Clinical trials: Portal Hypertension
Symptomatic Neurogenic Orthostatic Hypertension, nOH
Effect of Hepatic Impairment on the Pharmacokinetics of a Single Dose of TD-9855
An open-label study to characterize the effects of mild, moderate, and severe Hepatic Impairment (HI) on the pharmacokinetics (PK) of ampreloxetine following a single oral dose in comparison with healthy volunteers with normal…
- Trial name
- NCT04200573
- Testing
- Ampreloxetine
- Where
- 2 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Gastric Varix
The Validation and Efficacy of Varix Trainer as a Training Device Esophagogastroduodenoscopy (a Multicenter Study)
The goal of this exploratory validation study is to compare levels of expertise (or non-expertise) between GI fellows and experts with the varix trainer.
- Trial name
- NCT05614999
- Testing
- Endoscopy training curriculum
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Liver Cirrhosis, Portal Hypertension
Microparticles in Cirrhosis and Portal Hypertension
research on interactions between portal hypertension and microparticles
- Trial name
- MicroCir (NCT02859610)
- Testing
- research on interactions between portal hypertension and microparticles
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hypertension, Atherosclerosis
Age-Related Changes in Body Composition
Background: Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age.
- Trial name
- NCT01517113
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Liver Cirrhosis, Portal Hypertension
Evaluation of Probiotics in the Treatment of Portal Hypertension
This study is to evaluate the role of probiotics in the treatment of portal hypertension. In particular the role of probiotics on gut microbiota in liver cirrhosis patients will be studied and compared with cytokines and other…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Encephalopathy
- Trial name
- NCT00831337
- Testing
- VSL3
- Where
- Poland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Clinically Significant Portal Hypertension
The Impact of Carvedilol Posology on Clinically Significant Portal Hypertension
Carvedilol has emerged as the preferred non-selective β-blocker (NSBB) for treating portal hypertension. However, there is still a debate in dosing regimen, specially regarding dose interval, with a potential lower bioavalability…
- Trial name
- NCT06015373
- Testing
- supress the night dose of carvedilol
- Where
- Portugal
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Portal Hypertension
Ultrasound With Subharmonic Imaging and Subharmonic Aided Pressure Estimation (SHAPE) to Identify Portal Hypertension
This clinical trial tests the how well an ultrasound with subharmonic imaging and the subharmonic aided pressure estimation (SHAPE) technique works in identifying portal hypertension (PH).
- Trial name
- NCT06797193
- Testing
- Electronic Health Record Review, Liver Biopsy, Medical Device Usage and Evaluation
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Liver Cirrhosis, Acute-On-Chronic Liver Failure
Characterization and Pathogenesis of ACLF
This single-center prospective observational study aims at characterization of pathogenesis of ACLF. There will be three different cohorts investigated with the main endpoint mortality in these groups. 1.
- Conditions
- Liver Cirrhosis, Acute-On-Chronic Liver Failure, Portal Hypertension
- Trial name
- ACLF-I (NCT04975490)
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Porphyrias, Hepatic
Acute Intermittent Porphyria Related Abnormalities in Cardiovascular System
This study aims to assess the changes in the cardiovascular system in patients with acute intermittent porphyria (AIP).
- Trial name
- AIPRACUS (NCT05882136)
- Where
- 2 sites in Poland
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Cirrhosis, Compensated Cirrhosis
The Use of Endoscopic Ultrasound-Guided Portal Pressure Measurements to Guide Beta-Blocker Therapy in Patients With Compensated Cirrhosis
This pilot study to determine the feasibility of EUS-Portal Pressure Measurements to guide Beta-Blocker Therapy in patients with compensated cirrhosis .The study will be a prospective tandem controlled trial consisting of 30…
- Conditions
- Cirrhosis, Compensated Cirrhosis, Portal Hypertension
- Trial name
- NCT05357599
- Testing
- EUS
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Portal Hypertension, Liver Diseases
Hemodynamic Alterations in Liver Cirrhosis Validated by Non-invasive MR Compared to Invasive Assessment
Liver cirrhosis is a chronic disease characterized by a progressive accumulation of fibrosis, loss of liver function and portal hypertension leading to several hemodynamic changes.The exact pathophysiological mechanisms causing…
- Conditions
- Portal Hypertension, Liver Diseases, Liver Cirrhoses, Cirrhosis
- Trial name
- NCT03443934
- Where
- Denmark
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Esophageal Varices
Fecal Calprotectin for Prediction of Esophageal Varices in Cirrhotic Patients
The goal of this cross-sectional observational study is to evaluate the accuracy of fecal calprotectin versus non-invasive scores in assessing the presence and grading of esophageal varices in Egyptian patients.
