Clinical trials: Positive End-Expiratory Pressure
Pulmonary Atelectasis, Postoperative
Individual Optimal Positive End-expiratory Pressure During Robot-assisted Laparoscopic Radical Prostatectomy
During robot-assisted radical prostatectomy, pneumoperitoneum with Trendelenburg position is used. However, perioperative atelectasis and respiratory complications may occur with high incidence due to general anesthesia and…
- Trial name
- NCT04085146
- Testing
- Individualized optimal positive end-expiratory pressure, Conventional positive end-expiratory pressure
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Urinary Bladder Neoplasms, Prostatic Neoplasms
Effect of PEEP on Arterial Oxygen Partial Pressure in Elderly Patients With Lithotomy Position Using LMA Supreme™
The purpose of the present study is to compare the effect of PEEP on arterial oxygen partial pressure in elderly patients undergoing urologic surgery using LMA supreme™ in a lithotomy position.
- Trial name
- NCT03390127
- Testing
- PEEP
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Asan Medical Center
Lung Compliance
Individualized Positive End-expiratory Pressure Evaluation Using the Intratidal Compliance-volume Profile in Children
The investigators assess the changes in respiratory compliance according to different levels of positive end expiratory pressure (PEEP) in children under general anesthesia.
- Trial name
- NCT03533296
- Testing
- Positive end expiratory pressure (PEEP)
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Seoul National University Hospital
Mechanical Ventilation
Ventilation and Esophageal Pressure Changes
A study to observe the effect of variations in ventilator settings including tidal volume and PEEP on transpulmonary pressure monitored with an esophageal balloon catheter and to correlate intraoperative transpulmonary pressure…
- Trial name
- NCT05859672
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, Davis
Robot-Assisted Radical Prostatectomy
Effect of Control Ventilation, PEEP, and PEEP With ARM in Robot-assisted Radical Prostatectomy
The goal of this clinical trial is to determine whether different ventilatory strategies improve oxygenation and hemodynamic stability in patients undergoing robot-assisted radical prostatectomy under general anesthesia.
- Trial name
- NCT07462689
- Testing
- PEEP group, PEEP + ARM group
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ilsan Cha hospital
Respiratory Distress Syndrome, Adult
Effects of Positive End-expiratory Pressure and Tidal Volume on Fluid Responsiveness of Acute Respiratory Distress Syndrome
Fluid responsiveness (FR)refers to the ability of heart to increase its stroke volume in response to volume load.Low tidal volume and high PEEP exerts contrast effect on the prediction of fluid responsiveness, the aim of this…
- Trial name
- NCT01716962
- Testing
- Infusion of 6% tetrastarch for a total of 500 ml
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
PEEP, Intrinsic, PEEP, Occult
A New Method for Estimating Dynamic Intrinsic PEEP
Dinamic intrinsic PEEP is
- Conditions
- PEEP, Intrinsic, PEEP, Occult, Respiratory Insufficiency
- Trial name
- echoPEEPi (NCT02388282)
- Testing
- diaphragm ecography
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Pediatric Surgery
Determination of Best PEEP (Positive End-expiratory Pressure) in Anesthetized Infants in Terms of Prevention of Atelectasis
Purpose of research; to determine the appropriate positive end-expiratory pressure to minimize atelectasis during general anesthesia in infants.
- Trial name
- NCT03969173
- Testing
- applying PEEP3, applying PEEP6, applying PEEP9
- Where
- South Korea
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Prostate Cancer, Urinary Bladder Cancer
Lung US for PEEP Optimization in Robotic Radical Prostatectomy or Cystectomy Patients
There is an increasing trend in the use of robotic-assisted radical prostatectomy or cystectomy (RARPC). Preventing lung atelectasis without inducing overdistention of the lung is challenging.
- Conditions
- Prostate Cancer, Urinary Bladder Cancer, Surgery, Positive End Expiratory Pressure
- Trial name
- NCT06307704
- Testing
- Lung Ultrasound - guided Stepwise PEEP, Standard Ventilation Protocol
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Nazmy Edward Seif
Obesity
Deep Breathing With and Without Pressure Support and PEEP for Preoxygenation in Obese Patients
Obese patients are at increased risk of low oxygen levels during the induction of general anesthesia. Preoxygenation with a face mask before anesthesia is routinely used to increase oxygen reserves.
- Trial name
- NCT07380425
- Testing
- Deep Breathing Preoxygenation, Pressure Support Ventilation, Positive End-Expiratory Pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Pamukkale University
Lung Diseases
Comparison of Two Strategies of One-lung Ventilation in Patients Undergoing Carcinological Lung Resection Surgery.
