Clinical trials: Population at Risk
HIV Preexposure Prophylaxis
A Promotion and Implementation Project of HIV Pre-Exposure Prophylaxis Among High Risk Population
This study aims to use a social media mini-application-enabled intervention to successfully promote the initiation and persistence of pre-exposure prophylaxis (PrEP) among at-risk people 18 years and above (including men who have…
- Trial name
- NCT04754139
- Testing
- WeChat mobile mini-application
- Where
- 2 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Corneal Diseases, Cornea Transplant
Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure in Subjects at Increased Immunological Risk
This was a pivotal trial to determine whether LX201 reduces the likelihood of a graft rejection episode following corneal transplantation in patients at high immunological risk for rejection.
- Trial name
- NCT00447187
- Testing
- LX201
- Where
- 30 sites in United States, Germany
- Volunteers
- 368 people
- Sponsor
- Lux Biosciences, Inc.
Barrett Esophagus, Esophageal Adenocarcinoma
Efficacy of EsoGuard on Samples Collected Using EsoCheck Versus EGD for the Diagnosis of BE
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay on cells collected using the EsoCheck 510(k) cleared device, to detect Barrett's Esophagus, with and without dysplasia, and/or…
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
- Trial name
- ESOGUARDBE1 (NCT04293458)
- Testing
- EsoGuard
- Where
- 27 sites in United States, Spain
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Lucid Diagnostics, Inc.
Gastric Ulcer
Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers in High Risk Subjects Compared to Arthrotec
This randomized, double-blind, parallel-group, controlled, multi-center clinical trial of 6 months duration is designed to assess the efficacy, tolerability and safety of PN400 versus diclofenac/misoprostol in subjects at high…
- Trial name
- NCT00594854
- Testing
- PN400 (VIMOVO), Diclofenac/Misoprostol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- POZEN
Hepatocellular Carcinoma
A Prospective Study on the Application of Liquid Biopsy in the Surveillance of High-risk Population of HCC.
Liquid biopsy technology based on high-throughput sequencing can detect trace signals in the early stage of cancer in plasma free DNA, so it has become a new technology suitable for tumor diagnosis and screening.Relying on the…
- Trial name
- NCT06134973
- Testing
- ultrasonic testing
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tianjin Third Central Hospital
Colorectal Cancer
Implementing Fit Kit Colorectal Cancer (CRC) Screening in High Risk Populations
The purpose of this study is to understand best strategies for engaging high risk populations in a primary care setting to improved adherence to colorectal cancer screening guidelines.
- Trial name
- NCT04848051
- Testing
- CRC screening reminder, CRC Reminder & Short message, CRC Reminder and Navigation Program
- Where
- United States
- Volunteers
- 3,127 people, healthy volunteers welcome
- Sponsor
- Yale University
Lung Cancer
Early Stage Lung Cancer Screening With Low-dose Computed Tomographic
The present study is a randomized controlled trial of LDCT screening for lung cancer versus usual care. 6000 high-risk subjects (age 45-70) were recruited and randomized to the Active arm (Baseline + 2 biennial repeated LDCT…
- Trial name
- NCT02898441
- Testing
- Low Dose Computed Tomography
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Vaccination Refusal, Covid19
Improving Health Equity for COVID-19 Vaccination for At-risk Populations Using Online Social Networks
Social technologies for health have already become essential means for providing underserved populations greater social connectedness and increased access to novel health information.
- Conditions
- Vaccination Refusal, Covid19, Heart Diseases
- Trial name
- NCT04779827
- Testing
- Online Social Network and Collective Intelligence Intervention, Independent Control
- Where
- United States
- Volunteers
- 4,476 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hiv, Meningitis, Meningococcal
Evaluation of Safety and Immunogenicity of Meningococcal B and Meningococcal ACWY Vaccine in at Risk Population
This study aims to evaluate the immunogenicity, safety and tolerability of co-administration of vaccinations for meningitis B (Bexsero®) and meningitis ACWY (Menveo®) in adults and children aged 10-45 years living with HIV.
- Conditions
- Hiv, Meningitis, Meningococcal, HIV Infections
- Trial name
- ProPositive (NCT03682939)
- Testing
- Bexsero® (meningitis B vaccine), Menveo® (meningitis ACWY vaccine)
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- St George's, University of London
Anterior Cruciate Ligament Rupture, Ligament Knee Injury
Association of ALL and ACL Reconstruction Versus Isolated ACL Reconstruction in High-risk Population: a RCT.
Persistent rotational instability after standard ACL reconstruction have been extensively described, and it has been shown to keep straight correlation with worse outcomes post-operatively (Chouliaras 2007, Kocher 2004).
- Trial name
- NCT03229369
- Testing
- Isolated anatomic ACL reconstruction, Combined Anterior Cruciate Ligament and Anterolateral Ligament reconstruction
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Pharynx Cancer, Larynx Cancer
Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population
Randomized multicenter trial to assess the impact of a screening program for heavy alcohol drinkers and smokers treated in alcohol addiction clinics on upper aerodigestive tract cancer mortality.
