Clinical trials: Positive End Expiratory Pressure
Acute Brain Injury, Mechanical Ventilation
Brain Monitoring During PEEP-Based Respiratory Therapy in Critically Ill Patients
Mechanical ventilation is commonly used in critically ill patients with acute brain injury. Positive end-expiratory pressure (PEEP) and lung recruitment maneuvers are important ventilator strategies for improving oxygenation, but…
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Neurocritical Care
- Trial name
- NCT07716787
- Testing
- Recruitment Maneuver, Positive End-Expiratory Pressure Adjustment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shengli Oilfield Hospital
Supratentorial Neoplasms, Anesthesia, General
Effect of PEEP on Subdural Pressure, Optic Nerve Sheath Diameter, Lung Compliance and Brain Perfusion Pressure
We aim to determine the level of intraoperative PEEP that optimizes lung compliance without causing a rise in subdural pressure and if we can utilize optic nerve sheath diameter measurement as an indicator for ICP while…
- Conditions
- Supratentorial Neoplasms, Anesthesia, General, Optic Nerve
- Trial name
- NCT04316208
- Testing
- PEEP variations
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Postoperative Pulmonary Complications, Mechanical Ventilation
Driving Pressure-Guided Individualized PEEP Versus Standard PEEP: Effects on Postoperative Pulmonary Complications in Upper Abdominal Digestive Surgery
This randomized clinical trial compares two methods of setting positive end-expiratory pressure (PEEP) during general anesthesia in adults undergoing upper abdominal digestive surgery who are at moderate or high risk of…
- Trial name
- NCT07885124
- Testing
- Driving Pressure-Guided Individualized PEEP, Standard PEEP
- Where
- Tunisia
- Volunteers
- 210 people
- Sponsor
- Hopital Charles Nicolle
Severe Pneumonia
Lung Response to a Higher PEEP During Severe Pneumonia: a CT Study
At their institution, the investigators routinely assess the individual response of mechanically ventilated patients with acute respiratory failure to higher positive end-expiratory pressure (PEEP) by examining changes in lung…
- Trial name
- NCT07112976
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Istituto Clinico Humanitas
Postoperative Respiratory Complications
PROVHILO:Protective Ventilation During General Anesthesia for Open Abdominal Surgery
The purpose of this international, multicentre, double-blinded randomized controlled trial is to determine if the "open lung approach" providing recruitment maneuvers and PEEP(Positive End Expiratory Pressure) during general…
- Trial name
- PROVHILO (NCT01441791)
- Testing
- Lung protective strategy ventilation
- Where
- 30 sites in United States, Austria and 8 more
- Volunteers
- 900 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ARDS, Intra-abdominal Hypertension
The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation
Intra-abdominal hypertension can increase the pleural pressure, and then end-expiratory transpulmonary pressures will be turn to negative, Pulmonary atelectasis/acute lung injury/acute respiratory distress syndrome will appear.
- Trial name
- NCT01825304
- Testing
- titrated setting peep
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Nanjing Medical University
Pediatric Acute Respiratory Distress Syndrome
Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)
The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced.
- Trial name
- NCT06684119
- Testing
- Electrical Impedance Tomography positive end-expiratory pressure titration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Los Angeles
Intracranial Pressure, Mechanical Ventilation
The Brain and Lung Interaction (BALI) Study
The purpose of this study is to understand the relationship between intracranial pressure and airway pressures during mechanical ventilation.
- Conditions
- Intracranial Pressure, Mechanical Ventilation, Brain Injuries
- Trial name
- NCT04288076
- Testing
- PEEP Titrated Mechanical Ventilation
- Sponsor
- Beth Israel Deaconess Medical Center
Acute Respiratory Distress Syndrome
PEEP and Spontaneous Breathing During ARDS
Prospective, physiological study to systematically assess the effects of high positive end-expiratory pressure (PEEP) with and without inspiratory synchronization in patients with moderate to severe acute respiratory distress…
- Trial name
- EARDS (NCT04241874)
- Testing
- Mechanical Ventilation
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Postoperative Pulmonary Complications (PPCs), Postoperative Atelectasis
Optimal PEEP Level for Minimizing the Risk of Postoperative Atelectasis: A Retrospective Cohort Study Based on Lung Ultrasound Monitoring
Background: After surgery with general anesthesia, it is common for parts of the lungs to collapse, a condition called atelectasis. This can lead to low blood oxygen levels and other lung complications.
