Clinical trials: Positive End-expiratory Pressure
Positive Expiratory Pressure, Acute Respiratory Distress Syndrome
Determination of the Best Positive End-expiratory Pressure (PEEP)
Determination of the best positive end-expiratory pressure (PEEP) based on oxygenation or driving pressure in patients with acute respiratory distress syndrome (ARDS) after cardiothoracic surgery The use of a positive…
- Trial name
- DROP (NCT03969407)
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Respiratory Failure
Gas Exchange Derangement Physiopathology in Critically Ill Patients With COVID-19
The study was designed to understand the pathophysiology of gas exchange derangement in critically ill patients with COVID-19. Specifically we will evaluate the effect of 3 different levels of positive end-expiratory pressure…
- Trial name
- NCT05132933
- Testing
- PEEP trial - Electrical Impedance Tomography
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Policlinico Hospital
ARDS, Acute Respiratory Distress Syndrome
A Comparison of Optimal PEEP Determination Guided by EIT and Conventional Protective Ventilation Tool in ARDS Patients
The study of positive end-expiratory pressure(PEEP) in the setting mode has not yet been conclusive. there are several ways to choose the best positive end-expiratory pressure(PEEP) mode for ARDS patients.
- Trial name
- NCT03498807
- Testing
- Ventiltor P/V Loop, Electrical Impedance Tomography
- Where
- Taiwan
- Volunteers
- 87 people
- Sponsor
- Hui-Ju Hsu
Laparoscopic Surgery, Positive End-Expiratory Pressure
Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients
Abdominal laparoscopy is widely utilized due to its benefits, including minimal invasiveness, improved cosmetic outcomes, and shorter hospital stays.
- Conditions
- Laparoscopic Surgery, Positive End-Expiratory Pressure, Electrical Impedance Tomography
- Trial name
- PEEP-EIT (NCT06850844)
- Testing
- electrical impedance tomography, Conventional Ventilation
- Where
- Vietnam
- Volunteers
- 70 people
- Sponsor
- Nguyen Dang Thu
Ventilation Therapy, PEEP, Occult
PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge.
- Conditions
- Ventilation Therapy, PEEP, Occult, CPR, Cardiac Arrest (CA)
- Trial name
- PerAVent (NCT06836830)
- Testing
- PEEP 5 mbar, ZEEP 0 mbar
- Where
- 3 sites in Germany
- Volunteers
- 600 people
- Sponsor
- Muehlenkreiskliniken, MKK
Postoperative Pulmonary Complications, Positive End-expiratory Pressure
Individualized PEEP Titration on Postoperative Pulmonary Complications
This study aims to investigate the effectiveness and safety of implementing a personalized positive end-expiratory pressure (PEEP) management strategy guided by esophageal pressure (Pes), as well as its potential to reduce the…
- Conditions
- Postoperative Pulmonary Complications, Positive End-expiratory Pressure, Elderly, Laparoscopic Surgery
- Trial name
- NCT06150079
- Testing
- Pes-Guided PEEP titration
- Where
- 4 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Zhongshan Hospital
Atelectasis
Minimizing Lung Injury During Laparoscopy in Steep Trendelenburg Position
The investigators hypothesize that the level of PEEP is often suboptimally applied in certain operative conditions, such as in laparoscopy with head down (Trendelenburg) positioning.
- Trial name
- optiPEEP (NCT04900714)
- Testing
- Decremental PEEP, Lung ultrasound score, Blood gas analysis
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Urinary Bladder Neoplasms, Prostatic Neoplasms
Effect of PEEP on Arterial Oxygen Partial Pressure in Elderly Patients With Lithotomy Position Using LMA Supreme™
The purpose of the present study is to compare the effect of PEEP on arterial oxygen partial pressure in elderly patients undergoing urologic surgery using LMA supreme™ in a lithotomy position.
- Trial name
- NCT03390127
- Testing
- PEEP
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Asan Medical Center
Obesity
Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation
The main purpose of this study is to define at the bedside the "Titrated-PEEP" level for obese patients that increases the likelihood of extubation and ventilator liberation.
- Trial name
- NCT02492113
- Testing
- Positive end-expiratory pressure (PEEP), ZEEP
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Lung Injury, Preterm Birth
Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).
Premature babies often need help immediately after birth to open their lungs to air, start breathing and keep their hearts beating.
- Trial name
- POLAR (NCT04372953)
- Testing
- Positive End-Expiratory Pressure (PEEP)
- Where
- 27 sites in United States, Australia and 5 more
- Volunteers
- 906 people
- Sponsor
- Murdoch Childrens Research Institute
ARDS, Human, PEEP, Occult
Effect of Initial Empirical PEEP Setting on the Esophageal Pressure-guided PEEP Titration in ARDS
Esophageal manometry was used as surrogate of pleural pressure to titrate positive end-expiratory pressure (PEEP) in ARDS patients. However, Absolute values of esophageal pressure (Pes) could be affected by the PEEP setting.
