Clinical trials: Portal Blood Pressure
Neuromuscular Blockade, Intraoperative Bleeding
Bleeding in Laparoscopic Liver Surgery
Blood loss during liver resection surgery affects patients morbidity, short and long-term mortality. Among non-surgical interventions to minimize intraoperative blood loss and perioperative blood products transfusion, maintaining…
- Conditions
- Neuromuscular Blockade, Intraoperative Bleeding, Hepatic Cancer
- Trial name
- MODELS (NCT04609410)
- Testing
- Neuromuscular blockade
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Università Vita-Salute San Raffaele
Blood Pressure, Oxidative Stress
Influence of Microfiltered-seawater Supplementation and Variable Resistance Training in Blood Pressure, Oxidative Stress, Hepatic, and Renal Biomarkers in Older Women
This study was conducted to investigate the effects of the intake of deep sea water prior to resistance training on blood pressure, oxidative stress and hepatic and renal variables in older women.
- Conditions
- Blood Pressure, Oxidative Stress, Renal Disease, Hepatic Impairment
- Trial name
- NCT06600243
- Testing
- Resistance training + deep sea water, Control + deep sea water
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Hypertension, Portal
A Study to Test Whether Two Different Doses of Avenciguat Help People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver)
This study is open to adults with liver cirrhosis and high blood pressure in the portal vein (main vessel going to the liver). The purpose of this study is to find out whether a medicine called Avenciguat helps people with this…
- Trial name
- NCT05161481
- Testing
- Avenciguat (BI 685509)
- Where
- 45 sites in United States, Argentina and 20 more
- Volunteers
- 80 people
- Sponsor
- Boehringer Ingelheim
Systolic and Diastolic Blood Pressure Levels, Uric Acid Levels
Hyperuricemia on Hypertension and Metabolic Syndrome
The purpose of this study is to evaluate the influence of hyperuricemia treatment compared with placebo on participants with high risk of hypertension and metabolic syndrome.
- Conditions
- Systolic and Diastolic Blood Pressure Levels, Uric Acid Levels, Metabolic Syndrome Parameters, Hepatic Enzymes
- Trial name
- NCT01157936
- Testing
- Allopurinol
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Portal Blood Pressure, Liver Surgery
Optimization of Hepatic Hemodynamics During Liver Surgery
The purpose of this study is to determine if vasopressin and nitroglycerin in combination will affect hepatic hemodynamics, in the setting of liver surgery.
- Conditions
- Portal Blood Pressure, Liver Surgery, Hepatic Hemodynamics
- Trial name
- NCT02993640
- Testing
- vasopressin + nitro
- Volunteers
- 13 people
- Sponsor
- Sahlgrenska University Hospital
Acute Kidney Injury, Liver Failure
Renal Perfusion, Filtration and Oxygenation After Liver Transplantation -Effects of av Postoperative Blood Pressure
Comparing the effects of MAP 60, 75 and 90 mmHg, respectively, on renal blood flow, glomerular filtration rate and renal oxygen demand in patients with terminal liver failure directly after liver transplantation.
- Trial name
- NCT02455115
- Testing
- Alternating mean arterial pressure, Norepinephrine, Chromium ethylenediaminetetraacetic acid
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Sahlgrenska University Hospital
Hepatitis C
Pegylated Interferon and Ribavirin in Hepatitis C Virus Infection After Liver Transplantation.
The purpose of this study was to evaluate the efficacy (and safety) of antiviral therapy in patients with chronic hepatitis C after liver transplantation.
- Trial name
- NCT00383864
- Testing
- Pegylated interferon and ribavirin
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Hospital Clinic of Barcelona
Hereditary Hemorrhagic Telangiectasia, Rendu Osler Disease
Stress-Echography in Hereditary Haemorrhagic Telangiectasia Patient With Hepatic Involvement
The hepatic involvement of HHT (Hereditary Haemorrhagic Telangiectasia) disease is characterised by the formation of arterio-sus-hepatic shunts which lead to dilatation of the hepatic artery and may result in high output heart…
- Trial name
- ROSE (NCT05954481)
- Testing
- Stress echocardiography
- Where
- 2 sites in France
- Volunteers
- 47 people
- Sponsor
- Hospices Civils de Lyon
Hepatitis C, Cirrhosis
Peginterferon Alpha-2a Maintenance Therapy for Portal Hypertension in Patients With Hepatitis C
The primary purpose of this study is to determine if peginterferon alpha-2a maintenance therapy (90 mcg/week) will lower portal pressure in patients with hepatitis C virus infections and advanced fibrosis or cirrhosis.
