Clinical trials: Positive End-Expiratory Pressure
Obesity, Postoperative Bariatric Surgery
Lung Ultrasound Evaluation of the Effects of PEEP and Recruitment Strategies Adjusted for Intraoperative Dynamic Compliance on Postoperative Respiratory Complications in Obese Patients Planned for Laparoscopic Surgery
This study aims to investigate the effects of the personalized application of respiratory pressures applied to patients undergoing laparoscopic bariatric surgery when they are connected to a ventilator under general anesthesia…
- Conditions
- Obesity, Postoperative Bariatric Surgery, Laparoscopic Surgery, Individualized PEEP Treatment Strategy
- Trial name
- NCT06994780
- Testing
- dynamic compliance guided PEEP titration
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
General Anesthesia
Determination of Optimal Positive End-expiratory Pressure Using Electrical Impedance Tomography in Children Under General Anesthesia: Comparison Between Supine and Prone Positions
The purpose of this study was to determine the appropriate positive end-expiratory pressure (PEEP) using electrical impedance tomography (EIT) in children under general anesthesia and to investigate whether there is a difference…
- Trial name
- NCT05275309
- Testing
- Exploration of optimal PEEP in supine and prone position
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Seoul National University Hospital
Laparoscopic Surgery, Positive End-Expiratory Pressure
Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients
Abdominal laparoscopy is widely utilized due to its benefits, including minimal invasiveness, improved cosmetic outcomes, and shorter hospital stays.
- Conditions
- Laparoscopic Surgery, Positive End-Expiratory Pressure, Electrical Impedance Tomography
- Trial name
- PEEP-EIT (NCT06850844)
- Testing
- electrical impedance tomography, Conventional Ventilation
- Where
- Vietnam
- Volunteers
- 70 people
- Sponsor
- Nguyen Dang Thu
Gynecologic Cancers
Alveolar Recruitment in Obese Patients in Major Gynaecological Cancer Surgery
In this study, the investigators planned to evaluate the effect of alveolar recruitment strategy primarily on postoperative pulmonary complications in obese patients undergoing lung protective ventilation in major open…
- Trial name
- NCT06619626
- Testing
- alveolar recruitment strategy applied group, group without alveolar recruitment strategy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Intraabdominal Hypertension, Critically Ill
PEEP Levels on Intraabdominal Pressure and Hemodynamics in Critically Ill Patients
In this study, it was aimed to compare the effects of three different PEEP levels (0-4, 5-8, 9-12 cmH2O) on intraabdominal pressure and hemodynamic parameters of patients in intensive care unit.
- Conditions
- Intraabdominal Hypertension, Critically Ill, Hemodynamic Instability
- Trial name
- NCT03714724
- Testing
- Intraabdominal Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Yuzuncu Yil University
Gastric Insufflation, Face-mask Ventilation
Gastric Insufflation During Facemask Ventilation at Different Levels of End-expiratory Pressure in Obese Patients
Gastric insufflation occurs when the inspiratory pressure exceeds the lower esophageal sphincter pressure. Thus, it is desirable to avoid excessive positive pressure during mask ventilation after induction of anesthesia and…
- Conditions
- Gastric Insufflation, Face-mask Ventilation, Obese, Positive End Expiratory Pressure
- Trial name
- NCT05979129
- Testing
- zero PEEP, low PEEP, high PEEP
- Where
- Egypt
- Volunteers
- 162 people
- Sponsor
- Kasr El Aini Hospital
Mechanical Ventilation
Effect of Positive End-expiratory Pressure on Optimal Balloon Volume During Esophageal Pressure Monitoring
Esophageal pressure (PES), which has been used as a surrogate for pleural pressure. The volume of esophageal balloon can influence the accuracy of monitoring esophageal pressure.
- Trial name
- NCT02976844
- Testing
- Positive end-expiratory Pressure
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Capital Medical University
Thoracic Injuries, Non-invasive Ventilation
Optimization of Positive End Expiratory Pressure by Use of Pulmonary Ultrasound for Patients With Blunt Chest Trauma Treated by Non-Invasive Ventilation (Opti-PEP).
This is an open-label, randomized controlled study comparing two non-invasive ventilation initiation strategies.Patients may be included if they present with acute respiratory failure related to blunt chest trauma.The…
- Trial name
- Opti-PEP (NCT06072339)
- Testing
- Lung Ultrasound for PEEP setting, Non invasive ventilation session, Arterial blood gas
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Montpellier
Obesity, Postoperative Pulmonary Complications
Comparison of Standard Versus Dynamic Compliance-Guided Individualized PEEP in Obese Patients Undergoing Spinal Surgery
This study aims to compare standard positive end-expiratory pressure (PEEP) with dynamic compliance-guided individualized PEEP in obese patients undergoing elective spinal surgery under general anesthesia.
