Clinical trials: Positive End-expiratory Pressure (PEEP)
Acute Respiratory Distress Syndrome (ARDS)
Assessment of the Reproducibility of the Recruitment-to-inflation Ratio (R/I Ratio) Measurement in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a severe lung condition that often requires invasive mechanical ventilation in the intensive care unit.
- Trial name
- RIRR (NCT07666503)
- Where
- 4 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
One Lung Ventilation
Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation
Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial…
- Trial name
- NCT01652612
- Testing
- PEEP
- Where
- South Korea
- Volunteers
- 99 people
- Sponsor
- Yonsei University
Acute Respiratory Failure, High Flow Nasal Cannula
Tracheal Positive Pressure During High Flow Nasal Oxygen Administration in Critically Ill Patients: a Physiologic Study.
High flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation.
- Conditions
- Acute Respiratory Failure, High Flow Nasal Cannula, Critically Ill, Airway Disease
- Trial name
- HPEEP (NCT05467332)
- Testing
- HIGH FLOW NASAL OXYGEN
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Lung-protective Ventilation
Lung-protective Ventilation During Robot-assisted Laparoscopic Radical Cystectomy
Robot-assisted laparoscopic radical cystectomy (RARC) increases the incidence of postoperative complications. We conducted a study to determine the effect of lung-protective ventilation strategy.
- Trial name
- LPV-RARC (NCT03868319)
- Testing
- lung protective ventilation strategy, nonprotective ventilation
- Where
- China
- Volunteers
- 258 people
- Sponsor
- RenJi Hospital
Protective Lung Ventilation Using:, Low Tidal Volume (6-8 mL/kg Predicted Body Weight)
Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study)
The purpose of this study is to compare the influence of a lung protective ventilation with conventional ventilation on postoperative complications following major abdominal surgery.
- Conditions
- Protective Lung Ventilation Using:, Low Tidal Volume (6-8 mL/kg Predicted Body Weight), PEEP of 6-8 cmH2O, Intraoperative RMs
- Trial name
- NCT01282996
- Testing
- Abdominal surgery
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ventilator-free Days
REstricted Versus Liberal Positive End-Expiratory Pressure in Patients Without ARDS
The 'REstricted versus Liberal positive end-expiratory pressure in patients without Acute respiratory distress syndrome' (RELAx) trial is a national multicenter, open randomized controlled trial in ICU patients without ARDS at…
- Trial name
- RELAx (NCT03167580)
- Testing
- restricted PEEP, liberal PEEP
- Where
- 13 sites in Netherlands
- Volunteers
- 980 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Robotic Surgery, Urologic Surgical Procedures
Timing of Recruitment Maneuver in Robotic Prostate Surgery
Robotic prostate surgery is commonly performed under general anesthesia with carbon dioxide pneumoperitoneum and steep Trendelenburg positioning.
- Conditions
- Robotic Surgery, Urologic Surgical Procedures, Postoperative Pulmonary Complications (PPCs), Pulmonary Atelectasis
- Trial name
- ROBPROREC1 (NCT07662642)
- Testing
- Recruitment maneuver after insufflation and Trendelenburg positioning, Recruitment maneuver in the supine position
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Ankara University
Prostate Cancer
Effect of Optimized PEEP on Mechanical Ventilation During Robot Assisted Laparoscopic Prostatectomy
Steep trendelenburg posture or pneumoperitoneum for surgery causes ventilation problems during surgery, so finding a way to overcome is a challenging task for anesthesiologists.
- Trial name
- NCT05669443
- Testing
- conventional PEEP, optimized PEEP
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Gangnam Severance Hospital
Atelectasis
Lung Ultrasound Evaluation of Individualized Versus Standard PEEP on Postoperative Atelectasis in Gynecological Laparoscopy
The purpose of this study is to compare two different airway pressure (PEEP) strategies during gynecological laparoscopic surgery to see which one better prevents lung collapse (atelectasis).
- Trial name
- NCT07602543
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ankara Etlik City Hospital
Obesity
Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation
The main purpose of this study is to define at the bedside the "Titrated-PEEP" level for obese patients that increases the likelihood of extubation and ventilator liberation.