- Trial name
- NCT06908798
- Testing
- fecal calprotectin
- Where
- Egypt
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Tanta University
Portal Hypertension
The Effect of Probiotics (VSL) on Portal Hypertension
The investigators will address the hypothesis that portal hypertension is mediated in part by bacterial or endotoxin translocation and the production of inflammatory mediators (tumor necrosis factor-α (TNFα), etc.).
- Trial name
- NCT01032941
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Portal Hypertension, Chronic Liver Disease
EUS vs TJ for Liver Biopsy and Portal Pressure Gradient Measurement
This study will directly compare the endoscopic ultrasound guided approach to obtain adequate liver biopsies and portal pressure gradient measurements to the current standard of care which uses the transjugular approach.
- Conditions
- Portal Hypertension, Chronic Liver Disease, Cirrhosis
- Trial name
- NCT05118308
- Testing
- Transjugular hepatic venous pressure gradient measurement with liver biopsy, Endoscopic ultrasound portal pressure gradient measurement with liver biopsy
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Cirrhosis
Spleen Stiffness Measurement With FibroScan
FibroScan® (Echosens, Paris, France) is an active non implantable medical device marketed in Europe since December 2003 and is currently used in many countries.
- Trial name
- NCT02180113
- Testing
- Fibroscan® examination
- Where
- 7 sites in France, Italy and 2 more
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Echosens
Ascites, Blunt Abdominal Trauma
Telesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican Community
The role of teleradiology has far reaching implications for the health of remote and underserved populations. The ability to coordinate radiographic evaluation and diagnosis from a distance has the potential to raise the standard…
- Conditions
- Ascites, Blunt Abdominal Trauma, Cholelithiasis, Cholecystitis
- Trial name
- NCT00591968
- Testing
- SonoSite Titan portable ultrasound coupled with email telediagnosis
- Where
- Dominican Republic
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Portal Hypertension
Clinical,Endoscopic and Radiological Assessment of Portal Hypertension in Children With Chronic Liver Diseases
Portal hypertension is a significant cause of morbidity and mortality in children with chronic liver disease and portal vein obstruction.
- Trial name
- NCT06097715
- Testing
- upper gastrointestinal endoscopy, 1- Complete blood count 2- Coagulation profile
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Esophageal and Gastric Varices
Comparison of Endoscopic Band Ligation Plus 24-hour Versus 72-hour Terlipressin Therapy
In the Western world, liver cirrhosis is a significant issue. Acute variceal bleeding (AVB) is a considerable complication of cirrhosis associated with high mortality.
- Trial name
- NCT05331768
- Testing
- banding ligation plus terlipressin infusion
- Where
- Mexico
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Portal Hypertension, Cirrhosis
Early Precise Diagnosis and Intervention of CPT Based on a Noninvasive 3D-vHPS
The aim of this study is to investigate the possibilities of early and precise management to decrease portal vein pressure in cirrhotic patients, guided by a non-invasive 3D-virtual-model of hepatic portal system (3D-vHPS).
- Trial name
- NCT02925975
- Testing
- Carvedilol, 3D-vHPS, Routine endoscopic procedures
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Changqing Yang
Liver Cirrhosis, Portal Hypertension
Effect of Handgrip Strength on Portal Vein Hemodynamics in Patients With Liver Cirrhosis
1. Background Handgrip strength , a core indicator of muscle function, has been confirmed to be significantly associated with the clinical prognosis of patients with liver cirrhosis.
- Trial name
- NCT07116096
- Testing
- Jamar Hand Dynamometer, Hand Dynamometer
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanxi Provincial People's Hospital