- Conditions
- Hepatitis C, Cirrhosis, Fibrosis
- Trial name
- NCT00252642
- Testing
- Peginterferon Alpha-2a
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
General Anesthesia
Effect of Norepinephrine Infusion on Hepatic Blood Flow During Goal-directed Haemodynamic Therapy.
Maintaining adequate blood pressure is important for survival of organs. Recent studies have demonstrated that higher blood pressures were necessary for prevention of acute kidney injury and myocardial injury after non-cardiac…
- Trial name
- NCT03965117
- Testing
- Norepinephrine
- Where
- Belgium
- Volunteers
- 49 people
- Sponsor
- University Hospital, Ghent
Liver Diseases, Hypertension, Portal
A Study to Test Whether BI 685509 Alone or in Combination With Empagliflozin Helps People With Liver Cirrhosis Caused by Viral Hepatitis or Non-alcoholic Steatohepatitis (NASH) Who Have High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver)
This study is open to adults with liver cirrhosis caused by hepatitis B, hepatitis C or nonalcoholic steatohepatitis (NASH). People can join this study if they have high blood pressure in the portal vein (main vessel going to the…
- Trial name
- NCT05282121
- Testing
- Avenciguat, Empagliflozin
- Where
- 31 sites in United States, Argentina and 14 more
- Volunteers
- 90 people
- Sponsor
- Boehringer Ingelheim
Liver Transplantation, Portal Hypertension
Portal Pressure Effects of Phlebotomy Combined to Vasopressin Use in Cirrhotic Patients Undergoing Liver Transplantation
Liver transplantation is the standard treatment for chronic advanced liver disease, whether or not associated with a primary liver tumor.
- Conditions
- Liver Transplantation, Portal Hypertension, Blood Transfusion, Blood Loss, Surgical
- Trial name
- PORTAL (NCT04472312)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cirrhosis, Liver, Portal Hypertension
A Pilot Trial to Test the Feasibility of Utilizing Home Blood Pressure Monitoring to Optimize the Administration of Midodrine Among Decompensated Cirrhosis Patients
This is a randomized single-blind feasibility trial to test the utilization of home blood pressure devices to improve the clinical management of decompensated cirrhosis patients.
- Conditions
- Cirrhosis, Liver, Portal Hypertension, Ascites Hepatic
- Trial name
- WATCH (NCT05928624)
- Testing
- Withings Home Blood Pressure Device and Scale, Standard of Care
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of California, San Francisco
Hypertension, Portal, Liver Cirrhosis
A Study to Test Whether Avenciguat Helps People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver) Who Had Bleeding in the Esophagus or Fluid Accumulation in the Belly
This study is open to adults with advanced liver cirrhosis caused by hepatitis B, hepatitis C, alcohol-related liver disease, non-alcoholic steatohepatitis or other causes.
- Trial name
- NCT06082843
- Testing
- Avenciguat
- Where
- 15 sites in United States, Austria and 8 more
- Volunteers
- 22 people
- Sponsor
- Boehringer Ingelheim
Cirrhosis, Portal Hypertension
A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver Cirrhosis
Endothelin is a human hormone which has been associated with increased portal pressure in patients with liver cirrhosis (also called portal hypertension). Ambrisentan blocks the effects of endothelin.
- Conditions
- Cirrhosis, Portal Hypertension, Ascites
- Trial name
- NCT03827200
- Testing
- Ambrisentan
- Where
- 6 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Noorik Biopharmaceuticals AG
General Anesthesia
Effect of Dobutamine on Hepatic Blood Flow During Goal-directed Hemodynamic Therapy
Maintaining adequate perfusion pressure and oxygen supply is essential for organ survival. Splanchnic hypoperfusion during the perioperative period in abdominal surgery may result in mucosal ischemia with increased permeability…
- Trial name
- DOBU whipple (NCT04893655)
- Testing
- Dobutamine Hydrochloride
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- University Hospital, Ghent
Chronic Liver Disease
Non-invasive Evaluation of Portal Pressure by MRI
The objective of this research is to study the correlation between the portosystemic pressure gradient and azygos blood flow measured by MRI.
- Trial name
- ENIP (NCT02530567)
- Testing
- Intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse