Clinical trials: Positive End-expiratory Pressure (PEEP)
Bariatric Surgery Candidate
Ultrasonograpahic Evaluation of Diaphragmatic Functions in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy
Major laparoscopic sleeve gastrectomy surgery requires steep Trendelenburg position with pneumoperitoneum for a long time leading to decrease pulmonary compliance and lung volumes due to cephalic displacement and decrease…
- Trial name
- NCT04130217
- Testing
- addition of positive end expiratory pressure in ventilated patients, addition of positive end expiratory pressure and recruitment maneuver in ventilated patients
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Zagazig University
Apnea
Fraction of Oxygen on Induction of Anesthesia in Infants
Invesetigators evaluated the effect of positive end-expiratory pressure during anaesthesia induction on nonhypoxic apnoea time in infants.
- Trial name
- PEEP (NCT04722276)
- Testing
- positive end expiratory pressure, fraction of inspired oxygen 80%
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Seoul National University Hospital
Hepatectomy
Influence of Moderate Inspired Oxygen Fraction (FiO2) and Protective Ventilation on Postoperative Pulmonary Complication
The purpose of this study is to determine the influence of moderate FiO2 and the lung protective ventilation on postoperative pulmonary complications following hepatic resection surgery.
- Trial name
- NCT02198625
- Testing
- Moderate FiO2 and Protective Lung Ventilation Using
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Fenmei Shi
Acute Respiratory Distress Syndrome
Evaluation of POC Lung Ultrasound Combined With Pressure-volume Curve to Titration Adjust PEEP for ARDS Lung Recruitment
Using lung ultrasound re-aeration score(LUS-RAS) combined with pressure-volume curve(PVC) adjust maintain positive end-expiratory pressure(PEEP) after recruitment maneuver, to achieve real-time adjustment, reduce…
- Trial name
- NCT03076450
- Testing
- Lung Ultrasound, Maximum Oxygenation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Pudong New Area Gongli Hospital
Cardiac Surgery Subjects
Effect of PEEP on Cardiac Function
The purpose of this single-center, prospective study is to evaluate the physiologic effect of changes in PEEP on biventricular mechanics and RV-pulmonary arterial (RV-PA) coupling in adult patients undergoing cardiac surgery.
- Trial name
- NCT07531602
- Testing
- EIT Guided PEEP Trial
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Beth Israel Deaconess Medical Center
ARDS, Acute Respiratory Distress Syndrome
A Comparison of Optimal PEEP Determination Guided by EIT and Conventional Protective Ventilation Tool in ARDS Patients
The study of positive end-expiratory pressure(PEEP) in the setting mode has not yet been conclusive. there are several ways to choose the best positive end-expiratory pressure(PEEP) mode for ARDS patients.
- Trial name
- NCT03498807
- Testing
- Ventiltor P/V Loop, Electrical Impedance Tomography
- Where
- Taiwan
- Volunteers
- 87 people
- Sponsor
- Hui-Ju Hsu
Venous Hemodynamics
Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score
The hemodynamic effects of proning and PEEP may vary depending on pre- existing cardiac function, lung mechanics, and volume status, and the available evidence remains conflicting.
- Trial name
- VeNIVPro (NCT07273617)
- Testing
- application of PEEP: starting PEEP = 15 mbar, application of PEEP: starting PEEP = 0 mbar
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Regional Cerebral Oxygen Saturation
Effect of Different Positive End Expiratory Pressures on Regional Cerebral Oxygen Saturation
The goal of this prospective single-blind randomized clinical trial is to compare the effect of two different positive end expiratory pressure (PEEP) levels on regional cerebral oxygen saturation in patients scheduled for…
- Trial name
- NCT05961917
- Testing
- 5 cmH2O Positive end-expiratory pressure (PEEP), 10 cmH2O Positive end-expiratory pressure (PEEP)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bozyaka Training and Research Hospital
Respiratory System Mechanics, Pneumoperitoneum
Recruitment-to-inflation Ratio to Set Positive End-expiratory Pressure for Laparoscopic/Robotic Surgery: a Multicenter Study
The present investigation is focused to assess the effects of positive end-expiratory pressure (PEEP) on respiratory system compliance in obese patients invasive mechanical ventilation for laparoscopic or robotic surgery with…
- Trial name
- PEEP_LAP1 (NCT05702554)
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera di Perugia
Pediatrics, Fasting Period
Effect of Positive End-expiratory Pressure on Gastic Residual Volume
This study was designed as a prospective observational study.