- Conditions
- ARDS, Human, PEEP, Occult, Esophageal and Pleural Pressure
- Trial name
- NCT05442073
- Testing
- PEEP adjustment
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Peking Union Medical College Hospital
Acute Respiratory Distress Syndrome
Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS)
ARDS (Acute Respiratory Distress Syndrome) is a condition of severe inflammation and excess fluids in the lungs that impairs their function of oxygen uptake to the point of needing a ventilator (breathing machine) to help them…
- Trial name
- NCT00446706
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Robot-Assisted Radical Prostatectomy
Effect of Control Ventilation, PEEP, and PEEP With ARM in Robot-assisted Radical Prostatectomy
The goal of this clinical trial is to determine whether different ventilatory strategies improve oxygenation and hemodynamic stability in patients undergoing robot-assisted radical prostatectomy under general anesthesia.
- Trial name
- NCT07462689
- Testing
- PEEP group, PEEP + ARM group
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ilsan Cha hospital
Postoperative Respiratory Complication
Driving Pressure During General Anesthesia for Open Abdominal Surgery
The purpose of this international multicenter, patient and outcome-assessor blinded randomized controlled trial is to determine whether the application of an individualized high PEEP strategy, aiming at avoiding an increase in…
- Trial name
- DESIGNATION (NCT03884543)
- Testing
- Individualized high PEEP strategy
- Where
- 22 sites in Germany, Italy and 1 more
- Volunteers
- 1,468 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pulmonary Atelectasis, Obesity, Morbid
Effects of Individualized PEEP Guided by Driving Pressure on Postoperative Atelectasis in Patients With Morbid Obesity
Atelectasis is a common complication in patients undergoing surgery under general anesthesia, particularly in obese patients. Postoperative atelectasis could last for more than 24h and contribute to a variety of other…
- Trial name
- NCT06181279
- Testing
- Individualized PEEP group, Fixed PEEP group
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Yongtao Sun
Supratentorial Neoplasms, Anesthesia, General
Effect of PEEP on Subdural Pressure, Optic Nerve Sheath Diameter, Lung Compliance and Brain Perfusion Pressure
We aim to determine the level of intraoperative PEEP that optimizes lung compliance without causing a rise in subdural pressure and if we can utilize optic nerve sheath diameter measurement as an indicator for ICP while…
- Conditions
- Supratentorial Neoplasms, Anesthesia, General, Optic Nerve
- Trial name
- NCT04316208
- Testing
- PEEP variations
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Positive End-expiratory Pressure, Hemodynamic Variable
Individualized Positive End-Expiratory Pressure (PEEP) on Oxygenation, Hemodynamics, and Early Postoperative Atelectasis in Laparoscopic Bariatric Surgery
The aim of this study is to evaluate the effectiveness of intraoperative individualized positive end-expiratory pressure (PEEPIND) titration, compared to fixed positive end-expiratory pressure of 5 cmH2O, on oxygenation…
- Conditions
- Positive End-expiratory Pressure, Hemodynamic Variable, Postoperative Atelectasis, Laparoscopic Bariatric Surgery
- Trial name
- NCT06115668
- Testing
- Positive end-expiratory pressure 5 (PEEP 5), Individualized positive end-expiratory pressure (PEEPIND)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
ARDS (Acute Respiratory Distress Syndrome)
Titration of Positive End-expiratory Pressure: Comparison Between Manual Thoracic or Abdominal Compression and Electrical Impedance Tomography
Patients with acute respiratory distress syndrome are placed on mechanical ventilation, and the adjustment of ventilator parameters is an important step in their care, in particular positive expiratory pressure, applied at the…
- Trial name
- TICTAC (NCT07623590)
- Testing
- PEEP titrations
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Prostate Cancer
Effects of PEEP on Intracranial and Intraocular Pressure in Robot-assisted Laparoscopic Radical Prostatectomy
To investigate the effects of positive end-expiratory pressure (PEEP) on the intracerebral pressure (ICP) and intraocular pressure (IOP) in patients undergoing robot assisted laparoscopic radical prostatectomy (RALRP)
- Trial name
- NCT03031613
- Testing
- PEEP group, ZEEP group
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
ARDS, Acute Kidney Injury
Mechanical Ventilation-induced Acute Kidney Injury [AKI]
Positive end-expiratory pressure (PEEP) is a fundamental tool in the management of patients with acute respiratory distress syndrome (ARDS). However, there is currently no common criterion for deciding which level of PEEP to use.
- Trial name
- AKI (NCT06638255)
- Testing
- Sequence A involves administering Low PEEP for 12 hours, followed by High PEEP for 12 hours., Sequence B involves setting High PEEP for 12 hours, followed by Low PEEP for 12 hours.
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Pontificia Universidad Catolica de Chile