Clinical trials: Population Study
Healthy Population, Chronic Disease
Verily Clinical Study Watch Analytical Validation Study
This study is designed to evaluate the performance of the Verily Clinical Study Watch for the quantification of participants' movement and pulse rate when the wearer is at rest.
- Trial name
- NCT05534477
- Testing
- Verily Clinical Study Watch, Vivalink ECG Patch, Modus StepWatch 4
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Verily Life Sciences LLC
Healthy Participants
An Accessorised Prefilled Syringe to an Autoinjector Pharmacokinetic Bridging Study of Tozorakimab
The purpose of this study is to compare the pharmacokinetic (PK) exposures of a single subcutaneous (SC) dose of tozorakimab administered using AI or APFS in healthy participants.
- Trial name
- NCT06908577
- Testing
- Tozorakimab, Autoinjector (AI) Device, Accessorised Prefilled Syringe (APFS) Device
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of Inhaled AZD8683
The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of increasing single doses of AZD8683 administered via inhalation
- Trial name
- NCT01419600
- Testing
- AZD8683
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pandemic Influenza Immunization, Healthy Volunteers
Study to Evaluate the Safety and the Immunogenicity of a Second Generation Structurally Designed mRNA Vaccine Candidate Against Pandemic Influenza H5 HA Strain in Healthy Adult Participants Aged 18 Years and Older
The purpose of this phase 1/2 study is to investigate the safety and immunogenicity of different doses (high, medium and low) of a second generation structurally designed (SD2) H5 messenger ribonucleic acid (mRNA) vaccine against…
- Trial name
- NCT06907511
- Testing
- Pandemic flu H5 HA mRNA SD2 vaccine
- Where
- 13 sites in United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Sanofi
Prosthesis Failure, Dental
Clinical Success of Anterior and Posterior Crowns in a Group of Children Treated Under General Anesthesia
This incidence study aims to evaluate the clinical success of anterior and posterior full-coverage restorations among a group of Egyptian children treated under general anesthesia.
- Trial name
- NCT06201481
- Testing
- anterior and posterior full coverage crowns
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Safety, Tolerability
A Clinical Trial to Investigate Safety and Tolerability of ASP7962 in Healthy Humans
The purpose of the study is to see how safe the study drug is and how well it is tolerated after dosing. The study will also investigate how the study drug is taken up, metabolized (chemically broken down), distributed through…
- Conditions
- Safety, Tolerability, Pharmacokinetics of ASP7962
- Trial name
- NCT01981928
- Testing
- ASP7962
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.
ALS
Spinal Interneuron Excitability in ALS
Amyotrophic lateral sclerosis (ALS) is due to neurodegeneration of upper and lower motor neurons, leading to muscle atrophy, paralysis and death.
- Trial name
- SpineBioMark (NCT02429492)
- Testing
- Electrophysiology
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Healthy
PK, PD, Safety & Immunogenicity of ADL-018 Lyo in Healthy Adult Subjects
This will be a randomized, double blind, two-arm, single dose, parallel group, PK, PD and safety and immunogenicity study in healthy, adult, subjects.
- Trial name
- NCT05564611
- Testing
- Omalizumab 150mg
- Where
- India
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Kashiv BioSciences, LLC
Pneumococcal Infections
A Phase I Clinical Trial of a 13-valent Pneumococcal Conjugate Vaccine and 14-valent Pneumococcal Conjugate Vaccine in Adults
The purpose of this study is to evaluate the safety and immunogenicity of LBVE013 (Pneumococcal 13-valent conjugate vaccine [diphtheria CRM197 protein]) or LBVE014 (Pneumococcal 14-valent conjugate vaccine [diphtheria CRM197…
- Trial name
- NCT02892812
- Testing
- Pneumococcal conjugate vaccine
- Where
- South Korea
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Hepatic Impairment
A Study to Evaluate the Effect of Hepatic Impairment on JNJ-73763989
The purpose of the study is to evaluate the single-dose pharmacokinetic (PK) of JNJ-73763976 and JNJ-73763924 following a subcutaneous (SC) injection of JNJ-73763989 (JNJ-3989) in participants with liver cirrhosis and various…
- Trial name
- NCT04208386
- Testing
- JNJ-73763989
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Janssen Sciences Ireland UC
Hepatic Insufficiency, Healthy
Pharmacokinetics of Empagliflozin (BI 10773) in Patients With Impaired Liver Function
The main objective of this study is to assess the effect of mild, moderate and severe hepatic impairment on the pharmacokinetics, safety and tolerability of BI 10773 following oral administration of BI 10773 as a single dose.
