Clinical trials: Positive End-expiratory Pressure
Anesthesia Induced Atelectasis
Evaluation of the Effect of Lung Recruitment and Positive End- Expiratory Pressure (PEEP) on Anesthesia Induced Atelectasis Using Lung Ultrasound
Atelectasis is a side effect of general anesthesia which can be found in all types of interventions and patients of all ages.1-3 The reported incidence of anesthesia- induced atelectasis in children varies, ranging from 12 to 42%…
- Trial name
- NCT03069157
- Testing
- lung recruitment maneuver
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Obesity, Morbid, Ventilator-Induced Lung Injury
Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon
This is a research study to determine if identifying an optimal level of positive end-expiratory pressure (PEEP) targeted specifically to individualized patient characteristics will shorten the time on the ventilator.
- Conditions
- Obesity, Morbid, Ventilator-Induced Lung Injury, Respiratory Failure
- Trial name
- PROP OPEN (NCT03951064)
- Testing
- Esophageal balloon, Intervention Spontaneous Breathing Trial (SBT) and Extubation, Control Spontaneous Breathing Trial and Extubation
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of North Carolina, Chapel Hill
Transient Tachypnea of the Newborn
Positive End Expiratory Pressure With A T-piece Resuscitator For Near-Term and Term Infants With Respiratory Distress
Evaluating the effect of early application of Continuous positive airway pressure (CPAP) via Neopuff in cases of transient tachypnea of the newborn(TTN) and its role in decreasing the duration and complication of TTN.
- Trial name
- NCT01859533
- Testing
- Neopuff
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Acute Respiratory Failure, High Flow Nasal Cannula
Tracheal Positive Pressure During High Flow Nasal Oxygen Administration in Critically Ill Patients: a Physiologic Study.
High flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation.
- Conditions
- Acute Respiratory Failure, High Flow Nasal Cannula, Critically Ill, Airway Disease
- Trial name
- HPEEP (NCT05467332)
- Testing
- HIGH FLOW NASAL OXYGEN
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Lung-protective Ventilation
Lung-protective Ventilation During Robot-assisted Laparoscopic Radical Cystectomy
Robot-assisted laparoscopic radical cystectomy (RARC) increases the incidence of postoperative complications. We conducted a study to determine the effect of lung-protective ventilation strategy.
- Trial name
- LPV-RARC (NCT03868319)
- Testing
- lung protective ventilation strategy, nonprotective ventilation
- Where
- China
- Volunteers
- 258 people
- Sponsor
- RenJi Hospital
Mechanical Ventilation, Acute Respiratory Distress Syndrome
The Effect of Positive End-Expiratory Pressure on Functional Residual Capacity During Mechanical Ventilation
Although positive end-expiratory pressure (PEEP) has been widely used in mechanical ventilated patients with acute respiratory distress syndrome (ARDS), how to select the "optimal" PEEP is far from consensus.
- Conditions
- Mechanical Ventilation, Acute Respiratory Distress Syndrome, Functional Residual Capacity
- Trial name
- NCT03511651
- Testing
- PEEP
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Mechanical Ventilation
Positive End-expiratory Pressure Effects to Predict Fluid Responsiveness
Volume expansion is one of the main treatments for shock. A test to predict the effectiveness of volume expansion prior to administration would avoid the need for excess treatment if it proves to be unnecessary.PEEP test would be…
- Trial name
- PEEP-TEST (NCT04023786)
- Testing
- PEEP-TEST, The VenArt System
- Where
- 2 sites in France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Resection Surgery, One Lung Ventillation (OLV)
BMI-Adjusted PEEP During One-Lung Ventilation in Thoracic Surgery
One-lung ventilation (OLV) is required during many thoracic surgical procedures and is associated with reduced functional residual capacity, atelectasis, ventilation-perfusion mismatch, hypoxemia, and potentially…
- Conditions
- Pulmonary Resection Surgery, One Lung Ventillation (OLV), General Anesthetic
- Trial name
- SIMPLE-PEEP (NCT07851740)
- Testing
- Fixed PEEP, BMI-adjusted PEEP
- Where
- 4 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Jesús Manuel Nieves Alonso