- Trial name
- NCT06426394
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Duygu Akyol
Respiratory Distress Syndrome, Positive-Pressure Respiration
Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung…
- Conditions
- Respiratory Distress Syndrome, Positive-Pressure Respiration, Mechanical Ventilation
- Trial name
- NCT06430554
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Acute Respiratory Distress Syndrome
Stepwise Positive End Expiratory Pressure Elevation For Lung Recruitment in Acute Respiratory Distress Syndrome (ARDS)
Acute respiratory distress syndrome is a severe lung disease caused by a variety of direct and indirect issues. It is characterized by inflammation of the lung parenchyma leading to impaired gas exchange and persistent hypoxemia.
- Trial name
- NCT01373905
- Testing
- Recruitment maneuver
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- University of Alexandria
Acute Respiratory Distress Syndrome (ARDS)
Effect of Positive End-Expiratory Pressure Titration on Venous Excess Ultrasound Score and Renal Outcomes in Patients With Acute Respiratory Distress Syndrome
This study is a prospective observational cohort study conducted planned to include 40 patients with ARDS to assess the effect of different levels of PEEP titration on VExUS score and renal outcomes in patients with Acute…
- Trial name
- NCT07545252
- Testing
- VExUS score
- Volunteers
- 40 people
- Sponsor
- Fayoum University
Anesthesia
High Versus Low Positive End Expiratory Pressure With Alveolar Recruitment Maneuver in Laparoscopic Bariatric Surgeries
For the patients undergoing laparoscopic bariatric surgery, application of low (PEEP) with frequent alveolar recruitment maneuver could be beneficial and superior to conventional ventilation with a high (PEEP) in improving lung…
- Trial name
- NCT03505632
- Testing
- Recruitment with low PEEP, High PEEP without RM
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Extubation in Intensive Care Unit
EXtubation With SUctioning or With Positive End-Expiratory Pressure in Intensive Care Unit
Extubation in intensive care unit is a risky situation. Its failure is associated with an increase in the duration of mechanical ventilation and high morbidity and mortality.
- Trial name
- EXSUPEEP (NCT05147636)
- Testing
- Extubation with PEEP, Endotracheal Aspiration
- Where
- 11 sites in France
- Volunteers
- 425 people
- Sponsor
- Centre Hospitalier de Bourg en Bresse
Morbid Obesity, Obesity
Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients
Patients with morbid obesity who require a breathing machine (mechanical ventilator) in the Intensive Care Unit (ICU) frequently experience partial lung collapse.
- Conditions
- Morbid Obesity, Obesity, Respiratory Failure, Atelectasis
- Trial name
- NCT07542093
- Volunteers
- 45 people
- Sponsor
- Assiut University
Acute Lung Injury, Acute Respiratory Distress Syndrome
Strategies to Optimize Positive End-expiratory Pressure (PEEP) in Patients With Acute Lung Injury
The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Respiratory Failure
- Trial name
- EIT-PEEP (NCT01326208)
- Testing
- PEEP titration
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bonn
Critically Ill Adult Patients With Difficult Weaning
Pressure Support and Positive End Expiratory Pressure During Spontaneous Breathing Trial
The aim of this study is to assess if a bundle associating pressure support and positive end-expiratory pressure during spontaneous breathing trial and detection by T-piece of patients with high-risk of extubation failure can…
- Trial name
- SBT-ICU (NCT03861117)
- Testing
- Assisted strategy, Non assisted strategy
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Hospices Civils de Lyon
General Anesthesia, Elective Laparoscopic Cholecystectomy
The Effect of Positive End-Expiratory Pressure Levels on Perfusion Index and Neurocognitive Functions in Geriatric Patients
With the increasing geriatric population, age-related physiological changes and common comorbidities increase the risk of surgical and anesthesia-related complications in this patient group.
- Trial name
- NCT07505550
- Testing
- PEEP levels
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Ankara City Hospital Bilkent
Severe Pneumonia
Lung Response to a Higher PEEP During Severe Pneumonia: a CT Study
At their institution, the investigators routinely assess the individual response of mechanically ventilated patients with acute respiratory failure to higher positive end-expiratory pressure (PEEP) by examining changes in lung…
- Trial name
- NCT07112976
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Istituto Clinico Humanitas