- Trial name
- NCT01111318
- Testing
- BI 10773
- Where
- Romania
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Congestive Heart Failure, Renal Impairment
A Study to Learn How the Study Treatment BAY1753011 Moves Into, Through and Out of the Body, How it Works, How Safe it is, and How it Affects the Body When Given Once as Tablet in Male and Female Participants With Reduced Kidney Function Compared to Matched Participants With Normal Kidney Function
Researchers are looking for a better way to treat people with heart failure. Heart failure is a condition which occurs when the heart does not pump blood as well as it should leading to shortness of breath, tiredness, and ankle…
- Trial name
- NCT05599997
- Testing
- Pecavaptan (BAY1753011)
- Where
- 2 sites in Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Hepatitis C, Chronic, Healthy Volunteer
A Study of RO5428029 in Healthy Volunteers and Patients With Chronic Hepatitis C
This 2-part, randomized, double-blind, placebo-controlled study will assess the safety, pharmacokinetics and pharmacodynamics of RO5428029 in healthy volunteers and patients with hepatitis C infection.
- Trial name
- NCT01371162
- Testing
- RO5428029
- Where
- 6 sites in France, Netherlands and 1 more
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Malaria, Vivax
Assessment of Any Potential Retinal Effects of Tafenoquine (TQ)
The study aims to provide evidence of retinal safety to support the use of tafenoquine as a potential single dose radical cure treatment for patients with Plasmodium vivax (P.
- Trial name
- NCT02658435
- Testing
- Tafenoquine 150 mg
- Where
- 3 sites in United States
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
A Phase I Study of LY3502970 in Healthy Participants
The main purpose of this study is to evaluate how much of the study drug (LY3502970) and the radioactive substance 14C incorporated LY3502970 gets into the bloodstream, how its broken down, and how long it takes the body to get…
- Trial name
- NCT06085482
- Testing
- LY3502970, [14C]-LY3502970
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Breast Cancer Screening
AI-Enhanced Imaging in Population Breast Cancer Screening
Artificial Intelligence (AI)-assisted imaging technologies (including AI-assisted breast ultrasound and AI-assisted mammography) can effectively improve the accuracy and efficiency of breast imaging examinations, but their…
- Trial name
- NCT07411443
- Testing
- AI-assisted screening
- Where
- China
- Volunteers
- 16,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Healthy Participants
A Study to Evaluate the Safety and Tolerability of Cendakimab in Chinese Healthy Participants
The purpose of this study is to assess the drug levels, safety, and tolerability of cendakimab in healthy male and female Chinese participants.
- Trial name
- NCT05638282
- Testing
- Cendakimab
- Where
- China
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Telemedicine
Smartphone Applications to Improve Lifestyles in Olders Over 65 Years
This is a randomized controlled clinical trial performed in urban primary care centers in Salamanca (Spain). Its objective is to evaluate the effect of an intervention based on the use of new information and communication…
- Trial name
- EVIDENT-Age (NCT03574480)
- Testing
- Intervention (training in use of a Smartphone application), Control (Advice on healthy diet and physical activity recommendations)
- Where
- Spain
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Kidney Disease
GENomic Predictors in A Multi-Ethnic Population With Kidney Disease Study
To establish a prospective, longitudinal cohort of participants who can provide blood, tissue (including kidney histology), urine samples to establish a core biobank for kidney disease research.
- Trial name
- Genie (NCT06828562)
- Where
- 4 sites in Australia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Western Sydney Local Health District
Dry Eye
Mucin Levels in Dry Eye and Normal Populations
The purpose of this study is to evaluate changes in ocular mucin levels in response to a drying environment in subjects with dry eye disease as well as patients who report no history of dry eye disease.
- Trial name
- NCT05911555
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- ORA, Inc.
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