- Trial name
- NCT02492113
- Testing
- Positive end-expiratory pressure (PEEP), ZEEP
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Oxygenation
Obesity, PEEP and Postoperative Oxygenation
A study on overweight patients undergoing anesthesia for laparoscopic surgery. evaluation of positive end-expiratory pressure versus zero positive end-expiratory pressure during awakening on oxygenation in the early postoperative…
- Trial name
- ZAPPAII (NCT04150276)
- Testing
- ZEEP during awakening, PEEP during awakening
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Västmanland
Asthma, Helium
Use of Heliox Associated With PEEP in Patients With Asthma
In patients with obstructive lung disease like asthma aerosol therapy is the most used for drug administration. A order to make better use of aerosolized drugs in asthmatic patients, studies focus on ways to optimize this…
- Conditions
- Asthma, Helium, Oxygen, Positive End-Expiratory Pressure
- Trial name
- NCT01268462
- Testing
- Heliox+PEP, Oxygen+PEP, Heliox
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal de Pernambuco
Anesthesia, Child
Effect of PEEP on Gastric Insufflation During Face Mask Induction of General Anesthesia in Children
The aim of our study is first to assess the effect of different PEEP levels on gastric volume using ultrasonography during induction of general anesthesia in children undergoing elective surgery
- Trial name
- NCT06127173
- Testing
- Positive End Expiratory Pressure PEEP
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Kasr El Aini Hospital
PEEP, Intrinsic, PEEP, Occult
A New Method for Estimating Dynamic Intrinsic PEEP
Dinamic intrinsic PEEP is
- Conditions
- PEEP, Intrinsic, PEEP, Occult, Respiratory Insufficiency
- Trial name
- echoPEEPi (NCT02388282)
- Testing
- diaphragm ecography
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Laparoscopic Cholecystectomy
10cmH2O Peep Application and Cerebral Oxygenation in Laparoscopic Surgery: a Comparative Study With Invos and Foresight Devices
In this study the investigators investigated changes in hemodynamic parameters and cerebral oxygen saturation (rSO2) associated with 10 cmH2O PEEP, which is assumed beneficial for the respiratory functions and oxygenation during…
- Trial name
- NIRS AND PEEP (NCT02071550)
- Testing
- FORESİGHT cerebral oxygen monitor and INVOS cerebral oxygen monitor, FORESIGHT and INVOS monitor
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Turkiye Yuksek Ihtisas Education and Research Hospital
Postoperative Atelectasis, Ventilator Lung
Ventilator-driven Alveolar Recruitment Maneuver
During laparoscopic surgery, gas infiltration and head down position cause pulmonary atelectasis. Alveolar recruitment maneuvers are beneficial in reopening collapsed alveoli and improving lung mechanics.
- Conditions
- Postoperative Atelectasis, Ventilator Lung, Atelectasis, Recruitment
- Trial name
- NCT04258202
- Testing
- Alveolar recruitment maneuver
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Samsung Medical Center
Pulmonary Atelectasis
Atelectasis Formation: Role of Positive Pressure Breathing, Hyperoxia, and Hypobaria
The primary aim of this project is to get further knowledge of the physiology of flight atelectasis and its prevention. We seek to: 1) assess whether low levels of positive pressure breathing can prevent atelectasis formation in…
- Trial name
- NCT03311347
- Testing
- +Gz accelerations and positive pressure breathing
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Positive End-expiratory Pressure (PEEP), Intracranial Pressure
The Effects of Positive End-expiratory Pressure (PEEP) on Optic Nerve Sheath Diameter in Laparoscopic Cholecystectomy
This prospective interventional study will evaluate the effects of applying positive end-expiratory pressure (PEEP) at 10 cmH₂O on optic nerve sheath diameter (ONSD) in patients undergoing elective laparoscopic cholecystectomy…
- Conditions
- Positive End-expiratory Pressure (PEEP), Intracranial Pressure, Optic Nerve Sheath Diameter, Mechanical Ventilation
- Trial name
- PEEPON (NCT06979999)
- Testing
- Positive End-Expiratory Pressure (PEEP)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Nigde Omer Halisdemir University
Traumatic Brain Injury, Mechanical Ventilation Complication
Effects of Positive End-expiratory Pressure on Intracranial Pressure in Patients With Severe Traumatic Brain Injury
The impact of PEEP on ICP was dependent on the difference between elevated CVP levels and baseline ICP levels. ICP would increase once elevated CVP through PEEP adjustment exceeds the baseline ICP.
- Trial name
- PEEP，ICP，CVP (NCT03296293)
- Testing
- PEEP at 5cmH2O, PEEP at 10cmH2O, PEEP at 15cmH2O
- Volunteers
- 38 people
- Sponsor
- Hongpeng Li
Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure
EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS
Acute respiratory distress syndrome (ARDS) remains a serious and often fatal complication in patients following severe trauma or major surgery.
- Conditions
- Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure, Electrical Impedance Tomography, Trauma and Postoperative Pulmonary Insufficiency
- Trial name
- EIT-PEEP-SURG (NCT07313644)
- Testing
- EIT-giuded PEEP, Control
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- Nguyen Dang Thu