of PA Versus Enteric-Coated Aspirin
Primary: To compare the gastroprotective effects of a once-daily dose of PA 325 combination tablet combining 325 mg pH sensitive aspirin and 20 mg immediate release omeprazole versus a once-daily dose of 325 mg enteric coated…
- Trial name
- NCT00442052
- Testing
- aspirin, omeprazole
- Where
- 2 sites in United States, Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- POZEN
Healthy, Pharmacokinetics of Mirabegron
Pharmacokinetics of Oral Mirabegron With Different Release Rates Versus Intravenous (IV) Mirabegron
The purpose of this study is to assess the pharmacokinetics of three doses of oral mirabegron formulations with three different release rates versus three doses of mirabegron administered intravenously; to study safety and side…
- Trial name
- NCT00940121
- Testing
- mirabegron
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy
Single Increasing Doses of BIII 890 CL in Healthy Young Male Volunteers and in Healthy Elderly Male and Female Volunteers
Safety, tolerability and pharmacokinetics of BIII 890
- Trial name
- NCT02269215
- Testing
- BIII 890 CL
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Atopic Dermatitis, Food Allergies
Probiotic Supplementation in Breastfed Newborn Infants
The purpose of this study is to investigate the dose of a probiotic supplement (Bifidobacterium longum subsp. infantis) required to achieve predominant gut colonization in healthy newborn, breastfed infants.
- Trial name
- NCT02286999
- Testing
- B. infantis
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emanual Maverakis, MD
Actinic Keratosis
A Randomized, Double-Blind, Parallel-Group, Vehicle-Controlled, Multicenter Study Comparing Diclofenac Sodium Gel, 3% to Solaraze® Gel, 3% in the Treatment of Actinic Keratosis on the Face or Bald Scalp
To compare the efficacy and safety profiles of Teva's Diclofenac Sodium Gel, 5% (test product) to Solaraze® (diclofenac sodium) Gel, 3% (reference product) to demonstrate the clinical equivalence and to show that the efficacy of…
- Trial name
- NCT02611804
- Testing
- Diclofenac sodium
- Where
- 30 sites in United States
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Hepatic Impairment
A Phase 1 Study of Osilodrostat (LCI699) in Healthy Volunteers and Subjects With Impaired Hepatic Function
To assess the pharmacokinetics of a single oral dose of osilodrostat (LCI699) 30 mg in subjects with mild, moderate and severe hepatic impairment compared with subjects with normal hepatic function.
- Trial name
- NCT02372084
- Testing
- osilodrostat
- Where
- 3 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
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