Clinical trials: Positive End Expiratory Pressure (PEEP)
Pleural Effusion
Positive Airway Pressure on Pleural Effusion After Drainage
The purpose of this study is to determine if the addition of intermittent positive airway pressure breathing (specific lung expansion technique) to conventional chest physiotherapy chest drainage is effective to accelerate the…
- Trial name
- NCT02246946
- Testing
- Positive Airway Pressure, Conventional Chest Physiotherapy, Control group
- Where
- Brazil
- Volunteers
- 156 people
- Sponsor
- Universidade Cidade de Sao Paulo
Venous Hemodynamics
Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score
The hemodynamic effects of proning and PEEP may vary depending on pre- existing cardiac function, lung mechanics, and volume status, and the available evidence remains conflicting.
- Trial name
- VeNIVPro (NCT07273617)
- Testing
- application of PEEP: starting PEEP = 15 mbar, application of PEEP: starting PEEP = 0 mbar
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Acute Respiratory Distress Syndrome, Right Ventricular Dysfunction
Ventilator-induced Right Ventricular Injury During EIT-based PEEP Titration in Patients With ARDS
Right ventricular failure may be associated with mortality in patients with acute respiratory distress syndrome (ARDS). Mechanical ventilation may promote right ventricular failure by inducing alveolar overdistention and…
- Trial name
- RIGHTENARDS (NCT05583461)
- Testing
- Positive end-expiratory pressure titration
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- University of Padova
Hypoxia
Efficacy and Safety of Using Noninvasive Ventilation Associated With Recruitment Maneuver in Cardiac Surgery.
Cardiac surgery can evolve with complications in the postoperative period, atelectasis and hypoxemia are the major pulmonary dysfunctions.
- Trial name
- NCT02913391
- Testing
- recruitment group (RG), control group (CG)
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Mieko Cláudia Miura
Gastric Volume, Breast Cancer Female
Effect of Positive End-expiratory Pressure on the Gastric Volume
The main purpose of this study is to quantitatively evaluate the effect of applying PEEP during the use of SGA on gastric volume, aiming to provide objective evidence regarding the potential side effects, such as gastric volume…
- Conditions
- Gastric Volume, Breast Cancer Female, Anesthesia Complication
- Trial name
- NCT06861569
- Testing
- Positive end expiratory pressure
- Volunteers
- 128 people
- Sponsor
- Seoul National University Bundang Hospital
One Lung Ventillation (OLV), Two Lung Ventillation (TLV)
The Use of Constant-flow Technique for Determining the Lower Inflexion Point of Pressure-volume Curve and Intrinsic PEEP During One-lung Ventilation
One method for treating intraoperative hypoxia during one-lung ventilation (OLV) is application of PEEP to the dependent lung. However, only a minority of patients benefit from this maneuver.
- Conditions
- One Lung Ventillation (OLV), Two Lung Ventillation (TLV), Positive End Expiratory Pressure (PEEP), Zero End-expiratory Pressure (ZEEP)
- Trial name
- NCT01532245
- Testing
- two lung ventilation (TLV), one lung ventilation (OLV) without PEEP, One lung ventilation (OLV) with positive end-expiratory pressure (PEEP)
- Sponsor
- The Cleveland Clinic
Atelectasis
Role of Lung Ultrasound Imaging in the Comparison of Two Mechanical Ventilation Strategies During Laparotomy
The use of positive end-expiratory pressure (PEEP) and recruitment maneuvers during laparotomy will limit the development of atelectasis and therefore improve the aeration score.
- Trial name
- NCT02055807
- Testing
- PEEP and recruitment maneuvers, ZEEP (no PEEP nor recruitment maneuver)
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cardiac Surgery Subjects
Effect of PEEP on Cardiac Function
The purpose of this single-center, prospective study is to evaluate the physiologic effect of changes in PEEP on biventricular mechanics and RV-pulmonary arterial (RV-PA) coupling in adult patients undergoing cardiac surgery.