- Conditions
- Pharynx Cancer, Larynx Cancer, Oral Cavity Cancer, Oesophageal Cancer
- Trial name
- NCT00359645
- Testing
- Screening by head and neck clinical examination with a fiberoptic nasolaryngoscopy and an oesopharyngeal brush biopsy annually during 3 years
- Where
- 35 sites in France
- Volunteers
- 1,993 people, healthy volunteers welcome
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Insulin Resistance
The Effects of Cocoa Flavanols on Insulin Resistance in an 'At-risk' Population
The aim of the current study is to investigate the ability of antioxidants found in cocoa ('flavanols') to increase the body's sensitivity to the hormone insulin.
- Trial name
- NCT01201590
- Testing
- High Flavanol Cocoa, Low Flavanol Cocoa
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Clinical High Risk for Psychosis (CHR)
Telehealth Cognitive Behavioral Therapy for Youth at Risk for Psychosis
This study aims to evaluate the feasibility and effectiveness of telehealth interventions for individuals at clinical high risk for psychosis (CHR).
- Trial name
- NCT05968560
- Testing
- CBT Skills Group for CHR Youth, Individual CBT sessions, CBT Skills Group for Families
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gestational Diabetes Mellitus, Dietary Habits
A Study of the Intervention of Time-restricted Eating in High-risk Populations of GDM
This is a randomized controlled trial, aiming to investigate whether a time-restricted eating (TRE) can reduce the incidence of gestational diabetes mellitus (GDM) in high-risk pregnant women.
- Conditions
- Gestational Diabetes Mellitus, Dietary Habits, Lifestyle Intervention, Randomized Controlled Study
- Trial name
- NCT06431997
- Testing
- Time-limited eating
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Fudan University
Pre-Eclampsia
L-Arginine and Antioxidant Vitamins During Pregnancy to Reduce Preeclampsia
This study is intended to assess the efficacy of L-arginine supplementation with antioxidant vitamins delivered in a medical food in reducing the incidence of preeclampsia in a high-risk population.
- Trial name
- L-Arg (NCT00469846)
- Testing
- L-arginine supplementation in a medical food, Vitamin C and E supplementation in a medical food
- Where
- 2 sites in United States, Mexico
- Volunteers
- 585 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Transthyretin Amyloidosis, Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy
TRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positive Subjects
National, multicenter, epidemiological, longitudinal protocol to investigate the hATTR prevalence in an at-risk population for Hereditary Transthyretin Amyloidosis (hATTR) and subjects diagnosed with hATTR, to monitor the…
- Conditions
- Transthyretin Amyloidosis, Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy, Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy, Polyneuropathies
- Trial name
- TRAMmoniTTR (NCT03237494)
- Where
- 84 sites in Austria, Germany and 1 more
- Volunteers
- 5,028 people
- Sponsor
- CENTOGENE GmbH Rostock
Internet Addiction
Interpersonal Relational Role Analysis Group Therapy for Nursing Students at Risk of Internet Addiction
Internet addiction risk among nursing students may be associated with difficulties in emotion regulation, loneliness, and interpersonal relationships.
- Trial name
- Interpersonal (NCT07907133)
- Testing
- KAİRA
- Volunteers
- 60 people
- Sponsor
- Aydin Adnan Menderes University
Autism Spectrum Disorder
Social ABCs for Toddlers With Signs of Autism Spectrum Disorder: Trial of a Parent-Mediated Intervention
The Social ABCs is an innovative parent-mediated intervention for toddlers with confirmed or suspected Autism Spectrum Disorder (ASD).
- Trial name
- NCT02428452
- Testing
- Social ABCs parent-mediated intervention program
- Where
- 2 sites in Canada
- Volunteers
- 63 people
- Sponsor
- Jessica Brian
Covid19
An Outpatient Clinical Trial Using Ivermectin and Doxycycline in COVID-19 Positive Patients at High Risk to Prevent COVID-19 Related Hospitalization
The purpose of this Clinical trial is to explore the therapeutic benefits of Ivermectin and Doxycycline in different combinations in high risk patients diagnosed with COVID-19.
- Trial name
- NCT04729140
- Testing
- Ivermectin Tablets, Doxycycline Tablets
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Max Health, Subsero Health
Primary Knee Replacement Surgery
Does Supplementing of Quadriceps Strength With Exoskeleton After Total Knee Arthroplasty in High Risk Population Reduce Transfer to Extended Care Facility (ECF)
This study involves an exoskeleton which is believed to increase quadriceps muscle strength in the rehabilitation phase after TKA and reduce the discharge the such patients in Extended care facility (ECF) .
- Trial name
- NCT03762603
- Testing
- Robotic exoskeleton device
- Where
- United States
- Sponsor
- Stanford University