- Conditions
- Obesity, Postoperative Pulmonary Complications, Mechanical Ventilation
- Trial name
- NCT07388719
- Testing
- Standard PEEP
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Konya City Hospital
Intracranial Pressure Increase, Mechanical Ventilation Complication
Lung Recruitment and PEEP Effects on Intracranial Pressure in Cranial Surgery
High positive end-expiratory pressure (PEEP) levels required to achieve clinical benefits may increase ICP and reduce cerebral perfusion pressure (CPP) in patients at risk of intracranial hypertension.
- Trial name
- NCT06771232
- Testing
- Subdural pressure measurement
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- University of Chile
Lung Cancer
Effects of Positive End-Expiratory Pressure on Biventricular Function During One-Lung Ventilation
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Wang et al measured intrapulmonary shunt by transesophageal echocardiography.
- Trial name
- NCT02483806
- Testing
- PEEP
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Yonsei University
Obesity
Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation
The main purpose of this study is to define at the bedside the "Titrated-PEEP" level for obese patients that increases the likelihood of extubation and ventilator liberation.
- Trial name
- NCT02492113
- Testing
- Positive end-expiratory pressure (PEEP), ZEEP
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition…
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Positive End-expiratory Pressure (PEEP), Ventilation During Resuscitation
- Trial name
- Lazarus-PEEP (NCT06939335)
- Testing
- Disposable PEEP Valve set at 5 cm H20., Controle
- Where
- 7 sites in Belgium, France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Ghent
Positive End Expiratory Pressure
Titration of Intraoperative PEEP in Patients Undergoing Robotic Assisted Laparoscopic Prostatectomy
Optimal intraoperative positive end expiratory pressure (PEEP) improves the outcome. Optimal PEEP is not only very different among individuals, but each individual's optimal PEEP is affected by positioning, muscle paralysis, and…
- Trial name
- TIPPR (NCT05155371)
- Testing
- Titration of Optimal Positive End-expiratory Pressure
- Where
- 2 sites in China
- Volunteers
- 95 people
- Sponsor
- Fudan University
Spinal Diseases
Effect of PEEP on Intraoperative Hypothermia
Intraoperative hypothermia is associated with many clinical adverse outcomes. Many techniques were applied to prevent intraoperative hypothermia, and positive end-expiratory pressure (PEEP) has been known to blunt intraoperative…
- Trial name
- NCT02416557
- Testing
- PEEP
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Seoul National University Hospital
Intensive Care Ventilation
Pressure Support Ventilation With the Anesthetic Conserving Device
Sevoflurane inhalational anesthetic has got pulmonary effects such as bronchodilatation. These effects could be of interest in intensive care patients ventilated in pressure support ventilation mode.
- Trial name
- NCT01017744
- Testing
- Anesthetic Conserving Device
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Clermont-Ferrand
Respiratory Disease, Artificial Respiration
Non-invasive Assessment of Inspiratory Effort and Tidal Distension During Non-invasive Ventilation (INSPIRE)
The goal of this observational study is to evaluate whether the airway occlusion pressure recorded during a sudden end-expiratory breath-hold (ΔPocc) is correlated with esophageal swing in pressure and the reliability of P0.1…
- Trial name
- INSPIRE (NCT06344234)
- Testing
- End-inspiratory Maneuvers
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Bari
Respiratory Compliance
Exploration of the Appropriate Combination of Positive End Expiratory Pressure and Tidal Volume Using the Intratidal Compliance Volume Profile in Children
In children under 6 years of age undergoing regular surgery during general anesthesia, the intratidal compliance profile is evaluated when different tidal volumes are applied at different positive end expiratory pressures.
- Trial name
- NCT04633720
- Testing
- Changes in positive end-expiratory pressure and tidal volume
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Pneumoperitoneum, Trendelenburg Position
End-expiratory Pressure During Laparoscopic Surgery in the Trendelenburg Position by Electrical Impedance Tomography
Pneumoperitoneum (PNP) and the position of the patient required for laparoscopic surgery lead to pathophysiological changes that complicate anesthesia.
- Conditions
- Pneumoperitoneum, Trendelenburg Position, Laparoscopic Surgery
- Trial name
- CP-EIT (NCT06481124)
- Testing
- electrical impedance tomography
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Acute Respiratory Distress Syndrome
The EVLW for Set the Positive End Expiratory Pressure (PEEP) in the Acute Respiratory Distress Syndrome (ARDS)
ARDS is a severe pathology with high mortality and morbidity.Actual ventilatory management is clear for the set of the tidal volume and for the survey of the plateau pressure for the patients who require mechanical ventilation.
- Trial name
- NCT00714987
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France