During thoracic surgery, one-lung ventilation (OLV) is associated with hypoxemia, lung injury, and perioperative respiratory complications.
- Trial name
- I-PEEP-THO (NCT05525312)
- Testing
- "Open-lung" protective ventilation strategy, "Standard" protective ventilation strategy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Montpellier
Tricuspid Regurgitation, Mechanical Ventilation Pressure High
Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients
Prospective observational cohort study within the Pediatric Intensive Care Unit (PICU). We will perform point-of-care-ultrasound (POCUS) to quantify tricuspid regurgitant jet velocity (TRJV) on mechanically ventilated (MV)…
- Conditions
- Tricuspid Regurgitation, Mechanical Ventilation Pressure High, Pediatric Respiratory Diseases
- Trial name
- NCT06229886
- Testing
- Application of positive-end-expiratory pressure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Pulmonary Complications, Inflammatory Response
Intraoperative PEEP Optimization: Effects on Postoperative Pulmonary Complications and Inflammatory Response
The purpose of this prospective randomized controlled trial is to determine the effects of intraoperative lung protective mechanical ventilation using an individual optimal PEEP value on postoperative pulmonary complications and…
- Trial name
- NCT02931409
- Testing
- Optimal PEEP, Standard PEEP
- Where
- 2 sites in Hungary
- Volunteers
- 40 people
- Sponsor
- Péterfy Sándor Hospital
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
Personalized Ventilator Settings for Patients on ECMO
While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU
- Trial name
- PEEPECMO (NCT07673250)
- Testing
- Personalized Positive End-Expiratory Pressure (PEEP)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Respiratory Distress Syndrome, Positive-Pressure Respiration
Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung…
- Conditions
- Respiratory Distress Syndrome, Positive-Pressure Respiration, Mechanical Ventilation
- Trial name
- NCT06430554
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Acute Brain Injury, Mechanical Ventilation
Brain Monitoring During PEEP-Based Respiratory Therapy in Critically Ill Patients
Mechanical ventilation is commonly used in critically ill patients with acute brain injury. Positive end-expiratory pressure (PEEP) and lung recruitment maneuvers are important ventilator strategies for improving oxygenation, but…
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Neurocritical Care
- Trial name
- NCT07716787
- Testing
- Recruitment Maneuver, Positive End-Expiratory Pressure Adjustment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shengli Oilfield Hospital
Postoperative Pulmonary Complications (PPCs), Postoperative Atelectasis
Optimal PEEP Level for Minimizing the Risk of Postoperative Atelectasis: A Retrospective Cohort Study Based on Lung Ultrasound Monitoring
Background: After surgery with general anesthesia, it is common for parts of the lungs to collapse, a condition called atelectasis. This can lead to low blood oxygen levels and other lung complications.
- Conditions
- Postoperative Pulmonary Complications (PPCs), Postoperative Atelectasis, Lung Ultrasound
- Trial name
- ULTRASVENT-1 (NCT07211074)
- Where
- Russia
- Volunteers
- 450 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Lung Injury, Acute
Lung Atelectasis Improvement Through Positive End Expiratory Pressure During Anesthetic Induction
Anesthetic induction could lead to lung atelectasis, increase intrapulmonary shunt, and potentially impair oxygenation. The study aimed to validate that a positive end-expiratory pressure (PEEP) of 10 cmH2O could reduce lung…
- Trial name
- NCT06900426
- Testing
- 10 PEEP, ZEEP, 5PEEP
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fudan University
Pulmonary Atelectasis, Postoperative
Ultrasound Evaluation of Preventive Measures for Postoperative Lung Atelectasis After Surgery
the aim of this prospective randomized blinded clinical study will be to assess the ultrasound evaluation of different preventive measures of post operative lung atelectasis in abdominal surgeries; these measures include…
- Trial name
- LUS/PEEP/RM (NCT06654778)
- Testing
- PEEP, PEEP/RM, PEEP/RM/RF
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Postoperative Atelectasis, Ventilator Lung
Ventilator-driven Alveolar Recruitment Maneuver
During laparoscopic surgery, gas infiltration and head down position cause pulmonary atelectasis. Alveolar recruitment maneuvers are beneficial in reopening collapsed alveoli and improving lung mechanics.
- Conditions
- Postoperative Atelectasis, Ventilator Lung, Atelectasis, Recruitment
- Trial name
- NCT04258202
- Testing
- Alveolar recruitment maneuver
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Samsung Medical Center