- Conditions
- Postoperative Pulmonary Complications (PPCs), Postoperative Atelectasis, Lung Ultrasound
- Trial name
- ULTRASVENT-1 (NCT07211074)
- Where
- Russia
- Volunteers
- 450 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Obesity Associated Disorder
Respiratory and Hemodynamics Parameters Response to Positive End-Expiratory Pressure
In this study, the sixty mechanically ventilated class I obese patients were divided into two equal groups A and B. group A received RTP position + PEEP protocol, while group B underwent RTP position protocol only.
- Trial name
- Respiratory (NCT05508997)
- Testing
- respiratory parameters on mechanical ventilator (PEEP)
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Heidy F. Ahmed
PreTerm Neonate, Positive End Expiratory Pressure (PEEP)
PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY
Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed.
- Conditions
- PreTerm Neonate, Positive End Expiratory Pressure (PEEP), Lung Recruitment, Electrical Impedance Tomography (EIT)
- Trial name
- [PEOPLE] (NCT06705257)
- Testing
- Studying the effects of varying levels of PEEP using Electrical impedance tomography
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Lung Cancer
Effect of Optimal Positive End-Expiratory Pressure on Oxygenation and Intrapulmonary Shunt During One-lung Ventilation
To observe the effect of compliance guided an optimal Positive End-Expiratory Pressure（PEEP）on arterial oxygenation and intrapulmonary shunt during one-lung ventilation(OLV)，and discuss the lung protective effect of optimal PEEP…
- Trial name
- NCT03804398
- Testing
- compliance guided an optimal Positive End-Expiratory Pressure, PEEP level of 5 cmH2O
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Fujian Medical University Union Hospital
Mechanical Ventilation
Ventilation and Esophageal Pressure Changes
A study to observe the effect of variations in ventilator settings including tidal volume and PEEP on transpulmonary pressure monitored with an esophageal balloon catheter and to correlate intraoperative transpulmonary pressure…
- Trial name
- NCT05859672
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, Davis
Prostatic Neoplasm, Urinary Bladder Neoplasm
Positive End-expiratory Pressure-induced Increase in Central Venous Pressure as a Predictor of Fluid Responsiveness in Robot-assisted Laparoscopic Surgery
In urologic robotic surgery with steep Trendelenburg position, maintenance of cardiac preload and cardiac output is important for clinical prognosis.
- Trial name
- NCT02977143
- Testing
- Fluid loading of volulyte 300 ml
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Atelectasis, Postoperative Pulmonary
Optimizing PEEP in Laparoscopic Bariatric Surgery Using Bedside Lung Ultrasound
Lung ultrasound imaging is a promising non-invasive, non-radiant, portable and easy to use tool that as yet to be studied in the intraoperative setting.
- Trial name
- NCT04269564
- Testing
- stepwise PEEP
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
General Anesthesia
Determination of Optimal Positive End-expiratory Pressure Using Electrical Impedance Tomography in Children Under General Anesthesia: Comparison Between Supine and Prone Positions
The purpose of this study was to determine the appropriate positive end-expiratory pressure (PEEP) using electrical impedance tomography (EIT) in children under general anesthesia and to investigate whether there is a difference…
- Trial name
- NCT05275309
- Testing
- Exploration of optimal PEEP in supine and prone position
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Seoul National University Hospital
Respiratory Compliance
Exploration of the Appropriate Combination of Positive End Expiratory Pressure and Tidal Volume Using the Intratidal Compliance Volume Profile in Children
In children under 6 years of age undergoing regular surgery during general anesthesia, the intratidal compliance profile is evaluated when different tidal volumes are applied at different positive end expiratory pressures.
- Trial name
- NCT04633720
- Testing
- Changes in positive end-expiratory pressure and tidal volume
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Respiratory Physiological Phenomena
Functional Residual Capacity Measured by Capnography in Ventilated Patients
Changes in body position during anesthesia can alter functional residual capacity and gas exchange. The monitoring of such changes in functional residual capacity is difficult at the bedside.
- Trial name
- NCT03693352
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Acute Respiratory Distress Syndrome
Monitoring in Intensive Care Unit of Neuromuscular Blocking Agents Used for Acute Respiratory Distress Syndrome After Cardiothoracic Surgery
Mortality in Acute Respiratory Distress Syndrome (ARDS) is high (40 to 60 %). Protective mechanical ventilation is the cornerstone of the ARDS therapeutic strategies.
- Trial name
- CURAREA (NCT02546947)
- Testing
- Train of four monitoring
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Centre Chirurgical Marie Lannelongue