- Trial name
- NCT07531602
- Testing
- EIT Guided PEEP Trial
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Beth Israel Deaconess Medical Center
Postoperative Complications, Surgery
Driving Pressure During General Anesthesia for Minimally Invasive Abdominal Surgery (GENERATOR)
The purpose of this international multicenter, patient and outcome-assessor blinded randomized controlled trial is to determine whether the application of an individualized high Positive End Expiratory Pressure (PEEP) strategy…
- Trial name
- GENERATOR (NCT06101511)
- Testing
- Intraoperative ventilation with individualized high PEEP titrated to the lowest ΔP with RMs
- Where
- Netherlands
- Volunteers
- 1,806 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lung Cancer
Effect of Optimal Positive End-Expiratory Pressure on Oxygenation and Intrapulmonary Shunt During One-lung Ventilation
To observe the effect of compliance guided an optimal Positive End-Expiratory Pressure（PEEP）on arterial oxygenation and intrapulmonary shunt during one-lung ventilation(OLV)，and discuss the lung protective effect of optimal PEEP…
- Trial name
- NCT03804398
- Testing
- compliance guided an optimal Positive End-Expiratory Pressure, PEEP level of 5 cmH2O
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Fujian Medical University Union Hospital
One-Lung Ventilation, Postoperative Complications
Driving Pressure and Postoperative Pulmonary Complications in Thoracic Surgery
Pulmonary complications are the most common complication in thoracic surgery and the leading cause of mortality.Therefore, lung protection is utmost important, and protective ventilation is strongly recommended in thoracic…
- Conditions
- One-Lung Ventilation, Postoperative Complications, Driving Pressure, Postoperative Pulmonary Complication
- Trial name
- NCT04260451
- Testing
- ventilation
- Where
- South Korea
- Volunteers
- 1,300 people
- Sponsor
- Samsung Medical Center
Chronic Respiratory Failure
Impact of Patient Controlled Positive End-expiratory Pressure on Speech in Tracheostomized Ventilated Patients
Adequate communication is a major part of the quality of life of tracheostomized ventilator dependent patients. Maintaining speech is therefore major goal in the management of these patients.
- Trial name
- OptiPEP (NCT01479959)
- Testing
- Eole 3 ventilator - Resmed
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University of Versailles
Ventilator-free Days
REstricted Versus Liberal Positive End-Expiratory Pressure in Patients Without ARDS
The 'REstricted versus Liberal positive end-expiratory pressure in patients without Acute respiratory distress syndrome' (RELAx) trial is a national multicenter, open randomized controlled trial in ICU patients without ARDS at…
- Trial name
- RELAx (NCT03167580)
- Testing
- restricted PEEP, liberal PEEP
- Where
- 13 sites in Netherlands
- Volunteers
- 980 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Atelectasis, Perioperative Oxygenation
Individualized vs Standard PEEP and Oxygen Reserve Index in Laparoscopic Hernia Surgery
During laparoscopic surgery under general anesthesia, lung function can be affected by increased abdominal pressure and patient positioning.
- Conditions
- Atelectasis, Perioperative Oxygenation, Laparoscopic Inguinal Hernia Repair, Mechanical Ventilation
- Trial name
- NCT07775573
- Testing
- Standard PEEP Ventilation, Individualized PEEP Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Respiratory Failure
Transpulmonary Assessment for Individualized Lung Optimization in Obese Patients
This protocol describes a randomized controlled feasibility vanguard study designed to investigate the implementation and effects of esophageal pressure-guided positive end-expiratory pressure (PEEP) titration in patients with…
- Trial name
- TAILOR-PEEP (NCT07359261)
- Testing
- Esophageal pressure-guided PEEP titration, Standard care PEEP management
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Pulmonary Atelectasis, Postoperative
Individual Optimal Positive End-expiratory Pressure During Robot-assisted Laparoscopic Radical Prostatectomy
During robot-assisted radical prostatectomy, pneumoperitoneum with Trendelenburg position is used. However, perioperative atelectasis and respiratory complications may occur with high incidence due to general anesthesia and…
- Trial name
- NCT04085146
- Testing
- Individualized optimal positive end-expiratory pressure, Conventional positive end-expiratory pressure
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
General Anesthesia, Laparoscopic Cholecystectomy
Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity
It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEP) is present in grossly obese subjects especially in the supine position.
- Trial name
- NCT01267916
- Testing
- RR 6 + 0, RR 10 + 0, RR 16 + 0
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul Medical Center
Heart Rate Determination
Correlation Between Respiratory Variability of R-R Intervals and Systolic Pressure Variability
This prospective study is designed to assess and quantify the correlation between respiratory changes in R-R interval and the respiratory changed in invasive systolic blood pressure in ventilated patients during changes in…
- Trial name
- NCT03267017
- Testing
- posture changes
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Ventilation Therapy; Complications, Congenital Heart Disease
Influence of Positive-End-Expiratory-Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Children
Interventional Trial to determine the Effect of different PEEP levels on Cardiac output and right-ventricular function in mechanically ventilated children < 5 years of age with congenital heart disease.
- Conditions
- Ventilation Therapy; Complications, Congenital Heart Disease, Children, Only, Hemodynamic Instability
- Trial name
- IPCOM (NCT06270485)
- Testing
- PEEP
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 58 people
- Sponsor
- Charite University, Berlin, Germany
Acute Hypoxemic Respiratory Failure, Post-cardiac Surgery
Automated Analysis of EIT Data for PEEP Setting
First: to develop a computerized algorithm for automated analysis of the electrical impedance tomography (EIT) data. The algorithm calculates the "optimal" positive end-expiratory pressure (PEEP) and inspiratory pressure defined…
- Trial name
- NCT03653806
- Testing
- computerized algorithm for automated analysis
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center